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HUE043108T2 - (5,6-dihidro)pirimido[4,5-e]indolizinek - Google Patents

(5,6-dihidro)pirimido[4,5-e]indolizinek

Info

Publication number
HUE043108T2
HUE043108T2 HUE15712912A HUE15712912A HUE043108T2 HU E043108 T2 HUE043108 T2 HU E043108T2 HU E15712912 A HUE15712912 A HU E15712912A HU E15712912 A HUE15712912 A HU E15712912A HU E043108 T2 HUE043108 T2 HU E043108T2
Authority
HU
Hungary
Prior art keywords
indolizines
pyrimido
dihydro
Prior art date
Application number
HUE15712912A
Other languages
English (en)
Inventor
Man Adrianus Petrus Antonius De
Rogier Christian Buijsman
Jan Gerard Sterrenburg
Joost Cornelis Marinus Uitdehaag
Wit Joeri Johannes Petrus De
Guido Jenny Rudolf Zaman
Original Assignee
Netherlands Translational Res Center B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Netherlands Translational Res Center B V filed Critical Netherlands Translational Res Center B V
Publication of HUE043108T2 publication Critical patent/HUE043108T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HUE15712912A 2014-04-07 2015-03-30 (5,6-dihidro)pirimido[4,5-e]indolizinek HUE043108T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14163734 2014-04-07
EP15153207 2015-01-30

Publications (1)

Publication Number Publication Date
HUE043108T2 true HUE043108T2 (hu) 2019-07-29

Family

ID=52774240

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE15712912A HUE043108T2 (hu) 2014-04-07 2015-03-30 (5,6-dihidro)pirimido[4,5-e]indolizinek

Country Status (16)

Country Link
US (3) USRE48974E1 (hu)
EP (1) EP3129374B1 (hu)
JP (1) JP6518690B2 (hu)
KR (1) KR102432420B1 (hu)
CN (1) CN106132963B (hu)
AU (1) AU2015243694B2 (hu)
BR (1) BR112016022342B1 (hu)
CA (1) CA2944610C (hu)
DK (1) DK3129374T3 (hu)
ES (1) ES2716165T3 (hu)
HU (1) HUE043108T2 (hu)
MX (1) MX368767B (hu)
PL (1) PL3129374T3 (hu)
PT (1) PT3129374T (hu)
RU (1) RU2692479C2 (hu)
WO (1) WO2015155042A1 (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX368767B (es) * 2014-04-07 2019-10-15 Netherlands Translational Res Center B V (5,6-dihidro)pirimido[4,5-e]indolizinas.
FI3283642T3 (fi) * 2015-04-17 2024-01-11 Crossfire Oncology Holding B V Prognostisia biomarkkereita ttk-inhibiittorikemoterapiaan
EP3848373A1 (en) * 2016-02-19 2021-07-14 Phoenix Molecular Designs N-(1-((heterocyclyl)methyl)-1h-pyrazol-4-yl)-6-oxo-6,7,8,9- tetrahydropyrido[3',2':4,5]pyrrolo[l,2-a]pyrazine-2-carboxamide derivatives as p90 ribosomal s6 kinase (rsk) inhibitors for treating cancer
CA3026784A1 (en) 2016-06-07 2017-12-14 Jacobio Pharmaceuticals Co., Ltd. Heterocyclic pyrazine derivatives useful as shp2 inhibitors
CN106551938B (zh) * 2016-11-26 2017-11-24 广东安诺药业股份有限公司 一种治疗非酒精性脂肪肝的药物及其应用
DK3601239T3 (da) 2017-03-23 2024-09-30 Jacobio Pharmaceuticals Co Ltd Novel heterocyclic derivatives useful as shp2 inhibitors
CA3241213A1 (en) * 2021-12-15 2023-06-22 Heidi Lane Pharmaceutical combinations for use in the treatment of neoplastic diseases
MX2024007452A (es) * 2021-12-15 2024-07-09 Sillajen Inc Composiciones farmaceuticas que comprenden beta-ciclodextrinas modificadas.
WO2023113478A1 (en) * 2021-12-15 2023-06-22 Sillajen, Inc. Methods of treating neoplastic diseases
AU2023228543A1 (en) * 2022-03-04 2024-08-22 Sillajen, Inc. Pharmaceutical combinations for use in the treatment of neoplastic diseases.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE420879T1 (de) * 2001-09-19 2009-01-15 Aventis Pharma Sa Indolizine als kinaseproteinhemmer
DK1636236T3 (da) 2003-05-22 2013-12-09 Nerviano Medical Sciences Srl Pyrazolo-quinazolin-derivater, en fremgangsmåde til fremstilling deraf, og deres anvendelse som kinase-inhibitorer
US8207180B2 (en) 2006-11-28 2012-06-26 Nerviano Medical Sciences S.R.L. Tricyclic indoles and (4,5-dihydro) indoles
WO2009156315A1 (en) * 2008-06-26 2009-12-30 Nerviano Medical Sciences S.R.L. Pyrazolo-quinazolines
WO2010111406A2 (en) 2009-03-24 2010-09-30 Myriad Pharmaceuticals, Inc. Compounds and therapeutic uses thereof
WO2010125004A1 (en) 2009-04-29 2010-11-04 Nerviano Medical Sciences S.R.L. Cdk inhibitor salts
US8648078B2 (en) 2009-07-29 2014-02-11 Nerviano Medical Sciences S.R.L. PLK inhibitor salts
TW201107329A (en) 2009-07-30 2011-03-01 Oncotherapy Science Inc Fused imidazole derivative having ttk inhibitory action
EP2343297A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
CN103415518A (zh) 2010-12-17 2013-11-27 拜耳知识产权有限责任公司 在过度增殖性病症的治疗中用作mps-1和tkk抑制剂的咪唑并吡嗪
WO2012101032A1 (en) * 2011-01-26 2012-08-02 Nerviano Medical Sciences S.R.L. Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors
CN105658650B (zh) 2013-06-24 2019-01-08 默克专利有限公司 用作卵泡刺激素受体调节剂的咪唑化合物及其用途
MX368767B (es) * 2014-04-07 2019-10-15 Netherlands Translational Res Center B V (5,6-dihidro)pirimido[4,5-e]indolizinas.

Also Published As

Publication number Publication date
US20170096432A1 (en) 2017-04-06
WO2015155042A1 (en) 2015-10-15
AU2015243694B2 (en) 2019-01-17
CN106132963A (zh) 2016-11-16
USRE50082E1 (en) 2024-08-20
US9856258B2 (en) 2018-01-02
ES2716165T3 (es) 2019-06-10
BR112016022342A2 (pt) 2017-08-15
KR20170013866A (ko) 2017-02-07
USRE48974E1 (en) 2022-03-15
RU2016141405A (ru) 2018-05-07
EP3129374B1 (en) 2018-12-19
PT3129374T (pt) 2019-03-25
JP6518690B2 (ja) 2019-05-22
CN106132963B (zh) 2019-08-06
AU2015243694A1 (en) 2016-11-03
RU2692479C2 (ru) 2019-06-25
CA2944610A1 (en) 2015-10-15
KR102432420B1 (ko) 2022-08-17
EP3129374A1 (en) 2017-02-15
CA2944610C (en) 2024-01-09
BR112016022342B1 (pt) 2022-10-04
BR112016022342A8 (pt) 2021-07-20
PL3129374T3 (pl) 2019-07-31
RU2016141405A3 (hu) 2018-10-02
DK3129374T3 (en) 2019-04-08
MX368767B (es) 2019-10-15
JP2017510595A (ja) 2017-04-13
MX2016012997A (es) 2016-12-07

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