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HRP20221263T1 - Ciklički di-nukleotidni spojevi i postupci uporabe - Google Patents

Ciklički di-nukleotidni spojevi i postupci uporabe Download PDF

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Publication number
HRP20221263T1
HRP20221263T1 HRP20221263TT HRP20221263T HRP20221263T1 HR P20221263 T1 HRP20221263 T1 HR P20221263T1 HR P20221263T T HRP20221263T T HR P20221263TT HR P20221263 T HRP20221263 T HR P20221263T HR P20221263 T1 HRP20221263 T1 HR P20221263T1
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HR
Croatia
Prior art keywords
image
pharmaceutically acceptable
acceptable salt
compound according
structure connection
Prior art date
Application number
HRP20221263TT
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English (en)
Inventor
Boyu Zhong
Lijun Sun
Qi Wei
Yuanwei DAI
Chuo Chen
Zhijian Chen
Heping Shi
Original Assignee
Immune Sensor, Llc
The Board Of Regents Of The University Of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Immune Sensor, Llc, The Board Of Regents Of The University Of Texas System filed Critical Immune Sensor, Llc
Publication of HRP20221263T1 publication Critical patent/HRP20221263T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)

Claims (13)

1. Spoj strukture: [image] ili njegova farmaceutski prihvatljiva sol.
2. Spoj strukture: [image] ili njegova farmaceutski prihvatljiva sol.
3. Spoj strukture: [image] ili njegova farmaceutski prihvatljiva sol.
4. Spoj strukture: [image] ili njegova farmaceutski prihvatljiva sol.
5. Spoj strukture: [image] ili njegova farmaceutski prihvatljiva sol.
6. Spoj strukture: [image] ili njegova farmaceutski prihvatljiva sol.
7. Farmaceutski sastav koji sadrži spoj sukladno bilo kojem od patentnih zahtjeva 1-6 u kombinaciji s najmanje jednim terapijskim agensom i jednim ili više prihvatljivih ekscipijenata.
8. Spoj sukladno bilo kojem od patentnih zahtjeva 1-6 za liječenje.
9. Učinkovita količina spoja sukladno bilo kojem od patentnih zahtjeva 1-6 za induciranje ili pojačavanje odgovora imunološkog sustava.
10. Terapeutski učinkovita količina spoja sukladno bilo kojem od zahtjeva 1-6, naznačena time, da je za liječenje raka, ili zarazne bolesti, ili poremećaja imunološkog sustava.
11. Terapeutski učinkovita količina spoja sukladno bilo kojem od zahtjeva 1-6 u kombinaciji s antitijelom imunološke kontrolne točke, zračenjem ili antineoplastičnim sredstvom, za liječenje raka.
12. Imunogena tvar, naznačena time što sadrži antigen ili antigensku tvar i spoj sukladno bilo kojem od zahtjeva 1-6.
13. Imunogena tvar sukladno zahtjevu 12 za liječenje ili prevenciju bolesti, pri čemu se imunogena tvar treba isporučiti pacijentu koji boluje ili je osjetljiv na takvu bolest.
HRP20221263TT 2016-03-18 2017-03-17 Ciklički di-nukleotidni spojevi i postupci uporabe HRP20221263T1 (hr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662310364P 2016-03-18 2016-03-18
US201662355382P 2016-06-28 2016-06-28
US201662396140P 2016-09-17 2016-09-17
PCT/US2017/023093 WO2017161349A1 (en) 2016-03-18 2017-03-17 Cyclic di-nucleotide compounds and methods of use
EP17767683.0A EP3429596B1 (en) 2016-03-18 2017-03-17 Cyclic di-nucleotide compounds and methods of use

Publications (1)

Publication Number Publication Date
HRP20221263T1 true HRP20221263T1 (hr) 2023-03-03

Family

ID=59851227

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20221263TT HRP20221263T1 (hr) 2016-03-18 2017-03-17 Ciklički di-nukleotidni spojevi i postupci uporabe

Country Status (22)

Country Link
US (3) US10519188B2 (hr)
EP (2) EP3692996A1 (hr)
JP (3) JP6980198B2 (hr)
KR (1) KR102530488B1 (hr)
CN (3) CN114230625A (hr)
AU (1) AU2017233068C1 (hr)
BR (1) BR112018068748B1 (hr)
CA (1) CA3017524A1 (hr)
DK (1) DK3429596T3 (hr)
ES (1) ES2929628T3 (hr)
HR (1) HRP20221263T1 (hr)
HU (1) HUE060396T2 (hr)
IL (2) IL280430B2 (hr)
LT (1) LT3429596T (hr)
MA (1) MA43827A (hr)
MX (1) MX2022001755A (hr)
NZ (1) NZ746112A (hr)
PL (1) PL3429596T3 (hr)
PT (1) PT3429596T (hr)
SG (2) SG11201807660QA (hr)
WO (1) WO2017161349A1 (hr)
ZA (1) ZA201806074B (hr)

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