HRP20191929T1 - Liječenje progresivne osificirajuće fibrodisplazije - Google Patents
Liječenje progresivne osificirajuće fibrodisplazije Download PDFInfo
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- HRP20191929T1 HRP20191929T1 HRP20191929TT HRP20191929T HRP20191929T1 HR P20191929 T1 HRP20191929 T1 HR P20191929T1 HR P20191929T T HRP20191929T T HR P20191929TT HR P20191929 T HRP20191929 T HR P20191929T HR P20191929 T1 HRP20191929 T1 HR P20191929T1
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- Prior art keywords
- antibody
- use according
- activin
- seq
- heavy
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Links
- 206010068715 Fibrodysplasia ossificans progressiva Diseases 0.000 title 1
- 108010023082 activin A Proteins 0.000 claims 9
- 239000000488 activin Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000000750 progressive effect Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Claims (10)
1. Antitijelo protiv aktivina A za primjenu u metodi za liječenje progresivne osificirajuće fibrodisplazije (FOP), pri čemu se metoda sastoji od primjene učinkovitog režima antitijela protiv aktivina A kod subjekta koji ima FOP.
2. Antitijelo protiv aktivina A za primjenu prema patentnom zahtjevu 1, naznačeno time, što se antitijelo natječe za vezivanje s antitijelom koje obuhvaća varijabilne regije teškog i lakog lanca SEQ ID NO: 1 i 5.
3. Antitijelo protiv aktivina A za primjenu prema patentnom zahtjevu 1, naznačeno time, što se antitijelo natječe za vezivanje s antitijelom koje obuhvaća varijabilne regije teškog i lakog lanca SEQ ID NO: 9 i 13.
4. Antitijelo protiv aktivina A za primjenu prema patentnom zahtjevu 1, naznačeno time, što se antitijelo natječe za vezivanje sa antitijelom koje obuhvaća varijabilne regije teškog i lakog lanca SEQ ID NO: 18 i 17.
5. Antitijelo protiv aktivina A za primjenu prema patentnom zahtjevu 1, naznačeno time, što antitijelo obuhvaća varijabilne regije teškog i lakog lanca SEQ ID NO: 1 i 5.
6. Antitijelo protiv aktivina A za primjenu prema patentnom zahtjevu 1, naznačeno time, što antitijelo obuhvaća varijabilne regije teškog i lakog lanca SEQ ID NO: 9 i 13.
7. Antitijelo protiv aktivina A za primjenu prema patentnom zahtjevu 1, naznačeno time, što antitijelo obuhvaća varijabilne regije teškog i lakog lanca SEQ ID NO: 18 i 17.
8. Antitijelo protiv aktivina A za primjenu prema patentnom zahtjevu 1, naznačeno time, što je antitijelo kimerno, inaktivirano, humanizirano ili humano antitijelo.
9. Antitijelo protiv aktivina A za primjenu prema patentnom zahtjevu 1, naznačeno time, što je antitijelo netaknuto antitijelo.
10. Antitijelo protiv aktivina A za primjenu prema bilo kojem patentnom zahtjevu od 1 do 5, naznačeno time, što je antitijelo humano kapa IgG1 antitijelo.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462049869P | 2014-09-12 | 2014-09-12 | |
| US201562141775P | 2015-04-01 | 2015-04-01 | |
| EP15775835.0A EP3191512B1 (en) | 2014-09-12 | 2015-09-14 | Treatment of fibrodysplasia ossificans progressiva |
| PCT/US2015/000100 WO2016039796A2 (en) | 2014-09-12 | 2015-09-14 | Treatment of fibrodysplasia ossificans progressiva |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191929T1 true HRP20191929T1 (hr) | 2020-01-10 |
Family
ID=54207748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191929TT HRP20191929T1 (hr) | 2014-09-12 | 2019-10-23 | Liječenje progresivne osificirajuće fibrodisplazije |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US20160075772A1 (hr) |
| EP (2) | EP3191512B1 (hr) |
| JP (1) | JP6560341B2 (hr) |
| KR (1) | KR102564079B1 (hr) |
| CN (1) | CN107106648B (hr) |
| AU (1) | AU2015315829B2 (hr) |
| CA (1) | CA2960950C (hr) |
| CL (2) | CL2017000603A1 (hr) |
| CY (1) | CY1122188T1 (hr) |
| DK (1) | DK3191512T3 (hr) |
| ES (1) | ES2739605T3 (hr) |
| HR (1) | HRP20191929T1 (hr) |
| HU (1) | HUE046558T2 (hr) |
| IL (1) | IL251063B (hr) |
| LT (1) | LT3191512T (hr) |
| MA (1) | MA40621B1 (hr) |
| ME (1) | ME03541B (hr) |
| MX (1) | MX2017003175A (hr) |
| MY (1) | MY179654A (hr) |
| NZ (1) | NZ730773A (hr) |
| PL (1) | PL3191512T3 (hr) |
| PT (1) | PT3191512T (hr) |
| RS (1) | RS59412B1 (hr) |
| SG (2) | SG11201701913SA (hr) |
| SI (1) | SI3191512T1 (hr) |
| TW (1) | TWI688402B (hr) |
| WO (1) | WO2016039796A2 (hr) |
| ZA (1) | ZA201702112B (hr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| MX350355B (es) | 2011-11-14 | 2017-09-04 | Regeneron Pharma | Composiciones y metodos para aumentar la masa muscular y la fuerza muscular antagonizando especificamente gdf8 y/o activina a. |
| TW201920262A (zh) | 2013-07-30 | 2019-06-01 | 美商再生元醫藥公司 | 抗活化素ａ之抗體及其用途 |
| US20160075772A1 (en) | 2014-09-12 | 2016-03-17 | Regeneron Pharmaceuticals, Inc. | Treatment of Fibrodysplasia Ossificans Progressiva |
| AU2016249015B2 (en) | 2015-04-15 | 2022-03-24 | Regeneron Pharmaceuticals, Inc. | Methods of increasing strength and functionality with GDF8 inhibitors |
| KR20180006386A (ko) | 2015-04-22 | 2018-01-17 | 얼라이브젠 유에스에이 인코포레이티드 | 신규한 근육 소모 질환 치료용 하이브리드 ａｃｔｒｉｉｂ 리간드 트랩 단백질 |
| EP3415527A1 (de) | 2017-06-14 | 2018-12-19 | Technische Universität Dresden | Verwendung der extrazellulären domäne des transferrinrezeptor 2 zur diagnostik und behandlung von primär und sekundär sklerosierenden erkrankungen |
| US11248044B2 (en) | 2018-03-01 | 2022-02-15 | Regeneron Pharmaceuticals, Inc. | Methods for altering body composition by administering a GDF8 inhibitor and an Activin A inhibitor |
| SG11202008280TA (en) * | 2018-03-05 | 2020-09-29 | Univ Saitama Medical | Pharmaceutical composition for treating or preventing heterotopic ossification |
| AU2019284762A1 (en) | 2018-06-13 | 2020-11-19 | Regeneron Pharmaceuticals, Inc. | A rodent model of fibrodysplasia ossificans progressiva |
| CN112236166A (zh) | 2018-06-13 | 2021-01-15 | 科马布有限公司 | 用于治疗骨疾病的转铁蛋白受体-2的拮抗剂和激动剂 |
| KR20210086600A (ko) * | 2018-08-02 | 2021-07-08 | 다인 세라퓨틱스, 인크. | 근육 표적화 복합체 및 진행성 골화성 섬유이형성증을 치료하기 위한 그의 용도 |
| EP3830259A4 (en) | 2018-08-02 | 2022-05-04 | Dyne Therapeutics, Inc. | MUSCLE TARGETING COMPLEXES AND THEIR USES FOR THE TREATMENT OF FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY |
| BR112021007660A2 (pt) * | 2018-10-23 | 2021-08-03 | Keros Therapeutics, Inc. | anticorpos alk2 e métodos de uso dos mesmos |
| MX2021007394A (es) * | 2018-12-18 | 2021-07-15 | Regeneron Pharma | Composiciones y metodos para aumentar el peso corporal y la masa muscular magra mediante el uso de antagonistas contra el receptor de leptina, gdf8 y activina a. |
| WO2021142191A1 (en) * | 2020-01-08 | 2021-07-15 | Regeneron Pharmaceuticals, Inc. | Treatment of fibrodysplasia ossificans progressiva |
| WO2021142260A1 (en) * | 2020-01-10 | 2021-07-15 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for modulation of acvr1 |
| CN116322768A (zh) * | 2020-06-18 | 2023-06-23 | 里珍纳龙药品有限公司 | 激活素a抗体调配物和其使用方法 |
| US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
| TW202328190A (zh) * | 2021-09-03 | 2023-07-16 | 大陸商來凱醫藥科技（上海）有限公司 | 抗acvr2a抗體及其用途 |
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