HRP20191341T1 - Protutijela koja vežu ljudski cgrp receptor - Google Patents
Protutijela koja vežu ljudski cgrp receptor Download PDFInfo
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- HRP20191341T1 HRP20191341T1 HRP20191341TT HRP20191341T HRP20191341T1 HR P20191341 T1 HRP20191341 T1 HR P20191341T1 HR P20191341T T HRP20191341T T HR P20191341TT HR P20191341 T HRP20191341 T HR P20191341T HR P20191341 T1 HRP20191341 T1 HR P20191341T1
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- Prior art keywords
- antigen
- binding fragment
- monoclonal antibody
- seq
- antibody
- Prior art date
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- 108010078311 Calcitonin Gene-Related Peptide Receptors Proteins 0.000 title claims 10
- 102000008323 calcitonin gene-related peptide receptor activity proteins Human genes 0.000 title claims 10
- 239000000427 antigen Substances 0.000 claims 18
- 102000036639 antigens Human genes 0.000 claims 18
- 108091007433 antigens Proteins 0.000 claims 18
- 239000012634 fragment Substances 0.000 claims 18
- DNKYDHSONDSTNJ-XJVRLEFXSA-N chembl1910953 Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CN=CN1 DNKYDHSONDSTNJ-XJVRLEFXSA-N 0.000 claims 6
- 102100024654 Calcitonin gene-related peptide type 1 receptor Human genes 0.000 claims 2
- 101000760563 Homo sapiens Calcitonin gene-related peptide type 1 receptor Proteins 0.000 claims 2
- 101000584583 Homo sapiens Receptor activity-modifying protein 1 Proteins 0.000 claims 2
- 102100033770 Alpha-amylase 1C Human genes 0.000 claims 1
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 claims 1
- 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 claims 1
- 208000006561 Cluster Headache Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 101000779871 Homo sapiens Alpha-amylase 1A Proteins 0.000 claims 1
- 101000779870 Homo sapiens Alpha-amylase 1B Proteins 0.000 claims 1
- 101000779869 Homo sapiens Alpha-amylase 1C Proteins 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 208000018912 cluster headache syndrome Diseases 0.000 claims 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 102000050292 human RAMP1 Human genes 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000000159 protein binding assay Methods 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 230000024883 vasodilation Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Pain & Pain Management (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- General Engineering & Computer Science (AREA)
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Claims (11)
1. Monoklonsko protutijelo ili njegov antigen-vezujući fragment koji veže ljudski CGRP receptor, navedeni ljudski CGRP receptor obuhvaća ljudski CRLR polipeptid i ljudski RAMP1 polipeptid,
naznačeno time što se monoklonsko protutijelo ili njegov antigen-vezujući fragment veže za epitop formiran od aminokiselinskih ostataka iz oba polipeptida CRLR i RAMP1, te
pri čemu se monoklonsko protutijelo ili njegov antigen-vezujući fragment natječe za vezanje na ljudski CGRP receptor s referentnim protutijelom, pri čemu navedeno referentno protutijelo sadrži (i) varijabilnu regiju teškog lanca koja sadrži sekvencu odabranu iz skupine koja se sastoji od SEQ ID NOs: 161, 163, 164, 166, i 168; i (ii) varijabilnu regiju laganog lanca koja sadrži sekvencu odabranu iz skupine koja se sastoji od SEQ ID NOs: 140, 143, 146, 148, i 150.
2. Monoklonsko protutijelo ili njegov antigen-vezujući fragment prema patentnom zahtjevu 1, naznačeno time što se monoklonsko protutijelo ili njegov antigen-vezujući fragment specifično veže na ljudski CGRP receptor s KD ≤100 nM kao što je određeno pomoću FACS testa vezanja.
3. Monoklonsko protutijelo ili njegov antigen-vezujući fragment prema patentnom zahtjevu 1, naznačeno time što referentno protutijelo sadrži teški lanac i lagani lanac definiran jednim od sljedećih parova sekvenci:
SEQ ID NO: 32 i SEQ ID NO: 15;
SEQ ID NO: 34 i SEQ ID NO: 18;
SEQ ID NO: 35 i SEQ ID NO: 21;
SEQ ID NO: 37 i SEQ ID NO: 23; i
SEQ ID NO: 39 i SEQ ID NO: 25.
4. Monoklonsko protutijelo ili njegov antigen-vezujući fragment prema patentnom zahtjevu 1, naznačeno time što monoklonsko protutijelo ili njegov antigen-vezujući fragment selektivno inhibira ljudski CGRP receptor u usporedbi s ljudskim AM1, AM2, i AMY1 receptorima s omjerom selektivnosti od 100 ili više kao što je određeno s testom inhibicije cAMP.
5. Monoklonsko protutijelo ili njegov antigen-vezujući fragment prema bilo kojem od patentnih zahtjeva 1 do 4, naznačeno time što je monoklonsko protutijelo ili njegov antigen-vezujući fragment potpuno ljudsko protutijelo, humanizirano protutijelo, kimerno protutijelo, ili njihov fragment koji veže antigen.
6. Monoklonsko protutijelo ili njegov antigen-vezujući fragment prema bilo kojem od patentnih zahtjeva 1 do 4, naznačeno time što monoklonsko protutijelo je protutijelo tipa IgG1, IgG2, IgG3, ili IgG4.
7. Monoklonsko protutijelo ili njegov antigen-vezujući fragment prema bilo kojem od patentnih zahtjeva 1 do 6, naznačeno time što protutijelo ili njegov antigen-vezujući fragment inhibira vezanje CGRP na ljudski CGRP receptor.
8. Monoklonsko protutijelo ili njegov antigen-vezujući fragment prema bilo kojem od patentnih zahtjeva 4 ili 7 naznačeno time što je za uporabu za inhibiciju vazodilatacije kod pacijenta kojem je to potrebno.
9. Monoklonsko protutijelo ili njegov antigen-vezujući fragment prema bilo kojem od patentnih zahtjeva 4 ili 7 naznačeno time što je za uporabu za liječenje stanja povezanog s CGRP receptorom, pri čemu je stanje glavobolja.
10. Monoklonsko protutijelo ili njegov antigen-vezujući fragment prema bilo kojem od patentnih zahtjeva 4 ili 7 naznačeno time što je za uporabu za liječenje stanja povezanog s CGRP receptorom, pri čemu je stanje migrena.
11. Monoklonsko protutijelo ili njegov antigen-vezujući fragment prema bilo kojem od patentnih zahtjeva 4 ili 7 naznačeno time što je za uporabu za liječenje stanja povezanog s CGRP receptorom, pri čemu je stanje cluster glavobolja.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20356908P | 2008-12-23 | 2008-12-23 | |
| US26462209P | 2009-11-25 | 2009-11-25 | |
| EP16199717.6A EP3184546B8 (en) | 2008-12-23 | 2009-12-18 | Human cgrp receptor binding antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20191341T1 true HRP20191341T1 (hr) | 2019-10-18 |
| HRP20191341T8 HRP20191341T8 (hr) | 2020-02-07 |
Family
ID=41718325
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171690TT HRP20171690T1 (hr) | 2008-12-23 | 2017-11-06 | Antitijela koja se vežu za humani cgrp receptor |
| HRP20191341TT HRP20191341T8 (hr) | 2008-12-23 | 2019-07-25 | Protutijela koja vežu ljudski cgrp receptor |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171690TT HRP20171690T1 (hr) | 2008-12-23 | 2017-11-06 | Antitijela koja se vežu za humani cgrp receptor |
Country Status (40)
| Country | Link |
|---|---|
| US (6) | US9102731B2 (hr) |
| EP (3) | EP3569620A1 (hr) |
| JP (5) | JP5761805B2 (hr) |
| KR (4) | KR20180043850A (hr) |
| CN (2) | CN106084045B (hr) |
| AR (1) | AR074857A1 (hr) |
| AU (2) | AU2009330175C1 (hr) |
| BR (2) | BR122020010360B1 (hr) |
| CA (1) | CA2746858C (hr) |
| CL (1) | CL2011001578A1 (hr) |
| CO (1) | CO6400232A2 (hr) |
| CR (1) | CR20110400A (hr) |
| CY (3) | CY1119465T1 (hr) |
| DK (2) | DK2379594T3 (hr) |
| EA (2) | EA201891500A3 (hr) |
| ES (2) | ES2746571T3 (hr) |
| HR (2) | HRP20171690T1 (hr) |
| HU (3) | HUE034506T2 (hr) |
| IL (2) | IL213429A (hr) |
| JO (2) | JO3382B1 (hr) |
| LT (3) | LT2379594T (hr) |
| LU (1) | LUC00095I2 (hr) |
| MA (1) | MA32982B1 (hr) |
| ME (1) | ME03601B (hr) |
| MX (1) | MX2011006804A (hr) |
| MY (1) | MY180564A (hr) |
| NL (1) | NL300961I2 (hr) |
| NO (2) | NO2379594T3 (hr) |
| NZ (2) | NZ606090A (hr) |
| PE (1) | PE20120427A1 (hr) |
| PL (2) | PL2379594T3 (hr) |
| PT (2) | PT2379594T (hr) |
| RS (2) | RS56567B1 (hr) |
| SG (2) | SG172307A1 (hr) |
| SI (2) | SI2379594T1 (hr) |
| TN (1) | TN2011000283A1 (hr) |
| TW (4) | TWI574697B (hr) |
| UA (1) | UA108066C2 (hr) |
| WO (1) | WO2010075238A1 (hr) |
| ZA (1) | ZA201105418B (hr) |
Families Citing this family (112)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2380592T (pt) | 2005-11-14 | 2018-06-06 | Teva Pharmaceuticals Int Gmbh | Anticorpos antagonistas dirigidos contra o péptido relacionado com o gene da calcitonina e métodos utilizando os mesmos |
| EP2220118A2 (en) * | 2007-11-21 | 2010-08-25 | Amgen Inc. | Wise binding antibodies and epitopes |
| JP5537441B2 (ja) | 2008-03-04 | 2014-07-02 | ファイザー・リミテッド | 慢性疼痛を治療する方法 |
| JO3382B1 (ar) * | 2008-12-23 | 2019-03-13 | Amgen Inc | أجسام مضادة ترتبط مع مستقبل cgrp بشري |
| CN102740884A (zh) | 2009-08-28 | 2012-10-17 | 瑞纳神经科学公司 | 通过施用针对降钙素基因相关肽的拮抗性抗体来治疗内脏痛的方法 |
| US9855332B2 (en) | 2011-05-20 | 2018-01-02 | Alderbio Holdings Llc | Use of anti-CGRP antibodies and antibody fragments to treat diarrhea in subjects with diseases or treatments that result in elevated CGRP levels |
| WO2012162243A2 (en) | 2011-05-20 | 2012-11-29 | Alderbio Holdings Llc | Anti-cgrp compositions and use thereof |
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