HRP20180396T1 - Vodeni pripravak koji sadrži bromheksin - Google Patents
Vodeni pripravak koji sadrži bromheksin Download PDFInfo
- Publication number
- HRP20180396T1 HRP20180396T1 HRP20180396TT HRP20180396T HRP20180396T1 HR P20180396 T1 HRP20180396 T1 HR P20180396T1 HR P20180396T T HRP20180396T T HR P20180396TT HR P20180396 T HRP20180396 T HR P20180396T HR P20180396 T1 HRP20180396 T1 HR P20180396T1
- Authority
- HR
- Croatia
- Prior art keywords
- preparation
- amount
- bromhexine
- preparation according
- indicated
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 3
- OJGDCBLYJGHCIH-UHFFFAOYSA-N bromhexine Chemical compound C1CCCCC1N(C)CC1=CC(Br)=CC(Br)=C1N OJGDCBLYJGHCIH-UHFFFAOYSA-N 0.000 title claims 2
- 229960003870 bromhexine Drugs 0.000 title claims 2
- 239000003755 preservative agent Substances 0.000 claims 3
- 206010011224 Cough Diseases 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 239000004267 EU approved acidity regulator Substances 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 239000002518 antifoaming agent Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 238000004040 coloring Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 239000002562 thickening agent Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Claims (8)
1. Vodeni pripravak koji sadrži:
a) bromheksin u količini od 0.04 g do 0.4 g,
b) zgušnjivač u količini od 0.005 g do 5 g,
c) zaslađivač u količini od 0.01 g do 10 g,
d) daljnje prikladne aditive odabrane od konzervansa, regulatora kiselosti, pripravaka protiv pjenjenja, arome i bojila u količini od 0 do 10 g i
e) vodu do 100 ml, naznačen time da pripravak sadrži količinu šećernih alkohola manju od 10 g, bazirano na 100 ml pripravka.
2. Pripravak prema zahtjevu 1, naznačen time da pripravak ima viskoznost u rasponu od 50 mPas do 30 Pas na temperaturi od 20°C.
3. Pripravak u skladu s bilo kojim od prethodnih zahtjeva, naznačen time da sadrži prikladan konzervans.
4. Pripravak prema zahtjevu 3, naznačen time da je konzervans prisutan u količini od 0.01 g do 0.5 g, bazirano na 100 ml pripravka.
5. Pripravak prema bilo kojem od prethodnih zahtjeva, naznačen time da pripravak ima pH u rasponu od 2.0 do 6.0.
6. Pripravak prema bilo kojem od prethodnih zahtjeva, naznačen time da pripravak ima sadržaj vode od najmanje 70 masenih %.
7. Pripravak prema bilo kojem od prethodnih zahtjeva, naznačen time da pripravak je smjesa protiv kašlja ili sirup protiv kašlja.
8. Uporaba pripravka u skladu s bilo kojim od prethodnih zahtjeva naznačena time da je za upotrebu u sekrecijskoj terapiji kod akutnih i kroničnih bronhopulmonalnih poremećaja.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10169236 | 2010-07-12 | ||
| EP11733637.0A EP2593094B1 (de) | 2010-07-12 | 2011-07-07 | Wässrige zusammensetzung enthaltend bromhexin |
| PCT/EP2011/061527 WO2012007352A1 (de) | 2010-07-12 | 2011-07-07 | Wässrige zusammensetzung enthaltend bromhexin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20180396T1 true HRP20180396T1 (hr) | 2018-04-20 |
Family
ID=43063562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20180396TT HRP20180396T1 (hr) | 2010-07-12 | 2018-03-06 | Vodeni pripravak koji sadrži bromheksin |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9220693B2 (hr) |
| EP (1) | EP2593094B1 (hr) |
| JP (1) | JP5979763B2 (hr) |
| KR (1) | KR101943812B1 (hr) |
| CN (1) | CN103052384B (hr) |
| AR (1) | AR082381A1 (hr) |
| AU (1) | AU2011278451B2 (hr) |
| BR (1) | BR112013000537B1 (hr) |
| CA (1) | CA2803471C (hr) |
| CL (1) | CL2012003625A1 (hr) |
| CO (1) | CO6680609A2 (hr) |
| CY (1) | CY1120079T1 (hr) |
| DK (1) | DK2593094T3 (hr) |
| EA (1) | EA025640B1 (hr) |
| EC (1) | ECSP13012384A (hr) |
| ES (1) | ES2661973T3 (hr) |
| HR (1) | HRP20180396T1 (hr) |
| HU (1) | HUE038399T2 (hr) |
| LT (1) | LT2593094T (hr) |
| MX (1) | MX337454B (hr) |
| PE (1) | PE20131063A1 (hr) |
| PL (1) | PL2593094T3 (hr) |
| PT (1) | PT2593094T (hr) |
| SG (1) | SG187016A1 (hr) |
| SI (1) | SI2593094T1 (hr) |
| WO (1) | WO2012007352A1 (hr) |
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Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH085784B2 (ja) | 1987-06-17 | 1996-01-24 | 興和株式会社 | シロツプ剤 |
| US5624906A (en) * | 1994-12-08 | 1997-04-29 | Lever Brothers Company, Division Of Conopco, Inc. | Oral hygiene compositions comprising heteroatom containing alkyl aldonamide compounds |
| WO1997041832A1 (fr) | 1996-05-02 | 1997-11-13 | Taisho Pharmaceutical Co., Ltd. | Suspension de medicament acide difficilement soluble dans l'eau |
| JP3800437B2 (ja) | 1996-07-24 | 2006-07-26 | 大正製薬株式会社 | 苦味が軽減された液剤 |
| JPH10101581A (ja) | 1996-09-26 | 1998-04-21 | Taisho Pharmaceut Co Ltd | 塩酸ブロムヘキシンの安定化製剤及び安定化方法 |
| JPH10306038A (ja) | 1997-05-07 | 1998-11-17 | Taisho Pharmaceut Co Ltd | ブロムヘキシン含有液剤 |
| JP2000281562A (ja) * | 1999-03-30 | 2000-10-10 | Taisho Pharmaceut Co Ltd | ゲル状組成物 |
| JP2001106639A (ja) * | 1999-10-04 | 2001-04-17 | Taisho Pharmaceut Co Ltd | 経口用組成物 |
| EP1121940A1 (en) | 2000-01-31 | 2001-08-08 | New Pharma Research Sweden AB | Pharmaceutical compositions comprising an antibiotic and bromhexine, and process for their preparation |
| JP2002081562A (ja) | 2000-09-05 | 2002-03-22 | Kayaba Ind Co Ltd | リリーフ弁 |
| US6692725B2 (en) * | 2001-02-19 | 2004-02-17 | Daicel Chemical Industries, Ltd. | Composition for oral care |
| US7138133B2 (en) * | 2001-10-10 | 2006-11-21 | The Procter & Gamble Company | Orally administered liquid compositions |
| JP5134802B2 (ja) * | 2005-09-29 | 2013-01-30 | 第一三共ヘルスケア株式会社 | 塩酸ブロムヘキシン含有量低下の防止方法 |
| US10022339B2 (en) * | 2006-04-21 | 2018-07-17 | The Procter & Gamble Company | Compositions and methods useful for treatment of respiratory illness |
| JP2008013542A (ja) * | 2006-06-07 | 2008-01-24 | Daiichi Sankyo Healthcare Co Ltd | 去痰又は気道杯細胞過形成抑制のための医薬組成物 |
| CN100409835C (zh) * | 2007-04-06 | 2008-08-13 | 张嵩 | 含有溴己新盐的组合物及大容量注射剂和注射剂制备方法 |
| KR101025498B1 (ko) * | 2008-05-02 | 2011-03-31 | (주)이엘티사이언스 | 염산브롬헥신 경구용 액제 복합조성물 및 그 제조방법 |
| PL2593094T3 (pl) | 2010-07-12 | 2018-05-30 | Sanofi-Aventis Deutschland Gmbh | Kompozycja wodna zawierająca bromoheksynę |
-
2011
- 2011-07-07 PL PL11733637T patent/PL2593094T3/pl unknown
- 2011-07-07 ES ES11733637.0T patent/ES2661973T3/es active Active
- 2011-07-07 US US13/808,417 patent/US9220693B2/en active Active
- 2011-07-07 CN CN201180033796.5A patent/CN103052384B/zh active Active
- 2011-07-07 HU HUE11733637A patent/HUE038399T2/hu unknown
- 2011-07-07 PE PE2013000041A patent/PE20131063A1/es not_active Application Discontinuation
- 2011-07-07 PT PT117336370T patent/PT2593094T/pt unknown
- 2011-07-07 EA EA201201659A patent/EA025640B1/ru not_active IP Right Cessation
- 2011-07-07 CA CA2803471A patent/CA2803471C/en not_active Expired - Fee Related
- 2011-07-07 AU AU2011278451A patent/AU2011278451B2/en active Active
- 2011-07-07 MX MX2013000417A patent/MX337454B/es active IP Right Grant
- 2011-07-07 LT LTEP11733637.0T patent/LT2593094T/lt unknown
- 2011-07-07 KR KR1020137000722A patent/KR101943812B1/ko active IP Right Grant
- 2011-07-07 JP JP2013519036A patent/JP5979763B2/ja active Active
- 2011-07-07 DK DK11733637.0T patent/DK2593094T3/en active
- 2011-07-07 BR BR112013000537-8A patent/BR112013000537B1/pt active IP Right Grant
- 2011-07-07 EP EP11733637.0A patent/EP2593094B1/de active Active
- 2011-07-07 WO PCT/EP2011/061527 patent/WO2012007352A1/de active Application Filing
- 2011-07-07 SI SI201131443T patent/SI2593094T1/en unknown
- 2011-07-07 SG SG2013002019A patent/SG187016A1/en unknown
- 2011-07-11 AR ARP110102491A patent/AR082381A1/es not_active Application Discontinuation
-
2012
- 2012-12-20 CL CL2012003625A patent/CL2012003625A1/es unknown
-
2013
- 2013-01-11 CO CO13004940A patent/CO6680609A2/es not_active Application Discontinuation
- 2013-01-12 EC ECSP13012384 patent/ECSP13012384A/es unknown
-
2018
- 2018-03-06 HR HRP20180396TT patent/HRP20180396T1/hr unknown
- 2018-03-06 CY CY20181100277T patent/CY1120079T1/el unknown
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