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HRP20161350T1 - Angiogenesis using placental stem cells - Google Patents

Angiogenesis using placental stem cells Download PDF

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Publication number
HRP20161350T1
HRP20161350T1 HRP20161350TT HRP20161350T HRP20161350T1 HR P20161350 T1 HRP20161350 T1 HR P20161350T1 HR P20161350T T HRP20161350T T HR P20161350TT HR P20161350 T HRP20161350 T HR P20161350T HR P20161350 T1 HRP20161350 T1 HR P20161350T1
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HR
Croatia
Prior art keywords
placenta
adherent cells
population
derived
use according
Prior art date
Application number
HRP20161350TT
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Croatian (hr)
Inventor
Stewart Abbot
James Edinger
Aleksander Francki
Robert J. Hariri
Vladimir Jankovic
Aleksandr Kaplunovsky
Kristen Labazzo
Eric Law
Neerav Padliya
Jennifer Paredes
Jia-Lun Wang
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Anthrogenesis Corporation
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44761079&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20161350(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Anthrogenesis Corporation filed Critical Anthrogenesis Corporation
Publication of HRP20161350T1 publication Critical patent/HRP20161350T1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3808—Endothelial cells
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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Claims (10)

1. Populacija adherentnih stanica dobivenih iz placente koje su CD10+, CD34-, CD105+, i CD200+, kako je određeno citometrijom, za uporabu u postupku liječenja pojedinca koji ima bolest ili poremećaj cirkulatornog sustava, gdje je ta bolest ili poremećaj cirkulatornog sustava periferna vaskularna bolest, periferna arterijska bolest, dijabetički čir ili kritična ishemija udova.1. A population of placenta-derived adherent cells that are CD10+, CD34-, CD105+, and CD200+, as determined by cytometry, for use in a method of treating an individual having a disease or disorder of the circulatory system, wherein said disease or disorder of the circulatory system is peripheral vascular disease , peripheral arterial disease, diabetic ulcer or critical limb ischemia. 2. Populacija adherentnih stanica dobivenih iz placente za uporabu prema zahtjevu 1, gdje je ta bolest ili poremećaj cirkulatornog sustava periferna vaskularna bolest.2. A population of adherent cells derived from the placenta for use according to claim 1, wherein said disease or disorder of the circulatory system is peripheral vascular disease. 3. Populacija adherentnih stanica dobivenih iz placente za uporabu prema zahtjevu 1, gdje je ta bolest ili poremećaj cirkulatornog sustava periferna arterijska bolest.3. A population of adherent cells derived from the placenta for use according to claim 1, wherein said disease or disorder of the circulatory system is peripheral arterial disease. 4. Populacija adherentnih stanica dobivenih iz placente za uporabu prema zahtjevu 1, gdje je ta bolest ili poremećaj cirkulatornog sustava kritična ishemija udova.4. A population of adherent cells derived from the placenta for use according to claim 1, wherein said disease or disorder of the circulatory system is critical limb ischemia. 5. Populacija adherentnih stanica dobivenih iz placente za uporabu prema zahtjevu 2, gdje su simptom navedene periferne vaskularne bolesti hladna stopala s osjećajem trnjenja i koja pocrvene kada se objese; bol; ili slabost i umor u nogama.5. A population of adherent cells derived from the placenta for use according to claim 2, wherein the symptom of said peripheral vascular disease is cold, tingling feet that turn red when hung up; pain; or weakness and fatigue in the legs. 6. Populacija adherentnih stanica dobivenih iz placente za uporabu prema zahtjevu 4, gdje je simptom navedene kritične ishemije udova ishemijska bol u mirovanju; teška bol u nogama i stopalima dok se pojedinac ne kreće; rane na stopalima ili nogama koje ne zacjeljuju; bol ili utrnulost stopala; sjajna, glatka, suha koža nogu ili stopala; zadebljanje noktiju na nožnim prstima; odsutnost ili smanjenje pulsa u nogama ili stopalima; otvorene rane; kožne infekcije ili čirevi koji ne zacjeljuju; ili suha gangrena nogu ili stopala.6. A population of adherent cells derived from the placenta for use according to claim 4, wherein the symptom of said critical limb ischemia is ischemic pain at rest; severe pain in the legs and feet until the individual moves; sores on the feet or legs that do not heal; foot pain or numbness; shiny, smooth, dry skin on the legs or feet; thickening of toenails; absence or reduction of pulse in the legs or feet; open wounds; skin infections or ulcers that do not heal; or dry gangrene of the legs or feet. 7. Populacija adherentnih stanica dobivenih iz placente za uporabu prema zahtjevu 1, gdje su adherentne stanice dobivene iz placente dodatno jedna ili više od CD45-, ili CD90+, kako je određeno citometrijom.7. A population of adherent cells derived from the placenta for use according to claim 1, wherein the adherent cells derived from the placenta are additionally one or more of CD45-, or CD90+, as determined by cytometry. 8. Populacija adherentnih stanica dobivenih iz placente za uporabu prema zahtjevu 1, gdje su adherentne stanice dobivene iz placente dodatno OCT-4+, kako je određeno s RT-PCR.8. A population of placenta-derived adherent cells for use according to claim 1, wherein the placenta-derived adherent cells are additionally OCT-4+, as determined by RT-PCR. 9. Populacija adherentnih stanica dobivenih iz placente za uporabu prema bilo kojem od zahtjeva 1 do 8, gdje se te adherentne stanice dobivene iz placente primjenjuju intravenski, intraarterijski, intramuskularno, intradermalno ili subkutano.9. A population of placenta-derived adherent cells for use according to any one of claims 1 to 8, wherein said placenta-derived adherent cells are administered intravenously, intra-arterially, intramuscularly, intradermally or subcutaneously. 10. Populacija adherentnih stanica dobivenih iz placente za uporabu prema bilo kojem od zahtjeva 1 do 9, gdje se primjenjuje oko 1 x 105, 5 x 105, 1 x 106, 5 x 106, 1 x 107, 5 x 107, 1 x 108, 5 x 108, 1 x 109, 5 x 109, ili 1 x 1010 tih adherentnih stanica dobivenih iz placente.10. A population of adherent cells derived from the placenta for use according to any one of claims 1 to 9, wherein about 1 x 105, 5 x 105, 1 x 106, 5 x 106, 1 x 107, 5 x 107, 1 x 108 is administered. , 5 x 108, 1 x 109, 5 x 109, or 1 x 1010 of these placenta-derived adherent cells.
HRP20161350TT 2010-04-07 2016-10-17 Angiogenesis using placental stem cells HRP20161350T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32182210P 2010-04-07 2010-04-07
PCT/US2011/031335 WO2011127117A1 (en) 2010-04-07 2011-04-06 Angiogenesis using placental stem cells
EP11766619.8A EP2556145B1 (en) 2010-04-07 2011-04-06 Angiogenesis using placental stem cells

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HRP20161350T1 true HRP20161350T1 (en) 2016-12-16

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JP (5) JP6097684B2 (en)
KR (7) KR20230054905A (en)
CN (2) CN107699541A (en)
AR (2) AR081166A1 (en)
AU (1) AU2011237747B2 (en)
CA (1) CA2795518C (en)
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HR (1) HRP20161350T1 (en)
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