Nothing Special   »   [go: up one dir, main page]

HK61677A - Triazolobenzodiazepine derivatives - Google Patents

Triazolobenzodiazepine derivatives

Info

Publication number
HK61677A
HK61677A HK616/77A HK61677A HK61677A HK 61677 A HK61677 A HK 61677A HK 616/77 A HK616/77 A HK 616/77A HK 61677 A HK61677 A HK 61677A HK 61677 A HK61677 A HK 61677A
Authority
HK
Hong Kong
Prior art keywords
triazolobenzodiazepine
derivatives
triazolobenzodiazepine derivatives
Prior art date
Application number
HK616/77A
Other languages
English (en)
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27123060&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK61677(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of HK61677A publication Critical patent/HK61677A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Fodder In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
HK616/77A 1969-03-17 1977-12-15 Triazolobenzodiazepine derivatives HK61677A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80793369A 1969-03-17 1969-03-17
US04/872,394 US3987052A (en) 1969-03-17 1969-10-29 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines

Publications (1)

Publication Number Publication Date
HK61677A true HK61677A (en) 1977-12-23

Family

ID=27123060

Family Applications (1)

Application Number Title Priority Date Filing Date
HK616/77A HK61677A (en) 1969-03-17 1977-12-15 Triazolobenzodiazepine derivatives

Country Status (18)

Country Link
US (1) US3987052A (pl)
JP (1) JPS4940239B1 (pl)
AU (2) AU490626B2 (pl)
BE (1) BE747493A (pl)
BR (1) BR7017488D0 (pl)
CH (1) CH535788A (pl)
DE (1) DE2012190C3 (pl)
ES (1) ES376689A1 (pl)
FR (1) FR2034999A1 (pl)
GB (1) GB1291631A (pl)
HK (1) HK61677A (pl)
IL (1) IL33859A (pl)
NL (2) NL172510C (pl)
OA (1) OA03446A (pl)
PH (1) PH9329A (pl)
PL (1) PL80541B1 (pl)
SE (1) SE387641B (pl)
YU (1) YU35139B (pl)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE779988R (fr) * 1969-03-17 1972-08-29 Upjohn Co Nouvelles 6-phenyl-4h-s-triazolo(4,3-a)(1,4)- benzodiazepines douees d'activite pharmacologique et leur procede de
BE758921A (fr) * 1969-11-15 1971-04-16 Takeda Chemical Industries Ltd Derives de benzodiazepine
BE759099A (fr) * 1969-11-18 1971-04-30 Takeda Chemical Industries Ltd Procede de fabrication de composes heterocycliques
YU34997B (en) * 1970-03-27 1980-06-30 Hiroyuki Tawada Process for preparing benzodiazepine derivatives
DE2156472A1 (de) * 1970-11-23 1972-05-31 Ciba-Geigy Ag, Basel (Schweiz) Verfahren zur Herstellung von neuen Diazepinderivaten
CH544764A (de) * 1971-01-21 1974-01-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen Triazolo-benzodiazepinderivaten
US3709898A (en) * 1971-02-09 1973-01-09 Upjohn Co Process for the production of triazolobenzodiazepines and intermediates
DE2164778C2 (de) * 1971-03-03 1984-07-05 The Upjohn Co., Kalamazoo, Mich. 6-(o-Chlorphenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepin und dieses enthaltende pharmazeutische Präparat
YU36376B (en) * 1971-03-03 1983-06-30 Upjohn Co Process for producing dihalo-6-phenyltriazolobenzodiazepine-5-n-oxide
DE2164777A1 (de) * 1971-03-03 1972-09-07 Upjohn Co 8-Nitro-6-(o-halogenphenyl)-l-methyl-4H-s-triazolo eckige Klammer auf 4,3-a eckige Klammer zu-eckige Klammer auf 1-4 eckige Klammer zu benzodiazepine und diese enthaltende pharmazeutische Präparate
CH545302A (de) * 1971-04-08 1974-01-13 Ciba Geigy Ag Verfahren zur Herstellung von neuen Triazolo-benzodiazepinderivaten
GB1331015A (en) * 1971-04-28 1973-09-19 Upjohn Co 1-substituted-6-phenyl-4h-s-triazolo-4,3-a-1,4-benzodiazepines
US3709899A (en) 1971-04-28 1973-01-09 Upjohn Co 6-phenyl-4h-s-triazolo(4,3-a)(1,4)benzodiazepines and their production
US4141902A (en) 1971-04-28 1979-02-27 The Upjohn Company 1-Halomethyl-6-phenyl-4H-s-[4,3-a][1,4]benzodiazepines
US3759943A (en) * 1971-04-28 1973-09-18 Upjohn Co Amido and amino triazolo benzodiazepines
GB1323277A (en) * 1971-05-10 1973-07-11 Upjohn Co Triazolobenzodiazepines
US3734922A (en) * 1971-05-11 1973-05-22 Upjohn Co Certain 4h-s-triazolo(4,3-a)(1,4)benzodiazepines
US4000289A (en) * 1971-07-08 1976-12-28 The Upjohn Company Animal feed and process
BE787251A (fr) * 1971-08-04 1973-02-05 Upjohn Co Nouvelles benzodiazepines et leur preparation
US3870793A (en) * 1971-08-09 1975-03-11 Upjohn Co Animal feed and process
GB1373300A (en) * 1971-09-08 1974-11-06 Upjohn Co Triazolobenzodiazepines and the manufacture thereof
GB1381158A (en) * 1971-09-13 1975-01-22 Upjohn Co Benzodiazepines and the manufacture thereof
US3767661A (en) * 1971-09-13 1973-10-23 Upjohn Co 4h-s-triazolo(4,3-a)(1,4)benzodiazepines
US3714178A (en) * 1971-09-30 1973-01-30 Upjohn Co 6,7-DIHYDRO-7-ALKYL-5H-1,2,4-TRIAZOLO[4,3-d][1,4]BENZODIAZEPINES AND THEIR PRODUCTION
BE790838A (fr) * 1971-11-02 1973-04-30 Upjohn Co Nouvelles 1-aminophenyl-6-phenyl-s-triazolo (4,3-a) (1,4)- benzodiazepines, leur procede de preparation et medicament les contenant
FI53821C (fi) * 1971-11-15 1978-08-10 Ciba Geigy Ag Foerfarande foer framstaellning av farmakologiskt vaerdefull 6-fenyl-8-klor-4h-s-triazolo(4 3-a)(1 4)bensodiazepin-1-metanol
FR2128552A2 (en) * 1972-03-02 1972-10-20 Upjohn Co S-triazolo (4,3-a) (1,4) benzodiazepines - as anxiolytic agents, muscle relaxants
CH572056A5 (pl) * 1972-11-28 1976-01-30 Ciba Geigy Ag
CH579083A5 (pl) * 1972-12-29 1976-08-31 Ciba Geigy Ag
US4978753A (en) * 1973-01-15 1990-12-18 The Upjohn Company 7-phenylpyrimido[1,2-alpha][1,4]benzodiazepin-3(5H)-ones
US4082761A (en) * 1973-09-04 1978-04-04 The Upjohn Company Triazolo[4,3-a][1,4]benzodiazepinium quaternary salts
US4169150A (en) * 1975-11-12 1979-09-25 Teijin Limited Benzodiazepine derivatives and pharmaceutical compositions containing said derivatives
US4431589A (en) * 1980-12-11 1984-02-14 Lilly House Benzodiazepine compounds and their use as pharmaceuticals
US4375473A (en) * 1982-01-04 1983-03-01 The Upjohn Company Method
US4455307A (en) * 1982-01-04 1984-06-19 The Upjohn Company Antihypertensive use of triazolobenzodiazepines
US4508726A (en) * 1982-09-16 1985-04-02 The Upjohn Company Treatment of panic disorders with alprazolam
US4481208A (en) * 1983-06-06 1984-11-06 The Upjohn Company Treatment of panic disorders with estazolam
DE3332830A1 (de) * 1982-09-16 1984-03-22 The Upjohn Co., 49001 Kalamazoo, Mich. Verwendung von benzodiazepinen zur bekaempfung oder bei der behandlung von panikzustaenden
US4514407A (en) * 1983-03-17 1985-04-30 The Upjohn Company 1-Ethanamine-triazolo-benzodiazepines as diuretics
US4689413A (en) * 1983-03-17 1987-08-25 The Upjohn Company Triazolo-benzodiazepine-1-ethanamines as diuretics
US4474699A (en) * 1983-05-25 1984-10-02 The Upjohn Company Preparing 1-aminomethyl-6-substituted-4H-s-triazolo[4,3-a][1,4]benzodiazepines in improved procedures
US4588721A (en) * 1983-09-12 1986-05-13 The Upjohn Company Treatment of negative symptoms of schizophrenia
US4547499A (en) * 1984-05-10 1985-10-15 The Upjohn Company 2,4-Dihydro-2(omega-aminoalkyl)-1H-[1,2,4]triazolo[3,4-c]benzoxazin-1-one anti-allergy drug compounds, compositions and use
US4634703A (en) * 1985-10-25 1987-01-06 Bristol-Myers Company Method for alleviation of panic disorders
US4959361A (en) * 1987-12-18 1990-09-25 Hoffmann-La Roche Inc. Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
US5334592A (en) * 1988-04-27 1994-08-02 Schering Corporation Certain PAF antagonist antihistamine combinations and methods
US4856303A (en) * 1988-07-21 1989-08-15 Whirlpool Corporation Agitator thrust spacer for automatic washer
US5225198A (en) * 1991-08-27 1993-07-06 Cygnus Therapeutic Systems Transdermal administration of short or intermediate half-life benzodiazepines
US5900250A (en) * 1992-05-13 1999-05-04 Alza Corporation Monoglyceride/lactate ester permeation enhancer for oxybutnin
CA2165802A1 (en) * 1993-09-29 1995-04-06 Eun Soo Lee Monoglyceride/lactate ester permeation enhancer for oxybutynin
EP1100508B8 (en) 1998-06-09 2004-01-07 Takeda Chemical Industries, Ltd. Pharmaceutical combination comprising a tricyclic compound and at least one of zolpidem, zopiclone and brotizolam for treating or preventing sleep disorders
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US6737042B2 (en) 2001-05-24 2004-05-18 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
US20040234916A1 (en) 2003-05-21 2004-11-25 Alexza Molecular Delivery Corporation Optically ignited or electrically ignited self-contained heating unit and drug-supply unit employing same
US20050260268A1 (en) * 2003-09-26 2005-11-24 Modi Nishit B Methods and dosage forms for controlled delivery of alprazolam
US20050163843A1 (en) * 2003-12-31 2005-07-28 Garth Boehm Alprazolam formulations
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US7581540B2 (en) 2004-08-12 2009-09-01 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
WO2007010369A2 (en) * 2005-07-22 2007-01-25 Emcure Pharmaceuticals Limited Sustained release formulation of alprazolam
US20070087055A1 (en) * 2005-10-14 2007-04-19 David Jan Directly compressible extended release alprazolam formulation
US20070218135A1 (en) * 2006-03-14 2007-09-20 Glenmark Pharmaceuticals Limited Sustained release matrix pharmaceutical composition
EP2121088B1 (en) 2007-03-09 2016-07-13 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
US8530463B2 (en) * 2007-05-07 2013-09-10 Hale Biopharma Ventures Llc Multimodal particulate formulations
US8106189B2 (en) * 2007-10-03 2012-01-31 Centaur Chemicals Pvt Ltd Process for preparation of triazol-benzodiazepine derivatives
EP2087893B1 (en) 2008-02-05 2013-02-13 Laboratorios Bagó S.A. Compositions comprising alprazolam for treating primary insomnia and insomnia associated with anxiety states and processes for preparing them
JP5613657B2 (ja) 2008-03-28 2014-10-29 ヘイル バイオファーマ ベンチャーズ，エルエルシー ベンゾジアゼピン組成物の投与
US10289671B2 (en) * 2008-05-07 2019-05-14 Microsoft Technology Licensing, Llc Graphically displaying selected data sources within a grid
WO2010074753A1 (en) 2008-12-23 2010-07-01 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
DK2720699T3 (en) 2011-06-14 2018-08-20 Hale Biopharma Ventures Llc ADMINISTRATION OF BENZODIAZEPINE
JP7139323B2 (ja) 2016-11-01 2022-09-20 エフ．ホフマン－ラ ロシュ アーゲー Ｃｎｓ関連疾患を処置するための１，３－ジヒドロ－１，４－ベンゾジアゼピン－２－チオン
JP7379154B2 (ja) 2016-12-09 2023-11-14 アレクザ・ファーマシューティカルズ・インコーポレイテッド てんかんを処置する方法
CN109748922B (zh) * 2019-01-15 2020-04-14 山东安信制药有限公司 一种阿普唑仑i晶型的制备方法
CA3167543A1 (en) 2020-03-31 2021-10-07 F. Hoffmann-La Roche Ag Benzodiazepine derivatives as gaba a gamma1 pams
EP3901155A1 (en) * 2020-04-20 2021-10-27 F. Hoffmann-La Roche AG New benzodiazepine derivatives as gaba a gamma1 pam

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2891862A (en) * 1956-11-06 1959-06-23 Eastman Kodak Co Stabilized photographic silver halide emulsions
BE634438A (pl) * 1962-07-10
US3523947A (en) * 1966-11-23 1970-08-11 Hoffmann La Roche 1-cyclic amidine-5-aryl-1,4-benzodiazepine and process

Also Published As

Publication number Publication date
ES376689A1 (es) 1972-05-01
AU490626B2 (en) 1975-12-18
DE2012190B2 (de) 1980-03-06
NL170857C (nl) 1983-01-03
IL33859A0 (en) 1970-04-20
YU34570A (en) 1979-04-30
SE387641B (sv) 1976-09-13
GB1291631A (en) 1972-10-04
DE2012190A1 (de) 1970-09-24
JPS4940239B1 (pl) 1974-10-31
YU35139B (en) 1980-09-25
AU8549975A (en) 1975-12-18
OA03446A (fr) 1971-03-30
US3987052A (en) 1976-10-19
AU491139B2 (en) 1975-12-18
BR7017488D0 (pt) 1973-02-13
NL172510C (nl) 1983-09-16
IL33859A (en) 1973-01-30
PL80541B1 (pl) 1975-08-30
NL8100081A (nl) 1981-04-29
NL170857B (nl) 1982-08-02
NL7003750A (nl) 1970-09-21
CH535788A (de) 1973-04-15
FR2034999B1 (pl) 1973-07-13
AU8550075A (en) 1975-12-18
FR2034999A1 (fr) 1970-12-18
NL172510B (nl) 1983-04-18
DE2012190C3 (de) 1980-11-13
PH9329A (en) 1975-09-23
BE747493A (fr) 1970-09-17

Similar Documents

Publication Publication Date Title
HK61677A (en) Triazolobenzodiazepine derivatives
YU275170A (en) Brodska utovarna rampa
KE2582A (en) Alkanolaminie derivatives
YU33146B (en) Klizni zatvarac
YU31788B (en) Slemenjak
HK52076A (en) Nitrofuryl-pyrazolopyrimidinones
IL34685A (en) Dibenzodioxocine derivatives
IL34691A0 (en) Benzoyl-haloalkanesulfonanilides
IE34288L (en) Benzomorphanes
ZA704414B (en) Phenylaminoethanol derivatives
PH9290A (en) Tetrahydrocyclopropadibenzazepine derivatives
YU191670A (en) Poboljsani transmisioni mehanizam
CS13780A2 (en) Zpusob deformovani protahleho clenu
MY7500239A (en) Indenopyridine derivatives
ZA704674B (en) Nitrofuryl-aminoalkoxy-pyrimidines
HU171745B (hu) Duplicating machine
ZA707765B (en) New hydrazinecarbodithioate derivatives
IL34756A0 (en) N-phenacylcarbamates
ZA705176B (en) Hydroxyisoquinuclidine derivatives
ZA704094B (en) 2-hydroxy-5-benzamide derivatives
ZA704013B (en) Benzoisothiazol derivatives
CS153063B2 (en) Zpusob vyroby fenoxypropanolaminu
AU7332074A (en) Indenopyridine derivatives
ZA705161B (en) Pyrimidinylpyrazole derivatives
IL35307A0 (en) Pyrazolophthalazine derivatives