HK1224180A1 - 用於治療肌肉萎縮、肌無力和/或惡病質的方法和組合物 - Google Patents
用於治療肌肉萎縮、肌無力和/或惡病質的方法和組合物Info
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- HK1224180A1 HK1224180A1 HK16112393.0A HK16112393A HK1224180A1 HK 1224180 A1 HK1224180 A1 HK 1224180A1 HK 16112393 A HK16112393 A HK 16112393A HK 1224180 A1 HK1224180 A1 HK 1224180A1
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- Prior art keywords
- muscle
- cachexia
- compositions
- treatment
- methods
- Prior art date
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
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- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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- A61K31/16—Amides, e.g. hydroxamic acids
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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US201361847778P | 2013-07-18 | 2013-07-18 | |
PCT/US2014/047325 WO2015010107A1 (en) | 2013-07-18 | 2014-07-18 | Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia |
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HK1224180A1 true HK1224180A1 (zh) | 2017-08-18 |
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EP (2) | EP4082538B1 (zh) |
AU (2) | AU2014290368B2 (zh) |
CA (1) | CA2918071C (zh) |
ES (2) | ES2934319T3 (zh) |
HK (1) | HK1224180A1 (zh) |
WO (1) | WO2015010107A1 (zh) |
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EP4082538B1 (en) | 2013-07-18 | 2024-02-14 | Baylor College of Medicine | Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia |
EP3021839B1 (en) | 2013-07-18 | 2021-06-23 | Baylor College Of Medicine | Compositions for treatment of fibrosis |
CN109705045B (zh) * | 2017-10-25 | 2020-07-14 | 中国医科大学 | 嘧啶类抗肿瘤化合物及其制备方法和应用 |
US11452704B2 (en) | 2017-11-30 | 2022-09-27 | University Of South Florida | Prevention and treatment of muscle wasting with ketone supplementation |
EP3773537B1 (en) | 2018-04-19 | 2022-03-23 | Tvardi Therapeutics, Inc. | Stat3 inhibitors |
US11026905B2 (en) | 2018-04-19 | 2021-06-08 | Tvardi Therapeutics, Inc. | STAT3 inhibitors |
AU2020334194A1 (en) * | 2019-08-16 | 2022-02-24 | Volker Adams | Compounds suitable for the treatment and prophylaxis of muscle wasting and other conditions |
EP4442319A2 (en) * | 2019-12-23 | 2024-10-09 | Sitryx Therapeutics Limited | Carboxy derivatives with antiinflammatory properties |
CN115052584B (zh) | 2020-01-24 | 2024-08-23 | 特维迪疗法公司 | 治疗性化合物及其制剂和用途 |
WO2021150912A1 (en) * | 2020-01-24 | 2021-07-29 | Tvardi Therapeutics, Inc. | Therapeutic compounds, formulations, and uses thereof |
CN111973578A (zh) * | 2020-08-03 | 2020-11-24 | 天津医科大学 | C188-9、Venetoclax、Bumetanide在纤维化疾病药物中的应用 |
US11623918B2 (en) | 2020-11-18 | 2023-04-11 | Southern Research Institute | Compounds for the treatment of acute and chronic kidney disease |
US11753374B2 (en) | 2020-11-18 | 2023-09-12 | Southern Reserach Institute | Compounds for the treatment of acute and chronic kidney disease |
CN113845476B (zh) * | 2021-11-08 | 2024-04-30 | 中国药科大学 | 一种喹诺酮衍生物及其制备方法和用途 |
WO2023126951A1 (en) * | 2022-01-03 | 2023-07-06 | Yeda Research And Development Co. Ltd. | Inhibitors of autophagy-related protein-protein interactions |
WO2023244946A1 (en) | 2022-06-15 | 2023-12-21 | Tvardi Therapeutics, Inc. | Prodrugs of stat3 inhibitors |
WO2024173199A1 (en) * | 2023-02-13 | 2024-08-22 | Myos Corp. | Treatment for chronic kidney disease |
WO2024192873A1 (zh) * | 2023-03-20 | 2024-09-26 | 杭州天玑济世生物科技有限公司 | 一类具有萘胺结构的小分子化合物的用途 |
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US4279909A (en) | 1980-02-13 | 1981-07-21 | Fujisawa Pharmaceutical Co., Ltd. | Antiallergic method |
US6197749B1 (en) * | 1997-10-29 | 2001-03-06 | Ajinomoto Co., Inc. | Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes |
US20090264353A1 (en) * | 2007-10-19 | 2009-10-22 | Santaris Pharma A/S | Splice Switching Oligomers for TNF Superfamily Receptors and their Use in Treatment of Disease |
WO2009149192A1 (en) * | 2008-06-04 | 2009-12-10 | Baylor College Of Medicine | Stat3 inhibitors |
GB2463514C (en) * | 2008-09-11 | 2018-09-26 | Galapagos Nv | Imidazolidine compounds and uses therefor |
US20120003191A1 (en) * | 2008-12-19 | 2012-01-05 | Burkin Dean J | Valproic acid, derivatives, analogues, and compositions including same and methods for their therapeutic use |
EP2371826A4 (en) * | 2008-12-29 | 2012-06-27 | Takeda Pharmaceutical | NEW CONNECTION WITH CONDENSED RINGS AND ITS USE |
US9891213B2 (en) | 2009-01-12 | 2018-02-13 | The Board Of Trustees Of The Leland Stanford Junior University | Granulocyte-based methods for detecting and monitoring immune system disorders |
FR2962649A1 (fr) * | 2010-07-19 | 2012-01-20 | Conservatoire Nat Arts Et Metiers | Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide |
WO2012159107A1 (en) | 2011-05-19 | 2012-11-22 | Rhode Island Hospital | Inhibition of renal fibrosis |
WO2013078372A1 (en) | 2011-11-23 | 2013-05-30 | University Of Iowa Research Foundation | Compositions and methods for inhibiting muscle atrophy and inducing muscle hypertrophy |
EP2708535A1 (en) * | 2012-05-11 | 2014-03-19 | Les Laboratoires Servier | Agents for treating disorders involving modulation of ryanodine receptors |
EP4082538B1 (en) | 2013-07-18 | 2024-02-14 | Baylor College of Medicine | Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia |
EP3021839B1 (en) | 2013-07-18 | 2021-06-23 | Baylor College Of Medicine | Compositions for treatment of fibrosis |
CA2918264C (en) | 2013-07-18 | 2022-05-10 | Baylor College Of Medicine | Methods and compositions for prevention of allergic reaction |
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AU2014290368B2 (en) | 2019-07-11 |
AU2014290368A1 (en) | 2016-02-04 |
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US11161831B2 (en) | 2021-11-02 |
EP4082538A1 (en) | 2022-11-02 |
CA2918071C (en) | 2022-04-26 |
US10676455B2 (en) | 2020-06-09 |
WO2015010107A1 (en) | 2015-01-22 |
AU2019240646A1 (en) | 2019-10-24 |
EP3021841A4 (en) | 2017-05-31 |
US20150024032A1 (en) | 2015-01-22 |
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