HK1222659A1 - 吡咯並 嘧啶衍生物,它們的製備方法和它們作爲激酶抑制劑的用途 - Google Patents
吡咯並 嘧啶衍生物,它們的製備方法和它們作爲激酶抑制劑的用途Info
- Publication number
- HK1222659A1 HK1222659A1 HK16110876.0A HK16110876A HK1222659A1 HK 1222659 A1 HK1222659 A1 HK 1222659A1 HK 16110876 A HK16110876 A HK 16110876A HK 1222659 A1 HK1222659 A1 HK 1222659A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pyrrolo
- preparation
- kinase inhibitors
- pyrimidine derivatives
- pyrimidine
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000004943 pyrrolo[2,3-d]pyrimidines Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13167606 | 2013-05-14 | ||
PCT/EP2014/059342 WO2014184069A1 (en) | 2013-05-14 | 2014-05-07 | Pyrrolo[2,3-d]pyrimidine derivatives, process for their preparation and their use as kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1222659A1 true HK1222659A1 (zh) | 2017-07-07 |
Family
ID=48325518
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16110876.0A HK1222659A1 (zh) | 2013-05-14 | 2016-09-14 | 吡咯並 嘧啶衍生物,它們的製備方法和它們作爲激酶抑制劑的用途 |
Country Status (7)
Country | Link |
---|---|
US (1) | US9682083B2 (zh) |
EP (1) | EP2997030B1 (zh) |
JP (1) | JP6397897B2 (zh) |
CN (1) | CN105431436B (zh) |
ES (1) | ES2646019T3 (zh) |
HK (1) | HK1222659A1 (zh) |
WO (1) | WO2014184069A1 (zh) |
Families Citing this family (55)
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AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
FI3699181T3 (fi) | 2014-11-16 | 2023-03-28 | Array Biopharma Inc | Kiteinen muoto (s)-n-(5-((r)-2-(2,5-diluorifenyyli)-pyrrolidin-1-yyli)-pyratsolo[1,5-a]pyrimidin-3-yyli)-3-hydroksipyrrolidiini-1-karboksamidivetyysulfaatista |
CN105732614B (zh) * | 2014-12-09 | 2018-06-12 | 中国科学院广州生物医药与健康研究院 | 磺酰胺基芳基炔类化合物及其用途 |
CN105837575B (zh) * | 2015-01-13 | 2019-01-15 | 四川大学 | 3-乙炔基吡唑并嘧啶衍生物及其制备方法和用途 |
KR20180041135A (ko) | 2015-07-16 | 2018-04-23 | 어레이 바이오파마 인크. | Ret 키나아제 억제제로서 치환된 피라졸로[1,5-a]피리딘 화합물 |
MA41559A (fr) * | 2015-09-08 | 2017-12-26 | Taiho Pharmaceutical Co Ltd | Composé de pyrimidine condensé ou un sel de celui-ci |
CA3003153A1 (en) | 2015-10-26 | 2017-05-04 | Loxo Oncology, Inc. | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
EP4455145A2 (en) * | 2015-12-02 | 2024-10-30 | Astraea Therapeutics, LLC | Piperidinyl nociceptin receptor compounds |
US10112924B2 (en) | 2015-12-02 | 2018-10-30 | Astraea Therapeutics, Inc. | Piperdinyl nociceptin receptor compounds |
TWI687422B (zh) * | 2016-02-23 | 2020-03-11 | 日商大鵬藥品工業股份有限公司 | 新穎稠合嘧啶化合物或其鹽 |
FI3439663T3 (fi) | 2016-04-04 | 2024-08-28 | Loxo Oncology Inc | Menetelmiä lasten syöpien hoitamiseksi |
US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
CA3019671C (en) | 2016-04-04 | 2024-02-20 | Loxo Oncology, Inc. | Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
WO2017173604A1 (en) * | 2016-04-06 | 2017-10-12 | Hua Medicine (Shanghai) Ltd. | Pyrrole derivatives |
RS61463B1 (sr) | 2016-05-18 | 2021-03-31 | Loxo Oncology Inc | Priprema (s)-n-(5-((r)-2-(2,5-difluorofenil)pirolidin-1-il)pirazolo[1,5-a]pirimidin-3-il) -3-hidroksipirolidin-1-karboksamida |
JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
CN108117553B (zh) * | 2016-11-30 | 2019-08-16 | 暨南大学 | 炔苯基苯磺酰胺类选择性zak抑制剂及其应用 |
WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
US11168090B2 (en) | 2017-01-18 | 2021-11-09 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors |
JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
GB201705971D0 (en) * | 2017-04-13 | 2017-05-31 | Cancer Res Tech Ltd | Inhibitor compounds |
TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
TW202410896A (zh) | 2017-10-10 | 2024-03-16 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
WO2019143977A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
EP3740486A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
WO2019143991A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS |
US11840535B2 (en) | 2018-07-02 | 2023-12-12 | Shenzhen Targetrx, Inc. | Alkynyl(hetero)aromatic compound for inhibiting protein kinase activity |
US12109193B2 (en) | 2018-07-31 | 2024-10-08 | Loxo Oncology Inc. | Spray-dried dispersions, formulations, and polymorphs of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide |
CN109406786B (zh) * | 2018-08-29 | 2021-03-02 | 郑州工程技术学院 | 一种检测甲胺磷的免疫层析试纸 |
CN109085336B (zh) * | 2018-08-29 | 2021-03-02 | 郑州工程技术学院 | 一种检测伏马菌素b1的免疫层析试纸 |
CN108982863B (zh) * | 2018-08-29 | 2021-03-02 | 郑州工程技术学院 | 一种检测吡虫啉的免疫层析试纸 |
CN108776224B (zh) * | 2018-08-29 | 2021-01-01 | 郑州工程技术学院 | 一种检测赭曲霉毒素a的免疫层析试纸 |
CN108896766B (zh) * | 2018-08-29 | 2021-01-01 | 郑州工程技术学院 | 一种检测呕吐毒素的免疫层析试纸 |
CN109061167B (zh) * | 2018-08-29 | 2021-01-01 | 郑州工程技术学院 | 一种检测拟除虫菊酯的免疫层析试纸 |
WO2020055672A1 (en) | 2018-09-10 | 2020-03-19 | Array Biopharma Inc. | Fused heterocyclic compounds as ret kinase inhibitors |
CN113490666A (zh) | 2018-12-19 | 2021-10-08 | 奥瑞生物药品公司 | 作为fgfr酪氨酸激酶的抑制剂的取代的吡唑并[1,5-a]吡啶化合物 |
CN113474337A (zh) | 2018-12-19 | 2021-10-01 | 奥瑞生物药品公司 | 作为fgfr抑制剂用于治疗癌症的7-((3,5-二甲氧基苯基)氨基)喹喔啉衍生物 |
CN110885307B (zh) * | 2019-11-22 | 2023-03-17 | 湖北医药学院 | 环多肽2-苯乙烯基-5-吡咯烷酮-2-酰胺衍生物、制备方法及其应用 |
US20230101747A1 (en) | 2019-12-06 | 2023-03-30 | Schrödinger, Inc. | Cyclic compounds and methods of using same |
EP4081526A1 (en) | 2019-12-27 | 2022-11-02 | Schrödinger, Inc. | Cyclic compounds and methods of using same |
CN113087709A (zh) * | 2020-01-09 | 2021-07-09 | 沈阳药科大学 | 吡咯并嘧啶类衍生物及其制备方法和应用 |
MX2022013984A (es) | 2020-05-08 | 2023-01-30 | Halia Therapeutics Inc | Inhibidores de cinasa 7 relacionada con el gen nunca en mitosis a (nek7). |
CN111454261A (zh) * | 2020-05-27 | 2020-07-28 | 南京普锐达医药科技有限公司 | 一种4-氯吡咯并嘧啶化合物的合成方法 |
CN113214294A (zh) * | 2020-06-10 | 2021-08-06 | 深圳铂立健医药有限公司 | 三环化合物、药物组合物及其应用 |
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JP2024505890A (ja) | 2021-01-26 | 2024-02-08 | シュレーディンガー, インコーポレイテッド | がん、自己免疫及び炎症性障害の治療に有用な三環式化合物 |
TW202300150A (zh) | 2021-03-18 | 2023-01-01 | 美商薛定諤公司 | 環狀化合物及其使用方法 |
WO2022212326A1 (en) | 2021-03-29 | 2022-10-06 | Halia Therapeutics, Inc. | Nek7 inhibitors |
EP4320127A1 (en) | 2021-04-05 | 2024-02-14 | Halia Therapeutics, Inc. | Nek7 inhibitors |
WO2023169453A1 (zh) * | 2022-03-11 | 2023-09-14 | 中国科学院上海药物研究所 | 一类含杂芳环炔基化合物及其制备方法和用途 |
US20240158394A1 (en) | 2022-09-14 | 2024-05-16 | Halia Therapeutics, Inc. | Nek7 inhibitors |
CN115340557A (zh) * | 2022-09-19 | 2022-11-15 | 安徽大学 | 一种4-氯-5-碘-7-甲基-7H-吡咯并[2,3-d]嘧啶的合成方法 |
CN115684424A (zh) * | 2022-11-11 | 2023-02-03 | 贵州健安德科技有限公司 | 基于LC-MS/MS检测土壤和水中4-氯-7H-吡咯并[2,3-d]嘧啶的方法 |
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US5665721A (en) * | 1995-06-07 | 1997-09-09 | Abbott Laboratories | Heterocyclic substituted cyclopentane compounds |
US6143749A (en) | 1995-06-07 | 2000-11-07 | Abbott Laboratories | Heterocyclic substituted cyclopentane compounds |
CA2543116A1 (en) * | 2003-10-27 | 2005-05-19 | Genelabs Technologies, Inc. | Methods for preparing 7-(2'-substituted-.szlig.-d-ribofuranosyl)-4-(nr2r3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives |
US8476282B2 (en) * | 2008-11-03 | 2013-07-02 | Intellikine Llc | Benzoxazole kinase inhibitors and methods of use |
PE20150637A1 (es) * | 2012-10-16 | 2015-05-08 | Almirall Sa | Derivados de pirrolotriazinona como inhibidores de pi3k |
-
2014
- 2014-05-07 ES ES14721891.1T patent/ES2646019T3/es active Active
- 2014-05-07 WO PCT/EP2014/059342 patent/WO2014184069A1/en active Application Filing
- 2014-05-07 CN CN201480026990.4A patent/CN105431436B/zh active Active
- 2014-05-07 US US14/889,987 patent/US9682083B2/en active Active
- 2014-05-07 EP EP14721891.1A patent/EP2997030B1/en active Active
- 2014-05-07 JP JP2016513291A patent/JP6397897B2/ja not_active Expired - Fee Related
-
2016
- 2016-09-14 HK HK16110876.0A patent/HK1222659A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP2997030B1 (en) | 2017-08-09 |
CN105431436A (zh) | 2016-03-23 |
WO2014184069A1 (en) | 2014-11-20 |
ES2646019T3 (es) | 2017-12-11 |
JP6397897B2 (ja) | 2018-09-26 |
JP2016518419A (ja) | 2016-06-23 |
CN105431436B (zh) | 2017-11-28 |
US9682083B2 (en) | 2017-06-20 |
EP2997030A1 (en) | 2016-03-23 |
US20160166575A1 (en) | 2016-06-16 |
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