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HK1111360A1 - 樣受體 拮抗劑、方法和使用 - Google Patents

樣受體 拮抗劑、方法和使用

Info

Publication number
HK1111360A1
HK1111360A1 HK08102121.0A HK08102121A HK1111360A1 HK 1111360 A1 HK1111360 A1 HK 1111360A1 HK 08102121 A HK08102121 A HK 08102121A HK 1111360 A1 HK1111360 A1 HK 1111360A1
Authority
HK
Hong Kong
Prior art keywords
toll
antagonists
receptor
methods
uses toll
Prior art date
Application number
HK08102121.0A
Other languages
English (en)
Inventor
Jill Carton
Mark Cunningham
Anuk Das
Karen Duffy
David M Knight
Roberta Lamb
Mouhamadou L Mbow
Gopalan Raghunathan
Mateo Lani San
Robert T Sarisky
Nicole Stowell
Raymond Sweet
Shanrong Zhao
Shizhong Chen
Jill Giles-Komar
Kristen Picha
Vedrana Stojanovic-Susulic
Theresa J Goletz
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of HK1111360A1 publication Critical patent/HK1111360A1/zh

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    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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HK08102121.0A 2004-11-30 2008-02-26 樣受體 拮抗劑、方法和使用 HK1111360A1 (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US63181504P 2004-11-30 2004-11-30
US63639904P 2004-12-15 2004-12-15
US64187705P 2005-01-06 2005-01-06
US71319505P 2005-08-31 2005-08-31
US72761005P 2005-10-18 2005-10-18
PCT/US2005/043373 WO2006060513A2 (en) 2004-11-30 2005-11-30 Toll like receptor 3 antagonists, methods and uses

Publications (1)

Publication Number Publication Date
HK1111360A1 true HK1111360A1 (zh) 2008-08-08

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HK08102121.0A HK1111360A1 (zh) 2004-11-30 2008-02-26 樣受體 拮抗劑、方法和使用
HK09109752.0A HK1131744A1 (en) 2004-11-30 2009-10-21 Toll like receptor 3 antagonists, methods and uses toll

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HK09109752.0A HK1131744A1 (en) 2004-11-30 2009-10-21 Toll like receptor 3 antagonists, methods and uses toll

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US (1) US8153583B2 (zh)
EP (2) EP2481425A1 (zh)
JP (2) JP5039560B2 (zh)
KR (1) KR101317264B1 (zh)
AR (1) AR051836A1 (zh)
AU (1) AU2005311894A1 (zh)
BR (1) BRPI0518664A2 (zh)
CA (1) CA2589636C (zh)
EA (1) EA200701192A1 (zh)
HK (2) HK1111360A1 (zh)
IL (1) IL183541A (zh)
MX (1) MX2007006442A (zh)
NO (1) NO20073293L (zh)
NZ (1) NZ555475A (zh)
TW (1) TWI487535B (zh)
WO (1) WO2006060513A2 (zh)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
DK1945820T3 (da) * 2005-10-27 2013-11-11 Janssen Biotech Inc Toll-lignende receptor-3-modulatorer, fremgangsmåder og anvendelser
US8066981B2 (en) * 2006-11-14 2011-11-29 The Texas A & M University System Compositions and methods related to toll-like receptor-3
WO2008147956A2 (en) * 2007-05-25 2008-12-04 Centocor, Inc. Toll-like receptor 3 modulators and uses thereof
ME03057B (me) 2007-12-07 2019-01-20 Zymogenetics Inc Molekuli humanizovanih antitela specifični za il-31
JP2011507552A (ja) * 2007-12-26 2011-03-10 セントコア・オーソ・バイオテツク・インコーポレーテツド カニクイザルトール様受容体3
WO2009150531A1 (en) * 2008-06-09 2009-12-17 Novartis Ag Antibodies against neisserial factor h binding protein
DE602008004898D1 (de) * 2008-06-27 2011-03-24 Theranor Sprl Pharmazeutische Zusammensetzungen von Antikörpern von Viruserkrankungen
JP2012504651A (ja) * 2008-10-02 2012-02-23 ヤンセン バイオテツク,インコーポレーテツド Toll様受容体の活性を抑制するための方法
EA201500316A1 (ru) 2008-10-31 2016-01-29 Сентокор Орто Байотек Инк. Антагонисты толл-подобного рецептора 3
US8460659B2 (en) 2008-10-31 2013-06-11 Janssen Biotech, Inc. Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases
US20100137787A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Delivery devices for modulating inflammation
US20100136096A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100137246A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-inflammatory compositions and methods
US20100135983A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-inflammatory compositions and methods
US20100136095A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100136094A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100136097A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
AU2010241581A1 (en) * 2009-04-29 2011-11-17 Centocor Ortho Biotech Inc. Toll-Like Receptor 3 antagonists
CN102471382A (zh) * 2009-07-10 2012-05-23 依奈特制药公司 Tlr3 结合剂
JP2013506686A (ja) 2009-09-30 2013-02-28 プレジデント アンド フェロウズ オブ ハーバード カレッジ オートファジー阻害遺伝子産物の変調によりオートファジーを変調する方法
US20140065154A1 (en) 2011-01-12 2014-03-06 Innate Pharma Tlr3 binding agents
NO2748201T3 (zh) * 2011-08-23 2018-05-12
US20130078250A1 (en) * 2011-08-23 2013-03-28 Oliver Ast Bispecific t cell activating antigen binding molecules
EP2755685A4 (en) * 2011-09-12 2015-07-01 Janssen Biotech Inc TOLL-LIKE RECEPTOR-3 ANTAGONISTS FOR THE TREATMENT OF METABOLISM AND CARDIAC DISEASES
AU2013269652B2 (en) * 2012-05-31 2017-07-06 Innate Pharma TLR3 binding agents
TWI635098B (zh) 2013-02-01 2018-09-11 再生元醫藥公司 含嵌合恆定區之抗體
RS59992B1 (sr) 2013-02-26 2020-04-30 Roche Glycart Ag Bispecifični antigen vezujući molekuli koji aktiviraju t ćelije specifični za cd3 i cea
US9198898B2 (en) 2013-06-24 2015-12-01 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
US8906951B1 (en) 2013-06-24 2014-12-09 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
TWI754319B (zh) 2014-03-19 2022-02-01 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
EP3699198A1 (en) 2014-11-17 2020-08-26 Regeneron Pharmaceuticals, Inc. Methods for tumor treatment using cd3xcd20 bispecific antibody
DK3277725T3 (da) 2015-03-30 2021-01-11 Regeneron Pharma Konstante tungkædeområder med reduceret binding til FC-gammareceptorer
EP3356410B1 (en) 2015-10-02 2021-10-20 F. Hoffmann-La Roche AG Bispecific anti-ceaxcd3 t cell activating antigen binding molecules
MX2018005229A (es) 2015-12-09 2019-04-29 F Hoffmann­La Roche Ag Anticuerpo anti-cd20 de tipo ii y usos del mismo.
MX2018008347A (es) 2016-01-08 2018-12-06 Hoffmann La Roche Metodos de tratamiento de canceres positivos para ace utilizando antagonistas de union a eje pd-1 y anticuerpos biespecificos anti-ace/anti-cd3.
US20230041197A1 (en) 2018-06-20 2023-02-09 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
WO2019246317A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease or condition in a tissue originating from the endoderm
JP7605734B2 (ja) 2018-08-31 2024-12-24 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Cd3/c20二重特異性抗体のサイトカイン放出症候群を軽減する投与戦略

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
ES2331622T3 (es) 1997-05-07 2010-01-11 Schering Corporation Proteinas receptoras humanas similares a toll, reactivos y metodos relacionados.
US20030032090A1 (en) * 1997-05-07 2003-02-13 Schering Corporation, A New Jersey Corporation Human receptor proteins; related reagents and methods
PT1158989E (pt) 1999-03-09 2007-10-01 Hans-Dieter Volk Terapia e utilização de agentes na terapia da caquexia e sintomas debilitantes devido a doenças para além da falha cardíaca congestiva
GB9930616D0 (en) 1999-12-24 2000-02-16 Mathilda & Terence Kennedy Ins Activation and inhibition of the immune system
IL160561A0 (en) * 2001-09-07 2004-07-25 Univ Boston Method and composition for treating immune complex associated disorders
JP2005505284A (ja) 2001-10-05 2005-02-24 コリー ファーマスーティカル ゲーエムベーハー Toll様受容体3シグナリングアゴニストおよびアンタゴニススト
EP1495756A4 (en) 2002-04-08 2009-10-28 Takeda Pharmaceutical THERAPEUTIC AGENT FOR SEVERE SEPTIC STATE PREVENTION
JP2004016021A (ja) * 2002-06-12 2004-01-22 Japan Science & Technology Corp 抗体および阻害剤並びにそれを用いた形質転換方法および形質転換キット
CA2528774A1 (en) * 2003-06-20 2005-01-27 Coley Pharmaceutical Gmbh Small molecule toll-like receptor (tlr) antagonists

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