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HK1198832A1 - Fn14 binding proteins and uses thereof fn14 - Google Patents

Fn14 binding proteins and uses thereof fn14

Info

Publication number
HK1198832A1
HK1198832A1 HK14112278.2A HK14112278A HK1198832A1 HK 1198832 A1 HK1198832 A1 HK 1198832A1 HK 14112278 A HK14112278 A HK 14112278A HK 1198832 A1 HK1198832 A1 HK 1198832A1
Authority
HK
Hong Kong
Prior art keywords
binding proteins
proteins
binding
Prior art date
Application number
HK14112278.2A
Other languages
English (en)
Chinese (zh)
Inventor
Nicholas Johannes Hoogenraad
Amelia Jane Johnston
John Silke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of HK1198832A1 publication Critical patent/HK1198832A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
HK14112278.2A 2011-08-23 2014-12-05 Fn14 binding proteins and uses thereof fn14 HK1198832A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161526599P 2011-08-23 2011-08-23
PCT/AU2012/000989 WO2013026099A1 (fr) 2011-08-23 2012-08-23 Protéines de liaison à fn14 et leurs utilisations

Publications (1)

Publication Number Publication Date
HK1198832A1 true HK1198832A1 (en) 2015-06-12

Family

ID=47745774

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14112278.2A HK1198832A1 (en) 2011-08-23 2014-12-05 Fn14 binding proteins and uses thereof fn14

Country Status (9)

Country Link
US (6) US9006397B2 (fr)
EP (1) EP2748203B1 (fr)
JP (1) JP2014529597A (fr)
AU (1) AU2012300191B2 (fr)
CA (1) CA2845946A1 (fr)
ES (1) ES2748021T3 (fr)
HK (1) HK1198832A1 (fr)
SG (1) SG2014010334A (fr)
WO (1) WO2013026099A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2748203B1 (fr) 2011-08-23 2019-05-15 La Trobe University Protéines de liaison à fn14 et leurs utilisations
SG11201509116VA (en) * 2013-06-14 2015-12-30 Bayer Pharma AG Anti-tweakr antibodies and uses thereof
WO2015006508A2 (fr) 2013-07-09 2015-01-15 The Translational Genomics Research Institute Compositions et procédés de criblage pour des composés qui modulent l'activité à un site de liaison tweak sur un crd de fn14
US9797882B2 (en) 2013-07-09 2017-10-24 The Translational Genomics Research Institute Method of screening for a compound for inhibitory activity of FN14-tweak interaction
EP3209697A4 (fr) 2014-10-23 2018-05-30 La Trobe University Protéines de liaison à fn14 et leurs utilisations
KR20210084473A (ko) * 2018-10-31 2021-07-07 아스텔라스세이야쿠 가부시키가이샤 항인간 Fn14 항체
AU2019402163A1 (en) * 2018-12-20 2021-07-08 Kyowa Kirin Co., Ltd. Fn14 antibodies and uses thereof
WO2021214905A1 (fr) * 2020-04-22 2021-10-28 アステラス製薬株式会社 Composition pharmaceutique et procédé de prévention ou de traitement du cancer par utilisation conjointe d'un anticorps anti-fn14 humain et d'un inhibiteur de point de contrôle immunitaire
EP3984547A1 (fr) * 2020-10-14 2022-04-20 Universitat Pompeu Fabra Peptides pour le traitement du cancer
US20240092916A1 (en) 2021-01-13 2024-03-21 Astellas Pharma Inc. MULTISPECIFIC ANTIBODY BINDING TO ActRIIA, ActRIIB, AND Fn14
WO2022155705A1 (fr) * 2021-01-20 2022-07-28 La Trobe University Protéines de liaison à fn14 humanisées et leurs utilisations
WO2023062848A1 (fr) * 2021-10-14 2023-04-20 Astellas Pharma Inc. Composition pharmaceutique comprenant un anticorps fnl4 anti-humain ou un fragment de liaison à l'antigène de celui-ci pour la prévention ou le traitement du cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7495086B2 (en) * 1999-12-20 2009-02-24 Immunex Corporation TWEAK receptor
MXPA04009683A (es) * 2002-04-09 2005-01-11 Biogen Idec Inc Metodos para el tratamiento de condiciones relacionadas a tweak.
CN102006886A (zh) * 2007-08-03 2011-04-06 菲赛特生物技术公司 抗-tweak受体抗体的治疗用途
WO2009140177A2 (fr) * 2008-05-15 2009-11-19 Biogen Idec Ma Inc. Anticorps anti-fn14 et leurs utilisation
EP2748203B1 (fr) 2011-08-23 2019-05-15 La Trobe University Protéines de liaison à fn14 et leurs utilisations
EP3209697A4 (fr) * 2014-10-23 2018-05-30 La Trobe University Protéines de liaison à fn14 et leurs utilisations

Also Published As

Publication number Publication date
US20200239586A1 (en) 2020-07-30
US20150218278A1 (en) 2015-08-06
CA2845946A1 (fr) 2013-02-28
US20130273036A1 (en) 2013-10-17
US20200002430A1 (en) 2020-01-02
EP2748203A1 (fr) 2014-07-02
ES2748021T3 (es) 2020-03-12
AU2012300191A1 (en) 2013-04-04
JP2014529597A (ja) 2014-11-13
US20180057599A1 (en) 2018-03-01
US9006397B2 (en) 2015-04-14
EP2748203B1 (fr) 2019-05-15
US20170029519A1 (en) 2017-02-02
US10287359B2 (en) 2019-05-14
SG2014010334A (en) 2014-06-27
WO2013026099A1 (fr) 2013-02-28
EP2748203A4 (fr) 2015-04-22
AU2012300191B2 (en) 2014-04-17

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