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HK1186736A1 - (e)-n-(2-amino-phenyl)-3-1-[4-(1-methyl-1h-pyrazol-4-yl)-benzenesulfonyl]- 1h-pyrrol-3-yl-acrylamide tosylate salt (e)-n-(2--)-3-1-[4-(1--1h--4-)-]-1h--3-- - Google Patents

(e)-n-(2-amino-phenyl)-3-1-[4-(1-methyl-1h-pyrazol-4-yl)-benzenesulfonyl]- 1h-pyrrol-3-yl-acrylamide tosylate salt (e)-n-(2--)-3-1-[4-(1--1h--4-)-]-1h--3--

Info

Publication number
HK1186736A1
HK1186736A1 HK13114246.8A HK13114246A HK1186736A1 HK 1186736 A1 HK1186736 A1 HK 1186736A1 HK 13114246 A HK13114246 A HK 13114246A HK 1186736 A1 HK1186736 A1 HK 1186736A1
Authority
HK
Hong Kong
Prior art keywords
benzenesulfonyl
pyrrol
pyrazol
phenyl
amino
Prior art date
Application number
HK13114246.8A
Other languages
English (en)
Chinese (zh)
Inventor
于爾根．沃爾茲
馬丁．費斯
羅爾夫-彼得．胡梅爾
馬蒂亞斯．穆勒
托馬斯．梅艾爾
波恩德．穆勒
Original Assignee
股份公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 股份公司 filed Critical 股份公司
Publication of HK1186736A1 publication Critical patent/HK1186736A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Otolaryngology (AREA)
  • Psychology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
HK13114246.8A 2008-03-12 2013-12-24 (e)-n-(2-amino-phenyl)-3-1-[4-(1-methyl-1h-pyrazol-4-yl)-benzenesulfonyl]- 1h-pyrrol-3-yl-acrylamide tosylate salt (e)-n-(2--)-3-1-[4-(1--1h--4-)-]-1h--3-- HK1186736A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08004568A EP2100882A1 (fr) 2008-03-12 2008-03-12 Sels d'acrylamide (E) -N -(2-Amino-phényl) -3-{1-[4-(1-méthyl-1H-pyrazol-4-yl)-benzènesulfonyl] -1H-pyrrol-3-yl}

Publications (1)

Publication Number Publication Date
HK1186736A1 true HK1186736A1 (en) 2014-04-17

Family

ID=39322749

Family Applications (3)

Application Number Title Priority Date Filing Date
HK13114246.8A HK1186736A1 (en) 2008-03-12 2013-12-24 (e)-n-(2-amino-phenyl)-3-1-[4-(1-methyl-1h-pyrazol-4-yl)-benzenesulfonyl]- 1h-pyrrol-3-yl-acrylamide tosylate salt (e)-n-(2--)-3-1-[4-(1--1h--4-)-]-1h--3--
HK15108828.4A HK1208219A1 (en) 2008-03-12 2015-09-10 (e)-n-(2-amino-phenyl)-3-1-[4-(1-methyl-1h-pyrazol-4-yl)- benzenesulfonyl]-1h-pyrrol-3-yl-acrylamide tosylate salt (e)-n-(2--)-3-1-[4-(1--1h--4-)-]-1h-- 3--
HK18115376.2A HK1256310A1 (zh) 2008-03-12 2018-11-30 N-磺酰基吡咯衍生物

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK15108828.4A HK1208219A1 (en) 2008-03-12 2015-09-10 (e)-n-(2-amino-phenyl)-3-1-[4-(1-methyl-1h-pyrazol-4-yl)- benzenesulfonyl]-1h-pyrrol-3-yl-acrylamide tosylate salt (e)-n-(2--)-3-1-[4-(1--1h--4-)-]-1h-- 3--
HK18115376.2A HK1256310A1 (zh) 2008-03-12 2018-11-30 N-磺酰基吡咯衍生物

Country Status (16)

Country Link
US (1) US8557858B2 (fr)
EP (2) EP2100882A1 (fr)
JP (2) JP2011513466A (fr)
KR (1) KR101657718B1 (fr)
CN (5) CN103360371B (fr)
AU (1) AU2009224710B2 (fr)
BR (1) BRPI0908917A2 (fr)
CA (1) CA2719071C (fr)
EA (1) EA017533B1 (fr)
HK (3) HK1186736A1 (fr)
IL (1) IL207994A (fr)
MX (1) MX2010010014A (fr)
NZ (1) NZ587823A (fr)
UA (1) UA106351C2 (fr)
WO (1) WO2009112522A1 (fr)
ZA (1) ZA201006523B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS52937B (en) * 2004-03-11 2014-02-28 4Sc Ag SULFONYLPYROLS AS HDAC INHIBITORS
EP2330894B8 (fr) 2008-09-03 2017-04-19 BioMarin Pharmaceutical Inc. Compositions comprenant des dérivés d acide 6-aminohexanoïque utilisées comme inhibiteurs de hdac
JP6250403B2 (ja) 2011-02-28 2017-12-20 バイオマリン ファーマシューティカル インク ヒストン脱アセチル化酵素阻害剤
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
CN102526714B (zh) * 2011-08-24 2013-12-25 贵州神奇集团控股有限公司 治疗肿瘤的药物组合物及其制备方法
CN102716465B (zh) * 2012-06-18 2014-01-15 贵州金桥药业有限公司 治疗肿瘤的药物组合物及其制备方法
KR20150132345A (ko) 2013-03-15 2015-11-25 바이오마린 파머수티컬 인크. Hdac 저해제
WO2017060524A1 (fr) * 2015-10-09 2017-04-13 4Sc Ag (e)-n-(2-aminophényl)-3-(1-((4-(1-méthyl-1h-pyrazol-4-yl)phényl)sulfonyl)-1h-pyrrol-3-yl)acrylamide pour le traitement d'infections virales latentes
JP2020533320A (ja) 2017-09-08 2020-11-19 ４エスツェー アクチェンゲゼルシャフト 癌療法のための免疫チェックポイント調節薬と併用したｈｄａｃ阻害薬
JP2021519292A (ja) 2018-03-26 2021-08-10 ４エスツェー アクチェンゲゼルシャフト 癌療法のためのｈｄａｃ阻害薬とｃｄ１３７作動薬とを含む併用
TW202011959A (zh) 2018-04-14 2020-04-01 美商戴納瓦克斯技術公司 用於治療癌症之包括CpG-C 型寡核苷酸及組蛋白去乙醯酶抑制劑之組合
TW202012395A (zh) * 2018-04-14 2020-04-01 德商４Ｓｃ製藥公司 用於治療癌症的包含組蛋白去乙醯酶（hdac）抑制劑和tlr7 激動劑和/或tlr8 激動劑的藥物組合產品
MX2020011002A (es) * 2018-04-17 2021-01-29 4Sc Ag Combinacion que comprende inhibidor de hdac, inhibidor de lag-3 y un inhibidor de pd-1 o inhibidor de pd-l1 para el tratamiento del cancer.
TW202114659A (zh) 2019-10-02 2021-04-16 德商４Ｓｃ製藥公司 用於癌症治療之含ｈｄａｃ抑制劑、ｃｔｌａ—４抑制劑及ｐｄ—１抑制劑或ｐｄ—ｌ１抑制劑之組合
CN111973590A (zh) * 2020-07-06 2020-11-24 江苏省人民医院（南京医科大学第一附属医院） 新型hdac抑制剂laq824在治疗弥漫大b细胞淋巴瘤药物中的应用

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Publication number Priority date Publication date Assignee Title
US4960787A (en) 1989-02-06 1990-10-02 Ciba-Geigy Corporation Certain pyrrolyl-substituted hydroxamic acid derivatives
AU5886296A (en) 1995-06-02 1996-12-18 G.D. Searle & Co. Heterocyclo substituted hydroxamic acid derivatives as cyclo oxygenase-2 and 5-lipoxygenase inhibitors
KR20100035666A (ko) 1999-11-23 2010-04-05 메틸진 인크. 히스톤 디아세틸라제의 억제제
EP1425577A4 (fr) * 2001-08-10 2004-12-29 Symyx Technologies Inc Appareils et procedes permettant d'elaborer et de tester des pre-formulations et systemes correspondants
RS52937B (en) * 2004-03-11 2014-02-28 4Sc Ag SULFONYLPYROLS AS HDAC INHIBITORS
DE602006007558D1 (de) * 2005-03-15 2009-08-13 4Sc Ag N-sulfonylpyrrole und ihre verwendung als histondeacetylaseinhibitoren
WO2006105979A1 (fr) * 2005-04-07 2006-10-12 Nycomed Gmbh Sulfonylpyrroles en tant qu'inhibiteurs d'histone deacetylase
NZ566073A (en) * 2005-09-21 2011-08-26 4Sc Ag Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors
PL1928872T3 (pl) * 2005-09-21 2012-08-31 4Sc Ag Nowe sulfonylopirole jako inhibitory HDAC
EP2100878A1 (fr) * 2008-03-12 2009-09-16 4Sc Ag Nouveau procédé pour la production de sulphonylpyrroles en tant qu'inhibiteurs HDAC

Also Published As

Publication number Publication date
NZ587823A (en) 2012-05-25
EP2100882A1 (fr) 2009-09-16
CA2719071A1 (fr) 2009-09-17
JP2014132027A (ja) 2014-07-17
EA017533B1 (ru) 2013-01-30
EP2262775B1 (fr) 2024-09-04
JP5952328B2 (ja) 2016-07-13
CN108101890A (zh) 2018-06-01
KR20100133422A (ko) 2010-12-21
IL207994A0 (en) 2010-12-30
MX2010010014A (es) 2011-04-05
CN104803988A (zh) 2015-07-29
HK1256310A1 (zh) 2019-09-20
CA2719071C (fr) 2016-07-12
JP2011513466A (ja) 2011-04-28
ZA201006523B (en) 2011-09-28
CN110183425A (zh) 2019-08-30
HK1208219A1 (en) 2016-02-26
EA201001269A1 (ru) 2011-06-30
US8557858B2 (en) 2013-10-15
CN103360371A (zh) 2013-10-23
KR101657718B1 (ko) 2016-09-19
UA106351C2 (en) 2014-08-26
AU2009224710A1 (en) 2009-09-17
US20110086897A1 (en) 2011-04-14
CN101970411A (zh) 2011-02-09
IL207994A (en) 2015-10-29
EP2262775A1 (fr) 2010-12-22
BRPI0908917A2 (pt) 2021-04-13
CN103360371B (zh) 2015-03-25
AU2009224710B2 (en) 2013-05-02
WO2009112522A1 (fr) 2009-09-17

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