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HK1157345A1 - Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors - Google Patents

Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors

Info

Publication number
HK1157345A1
HK1157345A1 HK11111868.3A HK11111868A HK1157345A1 HK 1157345 A1 HK1157345 A1 HK 1157345A1 HK 11111868 A HK11111868 A HK 11111868A HK 1157345 A1 HK1157345 A1 HK 1157345A1
Authority
HK
Hong Kong
Prior art keywords
tumors
treatment
tyrosine kinase
kinase modulators
dihydropyrazole derivatives
Prior art date
Application number
HK11111868.3A
Other languages
English (en)
Inventor
Dieter Dorsch
Oliver Schadt
Frank Stieber
Andree Blaukat
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of HK1157345A1 publication Critical patent/HK1157345A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK11111868.3A 2008-05-29 2011-11-03 Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors HK1157345A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008025750A DE102008025750A1 (de) 2008-05-29 2008-05-29 Dihydropyrazolderivate
PCT/EP2009/003030 WO2009143945A1 (de) 2008-05-29 2009-04-24 Dihydropyrazolderivate als tyrosinkinase modulatoren zur behandlung von tumoren

Publications (1)

Publication Number Publication Date
HK1157345A1 true HK1157345A1 (en) 2012-06-29

Family

ID=40822993

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11111868.3A HK1157345A1 (en) 2008-05-29 2011-11-03 Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors

Country Status (17)

Country Link
US (1) US8404685B2 (xx)
EP (1) EP2300434B1 (xx)
JP (1) JP5643192B2 (xx)
KR (1) KR20110010821A (xx)
CN (1) CN102046605B (xx)
AR (1) AR071951A1 (xx)
AU (1) AU2009253432B2 (xx)
BR (1) BRPI0912970A2 (xx)
CA (1) CA2726009C (xx)
DE (1) DE102008025750A1 (xx)
EA (1) EA018394B1 (xx)
ES (1) ES2507573T3 (xx)
HK (1) HK1157345A1 (xx)
IL (1) IL209418A (xx)
MX (1) MX2010012804A (xx)
WO (1) WO2009143945A1 (xx)
ZA (1) ZA201009085B (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8791114B2 (en) * 2011-07-01 2014-07-29 Merck Patent Gmbh Dihydropyrazoles
HUE029559T2 (en) * 2012-07-10 2017-03-28 Ares Trading Sa Pyrimidine-pyrazolyl derivatives
AU2019387370A1 (en) 2018-11-30 2021-06-10 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
PL194689B1 (pl) 1996-02-13 2007-06-29 Astrazeneca Uk Ltd Pochodne chinazoliny, ich kompozycje farmaceutyczne oraz ich zastosowania
KR100489174B1 (ko) 1996-03-05 2005-09-30 제네카-파마 소시에떼아노님 4-아닐리노퀴나졸린유도체
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
BR0111230A (pt) 2000-05-31 2003-06-10 Astrazeneca Ab Composto, e, uso e processo para a preparação do mesmo
NZ522861A (en) 2000-07-07 2004-07-30 Angiogene Pharm Ltd Colchinol derivatives as vascular damaging agents
EE200300015A (et) 2000-07-07 2004-10-15 Angiogene Pharmaceuticals Limited Kolhinooli derivaadid kui angiogeneesi inhibiitorid
JP4399269B2 (ja) * 2002-03-08 2010-01-13 メルク エンド カムパニー インコーポレーテッド 有糸分裂性キネシン阻害薬
DE102005038537A1 (de) * 2005-08-16 2007-02-22 Merck Patent Gmbh 1-Acyldihydropyrazolderivate

Also Published As

Publication number Publication date
MX2010012804A (es) 2010-12-07
DE102008025750A1 (de) 2009-12-03
EA018394B1 (ru) 2013-07-30
IL209418A0 (en) 2011-01-31
ES2507573T3 (es) 2014-10-15
WO2009143945A1 (de) 2009-12-03
CN102046605A (zh) 2011-05-04
EA201001831A1 (ru) 2011-06-30
CN102046605B (zh) 2013-09-18
KR20110010821A (ko) 2011-02-07
ZA201009085B (en) 2011-10-26
JP2011520996A (ja) 2011-07-21
US20110071153A1 (en) 2011-03-24
EP2300434A1 (de) 2011-03-30
US8404685B2 (en) 2013-03-26
JP5643192B2 (ja) 2014-12-17
AU2009253432B2 (en) 2013-08-01
IL209418A (en) 2015-09-24
AR071951A1 (es) 2010-07-28
CA2726009C (en) 2016-08-23
CA2726009A1 (en) 2009-12-03
EP2300434B1 (de) 2014-07-23
AU2009253432A1 (en) 2009-12-03
BRPI0912970A2 (pt) 2015-10-13

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180424