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HK1020724A1 - Aminothiophene carboxylic acid amides and the use thereof as phosphodiesterase inhibitors - Google Patents

Aminothiophene carboxylic acid amides and the use thereof as phosphodiesterase inhibitors

Info

Publication number
HK1020724A1
HK1020724A1 HK99105058A HK99105058A HK1020724A1 HK 1020724 A1 HK1020724 A1 HK 1020724A1 HK 99105058 A HK99105058 A HK 99105058A HK 99105058 A HK99105058 A HK 99105058A HK 1020724 A1 HK1020724 A1 HK 1020724A1
Authority
HK
Hong Kong
Prior art keywords
carboxylic acid
acid amides
phosphodiesterase inhibitors
aminothiophene carboxylic
aminothiophene
Prior art date
Application number
HK99105058A
Other languages
English (en)
Inventor
Rochus Jonas
Pierre Schelling
Franz-Werner Kluxen
Maria Christadler
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of HK1020724A1 publication Critical patent/HK1020724A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK99105058A 1996-10-15 1999-11-04 Aminothiophene carboxylic acid amides and the use thereof as phosphodiesterase inhibitors HK1020724A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19642451A DE19642451A1 (de) 1996-10-15 1996-10-15 Aminothiophencarbonsäureamide
PCT/EP1997/005531 WO1998016521A1 (de) 1996-10-15 1997-10-08 Aminothiophencarbonsäureamide und ihre verwendung als phosphodiesterase inhibitoren

Publications (1)

Publication Number Publication Date
HK1020724A1 true HK1020724A1 (en) 2000-05-19

Family

ID=7808775

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99105058A HK1020724A1 (en) 1996-10-15 1999-11-04 Aminothiophene carboxylic acid amides and the use thereof as phosphodiesterase inhibitors

Country Status (26)

Country Link
US (1) US6143777A (es)
EP (1) EP0934301B1 (es)
JP (1) JP4243352B2 (es)
KR (1) KR100479811B1 (es)
CN (1) CN1110493C (es)
AR (1) AR009985A1 (es)
AT (1) ATE202347T1 (es)
AU (1) AU725741B2 (es)
BR (1) BR9712321A (es)
CA (1) CA2268886C (es)
CZ (1) CZ297253B6 (es)
DE (2) DE19642451A1 (es)
DK (1) DK0934301T3 (es)
ES (1) ES2159851T3 (es)
GR (1) GR3036341T3 (es)
HK (1) HK1020724A1 (es)
HU (1) HUP9904703A3 (es)
NO (1) NO991776L (es)
PL (1) PL192109B1 (es)
PT (1) PT934301E (es)
RU (1) RU2184731C2 (es)
SI (1) SI0934301T1 (es)
SK (1) SK283807B6 (es)
TW (1) TW438791B (es)
WO (1) WO1998016521A1 (es)
ZA (1) ZA979199B (es)

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US6077842A (en) * 1998-11-24 2000-06-20 Cell Pathways, Inc. Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives
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US7196207B2 (en) * 2002-07-24 2007-03-27 Mitsui Chemicals, Inc. Method for producing 2-alkyl-3-aminothiophene derivative
US7179836B2 (en) * 2002-09-20 2007-02-20 Smithkline Beecham Corporation Chemical compounds
FR2875807B1 (fr) 2004-09-30 2006-11-17 Servier Lab Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1928437A2 (en) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
CA2625153A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
MX2009002496A (es) * 2006-09-08 2009-07-10 Braincells Inc Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
RU2472791C2 (ru) * 2008-08-27 2013-01-20 КалсиМедика Инк. Соединения, модулирующие внутриклеточный кальций
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
RU2503671C1 (ru) * 2012-07-31 2014-01-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" (Z)-2-[(3-КАРБАМОИЛ-4,5,6,7-ТЕТРАГИДРОБЕНЗО[b]ТИЕН-2-ИЛ)АМИНО]-4-(4-R-ФЕНИЛ)-4-ОКСОБУТ-2-ЕНОВЫЕ КИСЛОТЫ, ОБЛАДАЮЩИЕ АНАЛЬГЕТИЧЕСКОЙ АКТИВНОСТЬЮ
RU2501795C1 (ru) * 2012-10-01 2013-12-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" N-R-АМИДЫ (Z)-2[(3-ЭТОКСИКАРБОНИЛ)-4,5,6,7-ТЕТРАГИДРОБЕНЗО[b]ТИЕН-2-ИЛ)АМИНО]-4-ФЕНИЛ-4-ОКСОБУТ-2-ЕНОВЫХ КИСЛОТ, ОБЛАДАЮЩИЕ АНАЛЬГЕТИЧЕСКОЙ АКТИВНОСТЬЮ
EP3157520B1 (en) 2014-06-23 2019-09-04 Celgene Corporation Apremilast for the treatment of a liver disease or a liver function abnormality
SI3796975T1 (sl) 2018-05-22 2024-02-29 Orsobio, Inc. Derivati sulfonilaminobenzamida
RU2722176C1 (ru) * 2019-09-06 2020-05-28 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (z)-2((4-r1-5-r2-3-(этоксикарбонил)тиофен-2-ил)амино)-4-оксо-4-r3-бут-2-еновые кислоты, обладающие противомикробной активностью
JP2023537271A (ja) * 2020-07-24 2023-08-31 イニファーム，インク． チオフェンｈｓｄ１７ｂ１３阻害剤とその使用

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Also Published As

Publication number Publication date
SK283807B6 (sk) 2004-02-03
TW438791B (en) 2001-06-07
JP2001501957A (ja) 2001-02-13
GR3036341T3 (en) 2001-11-30
NO991776D0 (no) 1999-04-14
DE19642451A1 (de) 1998-04-16
NO991776L (no) 1999-06-09
AU4945197A (en) 1998-05-11
HUP9904703A2 (hu) 2001-05-28
ZA979199B (en) 1998-05-11
WO1998016521A1 (de) 1998-04-23
AU725741B2 (en) 2000-10-19
CN1110493C (zh) 2003-06-04
SK43299A3 (en) 2000-04-10
DK0934301T3 (da) 2001-10-08
EP0934301B1 (de) 2001-06-20
KR100479811B1 (ko) 2005-03-30
CN1233246A (zh) 1999-10-27
CA2268886A1 (en) 1998-04-23
CZ124099A3 (cs) 1999-07-14
PT934301E (pt) 2001-10-31
DE59703869D1 (de) 2001-07-26
PL332802A1 (en) 1999-10-11
SI0934301T1 (en) 2001-12-31
CA2268886C (en) 2008-05-20
BR9712321A (pt) 1999-08-31
PL192109B1 (pl) 2006-08-31
ATE202347T1 (de) 2001-07-15
KR20000049154A (ko) 2000-07-25
US6143777A (en) 2000-11-07
EP0934301A1 (de) 1999-08-11
RU2184731C2 (ru) 2002-07-10
CZ297253B6 (cs) 2006-10-11
JP4243352B2 (ja) 2009-03-25
ES2159851T3 (es) 2001-10-16
AR009985A1 (es) 2000-05-17
HUP9904703A3 (en) 2001-06-28

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20051008