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HK1015382A1 - Chromatographic process for obtaining very pure cyclosporin a and related cyclosporins - Google Patents

Chromatographic process for obtaining very pure cyclosporin a and related cyclosporins

Info

Publication number
HK1015382A1
HK1015382A1 HK99100547A HK99100547A HK1015382A1 HK 1015382 A1 HK1015382 A1 HK 1015382A1 HK 99100547 A HK99100547 A HK 99100547A HK 99100547 A HK99100547 A HK 99100547A HK 1015382 A1 HK1015382 A1 HK 1015382A1
Authority
HK
Hong Kong
Prior art keywords
cyclosporin
obtaining
chromatographic process
cyclosporins
pure cyclosporin
Prior art date
Application number
HK99100547A
Other languages
English (en)
Inventor
Ullrich Voigt
Roland Hempel
Joachim Kinkel
Roger-Marc Nicoud
Original Assignee
Dresden Arzneimittel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dresden Arzneimittel filed Critical Dresden Arzneimittel
Publication of HK1015382A1 publication Critical patent/HK1015382A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK99100547A 1996-03-21 1999-02-10 Chromatographic process for obtaining very pure cyclosporin a and related cyclosporins HK1015382A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1996111094 DE19611094C2 (de) 1996-03-21 1996-03-21 Verfahren zur Reinigung von Cyclosporin A und/oder verwandten Cyclosporinen aus einem Cyclosporin-haltigen Rohextrakt unter Anwendung chromatographischer Verfahren mit Kieselgel als Adsorbens
PCT/DE1997/000525 WO1997034918A1 (de) 1996-03-21 1997-03-14 Chromatographisches verfahren zur gewinnung von hochgereinigtem cyclosporin a und verwandten cyclosporinen

Publications (1)

Publication Number Publication Date
HK1015382A1 true HK1015382A1 (en) 1999-10-15

Family

ID=7788939

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99100547A HK1015382A1 (en) 1996-03-21 1999-02-10 Chromatographic process for obtaining very pure cyclosporin a and related cyclosporins

Country Status (19)

Country Link
US (1) US6306306B1 (da)
EP (1) EP0888382B1 (da)
JP (1) JP3408818B2 (da)
KR (1) KR100467127B1 (da)
CN (1) CN1196711C (da)
AT (1) ATE210146T1 (da)
CZ (1) CZ293243B6 (da)
DE (3) DE19611094C2 (da)
DK (1) DK0888382T3 (da)
ES (1) ES2169384T3 (da)
HK (1) HK1015382A1 (da)
HU (1) HU222200B1 (da)
IL (1) IL125807A (da)
NO (1) NO321570B1 (da)
PL (1) PL187763B1 (da)
PT (1) PT888382E (da)
RU (1) RU2163607C2 (da)
SK (1) SK282836B6 (da)
WO (1) WO1997034918A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19858892A1 (de) * 1998-12-19 2000-06-21 Merck Patent Gmbh Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße
ATE404172T1 (de) 1998-12-30 2008-08-15 Dexcel Ltd Dispergierbares konzentrat zur verabreichung von cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
ES2266564T3 (es) 2001-10-19 2007-03-01 Isotechnika Inc. Sintesis de analogos de cicloporinas.
US6843854B2 (en) 2002-05-31 2005-01-18 Purdue Research Foundation Method and apparatus for separating a component from a mixture
DK1545574T3 (da) 2002-09-13 2014-09-08 Biogen Idec Inc Fremgangsmåde til rensning af polypeptider ved simuleret moving-bed-chromatografi
CN1763084B (zh) * 2005-10-11 2010-04-21 山东新时代药业有限公司 高纯度环孢菌素a的制备方法
EP2151450A1 (de) 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
CN102086226B (zh) * 2009-12-04 2012-10-10 山东新时代药业有限公司 一种制备环孢菌素a的方法
US9428711B2 (en) 2013-05-07 2016-08-30 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US8802880B1 (en) 2013-05-07 2014-08-12 Group Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
EP3118186B1 (fr) 2013-12-11 2022-02-09 Novasep Process Installation chromatographique de production d acides gras polyinsatures
EP3092218B1 (fr) 2014-01-07 2022-03-09 Novasep Process Solutions Procédé de purification d'acides aminés aromatiques
HUP1500502A2 (en) * 2015-10-26 2017-04-28 Rotachrom Tech Kft Process for the purification of cyclosporin-a

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB568698A (en) 1943-05-26 1945-04-17 M O Valve Co Ltd Improvements in the capping of thermionic valves, electric lamps and like devices
US2985589A (en) * 1957-05-22 1961-05-23 Universal Oil Prod Co Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets
US4117118A (en) 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4215199A (en) 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
SE448386B (sv) 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4402832A (en) * 1982-08-12 1983-09-06 Uop Inc. High efficiency continuous separation process
US4923616A (en) * 1987-09-24 1990-05-08 Mitsubishi Petrochemical Company, Ltd. Method of separating chemical components in simulated moving bed
HU201577B (en) 1988-12-20 1990-11-28 Gyogyszerkutato Intezet Process for producing cyclosporin antibiotics
JP3099365B2 (ja) * 1991-01-25 2000-10-16 藤沢薬品工業株式会社 シクロスポリンａおよび／またはｃの製造法
HU213553B (en) 1992-05-25 1997-07-28 Biogal Gyogyszergyar Process for isolating of cyclosporin-a
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins

Also Published As

Publication number Publication date
HUP9901801A2 (hu) 1999-09-28
HUP9901801A3 (en) 2001-01-29
DE59705670D1 (de) 2002-01-17
DE19611094A1 (de) 1997-09-25
ES2169384T3 (es) 2002-07-01
KR100467127B1 (ko) 2005-05-27
DK0888382T3 (da) 2002-04-02
DE19611094C2 (de) 1999-06-17
WO1997034918A1 (de) 1997-09-25
JP2000507237A (ja) 2000-06-13
IL125807A0 (en) 1999-04-11
KR20000064784A (ko) 2000-11-06
PT888382E (pt) 2002-05-31
NO984133L (no) 1998-09-08
PL187763B1 (pl) 2004-10-29
US6306306B1 (en) 2001-10-23
CN1196711C (zh) 2005-04-13
JP3408818B2 (ja) 2003-05-19
CZ293243B6 (cs) 2004-03-17
CZ299998A3 (cs) 1999-10-13
NO984133D0 (no) 1998-09-08
EP0888382B1 (de) 2001-12-05
CN1212703A (zh) 1999-03-31
IL125807A (en) 2003-10-31
HU222200B1 (hu) 2003-05-28
SK122298A3 (en) 1999-08-06
DE19716167A1 (de) 1998-10-22
EP0888382A1 (de) 1999-01-07
NO321570B1 (no) 2006-06-06
PL329113A1 (en) 1999-03-15
DE19716167C2 (de) 2000-06-29
RU2163607C2 (ru) 2001-02-27
ATE210146T1 (de) 2001-12-15
SK282836B6 (sk) 2002-12-03

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20060314

ARF Application filed for restoration

Effective date: 20061005

ARG Restoration of standard patent granted

Effective date: 20061122

PE Patent expired

Effective date: 20170313