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HK1071366A1 - Compounds which inhibit the release of inflammatory cytokines - Google Patents

Compounds which inhibit the release of inflammatory cytokines Download PDF

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Publication number
HK1071366A1
HK1071366A1 HK05104163A HK05104163A HK1071366A1 HK 1071366 A1 HK1071366 A1 HK 1071366A1 HK 05104163 A HK05104163 A HK 05104163A HK 05104163 A HK05104163 A HK 05104163A HK 1071366 A1 HK1071366 A1 HK 1071366A1
Authority
HK
Hong Kong
Prior art keywords
fluorophenyl
ethylamino
radical
hydrogen
group
Prior art date
Application number
HK05104163A
Other languages
English (en)
Chinese (zh)
Other versions
HK1071366B (en
Inventor
M.P.克拉克
M.J.罗弗斯威勒
J.F.-J.杜琼
B.德
Original Assignee
The Procter & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Publication of HK1071366A1 publication Critical patent/HK1071366A1/xx
Publication of HK1071366B publication Critical patent/HK1071366B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK05104163.8A 2001-09-20 2002-09-20 Compounds which inhibit the release of inflammatory cytokines HK1071366B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32362501P 2001-09-20 2001-09-20
US60/323,625 2001-09-20
PCT/US2002/030134 WO2003024970A1 (en) 2001-09-20 2002-09-20 Compounds which inhibit the release of inflammatory cytokines

Publications (2)

Publication Number Publication Date
HK1071366A1 true HK1071366A1 (en) 2005-07-15
HK1071366B HK1071366B (en) 2006-12-22

Family

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Also Published As

Publication number Publication date
DE60202782D1 (de) 2005-03-03
ZA200401403B (en) 2004-08-30
MXPA04002574A (es) 2004-06-18
ATE356126T1 (de) 2007-03-15
EP1427732B1 (en) 2006-07-12
ES2282459T3 (es) 2007-10-16
HUP0402378A3 (en) 2008-10-28
CO5560590A2 (es) 2005-09-30
WO2003024970A1 (en) 2003-03-27
ES2237691T3 (es) 2005-08-01
BR0212673A (pt) 2004-08-24
JP2005504083A (ja) 2005-02-10
HUP0500752A2 (en) 2006-01-30
MA27064A1 (fr) 2004-12-20
MXPA04002569A (es) 2004-05-31
EG24413A (en) 2009-05-25
KR100656126B1 (ko) 2006-12-12
CN1555379A (zh) 2004-12-15
EP1427728B1 (en) 2007-03-07
ATE332901T1 (de) 2006-08-15
PL370362A1 (en) 2005-05-16
HUP0402500A3 (en) 2008-10-28
KR20040035835A (ko) 2004-04-29
CZ2004361A3 (cs) 2004-07-14
KR20040035837A (ko) 2004-04-29
RU2272040C2 (ru) 2006-03-20
RU2004111803A (ru) 2005-10-10
HUP0402378A2 (hu) 2005-02-28
BR0212716A (pt) 2004-08-03
JP2005504082A (ja) 2005-02-10
WO2003024971A1 (en) 2003-03-27
DE60213108T2 (de) 2007-02-08
ZA200401402B (en) 2004-08-27
NZ531122A (en) 2005-09-30
CZ2004358A3 (cs) 2004-07-14
PE20030446A1 (es) 2003-07-21
IL160682A0 (en) 2004-08-31
SK1482004A3 (en) 2004-08-03
CY1106398T1 (el) 2011-10-12
EG24363A (en) 2009-03-04
ZA200401260B (en) 2004-08-30
PE20030430A1 (es) 2003-06-24
JP2005504081A (ja) 2005-02-10
WO2003024973A1 (en) 2003-03-27
PT1427728E (pt) 2007-05-31
MA27065A1 (fr) 2004-12-20
ATE287887T1 (de) 2005-02-15
PE20030474A1 (es) 2003-07-22
AR037145A1 (es) 2004-10-27
CZ2004345A3 (cs) 2004-06-16
NO20041605L (no) 2004-06-21
AU2002334641B2 (en) 2007-03-29
PT1427727E (pt) 2005-06-30
BR0212905A (pt) 2004-10-13
SA03230529B1 (ar) 2008-06-21
PT1427732E (pt) 2006-12-29
US6566357B1 (en) 2003-05-20
CN1555375A (zh) 2004-12-15
CN1556811A (zh) 2004-12-22
HUP0402500A2 (hu) 2005-03-29
PL370351A1 (en) 2005-05-16
RU2299885C2 (ru) 2007-05-27
ES2268154T3 (es) 2007-03-16
AR037502A1 (es) 2004-11-17
MY129329A (en) 2007-03-30
MY129069A (en) 2007-03-30
CO5560579A2 (es) 2005-09-30
IL160741A0 (en) 2004-08-31
IL160742A0 (en) 2004-08-31
DE60202782T2 (de) 2006-01-19
DE60218704T2 (de) 2007-11-08
RU2004111805A (ru) 2005-04-10
AR037237A1 (es) 2004-11-03
CA2461073A1 (en) 2003-03-27
KR20060036125A (ko) 2006-04-27
SK1492004A3 (en) 2004-11-03
AU2002327690B2 (en) 2006-07-20
CN1257905C (zh) 2006-05-31
KR20040035836A (ko) 2004-04-29
CA2461071A1 (en) 2003-03-27
PL370415A1 (en) 2005-05-30
EP1427727B1 (en) 2005-01-26
DK1427728T3 (da) 2007-07-09
HK1071565A1 (en) 2005-07-22
DE60218704D1 (de) 2007-04-19
KR100623879B1 (ko) 2006-09-19
DK1427732T3 (da) 2006-10-30
RU2004111806A (ru) 2005-03-27
SK1502004A3 (en) 2004-09-08
US20030105084A1 (en) 2003-06-05
EP1427732A1 (en) 2004-06-16
NO20041594L (no) 2004-06-21
CN1249066C (zh) 2006-04-05
MA27066A1 (fr) 2004-12-20
RU2278864C2 (ru) 2006-06-27
CA2461072A1 (en) 2003-03-27
DE60213108D1 (de) 2006-08-24
CN1250551C (zh) 2006-04-12
MXPA04002570A (es) 2004-05-31
NZ531063A (en) 2007-08-31
EP1427727A1 (en) 2004-06-16
US6821971B2 (en) 2004-11-23
CO5560589A2 (es) 2005-09-30
NZ531123A (en) 2006-08-31
EP1427728A1 (en) 2004-06-16

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100920