Nothing Special   »   [go: up one dir, main page]

HK1071162A1 - Method for differentiating mesenchymal stem cells into neural cells - Google Patents

Method for differentiating mesenchymal stem cells into neural cells

Info

Publication number
HK1071162A1
HK1071162A1 HK05104260.0A HK05104260A HK1071162A1 HK 1071162 A1 HK1071162 A1 HK 1071162A1 HK 05104260 A HK05104260 A HK 05104260A HK 1071162 A1 HK1071162 A1 HK 1071162A1
Authority
HK
Hong Kong
Prior art keywords
mesenchymal stem
cells
neural
stem cells
growth factor
Prior art date
Application number
HK05104260.0A
Other languages
English (en)
Inventor
Hyun Soo Kim
Hee Hoon Yoon
Original Assignee
Hyun Soo Kim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyun Soo Kim filed Critical Hyun Soo Kim
Publication of HK1071162A1 publication Critical patent/HK1071162A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK05104260.0A 2001-04-19 2005-05-20 Method for differentiating mesenchymal stem cells into neural cells HK1071162A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2001-0021064A KR100449141B1 (ko) 2001-04-19 2001-04-19 간엽 간세포를 신경세포로 분화시키는 방법
PCT/KR2002/000718 WO2002086108A1 (en) 2001-04-19 2002-04-19 Method for differentiating mesenchymal stem cells into neural cells

Publications (1)

Publication Number Publication Date
HK1071162A1 true HK1071162A1 (en) 2005-07-08

Family

ID=19708462

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05104260.0A HK1071162A1 (en) 2001-04-19 2005-05-20 Method for differentiating mesenchymal stem cells into neural cells

Country Status (9)

Country Link
US (1) US7229827B2 (ko)
EP (1) EP1379627B1 (ko)
JP (1) JP3976190B2 (ko)
KR (1) KR100449141B1 (ko)
CN (1) CN100535106C (ko)
CA (1) CA2444724C (ko)
DE (1) DE60228067D1 (ko)
HK (1) HK1071162A1 (ko)
WO (1) WO2002086108A1 (ko)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252280B1 (en) 1999-08-05 2012-08-28 Regents Of The University Of Minnesota MAPC generation of muscle
US8075881B2 (en) * 1999-08-05 2011-12-13 Regents Of The University Of Minnesota Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure
WO2001011011A2 (en) * 1999-08-05 2001-02-15 Mcl Llc Multipotent adult stem cells and methods for isolation
US8609412B2 (en) * 1999-08-05 2013-12-17 Regents Of The University Of Minnesota Mapc generation of lung tissue
US10638734B2 (en) 2004-01-05 2020-05-05 Abt Holding Company Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
CA2438501C (en) * 2001-02-14 2014-09-16 Leo T. Furcht Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
DE10144326B4 (de) * 2001-09-10 2005-09-22 Siemens Ag Verfahren und System zur Überwachung eines Reifenluftdrucks
BR0306902A (pt) * 2002-01-14 2006-04-11 Ford Henry Health System materiais de células estromais de medula óssea para uso na formação de vasos sanguìneos e produção de fatores angiogênicos e tróficos
WO2003066856A1 (en) 2002-02-06 2003-08-14 Sanbio, Inc. METHOD OF DIFFERENTIATING/INDUCING BONE MARROW INTERSTITIAL CELLS INTO NERVE CELLS AND SKELETON MUSCLE CELLS BY TRANSFERRING Notch GENE
KR100519227B1 (ko) * 2002-08-17 2005-10-07 서해영 간엽 줄기세포를 신경세포로 분화시키는 방법
KR100495532B1 (ko) * 2002-09-18 2005-06-14 에프씨비파미셀 주식회사 간엽 간세포를 신경세포로 분화 및 증식시키는 방법
US20060228798A1 (en) * 2002-11-27 2006-10-12 Catherine Verfaillie Homologous recombination in multipotent adult progenitor cells
CN1745168A (zh) * 2002-12-02 2006-03-08 安增子摩祺株式会社 利用肝细胞生长因子培养神经干细胞的方法
ZA200404101B (en) * 2003-05-26 2005-03-07 Reliance Life Sciences Pvt Ltd In vitro culture of Mesenchymal Stem Cells (MSC) and a process for the preparation thereof for therapeutic use.
WO2005003320A2 (en) * 2003-07-02 2005-01-13 Regents Of The University Of Minnesota Neuronal differentiation of stem cells
ATE388223T1 (de) * 2003-10-29 2008-03-15 Fcb Pharmicell Co Ltd Verfahren zur differenzierung einer mesenchym- stammzelle zu einer nervenzelle sowie die nervenzelle enthaltende pharmazeutische zusammensetzung gegen eine neurodegenerative krankheit
JP2005176659A (ja) * 2003-12-17 2005-07-07 Ikushu Fu 幹細胞からニューロンを生成する方法および幹細胞を培養するための培地
US7534606B2 (en) 2004-01-12 2009-05-19 National Health Research Institutes Placental stem cell and methods thereof
DK1737950T3 (da) * 2004-04-12 2011-12-05 Sanbio Inc Celler, der udviser neuronal-progenitorcelle-karakteristika
JP4624033B2 (ja) * 2004-08-11 2011-02-02 オリンパス株式会社 間葉系幹細胞の培養方法および肝細胞増殖因子の使用方法
EP2428563A1 (en) * 2005-02-10 2012-03-14 Regents Of The University Of Minnesota Vascular/lymphatic endothelial cells
WO2006121428A1 (en) * 2005-05-05 2006-11-16 Regents Of The University Of Minnesota Use of nk cell inhibition to facilitate persistence of engrafted mhc- i negative cells
AU2005331534B2 (en) * 2005-05-05 2011-12-08 Regents Of The University Of Minnesota Use of MAPC or progeny therefrom to populate lymphohematopoietic tissues
JP2008546385A (ja) 2005-06-16 2008-12-25 ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド Ｃｎｓ疾患を治療するための単離された細胞および単離された細胞を含む集団
US20080194024A1 (en) * 2005-07-29 2008-08-14 Mays Robert W Culture of Non-Embryonic Cells at High Cell Density
CA2625883A1 (en) * 2005-10-14 2007-04-26 Regents Of The University Of Minnesota Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype
CN101070532B (zh) * 2006-05-12 2011-03-30 上海国睿生命科技有限公司 一种诱导干细胞向血管平滑肌细胞分化的方法
WO2007136156A1 (en) * 2006-05-24 2007-11-29 Corestem Co., Ltd. Methods and compositions for treating motor neuron diseases comprising mesenchymal stem cells
US20080118477A1 (en) * 2006-11-09 2008-05-22 Rush University Medical Center Umbilical cord mesenchymal stem cells support cord blood hematopoiesis
US9387226B2 (en) 2006-11-30 2016-07-12 Medipost Co., Ltd Neural cell proliferation induced through the culture of neural cells with umbilical cord blood-derived mesenchymal stem cells
CN101848993A (zh) * 2007-07-19 2010-09-29 新加坡科技研究局 使胚胎干细胞分化成表达aqp-1的细胞的方法
KR100935639B1 (ko) * 2007-09-07 2010-01-07 부산대학교 산학협력단 조직재생능이 향상된 중간엽 줄기세포 및 그의 제조방법
EP2245141B1 (en) 2008-01-18 2018-03-14 Regents of the University of Minnesota Stem cell aggregates and methods for making and using
EP2620493B1 (en) 2008-05-28 2019-03-27 Ramot at Tel Aviv University Ltd. Mesenchymal stem cells for the treatment of CNS diseases
EP2362899A1 (en) 2008-10-31 2011-09-07 Katholieke Universiteit Leuven Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods for using the cells
KR20100054711A (ko) 2008-11-14 2010-05-25 메디포스트(주) 간엽 줄기세포 또는 이의 배양액을 포함하는 신경질환의 예방 또는 치료용 조성물
SG178065A1 (en) * 2009-07-21 2012-03-29 Abt Holding Co Use of stem cells to reduce leukocyte extravasation
KR20180014224A (ko) * 2009-07-21 2018-02-07 에이비티 홀딩 컴퍼니 백혈구 혈관외유출을 감소시키기 위한 줄기 세포의 용도
US20110206647A1 (en) * 2010-02-25 2011-08-25 Abt Holding Company Modulation of Angiogenesis
WO2011106476A1 (en) * 2010-02-25 2011-09-01 Abt Holding Company Modulation of microglia activation
JPWO2011118795A1 (ja) 2010-03-26 2013-07-04 国立大学法人名古屋大学 損傷部治療用組成物
CA2798895A1 (en) 2010-05-12 2011-11-17 Abt Holding Company Modulation of splenocytes in cell therapy
JP2010207245A (ja) * 2010-06-01 2010-09-24 Ikushu Fu 幹細胞からニューロンを生成する方法および幹細胞を培養するための培地
WO2011158125A2 (en) 2010-06-17 2011-12-22 Katholieke Universiteit Leuven Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells
WO2012027474A1 (en) 2010-08-24 2012-03-01 Regents Of The University Of Minnesota Non-static suspension culture of cell aggregates
WO2012048276A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
SG11201404603SA (en) 2012-02-10 2014-10-30 Japanic Corp Cosmetic product or skin regeneration promoter comprising nonhuman stem cell culture supernatant as starting material, and method for ion introduction for protein
EP3401393B1 (en) * 2012-02-22 2020-02-19 Exostem Biotec Ltd Micrornas for the generation of astrocytes
CN102978156A (zh) * 2012-11-13 2013-03-20 湖州市中心医院 一种骨髓间充质干细胞的体外扩增纯化培养方法及培养基
SG11201508403XA (en) 2013-04-12 2015-11-27 Saverio Lafrancesca Improving organs for transplantation
EP3058063B1 (en) * 2013-10-14 2018-06-06 Hadasit Medical Research Services and Development Ltd. Method of obtaining terminally differentiated neuronal lineages
KR101542848B1 (ko) * 2013-11-01 2015-08-10 주식회사 비비에이치씨 중간엽 줄기세포로부터 유도된 만능 줄기세포를 이용하여 골아세포로 분화시키는 방법
EP3068867B1 (en) 2013-11-16 2018-04-18 Terumo BCT, Inc. Expanding cells in a bioreactor
KR20150062817A (ko) * 2013-11-29 2015-06-08 가톨릭대학교 산학협력단 태반의 융모막 또는 와튼제대교질 유래 간엽줄기세포로부터 신경세포 및 유모세포를 분화시키는 방법
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
CN106715676A (zh) 2014-09-26 2017-05-24 泰尔茂比司特公司 按计划供养
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US10478458B2 (en) 2015-08-03 2019-11-19 The Johns Hopkins University In vitro pre-conditioned bone marrow-derived mesenchymal stem cells and uses thereof
KR20180102661A (ko) 2016-01-21 2018-09-17 에이비티 홀딩 컴퍼니 상처 치유를 위한 줄기 세포
CN105505875A (zh) * 2016-02-16 2016-04-20 杨廷稳 一种高效诱导干细胞定向分化的培养基和培养方法
CN105586314A (zh) * 2016-02-16 2016-05-18 赵顺英 用于诱导干细胞定向分化的方法
EP3464565A4 (en) 2016-05-25 2020-01-01 Terumo BCT, Inc. CELL EXPANSION
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
CN106190963A (zh) * 2016-07-13 2016-12-07 浙江大学 一种采用线粒体移植促进损伤神经元存活的方法
CN106244550A (zh) * 2016-09-30 2016-12-21 广州赛莱拉干细胞科技股份有限公司 一种细胞培养液及其应用和诱导骨骼肌干细胞向神经样细胞分化的方法
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion
CN109694851B (zh) * 2019-01-16 2021-03-16 吉林省拓华生物科技有限公司 一种人间充质干细胞的诱导组合物、诱导分化培养液及其体外诱导方法和应用
CN113439120A (zh) * 2019-01-22 2021-09-24 高丽大学校产学协力团 用于将神经干细胞分化为星形胶质细胞的基于直接细胞转化的方法
CN111733133B (zh) * 2020-07-22 2020-12-01 华夏源(上海)生命科技有限公司 一种促进表皮干细胞分化和生长的方法
CN112481213B (zh) * 2020-11-30 2022-08-09 德州蓝力生物技术有限公司 一种小分子活性肽在诱导hUC-MSCs分化方面的应用
WO2022204315A1 (en) 2021-03-23 2022-09-29 Terumo Bct, Inc. Cell capture and expansion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5980885A (en) * 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. Growth factor-induced proliferation of neural precursor cells in vivo
US6143714A (en) * 1994-10-24 2000-11-07 Regeneron Pharmaceuticals, Inc. Methods of using hepatocyte growth factor to promote survival, growth and differentiation of motor neurons
US5736396A (en) * 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5753506A (en) * 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
WO1999011287A1 (en) * 1997-09-04 1999-03-11 Osiris Therapeutics, Inc. Ligands that modulate differentiation of mesenchymal stem cells
WO2001021766A2 (en) * 1999-09-23 2001-03-29 Cell Science Therapeutics Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells

Also Published As

Publication number Publication date
JP3976190B2 (ja) 2007-09-12
CN100535106C (zh) 2009-09-02
DE60228067D1 (de) 2008-09-18
EP1379627B1 (en) 2008-08-06
EP1379627A1 (en) 2004-01-14
JP2004527250A (ja) 2004-09-09
CA2444724C (en) 2011-07-05
CN1549856A (zh) 2004-11-24
KR100449141B1 (ko) 2004-09-21
EP1379627A4 (en) 2005-08-31
US7229827B2 (en) 2007-06-12
KR20020082239A (ko) 2002-10-31
CA2444724A1 (en) 2002-10-31
US20040151701A1 (en) 2004-08-05
WO2002086108A1 (en) 2002-10-31

Similar Documents

Publication Publication Date Title
HK1071162A1 (en) Method for differentiating mesenchymal stem cells into neural cells
ATE513901T1 (de) Neurale vorläuferzellen
PT1218509E (pt) Polipéptidos do tipo factor de crescimento de fibroblastos
EP1416944A4 (en) COMPOSITION FOR TREATING DAMAGE TO THE CORRUPT
ATE342348T1 (de) Serum-freies medium für chondrozyt-ähnliche zellen
HK1049350A1 (en) Multipotent adult stem cells and methods for isolation
HK1093755A1 (en) Method for differentiating mesenchymal stem cell into neural cell
HK1091228A1 (en) Methods for making recombinant proteins using apoptosis inhibitors
WO2003050249A3 (en) Islet cells from human embryonic stem cells
EP1738717A3 (en) In vitro production of transplantable cartilage tissue
HK1019233A1 (en) Animal cells and processes for the replication of influenza viruses
AU2002258477A1 (en) Use of rna interference for the creation of lineage specific es and other undifferentiated cells and production of differentiated cells in vitro by co-culture
WO2006081190A3 (en) Compositions and methods for treating cardiac conditions
CY1108329T1 (el) Κυτταρικη καλλιεργεια
WO2002064748A3 (en) Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
DK1242578T3 (da) Celledyrkningsmedium indeholdende vækstfaktorer og L-glutamin
WO2003023018A3 (en) A method for isolating, culturing and differentiating intestinal stem cells for therapeutic use
WO2003085099A3 (en) A process for the preparation of stem cells from human muscle tissue and adipose tissue, and stem cells obtainable by this process
EP3031326A3 (en) Bone marrow-derived mesenchymal stem cells as a source of neural progenitors
DE69535300D1 (de) In-vitro-Musters für ZNS - Funktion und Dysfunktion
ATE364408T1 (de) Verfahren zur kultivierung von knorpelersatz und biomatrix nach diesem verfahren hergestellt
GR3032105T3 (en) Callus cell induction and the preparation of taxanes.
TW200617165A (en) Process for preparing a conditioned medium of astrocyte-like cells
TW200510011A (en) A method for regeneration of bone
DE60326003D1 (de) Ter verwendung des hepatozytenwachstumsfaktors

Legal Events

Date Code Title Description
AM Amended specification (according sect 146 of patent law)

Free format text: CORRECTION OF THE NAME OF APPLICANT FROM FCB-PHARMICELL CO., LTD. TO KIM, HYUN-SOO AND FCB-PHARMICELL CO., LTD. UNDER SECTION 146.

Effective date: 20070817

PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20140419