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HK1062266A1 - Combination comprising a signal transduction inhibitor and an epothilone derivative - Google Patents

Combination comprising a signal transduction inhibitor and an epothilone derivative

Info

Publication number
HK1062266A1
HK1062266A1 HK04105220.7A HK04105220A HK1062266A1 HK 1062266 A1 HK1062266 A1 HK 1062266A1 HK 04105220 A HK04105220 A HK 04105220A HK 1062266 A1 HK1062266 A1 HK 1062266A1
Authority
HK
Hong Kong
Prior art keywords
combination
signal transduction
transduction inhibitor
epothilone derivative
derivative
Prior art date
Application number
HK04105220.7A
Other languages
English (en)
Inventor
Elisabeth Buchdunger
Carl-Henrik Heldin
Arne Oestman
Kristian Pietras
Terence O'reilly
John David Rothermel
Peter Traxler
Markus Wartmann
Ralf Brandt
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0104840.4A external-priority patent/GB0104840D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1062266A1 publication Critical patent/HK1062266A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK04105220.7A 2001-02-27 2004-07-15 Combination comprising a signal transduction inhibitor and an epothilone derivative HK1062266A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0104840.4A GB0104840D0 (en) 2001-02-27 2001-02-27 Use of organic compounds
US33904001P 2001-10-30 2001-10-30
PCT/EP2002/002049 WO2002067941A2 (en) 2001-02-27 2002-02-26 Combination comprising a signal transduction inhibitor and an epothilone derivative

Publications (1)

Publication Number Publication Date
HK1062266A1 true HK1062266A1 (en) 2004-10-29

Family

ID=26245767

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04105220.7A HK1062266A1 (en) 2001-02-27 2004-07-15 Combination comprising a signal transduction inhibitor and an epothilone derivative

Country Status (23)

Country Link
US (1) US7723339B2 (xx)
EP (1) EP1385522B1 (xx)
JP (1) JP4499359B2 (xx)
KR (1) KR100848197B1 (xx)
CN (1) CN1511036B (xx)
AT (1) ATE434438T1 (xx)
AU (1) AU2002308218B2 (xx)
BR (1) BR0207649A (xx)
CA (1) CA2439268C (xx)
CY (1) CY1109347T1 (xx)
DE (1) DE60232719D1 (xx)
DK (1) DK1385522T3 (xx)
ES (1) ES2326264T3 (xx)
HK (1) HK1062266A1 (xx)
IL (2) IL157466A0 (xx)
MX (1) MXPA03007729A (xx)
NO (1) NO325416B1 (xx)
NZ (1) NZ527764A (xx)
PL (1) PL207197B1 (xx)
PT (1) PT1385522E (xx)
RU (1) RU2313345C2 (xx)
SK (1) SK287489B6 (xx)
WO (1) WO2002067941A2 (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0977563B1 (en) * 1996-12-03 2005-10-12 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US7312237B2 (en) 2001-03-14 2007-12-25 Bristol-Myers Squibb Co. Combination of epothilone analogs and chemotherapeutic agents for the treatment of prolilferative diseases
EP1704863A3 (en) * 2001-05-16 2010-11-24 Novartis AG Combination comprising N-5-4-(4-Methyl-Piperazino-Methyl-)Benzoyla Mido]-2-Methylphenyl -4-(3-Pyridyl)-2Phyrimidine-amine and a chemotherapeutic agent
ATE359790T1 (de) * 2001-05-16 2007-05-15 Novartis Pharma Gmbh Kombination von n- 5- 4-(4-methyl-piperazino- methyl)-benzoylamido -2-methylphenyl -4-(3- pyridil)-2pyrimidine-amin mit einem biphosphonat
WO2003037897A2 (en) * 2001-10-29 2003-05-08 Novartis Ag Use of 7h-pyrrolo[2,3-d]pyrimidine derivatives in the treatment of solid tumor diseases
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
ES2336937T3 (es) 2002-08-23 2010-04-19 Sloan-Kettering Institute For Cancer Research Sintesis de epotilonas, sus intermedios, analogos y usos.
US20050171167A1 (en) * 2003-11-04 2005-08-04 Haby Thomas A. Process and formulation containing epothilones and analogs thereof
JO2596B1 (en) * 2004-11-30 2011-02-27 نوفارتيس ايه جي Compositions include epothelones and tyrosine protein kinase inhibitors and their pharmaceutical uses
US20060121511A1 (en) 2004-11-30 2006-06-08 Hyerim Lee Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents
EP1856255A4 (en) 2005-02-11 2010-01-27 Univ Southern California METHODS OF EXPRESSING PROTEINS WITH DISULFIDE BRIDGES
EP2029156A4 (en) * 2006-05-01 2010-07-21 Univ Southern California POLY THERAPY FOR TREATING CANCER
WO2010056901A2 (en) 2008-11-13 2010-05-20 University Of Southern California Method of expressing proteins with disulfide bridges with enhanced yields and activity
WO2010108503A1 (en) 2009-03-24 2010-09-30 Life & Brain Gmbh Promotion of neuronal integration in neural stem cell grafts
CN105797168A (zh) 2010-05-18 2016-07-27 天蓝制药公司 用于治疗自身免疫性疾病或其它疾病的组合物和方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006692A1 (en) * 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
DE4138042C2 (de) 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
TW225528B (xx) * 1992-04-03 1994-06-21 Ciba Geigy Ag
CN1100778C (zh) * 1995-07-06 2003-02-05 诺瓦蒂斯有限公司 吡咯并嘧啶及其制备方法
DK0941227T5 (da) 1996-11-18 2009-10-05 Biotechnolog Forschung Gmbh Epothilon D, dens fremstilling samt dens anvendelse som cytostatisk middel og som plantebeskyttelsesmiddel
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
US6302838B1 (en) * 1998-02-25 2001-10-16 Novartis Ag Cancer treatment with epothilones
AU5036999A (en) * 1998-06-30 2000-01-17 Schering Aktiengesellschaft Epothilon derivatives, their preparation process, intermediate products and their pharmaceutical use
SK11452001A3 (sk) * 1999-02-11 2002-04-04 Schering Aktiengesellschaft Deriváty epotilónu, farmaceutický prípravok s ich obsahom a ich použitie
DE19908760A1 (de) * 1999-02-18 2000-08-24 Schering Ag Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung

Also Published As

Publication number Publication date
KR100848197B1 (ko) 2008-07-24
CA2439268C (en) 2010-01-19
NO325416B1 (no) 2008-04-21
CA2439268A1 (en) 2002-09-06
SK10712003A3 (sk) 2004-02-03
US20040132754A1 (en) 2004-07-08
PT1385522E (pt) 2009-09-04
EP1385522B1 (en) 2009-06-24
EP1385522A2 (en) 2004-02-04
CN1511036A (zh) 2004-07-07
AU2002308218B2 (en) 2005-11-10
JP4499359B2 (ja) 2010-07-07
PL363288A1 (en) 2004-11-15
MXPA03007729A (es) 2003-12-04
NO20033769D0 (no) 2003-08-25
RU2003127392A (ru) 2005-03-27
IL157466A (en) 2012-04-30
WO2002067941A3 (en) 2003-11-20
CN1511036B (zh) 2010-05-05
RU2313345C2 (ru) 2007-12-27
WO2002067941A2 (en) 2002-09-06
BR0207649A (pt) 2004-03-09
ATE434438T1 (de) 2009-07-15
IL157466A0 (en) 2004-03-28
JP2004527493A (ja) 2004-09-09
ES2326264T3 (es) 2009-10-06
PL207197B1 (pl) 2010-11-30
DE60232719D1 (de) 2009-08-06
KR20040025900A (ko) 2004-03-26
NZ527764A (en) 2006-01-27
NO20033769L (no) 2003-08-25
SK287489B6 (sk) 2010-11-08
CY1109347T1 (el) 2014-07-02
WO2002067941A8 (en) 2003-12-18
DK1385522T3 (da) 2009-10-12
US7723339B2 (en) 2010-05-25

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20140226