GR80439B - 2,5 disubstituted-4(3h)-pyrimidones having histamine h2-receptor antagonist activity - Google Patents

2,5 disubstituted-4(3h)-pyrimidones having histamine h2-receptor antagonist activity

Info

Publication number: GR80439B
Authority: GR; Greece
Prior art keywords: pyrimidones; histamine; disubstituted; receptor antagonist; antagonist activity
Prior art date: 1983-09-21

Application number

GR80439A

Other languages

English (en)

Inventor

Algieri A Aldo

Fayetteville Lane

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-09-21

Filing date

1984-09-21

Publication date

1985-01-22

1984-09-21 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1985-01-22 Publication of GR80439B publication Critical patent/GR80439B/el

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

GR80439A 1983-09-21 1984-09-21 2,5 disubstituted-4(3h)-pyrimidones having histamine h2-receptor antagonist activity GR80439B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/534,426 US4772704A (en)	1983-09-21	1983-09-21	2,5-disubstituted-4(3H)-pyrimidones having histamine H2 -receptor antagonist activity

Publications (1)

Publication Number	Publication Date
GR80439B true GR80439B (en)	1985-01-22

Family

ID=24129972

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR80439A GR80439B (en)	1983-09-21	1984-09-21	2,5 disubstituted-4(3h)-pyrimidones having histamine h2-receptor antagonist activity

Country Status (36)

Country	Link
US (1)	US4772704A (el)
JP (1)	JPH0643310B2 (el)
KR (1)	KR900001198B1 (el)
AR (2)	AR242385A1 (el)
AT (1)	AT387965B (el)
AU (1)	AU583479B2 (el)
BE (1)	BE900652A (el)
CA (1)	CA1260463A (el)
CH (1)	CH665840A5 (el)
CS (1)	CS249147B2 (el)
CY (1)	CY1561A (el)
DD (1)	DD226881A5 (el)
DE (1)	DE3434578A1 (el)
DK (1)	DK162987C (el)
ES (4)	ES8607253A1 (el)
FI (1)	FI83868C (el)
FR (1)	FR2552082B1 (el)
GB (1)	GB2146994B (el)
GR (1)	GR80439B (el)
HK (1)	HK73790A (el)
HU (1)	HU193227B (el)
IE (1)	IE58083B1 (el)
IL (1)	IL72990A (el)
IT (1)	IT1176739B (el)
LU (1)	LU85550A1 (el)
NL (1)	NL8402898A (el)
NO (1)	NO161561C (el)
NZ (1)	NZ209572A (el)
OA (1)	OA07820A (el)
PT (1)	PT79256B (el)
SE (1)	SE463209B (el)
SG (1)	SG60890G (el)
YU (1)	YU45205B (el)
ZA (1)	ZA847345B (el)
ZM (1)	ZM4984A1 (el)
ZW (1)	ZW16084A1 (el)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2873340B2 (ja) *	1988-04-29	1999-03-24	武田薬品工業株式会社	抗生物質ｔａｎ―１０５７，その製造法および用途
US20230349922A1 (en)	2020-08-11	2023-11-02	Université De Strasbourg	H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN151188B (el) *	1978-02-13	1983-03-05	Smith Kline French Lab
ES477520A1 (es) *	1978-02-25	1979-06-01	Thomae Gmbh Dr K	Procedimiento para la preparacion de nuevas penicilinas.
IL57005A (en) *	1978-04-11	1983-11-30	Smith Kline French Lab	Process for the preparation of 2-amino pyrimid-4-one derivatives and novel 2-nitroaminopyrimid-4-ones as intermediates therefor
US4496567A (en) *	1978-11-13	1985-01-29	Smith Kline & French Laboratories Limited	Phenyl alkylaminopyrimidones
US4521418A (en) *	1979-02-21	1985-06-04	Smith Kline & French Laboratories Limited	Guanidinothiazolyl derivatives
AU531142B2 (en) *	1979-04-04	1983-08-11	Smith Kline & French Laboratories Limited	2 amino- pyimindones
CA1140129A (en) *	1979-08-21	1983-01-25	Ronald J. King	4-pyrimidone derivatives
ZW21281A1 (en) *	1980-10-01	1981-11-18	Smith Kline French Lab	Amine derivatives
US4352933A (en) *	1981-02-06	1982-10-05	Smithkline Beckman Corporation	Chemical methods and intermediates for preparing substituted pyrimidinones
NZ202797A (en) *	1981-12-28	1985-08-30	Lilly Co Eli	Pyrimidine derivatives and pharmaceutical compositions
US4468399A (en) *	1981-12-28	1984-08-28	Eli Lilly And Company	2-[2-(2-Aminoalkyl-4-thiazolylmethylthio)alkyl]-amino-5-substituted-4-pyrimidones
GB8320505D0 (en) *	1983-07-29	1983-09-01	Smith Kline French Lab	Chemical compounds
CA1275097A (en) *	1984-10-02	1990-10-09	Fujio Nohara	Pyridyloxy derivatives

1983
- 1983-09-21 US US06/534,426 patent/US4772704A/en not_active Expired - Fee Related
1984
- 1984-09-17 NZ NZ209572A patent/NZ209572A/en unknown
- 1984-09-18 FI FI843643A patent/FI83868C/fi not_active IP Right Cessation
- 1984-09-18 IL IL72990A patent/IL72990A/xx not_active IP Right Cessation
- 1984-09-18 ZW ZW160/84A patent/ZW16084A1/xx unknown
- 1984-09-18 ZM ZM49/84A patent/ZM4984A1/xx unknown
- 1984-09-18 ZA ZA847345A patent/ZA847345B/xx unknown
- 1984-09-19 YU YU1613/84A patent/YU45205B/xx unknown
- 1984-09-19 NO NO843726A patent/NO161561C/no unknown
- 1984-09-19 ES ES536054A patent/ES8607253A1/es not_active Expired
- 1984-09-19 CA CA000463533A patent/CA1260463A/en not_active Expired
- 1984-09-20 IE IE240684A patent/IE58083B1/en not_active IP Right Cessation
- 1984-09-20 AU AU33351/84A patent/AU583479B2/en not_active Ceased
- 1984-09-20 FR FR8414463A patent/FR2552082B1/fr not_active Expired
- 1984-09-20 JP JP59195868A patent/JPH0643310B2/ja not_active Expired - Lifetime
- 1984-09-20 CH CH4510/84A patent/CH665840A5/de not_active IP Right Cessation
- 1984-09-20 IT IT22744/84A patent/IT1176739B/it active
- 1984-09-20 OA OA58396A patent/OA07820A/xx unknown
- 1984-09-20 SE SE8404729A patent/SE463209B/sv not_active IP Right Cessation
- 1984-09-20 DK DK450484A patent/DK162987C/da active
- 1984-09-20 GB GB08423863A patent/GB2146994B/en not_active Expired
- 1984-09-20 DE DE19843434578 patent/DE3434578A1/de not_active Withdrawn
- 1984-09-20 CS CS847103A patent/CS249147B2/cs unknown
- 1984-09-20 HU HU843539A patent/HU193227B/hu not_active IP Right Cessation
- 1984-09-21 AR AR84298041A patent/AR242385A1/es active
- 1984-09-21 BE BE0/213705A patent/BE900652A/fr not_active IP Right Cessation
- 1984-09-21 AT AT0300984A patent/AT387965B/de not_active IP Right Cessation
- 1984-09-21 LU LU85550A patent/LU85550A1/fr unknown
- 1984-09-21 NL NL8402898A patent/NL8402898A/nl not_active Application Discontinuation
- 1984-09-21 PT PT79256A patent/PT79256B/pt not_active IP Right Cessation
- 1984-09-21 KR KR1019840005791A patent/KR900001198B1/ko not_active IP Right Cessation
- 1984-09-21 DD DD84267496A patent/DD226881A5/de not_active IP Right Cessation
- 1984-09-21 GR GR80439A patent/GR80439B/el unknown
1985
- 1985-06-14 ES ES544213A patent/ES8704465A1/es not_active Expired
1986
- 1986-01-31 ES ES551501A patent/ES8702897A1/es not_active Expired
- 1986-01-31 ES ES551500A patent/ES8704155A1/es not_active Expired
1987
- 1987-09-18 AR AR87308766A patent/AR242789A1/es active
1990
- 1990-07-21 SG SG608/90A patent/SG60890G/en unknown
- 1990-09-20 HK HK737/90A patent/HK73790A/xx unknown
1991
- 1991-03-22 CY CY1561A patent/CY1561A/xx unknown

Also Published As

Publication number	Publication date
DK450484D0 (da)	1984-09-20
KR900001198B1 (ko)	1990-02-28
PT79256A (en)	1984-10-01
OA07820A (fr)	1986-11-20
IT8422744A0 (it)	1984-09-20
ES8607253A1 (es)	1986-05-16
YU45205B (en)	1992-05-28
ZM4984A1 (en)	1985-05-21
AT387965B (de)	1989-04-10
FR2552082B1 (fr)	1987-02-20
SG60890G (en)	1990-09-07
SE8404729D0 (sv)	1984-09-20
ZW16084A1 (en)	1985-01-16
FR2552082A1 (fr)	1985-03-22
SE463209B (sv)	1990-10-22
IT1176739B (it)	1987-08-18
ES544213A0 (es)	1987-04-01
NO843726L (no)	1985-03-22
GB2146994B (en)	1987-09-03
YU161384A (en)	1987-12-31
SE8404729L (sv)	1985-03-22
GB8423863D0 (en)	1984-10-24
AU583479B2 (en)	1989-05-04
AU3335184A (en)	1985-03-28
KR850002259A (ko)	1985-05-10
BE900652A (fr)	1985-03-21
GB2146994A (en)	1985-05-01
FI83868C (fi)	1991-09-10
CH665840A5 (de)	1988-06-15
NL8402898A (nl)	1985-04-16
AR242385A1 (es)	1993-03-31
ES551501A0 (es)	1987-01-16
HUT35259A (en)	1985-06-28
ES8704465A1 (es)	1987-04-01
ES551500A0 (es)	1987-03-16
DK162987C (da)	1992-06-01
LU85550A1 (fr)	1985-06-04
ES536054A0 (es)	1986-05-16
AR242789A1 (es)	1993-05-31
FI843643L (fi)	1985-03-22
HK73790A (en)	1990-09-28
ES8704155A1 (es)	1987-03-16
US4772704A (en)	1988-09-20
CY1561A (en)	1991-03-22
NZ209572A (en)	1988-05-30
FI843643A0 (fi)	1984-09-18
DK450484A (da)	1985-03-22
IE842406L (en)	1985-03-21
FI83868B (fi)	1991-05-31
ZA847345B (en)	1985-06-26
NO161561B (no)	1989-05-22
IE58083B1 (en)	1993-06-30
HU193227B (en)	1987-08-28
DK162987B (da)	1992-01-06
NO161561C (no)	1989-08-30
JPH0643310B2 (ja)	1994-06-08
JPS6087271A (ja)	1985-05-16
IL72990A (en)	1990-07-12
CS249147B2 (en)	1987-03-12
ATA300984A (de)	1988-09-15
ES8702897A1 (es)	1987-01-16
CA1260463A (en)	1989-09-26
IT8422744A1 (it)	1986-03-20
PT79256B (en)	1986-11-20
DD226881A5 (de)	1985-09-04
DE3434578A1 (de)	1985-04-11

Publication	Publication Date	Title
YU159284A (en)	1991-02-28	Some special 2(2-substituted benzoil) 1,3-cyclohexandiones
GB8401005D0 (en)	1984-02-15	Formate salts
KR870001234B1 (en)	1987-06-26	2,6-substituted compound
ZA849273B (en)	1986-07-30	Pyridone derivatives with histamine h2-receptor antagonist activity
GR80439B (en)	1985-01-22	2,5 disubstituted-4(3h)-pyrimidones having histamine h2-receptor antagonist activity
ZA832154B (en)	1983-12-28	Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine h2-receptor antagonist activity
ZA848327B (en)	1985-06-26	Substituted pyrimidines
CS642484A2 (en)	1987-12-17	Zpusob zpracovan.i vodnych odpadnich louhu obsahujicich halogenidy
ZA843772B (en)	1984-12-24	Substituted tetrahydrothiopyran-3,5-dione-4-carboxamides
CS39084A2 (en)	1986-01-16	Zpusob stanoveni obsahu kyseliny v oleji, zejmena v chladicich zarizenich pohanenych freonem
CS480584A1 (en)	1986-12-18	Rezaci zarizeni plastiskych hmot, zvlaste tramcu keramicke hmoty
GB8318910D0 (en)	1983-08-17	Equine bit
ZW10385A1 (en)	1986-02-05	Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine h2-receptor antagonist activity
DE3468859D1 (en)	1988-02-25	Substituted 5-cycloalkyl-2,2-dimethyl-pentan-3-one
GB8400530D0 (en)	1984-02-15	Substituted pyrimidines
IE842695L (en)	1985-04-21	Histamine h2 - antagonists
IE841721L (en)	1985-01-09	Pyrimidin-2-thiones and -2-ones, histamine h2-antagonists
SU1221878A1 (ru)	1995-08-27	I′ -БЕНЗИЛ-5,7-ДИМЕТИЛ-6-ОКСОСПИРО-(1,3-ДИАЗААДАМАНТАН- 2,4′ -ПИПЕРИДИН), ОБЛАДАЮЩИЙ α -АДРЕНОБЛОКИРУЮЩЕЙ АКТИВНОСТЬЮ
GB8304661D0 (en)	1983-03-23	2,6-dichloropyrazine
IL84155A (en)	1988-08-31	2-substituted propionyl cyanamides
CS383383A1 (en)	1985-09-17	Zpusob pripravy chelatacnich derivatu sfericke celulozy s o,o dihydroxyazoskupinou
IE830395L (en)	1983-08-24	Pyrimidines
GB8300585D0 (en)	1983-02-09	Substituted pyrimidines
CS881983A1 (en)	1985-05-15	Pneumaticka membranova stavba, zejmena obloukova hala
CS46283A1 (en)	1985-04-16	Zapojeni dvou asynchronnich krouzkovych motoru, pracujicich do mechanickeho uzlu