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GR79681B - - Google Patents

Info

Publication number
GR79681B
GR79681B GR72681A GR830172681A GR79681B GR 79681 B GR79681 B GR 79681B GR 72681 A GR72681 A GR 72681A GR 830172681 A GR830172681 A GR 830172681A GR 79681 B GR79681 B GR 79681B
Authority
GR
Greece
Prior art keywords
hydroxyalkyl
alkyl
hydrogen
compounds
hydroxy
Prior art date
Application number
GR72681A
Other languages
English (en)
Inventor
Howard J Schaeffer
Thomas A Krenitsky
Lilia Marie Beauchamp
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/434,384 external-priority patent/US4544634A/en
Priority claimed from US06/434,395 external-priority patent/US4609662A/en
Priority claimed from GB838320309A external-priority patent/GB8320309D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of GR79681B publication Critical patent/GR79681B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GR72681A 1982-10-14 1983-10-13 GR79681B (el)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US43439482A 1982-10-14 1982-10-14
US43439382A 1982-10-14 1982-10-14
US06/434,384 US4544634A (en) 1982-10-14 1982-10-14 Method of producing acyclovir
US06/434,395 US4609662A (en) 1982-10-14 1982-10-14 Method for using purine derivatives
GB838320309A GB8320309D0 (en) 1983-07-28 1983-07-28 Antiviral compounds

Publications (1)

Publication Number Publication Date
GR79681B true GR79681B (el) 1984-10-31

Family

ID=27516520

Family Applications (1)

Application Number Title Priority Date Filing Date
GR72681A GR79681B (el) 1982-10-14 1983-10-13

Country Status (19)

Country Link
EP (2) EP0158847B1 (el)
JP (1) JPS5989682A (el)
KR (1) KR890001487B1 (el)
AT (2) ATE33654T1 (el)
AU (1) AU573540B2 (el)
CA (1) CA1308714C (el)
CS (1) CS244697B2 (el)
DE (2) DE3376326D1 (el)
DK (1) DK472683A (el)
FI (1) FI74468C (el)
GB (2) GB2130204B (el)
GR (1) GR79681B (el)
IE (1) IE56416B1 (el)
MC (1) MC1551A1 (el)
NO (1) NO161116C (el)
NZ (1) NZ205955A (el)
PL (1) PL143208B1 (el)
PT (2) PT77494B (el)
ZW (1) ZW22283A1 (el)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
US5250688A (en) * 1984-09-20 1993-10-05 Beecham Group P.L.C. Purine derivatives
DK163985A (da) * 1984-04-13 1985-10-14 Wellcome Found Antivirale purinderivater, fremgangsmaade til deres fremstilling og farmaceutiske kompositioner indeholdende forbindelserne
DE3582399D1 (de) * 1984-09-20 1991-05-08 Beecham Group Plc Purin-derivate und ihre pharmazeutische verwendung.
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
EP0203736B1 (en) * 1985-05-02 1989-11-23 The Wellcome Foundation Limited Antiviral compounds
IL78643A0 (en) * 1985-05-02 1986-08-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
DE3627024A1 (de) 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
MY101126A (en) * 1985-12-13 1991-07-31 Beecham Group Plc Novel compounds
GB8602346D0 (en) * 1986-01-30 1986-03-05 Wellcome Found Antiviral combinations
JPS63280026A (ja) * 1987-04-24 1988-11-17 ザ　ウエルカム　フアウンデーション　リミテッド 抗ウイルス配合組成物
DE3889248T2 (de) * 1987-05-04 1994-11-17 Kemijski Inst Verfahren zu Herstellung von Purinverbindungen.
GB8713695D0 (en) * 1987-06-11 1987-07-15 Beecham Group Plc Process
US4965270A (en) * 1987-05-30 1990-10-23 Beecham Group P.L.C. Purine derivatives
SE8801729D0 (sv) * 1988-05-06 1988-05-06 Astra Ab Purine derivatives for use in therapy
US5284837A (en) * 1988-05-06 1994-02-08 Medivir Ab Derivatives of purine, process for their preparation and a pharmaceutical preparation
EP0363320A3 (de) * 1988-10-06 1991-11-21 Ciba-Geigy Ag Substituierte 9H-Purine
DE68922903T2 (de) * 1988-12-19 1995-11-23 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
DE3941658A1 (de) * 1989-12-16 1991-06-20 Hoechst Ag Verfahren zur herstellung von 2-acylamino-9-acyl-6-halogen-purin
US6110923A (en) * 1994-06-22 2000-08-29 Biochem Pharma Inc. Method for treating cancer using novel substituted purinyl derivatives with immunomodulating activity
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US6083953A (en) * 1994-07-28 2000-07-04 Syntex (U.S.A.) Inc. 2- (2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3- propanediol derivative
US6040446A (en) * 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
IE830186L (en) * 1982-02-01 1983-08-01 Syntex Inc Purines
US4556659A (en) * 1982-08-09 1985-12-03 Syntex (U.S.A.) Inc. Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents

Also Published As

Publication number Publication date
ZW22283A1 (en) 1985-05-22
PT77494A (en) 1983-11-01
KR840006483A (ko) 1984-11-30
JPH0549674B2 (el) 1993-07-26
EP0108285A3 (en) 1985-05-15
EP0158847A1 (en) 1985-10-23
AU2016383A (en) 1984-04-19
KR890001487B1 (ko) 1989-05-04
IE56416B1 (en) 1991-07-31
GB8421849D0 (en) 1984-10-03
CA1308714C (en) 1992-10-13
GB2130204A (en) 1984-05-31
CS244697B2 (en) 1986-08-14
EP0158847B1 (en) 1988-04-20
DE3376325D1 (en) 1988-05-26
PT79813B (en) 1986-10-28
GB2151222B (en) 1987-02-25
FI833730A0 (fi) 1983-10-13
NO161116C (no) 1989-07-05
IE832409L (en) 1984-04-14
GB8327513D0 (en) 1983-11-16
FI74468C (fi) 1988-02-08
AU573540B2 (en) 1988-06-16
GB2151222A (en) 1985-07-17
GB2130204B (en) 1986-03-05
NO833722L (no) 1984-04-16
PT77494B (en) 1986-08-14
ATE33653T1 (de) 1988-05-15
PT79813A (en) 1985-02-01
DE3376326D1 (en) 1988-05-26
FI833730A (fi) 1984-04-15
PL143208B1 (en) 1988-01-30
MC1551A1 (fr) 1984-08-31
NZ205955A (en) 1988-02-29
DK472683D0 (da) 1983-10-13
PL244141A1 (en) 1985-06-18
JPS5989682A (ja) 1984-05-23
NO161116B (no) 1989-03-28
FI74468B (fi) 1987-10-30
ATE33654T1 (de) 1988-05-15
EP0108285B1 (en) 1988-04-20
DK472683A (da) 1984-04-15
EP0108285A2 (en) 1984-05-16

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