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GR1000053B - Μορφη δοσολογιας συνισταμενη απο παραλληλα λεπτα φυλλα. - Google Patents

Μορφη δοσολογιας συνισταμενη απο παραλληλα λεπτα φυλλα.

Info

Publication number
GR1000053B
GR1000053B GR880100214A GR880100214A GR1000053B GR 1000053 B GR1000053 B GR 1000053B GR 880100214 A GR880100214 A GR 880100214A GR 880100214 A GR880100214 A GR 880100214A GR 1000053 B GR1000053 B GR 1000053B
Authority
GR
Greece
Prior art keywords
drug
thin sheet
dosage form
hydroxypropylcellulose
optional
Prior art date
Application number
GR880100214A
Other languages
English (en)
Other versions
GR880100214A (en
Inventor
Gurdish Kaur Bhatti
David Emil Edgren
Judy A Magruder
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of GR880100214A publication Critical patent/GR880100214A/el
Publication of GR1000053B publication Critical patent/GR1000053B/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η εφεύρεση, τιτλοφορούμενη "μορφή δοσολογίας συνιστάμενη από παράλληλα λεπτά φύλλα", που αναφέρεται σε παρατεταμένης απελευ?έρωσης μορφή δοσολογίας 10 σε διπλό λεπτό φύλλο, όπως περιγράφεται στις σελίδες 5-19 της περιγραφής και στις αξιώσεις 1-19 και όπως δείχνει στο σχήμα 2 των σχεδίων, εκτί?εται για την ελεγχόμενη μακροχρόνια απελευ?έρωση ευεργετικού φαρμάκου. Συνίσταται από τουλάχιστον 30% κατά βάρος αι?έρα κυτταρίνης και δύο λεπτά φύλλα -το λεπτό φύλλο 12 και το λεπτό φύλλο 13- κά?ε ένα δε αποτελείται από διαφορετική σύν?εση αι?έρα κυτταρίνης και ένα φάρμακο σε ένα τουλάχιστον από τα λεπτά φύλλα. Το λεπτό φύλλο 12, συνίσταται από υδροξυπροπυλμε?υλοκυτταρίνη, ένα φάρμακο 14 και μία προαιρετική υδροξυπροπυλκυτταρίνη. Το λεπτό φύλλο 13, συνίσταται από υδροξυπροπυλκυτταρίνη, ένα προεραιτικό φάρμακο 14 και μία προαιρετική υδροξυπροπυλκυτταρίνη. Το λεπτό φύλλο 12 και το λεπτό φύλλο 13 συνίσταται από διαφορετικές κυτταρίνες. Η μορφή δοσολογίας 12 παρέχει άμεση απελευ?έρωση του φαρμάκου 14 και παρατεταμένη απελευ?έρωση του φαρμάκου 14. ω
GR880100214A 1987-04-06 1988-04-01 Μορφη δοσολογιας συνισταμενη απο παραλληλα λεπτα φυλλα. GR1000053B (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/034,971 US4786503A (en) 1987-04-06 1987-04-06 Dosage form comprising parallel lamine
US07/039,405 US4871548A (en) 1987-04-06 1987-04-17 Controlled release dosage form comprising different cellulose ethers

Publications (2)

Publication Number Publication Date
GR880100214A GR880100214A (en) 1989-01-31
GR1000053B true GR1000053B (el) 1990-05-11

Family

ID=39967167

Family Applications (1)

Application Number Title Priority Date Filing Date
GR880100214A GR1000053B (el) 1987-04-06 1988-04-01 Μορφη δοσολογιας συνισταμενη απο παραλληλα λεπτα φυλλα.

Country Status (21)

Country Link
US (3) US4786503A (el)
EP (1) EP0413061B1 (el)
JP (2) JP2916147B2 (el)
KR (1) KR950003918B1 (el)
AT (1) ATE116844T1 (el)
AU (1) AU601033B2 (el)
BE (1) BE1001699A3 (el)
CA (1) CA1331739C (el)
CH (1) CH677447A5 (el)
DE (2) DE3811114C2 (el)
ES (2) ES2006394A6 (el)
FR (1) FR2613224B1 (el)
GB (1) GB2203338B (el)
GR (1) GR1000053B (el)
IE (1) IE67156B1 (el)
IT (1) IT1219750B (el)
LU (1) LU87189A1 (el)
NL (1) NL8800867A (el)
PT (1) PT91442B (el)
SE (1) SE503611C2 (el)
ZA (1) ZA882034B (el)

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KR950003918B1 (ko) 1995-04-20
CA1331739C (en) 1994-08-30
KR880012212A (ko) 1988-11-26
EP0413061A1 (en) 1991-02-20
GB2203338A (en) 1988-10-19
IE67156B1 (en) 1996-03-06
DE68920578T2 (de) 1995-05-04
BE1001699A3 (fr) 1990-02-13
ATE116844T1 (de) 1995-01-15
PT91442A (pt) 1990-03-08
SE8801240D0 (sv) 1988-04-05
ES2069588T3 (es) 1995-05-16
GB2203338B (en) 1991-07-17
SE8801240L (sv) 1988-10-07
JPH0776181B2 (ja) 1995-08-16
JPH0393731A (ja) 1991-04-18
DE3811114C2 (de) 1996-05-30
IT8867302A0 (it) 1988-04-05
ES2006394A6 (es) 1989-04-16
LU87189A1 (fr) 1988-11-17
JPS63258808A (ja) 1988-10-26
FR2613224A1 (fr) 1988-10-07
US4871548A (en) 1989-10-03
CH677447A5 (el) 1991-05-31
JP2916147B2 (ja) 1999-07-05
DE68920578D1 (de) 1995-02-23
PT91442B (pt) 1995-07-06
FR2613224B1 (fr) 1990-12-07
US4946685A (en) 1990-08-07
GB8807493D0 (en) 1988-05-05
AU1406588A (en) 1988-10-06
EP0413061B1 (en) 1995-01-11
US4786503A (en) 1988-11-22
AU601033B2 (en) 1990-08-30
IT1219750B (it) 1990-05-24
SE503611C2 (sv) 1996-07-15
DE3811114A1 (de) 1988-11-10
ZA882034B (en) 1988-09-15
NL8800867A (nl) 1988-11-01
IE892845A1 (en) 1991-03-13
GR880100214A (en) 1989-01-31

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