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GB864107A - Morphine derivatives - Google Patents

Morphine derivatives

Info

Publication number
GB864107A
GB864107A GB30321/59A GB3032159A GB864107A GB 864107 A GB864107 A GB 864107A GB 30321/59 A GB30321/59 A GB 30321/59A GB 3032159 A GB3032159 A GB 3032159A GB 864107 A GB864107 A GB 864107A
Authority
GB
United Kingdom
Prior art keywords
ethylmorphine
dihydro
acetyl
acid addition
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB30321/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ILSE LIEBRECHT
JULIUS LIEBRECHT
WALTER MAYER LIST
WALTER MAYER-LIST
Original Assignee
ILSE LIEBRECHT
JULIUS LIEBRECHT
WALTER MAYER LIST
WALTER MAYER-LIST
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ILSE LIEBRECHT, JULIUS LIEBRECHT, WALTER MAYER LIST, WALTER MAYER-LIST filed Critical ILSE LIEBRECHT
Publication of GB864107A publication Critical patent/GB864107A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises: 6-acetyl-7,8-dihydro-3-enthylmorphine and its acid addition salts; the preparation thereof by treating 7,8-dihydro-3-ethylmorphine with an acetylating agent, or by hydrogenating 6-acetyl-3-ethylmorphine, and in either case, if desired, converting the product to an acid addition salt thereof; and pharmaceutical compositions containing the product (see Group VI). 7,8-Dihydro-3-ethylmorphine is prepared by catalytic hydrogenation of 3-ethylmorphine hydrochloride in the presence of platinum oxide. 6-Acetyl-3-ethylmorphine is prepared by acetylation of ethylmorphine with acetic anhydride.ALSO:Pharmaceutical compositions comprise 6-acetyl - 7,8 - dihydro - 3 - ethylmorphine or an acid addition salt thereof and a pharmaceutical carrier. Examples describe tablets, a cough syrup and cough drops containing the bitartrate of the base. Other salts specified are the hydrohalides, phosphate and perchlorate.
GB30321/59A 1958-09-10 1959-09-04 Morphine derivatives Expired GB864107A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE864107X 1958-09-10

Publications (1)

Publication Number Publication Date
GB864107A true GB864107A (en) 1961-03-29

Family

ID=6801609

Family Applications (1)

Application Number Title Priority Date Filing Date
GB30321/59A Expired GB864107A (en) 1958-09-10 1959-09-04 Morphine derivatives

Country Status (1)

Country Link
GB (1) GB864107A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0577847A1 (en) * 1992-01-23 1994-01-12 Toray Industries, Inc. Morphinan derivative and medicinal use
EP0663401A1 (en) * 1993-07-23 1995-07-19 Toray Industries, Inc. Morphinan derivative and medicinal use

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0577847A1 (en) * 1992-01-23 1994-01-12 Toray Industries, Inc. Morphinan derivative and medicinal use
EP0577847A4 (en) * 1992-01-23 1994-12-07 Toray Industries Morphinan derivative and medicinal use.
US6277859B1 (en) 1992-01-23 2001-08-21 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications
US6323212B1 (en) 1992-01-23 2001-11-27 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications
EP0663401A1 (en) * 1993-07-23 1995-07-19 Toray Industries, Inc. Morphinan derivative and medicinal use
EP0663401A4 (en) * 1993-07-23 1996-06-26 Toray Industries Morphinan derivative and medicinal use.
US6177438B1 (en) 1993-07-23 2001-01-23 Toray Industries, Inc. Morphinan derivatives and pharmaceutical use thereof

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