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GB845486A - Improvements in or relating to 2-diarylalkyl-3,4,5,6-tetrahydropyrimidines - Google Patents

Improvements in or relating to 2-diarylalkyl-3,4,5,6-tetrahydropyrimidines

Info

Publication number
GB845486A
GB845486A GB14118/58A GB1411858A GB845486A GB 845486 A GB845486 A GB 845486A GB 14118/58 A GB14118/58 A GB 14118/58A GB 1411858 A GB1411858 A GB 1411858A GB 845486 A GB845486 A GB 845486A
Authority
GB
United Kingdom
Prior art keywords
compounds
radical
alkyl
hydrogen atom
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB14118/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of GB845486A publication Critical patent/GB845486A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula:- <FORM:0845486/IV(b)/1> wherein R1R2R3R4R5 and R6\h are each a hydrogen atom or an alkyl radical, Q is a hydrogen atom or an alkyl, benzoyl or alkanoyl radical; and Z is a C1-7 alkyl radical in which one hydrogen atom is replaced by a phenyl, alkylphenyl, a halophenyl radical and another by a phenyl, alkylphenyl, or halophenyl, or Z taken as a whole is a phenoxybenzyl, halophenoxybenzyl or tolyloxybenzyl radical, together with non-toxic acid addition salts thereof (other than 2-benzhydryl-3,4,5,6-tetrahydropyrimidine and non-toxic acid addition salts thereof). The compounds of the invention may be prepared by condensing an amine of the general formula: <FORM:0845486/IV(b)/2> with an acid, of the general formula:- Z,COOH; the N (C1-7 alkyl) derivatives of the invention being also prepared from the corresponding compounds wherein Q is a hydrogen atom by heating with an alkyl halide, the product being isolated as an acid addition salt from which the base is prepared on alkalisation, and the N-acyl compounds from the corresponding hydro compounds by admixture with an acid chloride in the presence of a basic catalyst, such as pyridine.
GB14118/58A 1957-05-02 1958-05-02 Improvements in or relating to 2-diarylalkyl-3,4,5,6-tetrahydropyrimidines Expired GB845486A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US845486XA 1957-05-02 1957-05-02

Publications (1)

Publication Number Publication Date
GB845486A true GB845486A (en) 1960-08-24

Family

ID=22185665

Family Applications (1)

Application Number Title Priority Date Filing Date
GB14118/58A Expired GB845486A (en) 1957-05-02 1958-05-02 Improvements in or relating to 2-diarylalkyl-3,4,5,6-tetrahydropyrimidines

Country Status (1)

Country Link
GB (1) GB845486A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4514320A (en) * 1980-10-27 1985-04-30 Petrolite Corporation Halide free corrosion inhibitors
US4525296A (en) * 1980-10-27 1985-06-25 Petrolite Corporation Halide free corrosion inhibitors
US4539140A (en) * 1980-10-27 1985-09-03 Petrolite Corporation Mixtures of non-halogen salts of nitrogen heterocyclics and nitrogen-sulfur heterocyclics
US4559163A (en) * 1980-10-27 1985-12-17 Petrolite Corporation Halide free octahydrophenanthridine corrosion inhibitors

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4514320A (en) * 1980-10-27 1985-04-30 Petrolite Corporation Halide free corrosion inhibitors
US4525296A (en) * 1980-10-27 1985-06-25 Petrolite Corporation Halide free corrosion inhibitors
US4539140A (en) * 1980-10-27 1985-09-03 Petrolite Corporation Mixtures of non-halogen salts of nitrogen heterocyclics and nitrogen-sulfur heterocyclics
US4559163A (en) * 1980-10-27 1985-12-17 Petrolite Corporation Halide free octahydrophenanthridine corrosion inhibitors

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