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GB2467882B - System for thermal modulation of neural activity - Google Patents

System for thermal modulation of neural activity

Info

Publication number
GB2467882B
GB2467882B GB1010164.0A GB201010164A GB2467882B GB 2467882 B GB2467882 B GB 2467882B GB 201010164 A GB201010164 A GB 201010164A GB 2467882 B GB2467882 B GB 2467882B
Authority
GB
United Kingdom
Prior art keywords
neural activity
thermal modulation
modulation
thermal
neural
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB1010164.0A
Other versions
GB2467882A (en
GB201010164D0 (en
Inventor
Ralph G Dacey Jr
Gregory J Della Rocca
Colin P Derdeyn
Joshua L Dowling
Eleanor V Goodall
Roderick A Hyde
Muriel Y Ishikawa
Jordin T Kare
Eric C Leuthardt
Nathan P Myhrvold
Michael A Smith
Lowell L Wood Jr
Victoria Y H Wood
Gregory J Zipfel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Searete LLC
Original Assignee
Searete LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/999,721 external-priority patent/US8180446B2/en
Priority claimed from US12/070,361 external-priority patent/US8195287B2/en
Priority claimed from US12/070,369 external-priority patent/US8165669B2/en
Priority claimed from US12/070,331 external-priority patent/US8170658B2/en
Priority claimed from US12/070,332 external-priority patent/US8165668B2/en
Application filed by Searete LLC filed Critical Searete LLC
Publication of GB201010164D0 publication Critical patent/GB201010164D0/en
Publication of GB2467882A publication Critical patent/GB2467882A/en
Application granted granted Critical
Publication of GB2467882B publication Critical patent/GB2467882B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
    • A61B5/4035—Evaluating the autonomic nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
    • A61F2007/0075—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating using a Peltier element, e.g. near the spot to be heated or cooled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071—Pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
    • A61N1/36535—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by body position or posture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
    • A61N1/36542—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by body motion, e.g. acceleration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Neurology (AREA)
  • Electrotherapy Devices (AREA)
  • Prostheses (AREA)
  • Feedback Control In General (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB1010164.0A 2007-12-05 2008-12-04 System for thermal modulation of neural activity Expired - Fee Related GB2467882B (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US11/999,721 US8180446B2 (en) 2007-12-05 2007-12-05 Method and system for cyclical neural modulation based on activity state
US12/070,361 US8195287B2 (en) 2007-12-05 2008-02-15 Method for electrical modulation of neural conduction
US12/070,369 US8165669B2 (en) 2007-12-05 2008-02-15 System for magnetic modulation of neural conduction
US12/070,331 US8170658B2 (en) 2007-12-05 2008-02-15 System for electrical modulation of neural conduction
US12/070,332 US8165668B2 (en) 2007-12-05 2008-02-15 Method for magnetic modulation of neural conduction
US12/080,787 US8170659B2 (en) 2007-12-05 2008-04-04 Method for thermal modulation of neural activity
US12/080,789 US8170660B2 (en) 2007-12-05 2008-04-04 System for thermal modulation of neural activity
PCT/US2008/013406 WO2009073208A1 (en) 2007-12-05 2008-12-04 System for thermal modulation of neural activity

Publications (3)

Publication Number Publication Date
GB201010164D0 GB201010164D0 (en) 2010-07-21
GB2467882A GB2467882A (en) 2010-08-18
GB2467882B true GB2467882B (en) 2012-12-05

Family

ID=40718052

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1010164.0A Expired - Fee Related GB2467882B (en) 2007-12-05 2008-12-04 System for thermal modulation of neural activity

Country Status (3)

Country Link
US (2) US8170659B2 (en)
GB (1) GB2467882B (en)
WO (1) WO2009073208A1 (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8750983B2 (en) * 2004-09-20 2014-06-10 P Tech, Llc Therapeutic system
US9492313B2 (en) 2006-04-20 2016-11-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Method and apparatus of noninvasive, regional brain thermal stimuli for the treatment of neurological disorders
US8425583B2 (en) 2006-04-20 2013-04-23 University of Pittsburgh—of the Commonwealth System of Higher Education Methods, devices and systems for treating insomnia by inducing frontal cerebral hypothermia
US9211212B2 (en) 2006-04-20 2015-12-15 Cerêve, Inc. Apparatus and method for modulating sleep
US11684510B2 (en) 2006-04-20 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Noninvasive, regional brain thermal stimuli for the treatment of neurological disorders
US8236038B2 (en) 2006-04-20 2012-08-07 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Method and apparatus of noninvasive, regional brain thermal stimuli for the treatment of neurological disorders
US8996131B1 (en) * 2006-09-28 2015-03-31 Lockheed Martin Corporation Apparatus and method for managing chronic pain with infrared light sources and heat
US8734499B2 (en) * 2007-03-29 2014-05-27 Cardiac Pacemakers, Inc. Systems and methods for thermal neuroinhibition
US8170658B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc System for electrical modulation of neural conduction
US8233976B2 (en) 2007-12-05 2012-07-31 The Invention Science Fund I, Llc System for transdermal chemical modulation of neural activity
US8165669B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc System for magnetic modulation of neural conduction
US8165668B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc Method for magnetic modulation of neural conduction
US8160695B2 (en) 2007-12-05 2012-04-17 The Invention Science Fund I, Llc System for chemical modulation of neural activity
US20090149799A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for chemical modulation of neural activity
US8180446B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method and system for cyclical neural modulation based on activity state
US8170659B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc Method for thermal modulation of neural activity
US8195287B2 (en) 2007-12-05 2012-06-05 The Invention Science Fund I, Llc Method for electrical modulation of neural conduction
US9681832B2 (en) 2008-04-11 2017-06-20 Glucovista Inc. Measurement apparatuses and methods using a combined substance cooling device
US8321012B2 (en) 2009-12-22 2012-11-27 The Invention Science Fund I, Llc Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject
US9101769B2 (en) 2011-01-03 2015-08-11 The Regents Of The University Of California High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury
CN103608067A (en) 2011-01-21 2014-02-26 加利福尼亚理工学院 A parylene-based microelectrode array implant for spinal cord stimulation
CA2825550C (en) 2011-03-24 2022-07-12 California Institute Of Technology Neurostimulator
US9107614B2 (en) 2011-07-12 2015-08-18 Xanadu Christina Halkias Systems, methods, and media for finding and matching tremor signals
KR20140098780A (en) 2011-11-11 2014-08-08 뉴로이네이블링 테크놀로지스, 인크. Non invasive neuromodulation device for enabling recovery of motor, sensory, autonomic, sexual, vasomotor and cognitive function
EP2776119B1 (en) 2011-11-11 2019-02-06 The Regents of The University of California Transcutaneous spinal cord stimulation: noninvasive tool for activation of locomotor circuitry
US10092750B2 (en) 2011-11-11 2018-10-09 Neuroenabling Technologies, Inc. Transcutaneous neuromodulation system and methods of using same
US10004557B2 (en) 2012-11-05 2018-06-26 Pythagoras Medical Ltd. Controlled tissue ablation
EP2941292B1 (en) 2013-01-02 2021-02-24 EBB Therapeutics, Inc. Systems for enhancing sleep
US8880167B2 (en) * 2013-02-13 2014-11-04 Flint Hills Scientific, Llc Selective recruitment and activation of fiber types in nerves for the control of undesirable brain state changes
AU2014228794B2 (en) 2013-03-15 2019-04-18 The Regents Of The University Of California Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion
CN105338899B (en) * 2013-06-23 2019-08-20 格鲁科威斯塔公司 The concentration measurements carried out using the cooling device with the endothermic reaction
EP3049148B1 (en) 2013-09-27 2020-05-20 The Regents Of The University Of California Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects
US20150217120A1 (en) 2014-01-13 2015-08-06 Mandheerej Nandra Neuromodulation systems and methods of using same
JP2017506120A (en) * 2014-02-21 2017-03-02 サーキット セラピューティクス， インコーポレイテッド System and method for treatment management of dry cough
WO2015142838A1 (en) 2014-03-18 2015-09-24 Case Western Reserve University Systems and methods for fast and reversible nerve block
US10478249B2 (en) 2014-05-07 2019-11-19 Pythagoras Medical Ltd. Controlled tissue ablation techniques
US10751533B2 (en) 2014-08-21 2020-08-25 The Regents Of The University Of California Regulation of autonomic control of bladder voiding after a complete spinal cord injury
US11464971B2 (en) 2014-08-26 2022-10-11 Avent, Inc. Selective nerve fiber block method and system
EP3185946B1 (en) 2014-08-27 2019-10-09 The Regents Of The University Of California Multi-electrode array for spinal cord epidural stimulation
US10383685B2 (en) 2015-05-07 2019-08-20 Pythagoras Medical Ltd. Techniques for use with nerve tissue
US11298533B2 (en) 2015-08-26 2022-04-12 The Regents Of The University Of California Concerted use of noninvasive neuromodulation device with exoskeleton to enable voluntary movement and greater muscle activation when stepping in a chronically paralyzed subject
US11097122B2 (en) 2015-11-04 2021-08-24 The Regents Of The University Of California Magnetic stimulation of the spinal cord to restore control of bladder and/or bowel
CA3006451A1 (en) * 2015-12-03 2017-06-08 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Device and method for nerve block by local cooling to room temperature
EP3457975A2 (en) 2016-05-18 2019-03-27 Pythagoras Medical Ltd. Helical catheter
EP3974021B1 (en) 2017-06-30 2023-06-14 ONWARD Medical N.V. A system for neuromodulation
US11992684B2 (en) 2017-12-05 2024-05-28 Ecole Polytechnique Federale De Lausanne (Epfl) System for planning and/or providing neuromodulation
WO2019178571A2 (en) * 2018-03-15 2019-09-19 Avent, Inc. System and method to percutaneously block painful sensations
EP3653260A1 (en) 2018-11-13 2020-05-20 GTX medical B.V. Sensor in clothing of limbs or footwear
EP3653256B1 (en) 2018-11-13 2022-03-30 ONWARD Medical N.V. Control system for movement reconstruction and/or restoration for a patient
EP3695878B1 (en) 2019-02-12 2023-04-19 ONWARD Medical N.V. A system for neuromodulation
EP3827871A1 (en) 2019-11-27 2021-06-02 ONWARD Medical B.V. Neuromodulation system

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5628769A (en) * 1994-09-30 1997-05-13 Saringer Research, Inc. Method and devices for producing somatosensory stimulation using temperature
US20020055779A1 (en) * 1996-03-05 2002-05-09 Brian J. Andrews Neural prosthesis
US20020068964A1 (en) * 1998-01-23 2002-06-06 Innercool Therapies, Inc. Heat pipe nerve cooler
US20030014097A1 (en) * 2001-07-13 2003-01-16 Putz David A. Heat-removal method and apparatus for treatment of movement disorder episodes
US20050149123A1 (en) * 1999-10-19 2005-07-07 The Johns Hopkins University Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders
US20050171585A1 (en) * 2002-05-31 2005-08-04 Vahid Saadat Apparatus and methods for cooling a region within the body
US20050234523A1 (en) * 2002-04-08 2005-10-20 Levin Howard R Renal nerve stimulation method and apparatus for treatment of patients
US20060122663A1 (en) * 2004-12-03 2006-06-08 Mandell Lee J Neuromuscular stimulation to avoid pulmonary embolisms
US20070060984A1 (en) * 2005-09-09 2007-03-15 Webb James S Apparatus and method for optical stimulation of nerves and other animal tissue
US7204833B1 (en) * 2002-10-11 2007-04-17 Flint Hills Scientific Llc Multi-modal system for detection and control of changes in brain state
US20070135875A1 (en) * 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20070135846A1 (en) * 2003-02-03 2007-06-14 Enteromedics, Inc. Vagal obesity treatment
US20070150025A1 (en) * 2005-12-28 2007-06-28 Dilorenzo Daniel J Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
US20070225781A1 (en) * 2006-03-21 2007-09-27 Nidus Medical, Llc Apparatus and methods for altering temperature in a region within the body
WO2008007360A2 (en) * 2006-07-13 2008-01-17 Yossi Gross Peltier unidirectional and selective nerve stimulation
WO2008121231A2 (en) * 2007-03-29 2008-10-09 Cardiac Pacemakers, Inc. Systems and leads for thermal neuroinhibition

Family Cites Families (185)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3841306A (en) 1972-10-25 1974-10-15 Univ Iowa State Res Found Inc Implantable, non-contacting nerve stimulating transducer
US4570640A (en) 1981-08-06 1986-02-18 Barsa John E Sensory monitoring apparatus and method
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
EP0132276B1 (en) 1983-01-21 1991-08-14 Ramm Associates Implantable hyperthermia device and system
US5224928A (en) 1983-08-18 1993-07-06 Drug Delivery Systems Inc. Mounting system for transdermal drug applicator
US4889526A (en) 1984-08-27 1989-12-26 Magtech Laboratories, Inc. Non-invasive method and apparatus for modulating brain signals through an external magnetic or electric field to reduce pain
US4608985A (en) * 1984-10-11 1986-09-02 Case Western Reserve University Antidromic pulse generating wave form for collision blocking
US4817628A (en) * 1985-10-18 1989-04-04 David L. Zealear System and method for evaluating neurological function controlling muscular movements
US5035891A (en) 1987-10-05 1991-07-30 Syntex (U.S.A.) Inc. Controlled release subcutaneous implant
US4939149A (en) * 1988-10-24 1990-07-03 The United States Of America As Represented By The Department Of Health And Human Services Resiniferatoxin and analogues thereof to cause sensory afferent C-fiber and thermoregulatory desensitization
US5057104A (en) 1989-05-30 1991-10-15 Cyrus Chess Method and apparatus for treating cutaneous vascular lesions
US5061234A (en) * 1989-09-25 1991-10-29 Corteks, Inc. Magnetic neural stimulator for neurophysiology
US5031618A (en) 1990-03-07 1991-07-16 Medtronic, Inc. Position-responsive neuro stimulator
DE69115471T2 (en) 1990-03-30 1996-05-02 Alza Corp., Palo Alto, Calif. DEVICE FOR IONTOPHORETIC ADMINISTRATION OF MEDICINES
US5092835A (en) 1990-07-06 1992-03-03 Schurig Janet L S Brain and nerve healing power apparatus and method
US5224927A (en) 1990-11-01 1993-07-06 Robert Tapper Iontophoretic treatment system
US5188104A (en) * 1991-02-01 1993-02-23 Cyberonics, Inc. Treatment of eating disorders by nerve stimulation
US5335657A (en) 1991-05-03 1994-08-09 Cyberonics, Inc. Therapeutic treatment of sleep disorder by nerve stimulation
US5251634A (en) 1991-05-03 1993-10-12 Cyberonics, Inc. Helical nerve electrode
US5192527A (en) 1991-07-01 1993-03-09 Abrahmsohn Glenn M Method of reversing local anesthesia and reagent system therefor
US5231988A (en) 1991-08-09 1993-08-03 Cyberonics, Inc. Treatment of endocrine disorders by nerve stimulation
US5354320A (en) 1991-09-12 1994-10-11 Biotronik Mess- Und Therapiegerate Gmbh & Co., Ingenieurburo Berlin Neurostimulator for production of periodic stimulation pulses
US5215089A (en) 1991-10-21 1993-06-01 Cyberonics, Inc. Electrode assembly for nerve stimulation
ES2120477T3 (en) 1992-01-21 1998-11-01 Macrochem Corp PERFECTED Iontophoretic Administration of Medicines.
US5499967A (en) 1992-02-27 1996-03-19 Societe Anonyme Dite: Laboratoires D'hygiene Societe Anonyme Dite: Et De Dietetique (L.H.D.) Transdermal drug delivery device with waveshape generator
US5330515A (en) 1992-06-17 1994-07-19 Cyberonics, Inc. Treatment of pain by vagal afferent stimulation
US5395398A (en) 1993-07-28 1995-03-07 C. R. Bard, Inc. Microelectric apparatus for the antisepsis, promulgation of healing and analgesia of wound and chronic skin ulcers
US5997501A (en) 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
US5458625A (en) 1994-05-04 1995-10-17 Kendall; Donald E. Transcutaneous nerve stimulation device and method for using same
US6405732B1 (en) 1994-06-24 2002-06-18 Curon Medical, Inc. Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
US5531778A (en) 1994-09-20 1996-07-02 Cyberonics, Inc. Circumneural electrode assembly
US5571150A (en) 1994-12-19 1996-11-05 Cyberonics, Inc. Treatment of patients in coma by nerve stimulation
US5458325A (en) 1994-12-27 1995-10-17 Klein; David A. Weather-resistant basketball net
US5643246A (en) 1995-02-24 1997-07-01 Gel Sciences, Inc. Electromagnetically triggered, responsive gel based drug delivery device
DE19509634C1 (en) 1995-03-17 1996-03-28 Fresenius Ag Implantable infusion pump with constant delivery rate
US5540730A (en) 1995-06-06 1996-07-30 Cyberonics, Inc. Treatment of motility disorders by nerve stimulation
US6245347B1 (en) 1995-07-28 2001-06-12 Zars, Inc. Methods and apparatus for improved administration of pharmaceutically active compounds
US5707400A (en) 1995-09-19 1998-01-13 Cyberonics, Inc. Treating refractory hypertension by nerve stimulation
US5755750A (en) 1995-11-13 1998-05-26 University Of Florida Method and apparatus for selectively inhibiting activity in nerve fibers
AU2260397A (en) 1996-01-31 1997-08-22 Trustees Of The University Of Pennsylvania, The Remote control drug delivery device
US6066163A (en) 1996-02-02 2000-05-23 John; Michael Sasha Adaptive brain stimulation method and system
WO1997029802A2 (en) * 1996-02-20 1997-08-21 Advanced Bionics Corporation Improved implantable microstimulator and systems employing the same
US5683422A (en) 1996-04-25 1997-11-04 Medtronic, Inc. Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation
US5861022A (en) * 1996-04-30 1999-01-19 Hipskind; S. Gregory Method for the treatment of hiccups
US6246912B1 (en) 1996-06-27 2001-06-12 Sherwood Services Ag Modulated high frequency tissue modification
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US7204832B2 (en) 1996-12-02 2007-04-17 Pálomar Medical Technologies, Inc. Cooling system for a photo cosmetic device
US5830208A (en) 1997-01-31 1998-11-03 Laserlite, Llc Peltier cooled apparatus and methods for dermatological treatment
US7460911B2 (en) 1997-02-26 2008-12-02 Alfred E. Mann Foundation For Scientific Research System and method suitable for treatment of a patient with a neurological deficit by sequentially stimulating neural pathways using a system of discrete implantable medical devices
US6208894B1 (en) 1997-02-26 2001-03-27 Alfred E. Mann Foundation For Scientific Research And Advanced Bionics System of implantable devices for monitoring and/or affecting body parameters
US6012457A (en) 1997-07-08 2000-01-11 The Regents Of The University Of California Device and method for forming a circumferential conduction block in a pulmonary vein
US6326020B1 (en) 1997-05-16 2001-12-04 Children's Medical Center Corporation Local anesthetic formulations
US5817139A (en) 1997-05-22 1998-10-06 Polytronics, Ltd. Skin-contact type antiallergic skin-therapeutic apparatus using voltage pulse train
US6164283A (en) 1997-07-08 2000-12-26 The Regents Of The University Of California Device and method for forming a circumferential conduction block in a pulmonary vein
US6238421B1 (en) 1997-08-15 2001-05-29 GüNTHER ROLF. W. Induction heating device and method for metallic implants in living beings
WO1999020339A1 (en) 1997-10-17 1999-04-29 Respironics, Inc. Muscle stimulating device and method for diagnosing and treating a breathing disorder
DE69921449T2 (en) 1998-01-12 2005-11-24 Ronald P. Lesser METHOD FOR THE TREATMENT OF HORN DRESSES BY MEANS OF CONTROLLED HEAT SUPPLY
CA2316945A1 (en) 1998-02-23 1999-08-26 Mnemoscience Gmbh Shape memory polymers
US6314325B1 (en) 1998-04-07 2001-11-06 William R. Fitz Nerve hyperpolarization method and apparatus for pain relief
US6589271B1 (en) 1998-04-21 2003-07-08 Alsius Corporations Indwelling heat exchange catheter
US5993414A (en) 1998-04-23 1999-11-30 Medtronic, Inc. Implantable device
US6266556B1 (en) 1998-04-27 2001-07-24 Beth Israel Deaconess Medical Center, Inc. Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation
US6058331A (en) 1998-04-27 2000-05-02 Medtronic, Inc. Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control
US6941171B2 (en) 1998-07-06 2005-09-06 Advanced Bionics Corporation Implantable stimulator methods for treatment of incontinence and pain
US5876422A (en) 1998-07-07 1999-03-02 Vitatron Medical B.V. Pacemaker system with peltier cooling of A-V node for treating atrial fibrillation
US7231254B2 (en) 1998-08-05 2007-06-12 Bioneuronics Corporation Closed-loop feedback-driven neuromodulation
US7209787B2 (en) 1998-08-05 2007-04-24 Bioneuronics Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US7277758B2 (en) 1998-08-05 2007-10-02 Neurovista Corporation Methods and systems for predicting future symptomatology in a patient suffering from a neurological or psychiatric disorder
US7324851B1 (en) * 1998-08-05 2008-01-29 Neurovista Corporation Closed-loop feedback-driven neuromodulation
EP1115454B1 (en) 1998-08-31 2006-10-25 Travanti Pharma Inc Controlled dosage drug delivery system
US7076307B2 (en) 2002-05-09 2006-07-11 Boveja Birinder R Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders
US6402739B1 (en) 1998-12-08 2002-06-11 Y-Beam Technologies, Inc. Energy application with cooling
IES20000018A2 (en) 1999-01-11 2000-08-23 Bmr Res & Dev Ltd An electrotherapy device and method
US6464687B1 (en) 1999-03-09 2002-10-15 Ball Semiconductor, Inc. Implantable drug delivery system
US6554822B1 (en) 1999-04-30 2003-04-29 University Of Southern California Microbolus infusion pump
US6796956B2 (en) 1999-04-30 2004-09-28 Medtronic, Inc. Method and apparatus to control drug therapy dosages in an implantable pump
US20020019652A1 (en) 1999-07-08 2002-02-14 Cyclotec Advanced Medical Technologies Two part tens bandage
CA2381951A1 (en) 1999-08-18 2001-02-22 Microchips, Inc. Thermally-activated microchip chemical delivery devices
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US6802811B1 (en) 1999-09-17 2004-10-12 Endoluminal Therapeutics, Inc. Sensing, interrogating, storing, telemetering and responding medical implants
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US20020173827A1 (en) 1999-11-24 2002-11-21 Jones Gary L. Apparatus and method for inducing epileptic seizures in test animals for anticonvulsant drug screening
WO2001039831A1 (en) * 1999-12-06 2001-06-07 Advanced Bionics Corporation Implantable device programmer
DE60027458T2 (en) 1999-12-10 2007-07-05 Massachusetts Institute Of Technology, Cambridge MICROCHIP DRUG DISABLING SYSTEMS AND MANUFACTURING METHOD
US6539250B1 (en) 1999-12-15 2003-03-25 David S. Bettinger Programmable transdermal therapeutic apparatus
US6421561B1 (en) 1999-12-30 2002-07-16 Birch Point Medical, Inc. Rate adjustable drug delivery system
US6527695B1 (en) 2000-01-11 2003-03-04 Emory University Magnetic stimulation coil and circuit design
US6885888B2 (en) * 2000-01-20 2005-04-26 The Cleveland Clinic Foundation Electrical stimulation of the sympathetic nerve chain
US6491061B1 (en) 2000-02-25 2002-12-10 University Of New Mexico Stimuli responsive hybrid materials containing molecular actuators and their applications
US6454759B2 (en) 2000-02-28 2002-09-24 The Regents Of The University Of California Microfabricated injectable drug delivery system
CA2408097A1 (en) * 2000-05-08 2001-11-15 Brainsgate Ltd. Method and apparatus for stimulating the sphenopalatine ganglion to modify properties of the bbb and cerebral blood flow
EP1280531B1 (en) 2000-05-12 2007-01-24 Novalar Pharmaceuticals, Inc. Formulation consisting of phentolamine mesylate and the use thereof
US6660247B1 (en) 2000-06-23 2003-12-09 Battelle Memorial Institute Multiple stimulus reversible hydrogels
US7010351B2 (en) 2000-07-13 2006-03-07 Northstar Neuroscience, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
IT1319170B1 (en) 2000-07-28 2003-09-26 Lorenzo Piccone APPARATUS ABLE TO MODULATE THE NEUROVEGETATIVE SYSTEM AND INTEGRATE ITS ACTION WITH THAT OF THE CENTRAL NERVOUS SYSTEM:
DE10039240A1 (en) 2000-08-11 2002-02-28 Hans Ulrich May Electrotherapeutic device
WO2002013906A1 (en) 2000-08-16 2002-02-21 Vanderbilt University Methods and devices for optical stimulation of neural tissues
US6871099B1 (en) 2000-08-18 2005-03-22 Advanced Bionics Corporation Fully implantable microstimulator for spinal cord stimulation as a therapy for chronic pain
US6505079B1 (en) 2000-09-13 2003-01-07 Foster Bio Technology Corp. Electrical stimulation of tissue for therapeutic and diagnostic purposes
US8086314B1 (en) 2000-09-27 2011-12-27 Cvrx, Inc. Devices and methods for cardiovascular reflex control
US6416495B1 (en) 2000-10-10 2002-07-09 Science Incorporated Implantable fluid delivery device for basal and bolus delivery of medicinal fluids
US6832114B1 (en) 2000-11-21 2004-12-14 Advanced Bionics Corporation Systems and methods for modulation of pancreatic endocrine secretion and treatment of diabetes
US6799149B2 (en) 2000-12-29 2004-09-28 Medtronic, Inc. Therapy management techniques for an implantable medical device
US6666845B2 (en) 2001-01-04 2003-12-23 Advanced Neuromodulation Systems, Inc. Implantable infusion pump
EP1372602B1 (en) 2001-01-09 2007-04-18 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US6571125B2 (en) 2001-02-12 2003-05-27 Medtronic, Inc. Drug delivery device
CA2438541A1 (en) * 2001-02-20 2002-08-29 Case Western Reserve University Systems and methods for reversibly blocking nerve activity
US8060208B2 (en) * 2001-02-20 2011-11-15 Case Western Reserve University Action potential conduction prevention
US6453195B1 (en) 2001-03-19 2002-09-17 Medtronic, Inc. Closed loop drug delivery system and remote management thereof
US6907295B2 (en) 2001-08-31 2005-06-14 Biocontrol Medical Ltd. Electrode assembly for nerve control
US6761715B2 (en) 2001-04-26 2004-07-13 Ronald J. Carroll Method and device for neurocryo analgesia and anesthesia
US6684105B2 (en) 2001-08-31 2004-01-27 Biocontrol Medical, Ltd. Treatment of disorders by unidirectional nerve stimulation
US6928320B2 (en) 2001-05-17 2005-08-09 Medtronic, Inc. Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated
US6551235B2 (en) 2001-06-28 2003-04-22 Potencia Medical Ag Implantable pump
US6600956B2 (en) 2001-08-21 2003-07-29 Cyberonics, Inc. Circumneural electrode assembly
US7885709B2 (en) 2001-08-31 2011-02-08 Bio Control Medical (B.C.M.) Ltd. Nerve stimulation for treating disorders
US7209788B2 (en) 2001-10-29 2007-04-24 Duke University Closed loop brain machine interface
GB0129390D0 (en) 2001-12-07 2002-01-30 Clark Terrence D Electrodynamic sensors and applications thereof
US20050138934A1 (en) 2002-02-14 2005-06-30 Martin Weigert Optoelectronic component with a peltier cooler
US7819869B2 (en) * 2004-11-15 2010-10-26 Kimberly-Clark Inc. Methods of treating the sacroilac region of a patient's body
US7108680B2 (en) 2002-03-06 2006-09-19 Codman & Shurtleff, Inc. Closed-loop drug delivery system
US7340304B2 (en) 2002-03-15 2008-03-04 Biomed Soutions, Llc Biothermal power source for implantable devices
US7236822B2 (en) 2002-03-22 2007-06-26 Leptos Biomedical, Inc. Wireless electric modulation of sympathetic nervous system
US7689277B2 (en) 2002-03-22 2010-03-30 Leptos Biomedical, Inc. Neural stimulation for treatment of metabolic syndrome and type 2 diabetes
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US8774913B2 (en) * 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
AU2003221752A1 (en) 2002-04-23 2003-11-10 Alza Corporation Transdermal analgesic systems with reduced abuse potential
US6745078B1 (en) 2002-04-24 2004-06-01 Kelly W. Buchner Procedure and machine for electro-inducing/stimulating deep-layered muscle contractions using a biphasic faradic pulse sequence
US20040049134A1 (en) 2002-07-02 2004-03-11 Tosaya Carol A. System and methods for treatment of alzheimer's and other deposition-related disorders of the brain
US7226426B2 (en) 2002-07-25 2007-06-05 Thomson Paul E Apparatus and method for the detection and quantification of joint and tissue inflammation
US7377546B2 (en) * 2002-09-16 2008-05-27 Trw Vehicle Safety Systems, Inc. Air bag module with vent controlled by tether
US20040127886A1 (en) 2002-09-23 2004-07-01 Triton Biosystems, Inc. Stent and method for drug delivery from stents
WO2004036370A2 (en) 2002-10-15 2004-04-29 Medtronic Inc. Channel-selective blanking for a medical device system
US6860852B2 (en) 2002-10-25 2005-03-01 Compex Medical S.A. Ultrasound therapeutic device
WO2004064918A1 (en) 2003-01-14 2004-08-05 Department Of Veterans Affairs, Office Of General Counsel Cervical wagal stimulation induced weight loss
US20040172084A1 (en) * 2003-02-03 2004-09-02 Knudson Mark B. Method and apparatus for treatment of gastro-esophageal reflux disease (GERD)
US7613515B2 (en) * 2003-02-03 2009-11-03 Enteromedics Inc. High frequency vagal blockage therapy
US8118722B2 (en) * 2003-03-07 2012-02-21 Neuronetics, Inc. Reducing discomfort caused by electrical stimulation
US7783358B2 (en) * 2003-03-14 2010-08-24 Endovx, Inc. Methods and apparatus for treatment of obesity with an ultrasound device movable in two or three axes
US6921099B2 (en) * 2003-03-25 2005-07-26 Detlef Uwe Hoffmann Apparatus for releasably coupling a trailer or other vehicle accesory to a vehicle
US7155279B2 (en) 2003-03-28 2006-12-26 Advanced Bionics Corporation Treatment of movement disorders with drug therapy
US7319899B2 (en) 2003-04-23 2008-01-15 Medtronic, Inc. Sensing techniques for implantable medical devices
US7221979B2 (en) 2003-04-30 2007-05-22 Medtronic, Inc. Methods and apparatus for the regulation of hormone release
WO2005007223A2 (en) 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
US8606356B2 (en) 2003-09-18 2013-12-10 Cardiac Pacemakers, Inc. Autonomic arousal detection system and method
US7616988B2 (en) 2003-09-18 2009-11-10 Cardiac Pacemakers, Inc. System and method for detecting an involuntary muscle movement disorder
US7263405B2 (en) 2003-08-27 2007-08-28 Neuro And Cardiac Technologies Llc System and method for providing electrical pulses to the vagus nerve(s) to provide therapy for obesity, eating disorders, neurological and neuropsychiatric disorders with a stimulator, comprising bi-directional communication and network capabilities
US20050070974A1 (en) 2003-09-29 2005-03-31 Knudson Mark B. Obesity and eating disorder stimulation treatment with neural block
US20050075702A1 (en) 2003-10-01 2005-04-07 Medtronic, Inc. Device and method for inhibiting release of pro-inflammatory mediator
US20050075889A1 (en) * 2003-10-01 2005-04-07 Gomes Dennis C. Progressive customer reward program
US7418292B2 (en) 2003-10-01 2008-08-26 Medtronic, Inc. Device and method for attenuating an immune response
US7206632B2 (en) 2003-10-02 2007-04-17 Medtronic, Inc. Patient sensory response evaluation for neuromodulation efficacy rating
US7286880B2 (en) 2003-10-02 2007-10-23 Medtronic, Inc. System and method for transcutaneous energy transfer achieving high efficiency
JP2007526794A (en) 2003-11-13 2007-09-20 アルザ・コーポレーシヨン System and method for transdermal delivery
WO2005051479A2 (en) * 2003-11-20 2005-06-09 Advanced Neuromodulation Systems, Inc. Electrical stimulation system and method for treating tinnitus
US7395113B2 (en) 2004-03-16 2008-07-01 Medtronic, Inc. Collecting activity information to evaluate therapy
US7366572B2 (en) 2004-03-16 2008-04-29 Medtronic, Inc. Controlling therapy based on sleep quality
WO2006004595A2 (en) 2004-05-28 2006-01-12 Georgia Tech Research Corporation Methods and devices for thermal treatment
WO2005122740A2 (en) 2004-06-15 2005-12-29 Compex Technologies, Inc. Interferential and neuromuscular electrical stimulation system and apparatus
US20060004417A1 (en) 2004-06-30 2006-01-05 Cvrx, Inc. Baroreflex activation for arrhythmia treatment
US7450993B2 (en) * 2004-09-08 2008-11-11 Spinal Modulation, Inc. Methods for selective stimulation of a ganglion
WO2006055582A2 (en) 2004-11-15 2006-05-26 Christopher Decharms Stimulation of neural tissue with light
US7155281B1 (en) 2004-12-03 2006-12-26 Pacesetter, Inc. Complimentary activity sensor network for disease monitoring and therapy modulation in an implantable device
US9089691B2 (en) 2004-12-07 2015-07-28 Cardiac Pacemakers, Inc. Stimulator for auricular branch of vagus nerve
US20060173493A1 (en) 2005-01-28 2006-08-03 Cyberonics, Inc. Multi-phasic signal for stimulation by an implantable device
US7389147B2 (en) 2005-04-29 2008-06-17 Medtronic, Inc. Therapy delivery mode selection
US7310557B2 (en) 2005-04-29 2007-12-18 Maschino Steven E Identification of electrodes for nerve stimulation in the treatment of eating disorders
US7899540B2 (en) 2005-04-29 2011-03-01 Cyberonics, Inc. Noninvasively adjustable gastric band
US20060282134A1 (en) 2005-06-10 2006-12-14 Shapiro Ronald S Photo-thermal therapeutic device
US20060293721A1 (en) * 2005-06-28 2006-12-28 Cyberonics, Inc. Vagus nerve stimulation for treatment of depression with therapeutically beneficial parameter settings
US20070027497A1 (en) 2005-07-27 2007-02-01 Cyberonics, Inc. Nerve stimulation for treatment of syncope
US8660647B2 (en) 2005-07-28 2014-02-25 Cyberonics, Inc. Stimulating cranial nerve to treat pulmonary disorder
US20070027484A1 (en) 2005-07-28 2007-02-01 Cyberonics, Inc. Autonomic nerve stimulation to treat a pancreatic disorder
US7988688B2 (en) 2006-09-21 2011-08-02 Lockheed Martin Corporation Miniature apparatus and method for optical stimulation of nerves and other animal tissue
US7620455B2 (en) 2005-10-25 2009-11-17 Cyberonics, Inc. Cranial nerve stimulation to treat eating disorders
US7853322B2 (en) 2005-12-02 2010-12-14 Medtronic, Inc. Closed-loop therapy adjustment
US7957809B2 (en) 2005-12-02 2011-06-07 Medtronic, Inc. Closed-loop therapy adjustment
US20070156032A1 (en) 2006-01-04 2007-07-05 Gordon Linda S Electronic disease management system
US7801601B2 (en) * 2006-01-27 2010-09-21 Cyberonics, Inc. Controlling neuromodulation using stimulus modalities
US20070191906A1 (en) 2006-02-13 2007-08-16 Anand Iyer Method and apparatus for selective nerve stimulation
US7962220B2 (en) * 2006-04-28 2011-06-14 Cyberonics, Inc. Compensation reduction in tissue stimulation therapy
US8140167B2 (en) 2007-05-31 2012-03-20 Enteromedics, Inc. Implantable therapy system with external component having multiple operating modes
US8170659B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc Method for thermal modulation of neural activity
US8165668B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc Method for magnetic modulation of neural conduction

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5628769A (en) * 1994-09-30 1997-05-13 Saringer Research, Inc. Method and devices for producing somatosensory stimulation using temperature
US20020055779A1 (en) * 1996-03-05 2002-05-09 Brian J. Andrews Neural prosthesis
US20020068964A1 (en) * 1998-01-23 2002-06-06 Innercool Therapies, Inc. Heat pipe nerve cooler
US20050149123A1 (en) * 1999-10-19 2005-07-07 The Johns Hopkins University Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders
US20030014097A1 (en) * 2001-07-13 2003-01-16 Putz David A. Heat-removal method and apparatus for treatment of movement disorder episodes
US20050234523A1 (en) * 2002-04-08 2005-10-20 Levin Howard R Renal nerve stimulation method and apparatus for treatment of patients
US20070135875A1 (en) * 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20050171585A1 (en) * 2002-05-31 2005-08-04 Vahid Saadat Apparatus and methods for cooling a region within the body
US7204833B1 (en) * 2002-10-11 2007-04-17 Flint Hills Scientific Llc Multi-modal system for detection and control of changes in brain state
US20070135846A1 (en) * 2003-02-03 2007-06-14 Enteromedics, Inc. Vagal obesity treatment
US20060122663A1 (en) * 2004-12-03 2006-06-08 Mandell Lee J Neuromuscular stimulation to avoid pulmonary embolisms
US20070060984A1 (en) * 2005-09-09 2007-03-15 Webb James S Apparatus and method for optical stimulation of nerves and other animal tissue
US20070150025A1 (en) * 2005-12-28 2007-06-28 Dilorenzo Daniel J Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
US20070225781A1 (en) * 2006-03-21 2007-09-27 Nidus Medical, Llc Apparatus and methods for altering temperature in a region within the body
WO2007109656A2 (en) * 2006-03-21 2007-09-27 Nidus Medical, Llc Apparatus and methods for altering temperature in a region within the body
WO2008007360A2 (en) * 2006-07-13 2008-01-17 Yossi Gross Peltier unidirectional and selective nerve stimulation
WO2008121231A2 (en) * 2007-03-29 2008-10-09 Cardiac Pacemakers, Inc. Systems and leads for thermal neuroinhibition

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US20090149926A1 (en) 2009-06-11
US20090149919A1 (en) 2009-06-11
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US8170660B2 (en) 2012-05-01
WO2009073208A1 (en) 2009-06-11
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