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GB2441268A - Engineered extracellular matrices control stem cell behavior - Google Patents

Engineered extracellular matrices control stem cell behavior

Info

Publication number
GB2441268A
GB2441268A GB0724345A GB0724345A GB2441268A GB 2441268 A GB2441268 A GB 2441268A GB 0724345 A GB0724345 A GB 0724345A GB 0724345 A GB0724345 A GB 0724345A GB 2441268 A GB2441268 A GB 2441268A
Authority
GB
United Kingdom
Prior art keywords
stem cell
cell behavior
extracellular matrices
control stem
engineered extracellular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB0724345A
Other versions
GB0724345D0 (en
GB2441268B (en
Inventor
Sherry L Voytik-Harbin
Beverly Z Waisner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of GB0724345D0 publication Critical patent/GB0724345D0/en
Publication of GB2441268A publication Critical patent/GB2441268A/en
Application granted granted Critical
Publication of GB2441268B publication Critical patent/GB2441268B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Biophysics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A composition for culturing stem cells is provided. The composition comprises an engineered purified collagen based matrix that has been formed under controlled conditions to have the desired microstructure and mechanical properties. The engineered purified collagen based matrix compositions of the present invention can be used alone or in combination with cells as a tissue graft construct to enhance the repair of damaged or diseased tissues.
GB0724345A 2005-05-16 2006-05-16 Engineered extracellular matrices control stem cell behavior Expired - Fee Related GB2441268B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US68152205P 2005-05-16 2005-05-16
US68168905P 2005-05-16 2005-05-16
US68151105P 2005-05-16 2005-05-16
US68127805P 2005-05-16 2005-05-16
PCT/US2006/019130 WO2006125025A2 (en) 2005-05-16 2006-05-16 Engineered extracellular matrices control stem cell behavior

Publications (3)

Publication Number Publication Date
GB0724345D0 GB0724345D0 (en) 2008-01-30
GB2441268A true GB2441268A (en) 2008-02-27
GB2441268B GB2441268B (en) 2009-10-21

Family

ID=37106236

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0724345A Expired - Fee Related GB2441268B (en) 2005-05-16 2006-05-16 Engineered extracellular matrices control stem cell behavior

Country Status (4)

Country Link
AU (1) AU2006247228B2 (en)
CA (1) CA2608422C (en)
GB (1) GB2441268B (en)
WO (1) WO2006125025A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007136634A1 (en) * 2006-05-16 2007-11-29 Purdue Research Foundation Three dimensional purified collagen matrices
US20070269476A1 (en) 2006-05-16 2007-11-22 Voytik-Harbin Sherry L Engineered extracellular matrices control stem cell behavior
GB2455041B (en) 2006-09-21 2012-03-07 Purdue Research Foundation Collagen preparation and method of isolation
CA2708615C (en) 2007-12-10 2019-12-31 Purdue Research Foundation Collagen-based matrices with stem cells
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
WO2016172365A1 (en) 2015-04-21 2016-10-27 Purdue Research Foundation Office Of Technology Commercialization Cell-collagen-silica composites and methods of making and using the same
WO2018200750A1 (en) 2017-04-25 2018-11-01 Purdue Research Foundation 3-dimensional (3d) tissue-engineered muscle for tissue restoration
CN109224129B (en) * 2018-09-30 2021-09-24 四川大学华西医院 Skin defect repairing material
WO2021202619A1 (en) * 2020-03-30 2021-10-07 Northeastern University Collagen nucleation inhibitors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102237A2 (en) * 2001-06-15 2002-12-27 The Cleveland Clinic Foundation Tissue engineered mitral valve chrodae and methods of making and using same
WO2003068287A1 (en) * 2002-02-11 2003-08-21 Neocutis Sa Compositions comprising undifferentiated fetal cells for the treatment of skin disorders
WO2003087337A2 (en) * 2002-04-12 2003-10-23 Yale University Vascularized human skin equivalent
WO2006003442A2 (en) * 2004-07-05 2006-01-12 Ucl Business Plc Cell-independent fabrication of tissue equivalents
EP1674116A2 (en) * 2004-12-22 2006-06-28 DePuy Products, Inc. Self-assembling protein matrix prepared from natural extracellular matrices

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7615373B2 (en) * 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102237A2 (en) * 2001-06-15 2002-12-27 The Cleveland Clinic Foundation Tissue engineered mitral valve chrodae and methods of making and using same
WO2003068287A1 (en) * 2002-02-11 2003-08-21 Neocutis Sa Compositions comprising undifferentiated fetal cells for the treatment of skin disorders
WO2003087337A2 (en) * 2002-04-12 2003-10-23 Yale University Vascularized human skin equivalent
WO2006003442A2 (en) * 2004-07-05 2006-01-12 Ucl Business Plc Cell-independent fabrication of tissue equivalents
EP1674116A2 (en) * 2004-12-22 2006-06-28 DePuy Products, Inc. Self-assembling protein matrix prepared from natural extracellular matrices

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIOPOLYMERS, Vol. 54, 2000, Brightman et al, "Time-lapse confocal reflection microscopy of collagen fibrillogenesis and extracellular matrix assembly in vitro", 222-234 *

Also Published As

Publication number Publication date
GB0724345D0 (en) 2008-01-30
AU2006247228B2 (en) 2012-04-26
GB2441268B (en) 2009-10-21
AU2006247228A1 (en) 2006-11-23
CA2608422A1 (en) 2006-11-23
WO2006125025A2 (en) 2006-11-23
WO2006125025A3 (en) 2007-06-07
CA2608422C (en) 2014-10-28

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20190516