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GB2211104A - All-in-one drug/substance and solvent package for injection - Google Patents

All-in-one drug/substance and solvent package for injection Download PDF

Info

Publication number
GB2211104A
GB2211104A GB8724700A GB8724700A GB2211104A GB 2211104 A GB2211104 A GB 2211104A GB 8724700 A GB8724700 A GB 8724700A GB 8724700 A GB8724700 A GB 8724700A GB 2211104 A GB2211104 A GB 2211104A
Authority
GB
United Kingdom
Prior art keywords
solvent
drug
substance
syringe
injection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB8724700A
Other versions
GB2211104B (en
GB8724700D0 (en
Inventor
R Louise Caroline Wilson
R David Mangham
R Francisco De Asst Leyva-Leon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LEYVA LEON DR FRANCISCO DE ASS
MANGHAM DR DAVID
WILSON DR LOUISE CAROLINE
Original Assignee
LEYVA LEON DR FRANCISCO DE ASS
MANGHAM DR DAVID
WILSON DR LOUISE CAROLINE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LEYVA LEON DR FRANCISCO DE ASS, MANGHAM DR DAVID, WILSON DR LOUISE CAROLINE filed Critical LEYVA LEON DR FRANCISCO DE ASS
Priority to GB8724700A priority Critical patent/GB2211104B/en
Publication of GB8724700D0 publication Critical patent/GB8724700D0/en
Priority to GB8800040A priority patent/GB8800040D0/en
Publication of GB2211104A publication Critical patent/GB2211104A/en
Application granted granted Critical
Publication of GB2211104B publication Critical patent/GB2211104B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2044—Separating means having slits

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The package for injection comprises a solvent chamber (10) containing solvent (11) and a syringe (13, 18) containing the drug/substance. The two are separated by a breakable diaphragm (12) and the syringe (13, 18) is held within the casing (19) which is an extension of the solvent chamber (10). A circular seal (15) between the casing (19) and the syringe barrel (13) ensures sterility of the contents. To operate, the syringe nozzle (16) is a pushed through the breakable diaphragm (12) simultaneously breaking the circular seal (15) thus permitting withdrawal of the solvent (11) into the syringe barrel (13). After dissolution of the drug/substance (17), the syringe (13, 18) is separated from the casing (19) and the dissolved drug/substance is ready for injection. <IMAGE>

Description

ALL-IN-ONE DRUG/SUBSTANCE AND SOLVENT PACKAGE FOR INJECTION This invention relates to an all-in one drug/substance and solvent package for injection.
Solid or liquid substances which have to be dissolved or diluted prior to administration are conventionally packaged in separate containers. In order to mix the two the appropriate volume of solvent/diluent is withdrawn from one container and injected into the other using a conventional syringe and hypodermic needle. Therefore the equipment needed for the administration of such substances is: one glass vial containing a standard volume of solvent/diluent; one syringe and hypodermic needle; one rubber sealed container containing the substance to be administered.The sequential steps in the preparation and administration of such substances are as follows: snapping open a glass vial and withdrawing the appropriate volume of snlvtdiluent using a syringe and needle; injecting the solvent/diluent into the container containing the substance to be administered; shaking to mix the two; withdrawing the resulting solution: injecting the solution directly into the recipient or removing the needle and injecting via a suitable portal of entry.
The conventional method of preparation of substances for injection as described above is, however, both time consuming and expensive by virtue of the number of procedures and number of independently supplied items involved. Moreover, the presently employed procedure involves disposal of sharps, risk of injury to the user, the possibility of lluman error and poor aseptic technique.
According to the present invention there is provided an all-in-one drug/substance and solvent package for injection. This comprises a syringe containing a measured quantity of substance, an attached solvent chamber containig the appropiate volume of solvent/diluent, a breakable diaphragm providing a separation between the solvent chamber and the syringe and a seal for securing attachment of the syringe to the casing and the sterility of sts contents. In addition there is provided a small hole in the syringe barrel, for means of escape of air or instillation of substances, which is later sealed.
A specific embodimerzt of the invention will now be described by way of example with reference to the accompanying drawing in which: Figure 1 shows in perspective the a3i-in-one drug/substance and solvent package for injection.
Figure 2 illustrates a longitudinal section of the all-in-one drug/substance and solvent package for injection.
Figure 3 shows a view of the diaphragm from the solvent chamber.
Figure 4 shows a longitudinal section of the all-in-one drug/substance and solvent package for injection after having broken the seal and the diaphragm by means of pushing together the syringe barrel and the solvent chamber' Figure 5 shows a longitudinal section of the all-in-one drug/sustance and solvent package for injection after having drawn the solvent into the syringe barrel.
Figure 6 shows a longitudinal section of the syringe and solvent chamber after detachment from one another.
With reference to the figures the all-in-one drug/substance and solvent package for injection comprises a solvent chamber (10) containing the solvent (11) sealed by a breakable diaphragm (12). The syringe barrel (13) fits into the casing (19) which is an extension of the solvent chamber (10) and is attached to this by a circular seal (15) in such a way that the syringe nozzle (16) is closely applied to the breakable diaphragm (12) The syringe barrel (13) contains the drug (17) and its plunger (is).
In order to mix the drug (17) and the solvent (11) force is applied to push the syringe barrel (13) and the solvent chamber (io) together thereby permitting the syringe nozzle (16) to penetrate the breakable diaphragm (12) thus gaining access to the solvenL (It). The circular seal (15) is simultaneously broken. This done, by drawing on the plunger (18) extraction of the solvent (11) from the solvent chamber (to) into the syringe barrel (13) is effected. Once the solvent (it) is within the syringe barrel (13) the syringe barrel is separated from the casing (19).
To achieve dissolution of the drug the syringe (13 and 1S) is shaken. The drug is then in a suitable form for injection.

Claims (3)

CLAINS
1 The essential features of the all-in-one drug/substance and solvent package for injection are that the drugsubstance to be injected is packaged in an air-tight environment within the syringe and subsequently dissolved within the syringe which is to be used for its injection, tht the appropriate solvent is incorporated into the unit also in an air-tight environment, and that the drug/substance and its appropriate solvent are separated by a diaphragm or any other means of separation which when broken or removed allows the drug/substance and solvent to be mixed.
2 An all-in-one rugsubsiance and solvent package for injection as in claim 1 wherein the drug/substance is contained in the solvent chamber and the solvent is contained in the syringe.
3 An all-in-one drug/substance and solvent package for injection sustantially as described herein with reference to figures 1 to 6 of the accompanying drawings.
GB8724700A 1987-10-13 1987-10-13 Syringe arrangment Expired - Fee Related GB2211104B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB8724700A GB2211104B (en) 1987-10-13 1987-10-13 Syringe arrangment
GB8800040A GB8800040D0 (en) 1987-10-13 1988-01-04 All-in-one drug/substance & solvent package for injection

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8724700A GB2211104B (en) 1987-10-13 1987-10-13 Syringe arrangment

Publications (3)

Publication Number Publication Date
GB8724700D0 GB8724700D0 (en) 1987-11-25
GB2211104A true GB2211104A (en) 1989-06-28
GB2211104B GB2211104B (en) 1991-10-02

Family

ID=10625698

Family Applications (2)

Application Number Title Priority Date Filing Date
GB8724700A Expired - Fee Related GB2211104B (en) 1987-10-13 1987-10-13 Syringe arrangment
GB8800040A Pending GB8800040D0 (en) 1987-10-13 1988-01-04 All-in-one drug/substance & solvent package for injection

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB8800040A Pending GB8800040D0 (en) 1987-10-13 1988-01-04 All-in-one drug/substance & solvent package for injection

Country Status (1)

Country Link
GB (2) GB2211104B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171219A (en) * 1989-06-08 1992-12-15 Sumitomo Pharmaceuticals Co., Ltd. Pharmaceutical preparation administrator
WO1995007066A1 (en) * 1993-09-07 1995-03-16 Debiotech S.A. Syringe device for mixing two compounds
US8022375B2 (en) 2003-12-23 2011-09-20 Baxter International Inc. Method and apparatus for validation of sterilization

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090092A (en) 1997-12-04 2000-07-18 Baxter International Inc. Sliding reconstitution device with seal
US20050137566A1 (en) 2003-12-23 2005-06-23 Fowles Thomas A. Sliding reconstitution device for a diluent container
US6113583A (en) 1998-09-15 2000-09-05 Baxter International Inc. Vial connecting device for a sliding reconstitution device for a diluent container
AR021220A1 (en) 1998-09-15 2002-07-03 Baxter Int CONNECTION DEVICE FOR ESTABLISHING A FLUID COMMUNICATION BETWEEN A FIRST CONTAINER AND A SECOND CONTAINER.

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1043954A (en) * 1964-02-20 1966-09-28 Stanley Jay Sarnoff Syringe package
GB1120897A (en) * 1965-07-06 1968-07-24 Ogle Robert Walter Improvements in or relating to a dual medicinal vial
GB1130593A (en) * 1965-04-30 1968-10-16 Novo Terapeutisk Labor As Injection syringe with two coaxial cylindrical chambers
GB1241571A (en) * 1968-04-08 1971-08-04 David Slome Improvements in and relating to hypodermic syringes
GB1274474A (en) * 1968-08-28 1972-05-17 Pfizer Dual-chamber ejector and filling connector
GB1431015A (en) * 1972-05-18 1976-04-07 Dentipressions Inc Disposable mixing syringe assembly

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1043954A (en) * 1964-02-20 1966-09-28 Stanley Jay Sarnoff Syringe package
GB1130593A (en) * 1965-04-30 1968-10-16 Novo Terapeutisk Labor As Injection syringe with two coaxial cylindrical chambers
GB1120897A (en) * 1965-07-06 1968-07-24 Ogle Robert Walter Improvements in or relating to a dual medicinal vial
GB1241571A (en) * 1968-04-08 1971-08-04 David Slome Improvements in and relating to hypodermic syringes
GB1274474A (en) * 1968-08-28 1972-05-17 Pfizer Dual-chamber ejector and filling connector
GB1431015A (en) * 1972-05-18 1976-04-07 Dentipressions Inc Disposable mixing syringe assembly

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171219A (en) * 1989-06-08 1992-12-15 Sumitomo Pharmaceuticals Co., Ltd. Pharmaceutical preparation administrator
WO1995007066A1 (en) * 1993-09-07 1995-03-16 Debiotech S.A. Syringe device for mixing two compounds
US5827262A (en) * 1993-09-07 1998-10-27 Debiotech S.A. Syringe device for mixing two compounds
US8022375B2 (en) 2003-12-23 2011-09-20 Baxter International Inc. Method and apparatus for validation of sterilization

Also Published As

Publication number Publication date
GB2211104B (en) 1991-10-02
GB8800040D0 (en) 1988-02-10
GB8724700D0 (en) 1987-11-25

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee