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GB2197323B - Antibodies - Google Patents

Antibodies

Info

Publication number
GB2197323B
GB2197323B GB8725812A GB8725812A GB2197323B GB 2197323 B GB2197323 B GB 2197323B GB 8725812 A GB8725812 A GB 8725812A GB 8725812 A GB8725812 A GB 8725812A GB 2197323 B GB2197323 B GB 2197323B
Authority
GB
United Kingdom
Prior art keywords
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB8725812A
Other versions
GB8725812D0 (en
GB2197323A (en
Inventor
Lisa Kim Gilliland
Michael Ronald Clark
Herman Waldmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Development Corp UK
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Publication of GB8725812D0 publication Critical patent/GB8725812D0/en
Publication of GB2197323A publication Critical patent/GB2197323A/en
Application granted granted Critical
Publication of GB2197323B publication Critical patent/GB2197323B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
GB8725812A 1986-11-05 1987-11-04 Antibodies Expired - Fee Related GB2197323B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868626413A GB8626413D0 (en) 1986-11-05 1986-11-05 Antibodies

Publications (3)

Publication Number Publication Date
GB8725812D0 GB8725812D0 (en) 1987-12-09
GB2197323A GB2197323A (en) 1988-05-18
GB2197323B true GB2197323B (en) 1990-10-31

Family

ID=10606822

Family Applications (2)

Application Number Title Priority Date Filing Date
GB868626413A Pending GB8626413D0 (en) 1986-11-05 1986-11-05 Antibodies
GB8725812A Expired - Fee Related GB2197323B (en) 1986-11-05 1987-11-04 Antibodies

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB868626413A Pending GB8626413D0 (en) 1986-11-05 1986-11-05 Antibodies

Country Status (5)

Country Link
EP (1) EP0293405A1 (en)
JP (1) JPH01501201A (en)
AU (1) AU616870B2 (en)
GB (2) GB8626413D0 (en)
WO (1) WO1988003566A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9982013B2 (en) 2009-06-26 2018-05-29 Regeneron Pharmaceuticals, Inc. Readily isolated bispecific antibodies with native immunoglobulin format

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2621127B1 (en) * 1987-09-30 1992-01-31 Roussy Inst Gustave MONOCLONAL ANTIBODIES RECOGNIZING A GAMMA CHAIN EPITOPE OF HUMAN T CELL SURFACE RECEPTORS, LINE OF HYBRIDOMA CELLS PRODUCING THE SAME, AND USE OF THIS MONOCLONAL ANTIBODY
EP0334300A1 (en) * 1988-03-21 1989-09-27 Neorx Corporation The use of monoclonal antibodies and conjugates thereof as signals to direct sensitized effector cells to tumor sites
US5766947A (en) * 1988-12-14 1998-06-16 Astra Ab Monoclonal antibodies reactive with an epitope of a Vβ3.1 variable region of a T cell receptor
US5223426A (en) * 1988-12-15 1993-06-29 T Cell Sciences, Inc. Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor
AU641673B2 (en) * 1989-06-29 1993-09-30 Medarex, Inc. Bispecific reagents for aids therapy
US5897861A (en) * 1989-06-29 1999-04-27 Medarex, Inc. Bispecific reagents for AIDS therapy
US5858363A (en) * 1990-07-20 1999-01-12 Pharmacia & Upjohn Ab Target specific antibody-superantigen conjugates and their preparation
HU218603B (en) * 1990-07-20 2000-10-28 Kabi Pharmacia Ab Target specific antibody-superantigen conjugates and their preparation
JP3105629B2 (en) † 1991-04-23 2000-11-06 サングスタット メディカル コーポレイション Cell activity regulating conjugates of members of specific binding pairs
US5587458A (en) * 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
DE4419399C1 (en) * 1994-06-03 1995-03-09 Gsf Forschungszentrum Umwelt Process for the preparation of heterologous bispecific antibodies
US5945311A (en) * 1994-06-03 1999-08-31 GSF--Forschungszentrumfur Umweltund Gesundheit Method for producing heterologous bi-specific antibodies
SK288201B6 (en) 2000-03-31 2014-06-03 Purdue Research Foundation Pharmaceutical composition
JP5168538B2 (en) * 2007-05-24 2013-03-21 アボットジャパン株式会社 Antibody-antibody conjugates and application to diagnostic antibodies
JP5997154B2 (en) 2010-08-16 2016-09-28 ノビミューン エスアー Method for producing multispecific multivalent antibody
HUE047278T2 (en) 2011-08-05 2020-04-28 Regeneron Pharma Humanized universal light chain mice
AR101262A1 (en) 2014-07-26 2016-12-07 Regeneron Pharma PURIFICATION PLATFORM FOR Bispecific Antibodies

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
CA1213229A (en) * 1982-04-12 1986-10-28 Gary S. David Antibodies having dual specificities, their preparation and uses therefor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Proc.Natl.Acad.Sci. USA (1985) Vol.8 *
Proc.Natl.Acad.Sci. USA (1986) Vol.8 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9982013B2 (en) 2009-06-26 2018-05-29 Regeneron Pharmaceuticals, Inc. Readily isolated bispecific antibodies with native immunoglobulin format

Also Published As

Publication number Publication date
AU8156887A (en) 1988-06-01
GB8626413D0 (en) 1986-12-03
GB8725812D0 (en) 1987-12-09
WO1988003566A1 (en) 1988-05-19
JPH01501201A (en) 1989-04-27
AU616870B2 (en) 1991-11-14
EP0293405A1 (en) 1988-12-07
GB2197323A (en) 1988-05-18

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19931104