GB202406294D0 - Methods and compositions for producing capped mRNA - Google Patents
Methods and compositions for producing capped mRNAInfo
- Publication number
- GB202406294D0 GB202406294D0 GBGB2406294.5A GB202406294A GB202406294D0 GB 202406294 D0 GB202406294 D0 GB 202406294D0 GB 202406294 A GB202406294 A GB 202406294A GB 202406294 D0 GB202406294 D0 GB 202406294D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- compositions
- methods
- capped mrna
- producing capped
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020004999 messenger RNA Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2406294.5A GB202406294D0 (en) | 2024-05-06 | 2024-05-06 | Methods and compositions for producing capped mRNA |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2406294.5A GB202406294D0 (en) | 2024-05-06 | 2024-05-06 | Methods and compositions for producing capped mRNA |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB202406294D0 true GB202406294D0 (en) | 2024-06-19 |
Family
ID=91248230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GBGB2406294.5A Pending GB202406294D0 (en) | 2024-05-06 | 2024-05-06 | Methods and compositions for producing capped mRNA |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB202406294D0 (en) |
Citations (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995008626A1 (en) | 1993-09-20 | 1995-03-30 | The Regents Of The University Of Colorado | Strategy for the production of rna from immobilized templates |
| EP1165826B1 (en) | 1999-03-25 | 2006-12-06 | Roche Diagnostics GmbH | Method for synthesis of polypeptides in cell-free systems |
| WO2010016621A1 (en) | 2008-08-08 | 2010-02-11 | 東ソー株式会社 | Rna polymerase mutant with improved functions |
| WO2013052523A1 (en) | 2011-10-03 | 2013-04-11 | modeRNA Therapeutics | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| WO2016193226A1 (en) | 2015-05-29 | 2016-12-08 | Curevac Ag | Method for adding cap structures to rna using immobilized enzymes |
| WO2017062343A1 (en) | 2015-10-06 | 2017-04-13 | Pierce Biotechnology, Inc. | Devices and methods for producing nucleic acids and proteins |
| WO2017123748A1 (en) | 2016-01-13 | 2017-07-20 | New England Biolabs, Inc. | Thermostable variants of t7 rna polymerase |
| WO2018236617A1 (en) | 2017-06-21 | 2018-12-27 | New England Biolabs, Inc. | Use of thermostable rna polymerases to produce rnas having reduced immunogenicity |
| WO2019005540A1 (en) | 2017-06-30 | 2019-01-03 | Codexis, Inc. | T7 rna polymerase variants |
| WO2019005539A1 (en) | 2017-06-30 | 2019-01-03 | Codexis, Inc. | T7 rna polymerase variants |
| WO2019122371A1 (en) | 2017-12-21 | 2019-06-27 | Curevac Ag | Linear double stranded dna coupled to a single support or a tag and methods for producing said linear double stranded dna |
| WO2019199807A1 (en) | 2018-04-10 | 2019-10-17 | Greenlight Biosciences, Inc. | T7 rna polymerase variants |
| WO2020002598A1 (en) | 2018-06-28 | 2020-01-02 | Curevac Ag | Bioreactor for rna in vitro transcription |
| US20200340028A1 (en) | 2019-04-24 | 2020-10-29 | The University Of Massachusetts | Novel enzymatic methods to generate high yields of sequence specific rna oligonucleotides with extreme precision |
| CN112831484A (en) | 2021-01-13 | 2021-05-25 | 华中科技大学 | T7-RNA polymerase mutant and application thereof |
| US11066686B2 (en) | 2017-08-18 | 2021-07-20 | Modernatx, Inc. | RNA polymerase variants |
| US11072808B2 (en) | 2018-10-04 | 2021-07-27 | New England Biolabs, Inc. | Methods and compositions for increasing capping efficiency of transcribed RNA |
| WO2022081519A1 (en) | 2020-10-12 | 2022-04-21 | Life Technologies As | Magnetic particle processing systems for use with biological cells and related methods |
| US11485960B2 (en) | 2019-02-20 | 2022-11-01 | Modernatx, Inc. | RNA polymerase variants for co-transcriptional capping |
| WO2022261050A1 (en) | 2021-06-07 | 2022-12-15 | The University Of Massachusetts | Apparatus and method for continuous production of rna |
| US20230265476A1 (en) | 2020-05-12 | 2023-08-24 | Charalampos Makatsoris | A method and modular apparatus for the synthesis of rna-based therapeutics |
-
2024
- 2024-05-06 GB GBGB2406294.5A patent/GB202406294D0/en active Pending
Patent Citations (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995008626A1 (en) | 1993-09-20 | 1995-03-30 | The Regents Of The University Of Colorado | Strategy for the production of rna from immobilized templates |
| EP1165826B1 (en) | 1999-03-25 | 2006-12-06 | Roche Diagnostics GmbH | Method for synthesis of polypeptides in cell-free systems |
| WO2010016621A1 (en) | 2008-08-08 | 2010-02-11 | 東ソー株式会社 | Rna polymerase mutant with improved functions |
| WO2013052523A1 (en) | 2011-10-03 | 2013-04-11 | modeRNA Therapeutics | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| WO2016193226A1 (en) | 2015-05-29 | 2016-12-08 | Curevac Ag | Method for adding cap structures to rna using immobilized enzymes |
| WO2017062343A1 (en) | 2015-10-06 | 2017-04-13 | Pierce Biotechnology, Inc. | Devices and methods for producing nucleic acids and proteins |
| WO2017123748A1 (en) | 2016-01-13 | 2017-07-20 | New England Biolabs, Inc. | Thermostable variants of t7 rna polymerase |
| WO2018236617A1 (en) | 2017-06-21 | 2018-12-27 | New England Biolabs, Inc. | Use of thermostable rna polymerases to produce rnas having reduced immunogenicity |
| WO2019005540A1 (en) | 2017-06-30 | 2019-01-03 | Codexis, Inc. | T7 rna polymerase variants |
| WO2019005539A1 (en) | 2017-06-30 | 2019-01-03 | Codexis, Inc. | T7 rna polymerase variants |
| US11066686B2 (en) | 2017-08-18 | 2021-07-20 | Modernatx, Inc. | RNA polymerase variants |
| WO2019122371A1 (en) | 2017-12-21 | 2019-06-27 | Curevac Ag | Linear double stranded dna coupled to a single support or a tag and methods for producing said linear double stranded dna |
| WO2019199807A1 (en) | 2018-04-10 | 2019-10-17 | Greenlight Biosciences, Inc. | T7 rna polymerase variants |
| WO2020002598A1 (en) | 2018-06-28 | 2020-01-02 | Curevac Ag | Bioreactor for rna in vitro transcription |
| US11072808B2 (en) | 2018-10-04 | 2021-07-27 | New England Biolabs, Inc. | Methods and compositions for increasing capping efficiency of transcribed RNA |
| US11485960B2 (en) | 2019-02-20 | 2022-11-01 | Modernatx, Inc. | RNA polymerase variants for co-transcriptional capping |
| US20200340028A1 (en) | 2019-04-24 | 2020-10-29 | The University Of Massachusetts | Novel enzymatic methods to generate high yields of sequence specific rna oligonucleotides with extreme precision |
| US20230265477A1 (en) | 2019-04-24 | 2023-08-24 | University Of Massachusetts | Novel enzymatic methods to generate high yields of sequence specific rna oligonucleotides with extreme precision |
| US20230265476A1 (en) | 2020-05-12 | 2023-08-24 | Charalampos Makatsoris | A method and modular apparatus for the synthesis of rna-based therapeutics |
| WO2022081519A1 (en) | 2020-10-12 | 2022-04-21 | Life Technologies As | Magnetic particle processing systems for use with biological cells and related methods |
| CN112831484A (en) | 2021-01-13 | 2021-05-25 | 华中科技大学 | T7-RNA polymerase mutant and application thereof |
| WO2022261050A1 (en) | 2021-06-07 | 2022-12-15 | The University Of Massachusetts | Apparatus and method for continuous production of rna |
Non-Patent Citations (17)
| Title |
|---|
| ARNDT-JOVIN ET AL., EUR. J. BIOCHEM., vol. 54, no. 2, 1975, pages 1 - 8 |
| BAR ET AL., LANGMUIR, vol. 12, 1996, pages 1172 |
| BETHELL ET AL., J. ELECTROANAL. CHEM., vol. 409, 1996, pages 137 |
| CAZENAVE CUHLENBECK OC: "RNA Template-Directed RNA Synthesis by T7 RNA Polymerase", PROC. NATL. ACAD. SCI. USA, vol. 91, 1994, pages 6972 - 6976, XP002049779, DOI: 10.1073/pnas.91.15.6972 |
| COLVIN ET AL., J. AM. CHEM. SOC., vol. 114, 1992, pages 5221 |
| EGLOFF ET AL.: "An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization", THE EMBO JOURNAL, 2002 |
| GRABAR ET AL., ANALYT. CHEM., vol. 67, 1995, pages 73 - 743 |
| KERN ET AL., BIOTECHNOL. PROG, vol. 13, 1997, pages 747 - 756 |
| KERN ET AL., BIOTECHNOL. PROG., vol. 15, 1999, pages 174 - 184 |
| KERRIGAN ET AL., CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, vol. 24, 2001 |
| KUGE ET AL., NUCL. ACIDS RES., vol. 26, no. 13, 1998, pages 3208 - 3214 |
| LEGNINI, I.ALLES, J.KARAISKOS, N ET AL.: "FLAM-seq: full-length mRNA sequencing reveals principles of poly(A) tail length control", NAT METHODS, vol. 16, 2019, pages 879 - 886, XP036954228, DOI: 10.1038/s41592-019-0503-y |
| MUTTACH ET AL., J. ORG CHEM, vol. 13, 2017, pages 2819 - 2832 |
| PERZANOWSKA O. ET AL.: "Chemically Modified Poly(A) Analogs Targeting PABP: Structure Activity Relationship and Translation Inhibitory Properties", CHEMISTRY - A EUROPEAN JOURNAL, vol. 28, 2022, pages e202201115 |
| QIN, S.TANG, X.CHEN, Y ET AL.: "mRNA-based therapeutics: powerful and versatile tools to combat diseases", SIG TRANSDUCT TARGET THER, vol. 7, 2022, pages 166 |
| SHERIDAN, C.: "mRNA printers kick-start personalized medicines for all", NAT BIOTECHNOL, vol. 40, 2022, pages 1160 - 1162 |
| STRZELECKA D. ET AL., RNA, vol. 26, no. 12, December 2020 (2020-12-01), pages 1815 - 1837 |
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