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GB2000137B - Process for the preparation of 7,8-dihydro-14-hydroxynormorphine - Google Patents

Process for the preparation of 7,8-dihydro-14-hydroxynormorphine

Info

Publication number
GB2000137B
GB2000137B GB7827483A GB7827483A GB2000137B GB 2000137 B GB2000137 B GB 2000137B GB 7827483 A GB7827483 A GB 7827483A GB 7827483 A GB7827483 A GB 7827483A GB 2000137 B GB2000137 B GB 2000137B
Authority
GB
United Kingdom
Prior art keywords
hydroxynormorphine
dihydro
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7827483A
Other versions
GB2000137A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of GB2000137A publication Critical patent/GB2000137A/en
Application granted granted Critical
Publication of GB2000137B publication Critical patent/GB2000137B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB7827483A 1977-06-21 1978-06-21 Process for the preparation of 7,8-dihydro-14-hydroxynormorphine Expired GB2000137B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772727805 DE2727805A1 (en) 1977-06-21 1977-06-21 METHOD FOR PRODUCING OXYNORMORPHONE

Publications (2)

Publication Number Publication Date
GB2000137A GB2000137A (en) 1979-01-04
GB2000137B true GB2000137B (en) 1982-01-06

Family

ID=6011952

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7827483A Expired GB2000137B (en) 1977-06-21 1978-06-21 Process for the preparation of 7,8-dihydro-14-hydroxynormorphine

Country Status (7)

Country Link
JP (1) JPS549300A (en)
DE (1) DE2727805A1 (en)
FI (1) FI781962A (en)
FR (1) FR2395269A1 (en)
GB (1) GB2000137B (en)
HU (1) HU177923B (en)
NL (1) NL7806658A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8921556B2 (en) 2010-06-11 2014-12-30 Rhodes Technologies Process for N-dealkylation of tertiary amines
US9127014B2 (en) 2010-06-11 2015-09-08 Rhodes Technologies Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
EP3252055A1 (en) 2016-05-31 2017-12-06 Alcaliber Investigacion Desarrollo e Innovacion, S.L. Process for obtaining 3,14-diacetyloxymorphone from oripavine

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
EP0158476B1 (en) * 1984-03-27 1991-01-23 Mallinckrodt, Inc. (a Delaware corporation) Preparation of noroxymorphone from morphine
FR2564838B1 (en) * 1984-05-25 1986-11-07 Sanofi Sa PROCESS FOR DEALKYLATION OF ALKALOIDS AND INTERMEDIATES
HU197750B (en) * 1984-07-17 1989-05-29 Alkaloida Vegyeszeti Gyar Process for n-demethylation of morphine alkaloids
WO2006084389A1 (en) 2005-02-11 2006-08-17 Cilag Ltd. Method for purifying noroxymorphone compounds
GB2444052A (en) * 2006-05-25 2008-05-28 Alpharma Aps Processes of preparing morphinan derivatives such as naltrexone and naloxone comprising O- and N-demethylation and reductive alkylation steps
GB2438400A (en) * 2006-05-25 2007-11-28 Alpharma Aps N-Demethylation of 14-hydroxy morphinans with alpha-chloroethyl chloroformate
GB2471801B (en) * 2006-05-25 2011-02-16 Alpharma Process useful in the preparation of morphine antagonists
BR112013028467A2 (en) 2011-05-06 2016-08-16 Univ Brock process for the preparation of morphine analogs through metal catalysed n-demethylation / functionalization and intramolecular group transfer
WO2019165298A1 (en) * 2018-02-23 2019-08-29 Rhodes Technologies Novel opioid compounds and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3905981A (en) * 1973-10-12 1975-09-16 Research Corp N-dealkylation of tertiary amines

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8921556B2 (en) 2010-06-11 2014-12-30 Rhodes Technologies Process for N-dealkylation of tertiary amines
US9127014B2 (en) 2010-06-11 2015-09-08 Rhodes Technologies Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
US9309258B2 (en) 2010-06-11 2016-04-12 Rhodes Technologies Process for N-dealkylation of tertiary amines
US9499557B2 (en) 2010-06-11 2016-11-22 Rhodes Technologies Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
US9593124B2 (en) 2010-06-11 2017-03-14 Rhodes Technologies Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
EP3252055A1 (en) 2016-05-31 2017-12-06 Alcaliber Investigacion Desarrollo e Innovacion, S.L. Process for obtaining 3,14-diacetyloxymorphone from oripavine
WO2017207519A1 (en) 2016-05-31 2017-12-07 Alcaliber Investigación Desarrollo E Innovación, S.L. Process for obtaining 3,14-diacetyloxymorphone from oripavine

Also Published As

Publication number Publication date
FR2395269A1 (en) 1979-01-19
HU177923B (en) 1982-01-28
FI781962A (en) 1978-12-22
FR2395269B1 (en) 1983-06-10
NL7806658A (en) 1978-12-27
GB2000137A (en) 1979-01-04
DE2727805A1 (en) 1979-01-04
JPS549300A (en) 1979-01-24

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee