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GB1533129A - Process for producing a peptide in the presence of an enzyme - Google Patents

Process for producing a peptide in the presence of an enzyme

Info

Publication number
GB1533129A
GB1533129A GB42958/76A GB4295876A GB1533129A GB 1533129 A GB1533129 A GB 1533129A GB 42958/76 A GB42958/76 A GB 42958/76A GB 4295876 A GB4295876 A GB 4295876A GB 1533129 A GB1533129 A GB 1533129A
Authority
GB
United Kingdom
Prior art keywords
peptide
enzyme
formula
amino acid
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB42958/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP50126876A external-priority patent/JPS5251092A/en
Priority claimed from JP50126878A external-priority patent/JPS5251093A/en
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Publication of GB1533129A publication Critical patent/GB1533129A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A peptide of the formula X-A-B-Y where A and B are identical or different and in each case denote an amino acid residue or a peptide residue and where X denotes an amino protective group and where Y denotes one of the following carboxyl protective groups: tert-alkoxy group, benzyloxy, benzylamino and benzhydrylamino group, which is optionally substituted by an inert substituent, is prepared by reacting an amino acid or a peptide with an N-terminal protective group or a salt thereof of the formula X-A-OH with an amino acid or a peptide of a C-terminal protective group or a salt thereof of the formula H-B-Y in particular in the presence of a thiol proteinase enzyme or a serine proteinase enzyme in an aqueous solution having a pH at which the enzyme activity of the thiol proteinase or the serine proteinase is retained.
GB42958/76A 1975-10-23 1976-10-15 Process for producing a peptide in the presence of an enzyme Expired GB1533129A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP50126876A JPS5251092A (en) 1975-10-23 1975-10-23 Method of preparing peptides
JP50126878A JPS5251093A (en) 1975-10-23 1975-10-23 Mthod of preparing peptides

Publications (1)

Publication Number Publication Date
GB1533129A true GB1533129A (en) 1978-11-22

Family

ID=26462969

Family Applications (1)

Application Number Title Priority Date Filing Date
GB42958/76A Expired GB1533129A (en) 1975-10-23 1976-10-15 Process for producing a peptide in the presence of an enzyme

Country Status (7)

Country Link
CA (1) CA1059938A (en)
CH (1) CH620671A5 (en)
DE (1) DE2647188C2 (en)
FR (1) FR2328694A1 (en)
GB (1) GB1533129A (en)
IT (1) IT1077078B (en)
NL (2) NL173979C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002872A (en) * 1989-05-10 1991-03-26 W. R. Grace & Co.-Conn. Enzyme mediated coupling reactions

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2546164B1 (en) * 1983-05-16 1987-07-17 Centre Nat Rech Scient NOVEL PEPTIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS ELASTASE INHIBITORS
IT1186733B (en) * 1985-06-05 1987-12-16 Eniricerche Spa TRIPEPTIDIC COMPOUNDS WITH HYPOTHENSIVE ACTION

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002872A (en) * 1989-05-10 1991-03-26 W. R. Grace & Co.-Conn. Enzyme mediated coupling reactions

Also Published As

Publication number Publication date
DE2647188C2 (en) 1983-03-24
NL7611698A (en) 1977-04-26
NL173979C (en) 1984-04-02
FR2328694B1 (en) 1980-03-28
NL173979B (en) 1983-11-01
FR2328694A1 (en) 1977-05-20
IT1077078B (en) 1985-04-27
CA1059938A (en) 1979-08-07
DE2647188A1 (en) 1977-04-28
CH620671A5 (en) 1980-12-15
NL8301093A (en) 1983-08-01

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Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years

Effective date: 19961014