GB1567902A - 1-aminoalkyl-7,7-dimethylnorbornanes - Google Patents
1-aminoalkyl-7,7-dimethylnorbornanes Download PDFInfo
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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Description
(54) 1-AMINOALKYL-7,7-DIMETHYLNORBORNANES
(71) We, GLAXO LABORATORIES
LIMITED, a British company, of Greenford,
Middlesex, do hereby declare this invention, for which we pray that a patent may be granted to us, and the method by which it is to be performed, to be particularly described in and by the following statement:- This invention relates to new derivatives of 7,7-dimethylnornornane (i.e. 7,7 - dimethyl [2,2,1] - bycyloheptane).
1-Aminoethyl, l-aminopropyl- and 1aminobutyl - 7,7 - dimethyl - norbornane and the derivatives thereof described below are new compound and we have found that compounds in this series possess interesting central nervous system activity.
Thus in one aspect the invention provides 7,7 - dimethyl - f2,2,1 1 - bicycloheptanes of the formula:
wherein
A is
-(CH2nNRZ3R where n is 2, 3 or 4 (i.e.
-10CH211CH2NRR,
-10CH211CH212CH2 -NR1R2 or
10CH211CH212CH213CH2NRR); Rl and R2, which may be the same or different, are hydrogen atoms or C16 alkyl or C2, alkenyl groups or, together with intervening nitrogen atom, represent a 4-7 membered saturated heterocyclic ring which is unsubstituted or substituted by a -6 @ alkyl group; and
R is a hydrogen or chlorine atom in the endo configuration; which compounds are optionally substituted by a C14 alkyl group at any position in the alkylene chain of A or by an oxo or hydroxy group at the iss- position of the alkylene chain of A relative to the nitrogen atom (i.e. at the 10;position when n is 2, at the ll-position when n is 3, or at the 12-position when n is 4); and the physiologically acceptable salts thereof. The compounds just defined will be referred to herein as compounds of formula I.
Tests we have carried out in mice (including anti-nicotine, anti-rage and maximal electroshock tests) have shown that compounds of formula I possess central nervous system activity. The results of these tests indicate that these compounds are of potential interest as anti-Parkinson and/or tranquilising drugs. Our anti-nicotine test is based on the methods of Bianchi and Tomasi (Pharmacology, 1973, 10. 226-237) and Aceto,
Bentley & Dembinski (Brit. J. Pharmacology, 1969, 37, 104 111). Convulsions are induced in mice by the intravenous (iv) intracerebral (ic) injection of nicotine, the end point of the test being taken as the tonic extensor convulsion in the iv tests and the clonic convulsion in the ic tests. The anti-rage test used was that of Tedeschi et al (J. Pharmac.
Exp. Ther. 125, 28-34), and the maximal electroshock test that of Swinyard et al (J.
Pharmac. Exp. Ther. 106, 319-330).
The invention thus also includes pharmaceutical (including veterinary) compositions comprising a compound in accordance with the invention or a physiologically acceptable salt thereof together with a pharmaceutical carrier or excipient. The invention also includes a method for the treatment of Parkinson's disease or anxiety comprising administering an effective amount of a compound of the invention to an animal (other than man).
In the compounds of the invention R1 and
R2 may for example be c1-4 alkyl or C2 all:enyl groups such as methyl, ethyl, n-propyl, n-butyl and allyl. When R1 and R2 together with the intervening nitrogen atom represent a heterocyclic ring, the group preferably has 5 or 6 ring members and may for example be a piperidino or pyrrolidino group; such groups may be substituted by a C1, alkyl (e.g. methyl) group. Examples of alkyl groups which may be present on the alkylene chain of A are methyl, ethyl, n-propyl and n-butyl.
In general, the preferred compounds are those in which both R1 and R2 are hydrogen atoms, and also those in which the alkylene chain of A is unsubstituted. Compounds in which n is 3 (i.e. aminopropyl compounds) are also generally preferred, as are those in which Rs is a chlorine atom.
When -NR1R2 represents a substituted amino group it is preferably a monomethylamino group or (particularly when R3 is a chlorine atom) a dimethylamino group. When -NR1R2 represents a heterocyclic amino group the ring preferably has 5 or 6 members, and R3 is preferably a chlorine atom in such compounds. When the alkylene chain of A is substituted by an alkyl group the substituent is preferably a methyl group in the a- or ss- position relative to the nitrogen atom.
Specific compounds which are preferred on account of the activity they have shown in our tests are:
1) 1 - (2 - aminoethyl) - 7,7 - dimethyl- norbornane;
2) 1 - (2 - aminoethyl) - 2 - endo chloro 7,7 - dimethylnorbornane;
3) 1 - (2 - methylaminoethyl) - 7,7dimethylnorbornane;
4) 1 - (2 - dimethylaminoethyl) - 7,7dimethylnorbornane;
5) 1 - (2 - dimethylaminoethyl) - 2endo - chloro - 7,7 - dimethylnorbornane;
6) - 1 - (2 - pyrrolidinoethyl) - 2 - endochloro - 7,7 - dimethylnorbornane;
7) 1 - (2 - piperidinoethyl) - 2 - endochloro - 7,7 - dimethylnorbornane;
8) 1 - (2 - amino - n - propyl) - 7,7dimethylnorbornane;
9) 1 - (2 - amino - n - propyl) - 2 - endo- chloro - 7,7 - dimethylnorbornane;
10) 1 - (1 - oxo - 2 - dimethylaminoethyl) - 7,7 - dimethylnorbornane;
11) 1 - (3 - amino - n - propyl) - 7,7dimethylnorbornane; 12) 1 - (3 -amino-n-propyl) - 2 - endo- chloro - 7,7 - dimethylnorbornane;
13) 1 - (3 - methylamino - n - propyl)7,7- dimethylnorbornane;
14) 1 - (3 - methylamino - n - propyl) 2 - endo - chloro - 7- chloro - 7,7 - dimethylnorbornane;
15) 1 - (3 - dimethylamino - n - propyl) 2 - endo - chloro - 7,7 - dimethylnorbornane;
16) 1 - (2 - oxo - 3 - methylamino propyl) - 2 - endo - chloro - 7,7 - dimethyl- norbornane;
17) 1 - (2 - hydroxy - 3 - amino propyl) - 7,7 - dimethylnorbomane; 18) 1 - (2 - hydroxy - 3 - amino propyl) - 2 - endo - chloro - 7,7 - dimethylnorbornane;
19) 1 - (4 - amino - n - butyl) - 7,7dimethylnorbornane;
20) 1 - (4 - methylamino - n - butyl)7,7 - dimethylnorbornane;
21) 1 - (2 - pyrrolidinoethyl) - 7,7dimethylnorbornane;
22) 1 - (2 - piperidinoethyl) - 7,7dimethylnorbornane; and
23) 1 - (2 - hexamethyleneiminoethyl)7,7 - dimethylnorbornane.
These compounds may be in the form of their salts, in particular hydrochlorides.
Examples of physiologically acceptable acid addition salts which are included in the invention are hydrochlorides, hydrobromides, phosphates, sulphates, p-toluene sulphonates, methane sulphonates, citrates, tartrates, acetates, ascorbates, Iactates, maleates and succinates.
The compounds of the invention may be formulated for administration with one or more conventional carriers or excipients, together if desired with other medicinal agents, in a form suitable for oral, rectal or parenteral administration. If desired, the compositions may be formulated to provide delayed or sustained release of the active comnound.
Thus for example the compositions may be presented in the form of tablets, capsules, suppositories and aqueous or oily solutions for injection, e.g. in ampoules. The compositions are preferably presented in dosage unit form, the units for example being formulated to provide 10 to 500 mg of the active compound per day (for the average adult having a body weight of 70 kg). These doses may of course be varied for children or animals according to weight.
The compounds of the invention which are unsubstituted at the a-position in relation to the nitrogen atom and the position is not substituted by an oxo - or hydroxy group, are conveniently prepared by reduction of the corresponding carbonamide, i.e. a compound of formula I wherein the 11-, 12- or 13position, as appropriate, is substituted by an oxo group (compounds of formula I except in that A is the group (CH2)n1 CONR1R2).
This reaction may for example be carried out with a hydride reagent capable of reducing amides to amines, such as lithium aluminium hydride or diborane, in an inert organic solvent, for example a hydrocarbon solvent such as benzene or toluene or an ether solvent such as diethyl ether or tetrahydrofuran. The reaction with lithium aluminium hydride is suitably carried out at the reflux temperature of the reaction mixture although lower temperatures may be used if desired. Reaction with diborane may for example be effected at temperatures of -10 to +30 C, conveniently at room temperature.
The amine produced is conveniently isolated in the form of a salt, e.g. the hydrochloride.
The amides required for the reduction reaction may be prepared from the corresponding carboxylic acid, i.e. compounds of formula I wherein A is --CH2COOH, uC2H4COOH or -C,HCOOH or such a group in which the alkylene chain is substituted by an alkyl group.
The amides may be prepared by reacting the acid itself or a reactive derivative thereof (e.g. an acid halide such as an acid chloride) with ammonia or an amine of the formula
HNR1R2.
This reaction is desirably carried out at a low temperature (e.g. -80 to +10 C) in the presence of an acid binding agent (e.g. a base, which is conveniently provided by an excess of the amine). The reaction is conveniently carried out in a hydrocarbon solvent such as toluene or an ether solvent such as diethyl ether.
Where an acid halide is chosen for the reaction, it may be prepared by conventional techniques, e.g. by reacting the acid with thionyl chloride.
As regards the carboxylic acids required as starting materials in the amide preparations, the compound in which A is wCH2COOH is known (i.e. l-apocamphane acetic acid), as is its 2-chloro derivative. The compounds wherein A is (CH2)2COOH are for example conveniently prepared from a compound of formula I wherein A is (CH2)2OH (e.g. 1 -(2 - hydroxyethyl) - 7,7 - dimethyl- norbomane) by first forming the corresponding 1 1-bromo compound, for example by refluxing with hydrobromic acid in the presence of a strong acid (e.g. sulphuric acid). The bromo compound may then be converted into the desired acid either by reaction with magnesium and carbon dioxide or by reaction with an alkali metal cyanide (e.g. KCN) followed by treatment with a strong base, e.g. an alkali metal hydroxide such as KOH.
The carboxylic acid starting materials in which A is (CH2)sCOOH (or such a group substituted by alkyl) may for example be prepared by treating a corresponding bromoethyl compound with an alkali metal dialkylmalonate (e.g. sodium diethylmalonate) and then hydrolysing the product (e.g. with KOH). The dicarboxylic acid produced may then be decarboxylated (e.g. by heating at 170-180 C) to give the required intermediate.
The amides of formula I in which A is 3(CH2) 2CONR1R2
or -(cH, ) 3CONR1R2 and the methylene group adjacent to the carbonyl group is unsubstituted may also be prepared by reaction of a p-keto diazo compound (i.e. a compound of formula r except that A is -cH2C0CHN2 or -(CH2)2COCHN2) with ammonia or an amine of the formula
-HNRR in the presence of silver nitrate. This reaction preferably performed in aqueous dioxan solution at a moderate temperature (e.g. 60800C).
The 8-keto diazo compounds required for this latter reaction (as well as those in which
A is COCHN2) may themselves be prepared by reaction of an appropriate carboxylic acid halide (i.e. a compound of formula I in which A is -COX, -CH2COX or -CH2H4COX where X is halogen, e.g. chlorine) with diazomethane. This reaction is desirably carried out at low temperature (e.g. 0 C) in an ether solvent (e.g. diethyl ether), using an excess of diazomethane. Acid halides used as starting materials in this reaction may again be prepared by conventional techniques.
Compounds which are substituted at the
P-position in relation to the nitrogen atom by an oxo or hydroxy group (i.e. compounds where A is (CH,), ..COCH2NR'R2 or
-(Ch2)n-2CHOHCH2NRR) may also be prepared from the ss-keto diazo compounds just described.
The ss-keto amines may for example be prepared by first converting the diazo compound into the corresponding halo compound (e.g. a compound of formula I wherein A is -COCH2Cl,
sCH2COCH2CI or -C2H4COCH2Cl) and secondly reacting the halo compound with an amine of the formula HNR1R2 The first step of this reaction may be carried out by reacting the diazo compound with a hydrogen halide (e.g. HC1), e.g. at a low temperature (e.g. OOC) in an ether solvent. The second step may be carried out generally as described above with regard to the preparation of amides from acid halides.
When a P-hydroxy compound is required, it may for example be prepared by subsequently reducing the P-keto amine, for example as described above for the reduction of amides to amines.
ss-Hydroxy compounds wherein -NR1R2 is an unsubstituted amino group may be prepared by reducing the corresponding P-keto diazo compounds. The reduction may again be effected with lithium aluminium hydride or diborane, as described above. The diazo starting materials may be prepared as described above, and they have the formula
R4COCHN2 where R4 is the group of formula I given by removal of the terminal -CH2CH2NR1R2 group.
Compounds having a Cl-i alkyl group at the position may be prepared by reacting an ester of the formula R4CH2COOR5 (where R5 is an alkyl group, e.g. ethyl, and R4 is as just defined) firstly with N - cyclo- hexyl - N - iso - propylamino lithium and secondly with an alkyl halide (e.g. methyl iodide) to give a compound of the formula
where Rb is the alkyl group. This ester may then be converted to its parent acid, for example with boron tribromide; the acid may then be converted into the desired amino compound as described above, i.e. via the acid halide and amide. Alternatively, the ester
may be converted first into a hydroxyethyl, hydroxypropyl or hydroxybutyl compound (i.e.
by reduction, for example with lithium aluminium hydride. This hydroxyalkyl compound may then be converted into the corresponding haloalkyl compound, for example by treatment with a hydrohalic acid; the desired amine may then be prepared from this haloalkyl compound by the method described generally below.
The compounds of the invention in which the position in relation to the nitrogen atom is not substituted by hydroxy may also be prepared by reacting the corresponding haloalkyl compound with ammonia or an amine of the formula HNRtR2.
This reaction may for example be carried out by refluxing the halo compound with the amine in a suitable solvent (e.g. the amine itself, a hydrocarbon such as toluene, or an alcohol) in the presence of an acid binding agent (e.g. potassium carbonate or an excess of the amine). This process is particularly suitable for the preparation of compounds which are either unsubstituted in the alkylene chain of A or which are substituted by an alkyl group at the fl-position.
Compounds in which the α-position is substituted by a C2-4 alky group may be prepared by reductive amination of an appropriate ketone (i.e. a compound of the formula R4Cll.2COR, where R is the C1. alkyl group. This reaction may for example be performed by reacting the ketone with ammonia or an amine of the formula HNR1R2 either in the presence of hydrogen (under a pressure of, for example, 4 atmospheres) over a platinum oxide catalyst (e.g. Adams' catalyst), or in the presence of sodium cyano borohydride. In the former method, the reaction solvent is suitably a mixture of acetic acid and ethanol, and in the latter method an alcohol such as methanol may be used. The starting materials for the reaction may be prepared from the acid
R4CH2COOH by reaction with an alkyl lithium.
Compounds in which R' is an alkyl (e.g. methyl group and R2 is a C1--d alkyl or alkenyl group may be prepared by alkylating the corresponding monosubstituted compound (i.e. Rt=H); compounds in which R4 is a methyl group may thus for example be pre pered by reacting the corresponding monosubstituted compound with formaldehyde and formic acid. Similarly, the corresponding unsubstituted amines can be alkylated to form di-Cl~6 alkylsubstituted amines.
The compounds of formula I in which R1 and R2 are both hydrogen, the exposition in relation to the nitrogen atom is unsubstituted and the position is not substituted by an oxo or hydroxy group may also be prepared by reducing the corresponding cyanoalkyl compound (i.e. a compound of the formula R4QI2CN).
The reduction may for example be effected with lithium aluminium hydride, using the above described reaction conditions.
The cyanoalkyl compounds required as starting materials in the latter reaction may for example be prepared from the corresponding hydroxyalkyl compound by: (1) reacting the hydroxyalkyl compound with a hydro carbylsulphonyl halide (e.g. p-toluene-sulphonyl chloride or preferably methane sulphonyl chloride) in the presence of triethylamine, e.g. at about 0 C in an ether solvent, and (2) treating the hydrocarbyl sulphonate produced with an alkali metal cyanide (e.g.
NaCN) at elevated temperatures, in a solvent (e.g. dimethylformamide or dimethylsulphoxide).
The following examples illustrate the invention. Temperatures are in "C. "t.l.c." refers to thin layer chromatography, carried out on silica.
Examples 1-6.
Preparation of 7,7-dimethylnorborn-l-yl aminoketones.
The aminoketones whose properties are summarized in Table I were prepared by the following general method.
The appropriate carboxylic acid and excess thionyl chloride were heated on a steam bath and evaporated to an oil in vacuo. A solution of the oil in dry ether was added dropwise with stirring to an ice-cold solution of diazomethane (approximately 2 equivalents) in ether. The mixture was stirred at 0" for 2 hours and then hydrogen chloride was passed through the cooled solution for 1 hour. After standing at room temperature ovemight the solution was poured onto ice/ water and the ether layer separated. The aqueous layer was extracted again with ether and the ethereal solutions combined. The extracts were washed with water, dilute sodium bicarbonate and water, dried (MgSO4) and evaporated in vacuo to yield the crude a-chloroketone which was used without further purification.
A solution of the a-chloroketone and the appropriate amine (2.2 equivalents) in toluene were set aside for the periods shown in Table 1 at room temperature and filtered.
The filtrate was evaporated in vacuo, dissolved in dry ether and cooled. A cold solution of hydrogen chloride in ether was added, the hydrochloride filtered and recrystallised from the given solvent.
TABLE 1
d q rl f 00 4 vi io J: v, 7,7 -DIMETHYLNORBO RN- 1-YL \ o v; a' ci tn' U I -e FI N X H < H es > > EN rf Reaction d\ow -\om o afi o co cO oO 71 C'O C''.09rl".
Lo o oo cc co cnim' P\ou, CQ U DS z NMe2 n 200-2 Methyl Acetate Ci4H2sCl2NO 57.2 57.1 o 8.6 > 24.1 4.4 .4.8 5 P Cl V m (d) Propan-2-ol C17H29C12N0 60.9 61.0 8.7 8.7 21.4 21.2 4.0 4.2 O NHMe O 1.5 245-7 (d) V U V Q V E N t t . ~ N N = m N N > vE U V V V O V H Z O O 7 ? Q O V Q 2 t R R R B B W1 gg ~ IS C CL a e X e O É t I t | ? co > O 0 t cq > N es o E = > co , m Y H PS cz : V U @ N S N S S o ~ > erZ m I.M.S. = industrial methylated spirits P = piperidino d = decomposition
X = -COCH2 in Ex. 1 and 2, -CH2COCH2 in Ex. 3-6.
Examples 7-40.
Preparation of 1 - (alkylamino)- and 1 (hydroxyalkylamino) - 7,7 - dimethylnorbornantes.
The amines, whose properties are described in Table 2 were prepared by the following general method.
A solution of the appropriate aminoketone (in Examples 14-16, 23 and 24) or carbonamide (in Examples 7-13, 17-22 and 25 -40) in tetrahydrofuran was carefully added to a stirred suspension of an excess of lithium aluminium hydride in the same solvent and the resulting mixture refluxed until the reaction, as judged by thin-layer chromatography, was complete The excess lithium alluminium hydride was destroyed by the careful additon of water and dilute sodium hydroxide solution. The mixture was stirred at room temperature for 0.5 hours and insoluble material removed by filtration.
The filtrate was evaporated, extracted into ether, washed with water dried (MgSO4) and evaporated in vacuo. The residual crude amine was dissolved in ether and the hydrochloride precipitated by addition of an ethereal solution aof hydrogen chloride. The hydrochloride was collected by filtration, re- crystallised from the given solvent and dried.
The reduction of the aminoketones produtes ss-hydroxy compounds, and the reduc- tion of the carbonamide group gives the group -CH2NRR.
TABLE 2
,I n \0 31 CI c 6 d Y; d y, Z OOm 9 t f o o n e o l- Mo eS o t ti Q nc vs o No o - t 1-(ALKYLAMINO)- AND 1HYDRO XYALKYLAMINO)-7 7-DIMEThYLNO n RNANES 4 cn ofl Cls O V) X X O - 0s - Ch O O O v rn O C H CL N Exanpie 9 4 Empirical No. X ~ ~ ~ 0C tion Solvent Formula Found Req. Found Req. Found Req. Found Req.
7 CM2 NH2 H > 350 Propan-2-ol C:iH22CIN 64.7 64.7 11.0 10.9 17.5 17.4 o. 6.9 cjo z H > 350 I.M.S. C12H24C1N 66.2 66.2 11.15 11.1 b 16.3 90 6.4 9 CM2 NHMe Cl 287(d) l.M.S. Cz2M2Cl2N 57.6 57.1 9.4 9.2 27.9 28.1 5.2 b 10 NMe2 H 310(d) 1.M. & C3H26ClN 67.1 67.3 11.5 11.3 15.55 15.3 5.8 6.0 O 8 Z Z N 2368 M.A. CuH2sCl2N Z 58.7 9.5 ;iC Z z -3 u' u" u' u' u' u~ u' B o' 12 mE M H 70.6 70.7 11.2 11.1 13.05 13.0 4.8 5.15 UUOUUUU Cl 281(d) Pnpan-2-ol C1M29Cl2N 62.6 62.7 9.3 9.5 23.6 23.2 4.2 4.6 4 E 1 = O r 4 4 Y Q OH ffi H 280(d) Propan-2-ol C1,H26Cl NO 2 a E 63.0 10.8 10.6 14.1 14.3 5.45 5.7 CM a Z E O O re SB 1 > X e X X 3 vw vl rs X r ~ 5? rx ra r o o O we g z z z w z z X X z z X m w#t X v SG S S O~S S O~S Svzo F X Ch O e O m TABLE 2 (Continued)
I .I cr oo,ru v; i b \d -J: vr Z o t l~ H t t~ ~ H 1-(ALKYL AMINO)- es rq xo vs X ~ ~ > ~ ~ ~ ~ > rq n a w U ,i m q P h r % m ? 1 5 1 ? Oz o H o co ~ ~ cn z > s vo ov co t O O. F LO ; OgrQI 1 CI I ' n o: r: 1 d: 4 \9 Ic. z c) ~ 18 Cli2 a M 00 Pmpan-2-ol v > t 90 O 00 90 z o 00 vO > ~ 00 0 m o CH2 L Cl 259-260(d) Propan-ol C17M11Cl2N NO X0 9.8 9.8 22.0 22.1 4.4 4.4 a Z Z n n Q ~ ~ ~ ~ 3 ~ ~ ~ ~ ,u u u uuuu 20 (CH2)2 NH2 Ii l.M.S./ether C12M24C1N ffi t 11.4 11.1 16.25 16.3 On = b.4 a (C112)2 NIlMe M 255(d) 1.M.S./cther CiiH2aClN 67.6 67.4 U O Y a L( 23 CM2.CM(OH) P H 292-4(d) < o C17M32ClNO eq 67.6 10.7 10.7 11.8 11.7 ç 4.6 I c; fdc m CH TABLE 2 (Continued)
I i v; i rt: X v) m t m m v} t t t Z 1 n v, cr O g\ crl Y; 6 ci Ej y) rrr 1 0 O a, N o wo m es m t e ~ t ~ e X - o P' C? q\ N Q l-(ALKYLAMINO)- AND o sn v} es st t i ~ et o t=l n r- a m q q o\ q q cz o: o; ; ; o a, o 73 V) 0 9 m , o \o a v, ? s m LLO J: g; g; S 0 rr, ru N CI c ez oo o; rr; v; o' o: , v, v, 9 y, O O P- \O \O V1 u lw r g r- ml a: q q q N c t O oo ^ > ct o t O eq 28 (CH2)2 P Cl 273(d) Propan-2-ol C17H,1C12N 63.8 63.8 9.85 9.8 22.0 22.15 4.1 4.4 29 (CM2)3 io m M 245-7(d) Ethaiol/Ether C11M2ClN. NO 65.95 M0 M0 SO e- vlo 5.9 1 111 zn Zn Zn i z Z Z Zn Zn Zn O ~ Z Z Z Z N r < Z (CM2) NMMe H 195-200(d) W0 C34M2ClN 68.9 68.4 11.6 11.4 14.3 14.4 5.4 5.7 2 .~ E n < s 31 (CM2)3 NMe2 w 233-5 E.A. CisM3oClN 68.9 69.3 11.8 11.6 13.55 13.6 4.9 5.4 a 32 (CM2)3 P Ii 308-9 Propan-2.ol C3aM34C1N 72.0 72.2 11.5 11.4 11.9 11.8 4.5 4.7 x (CM2)3 NMe2 Z 210-3(d) Propan-2-ol/ C3,M2Cl2N 61.4 61.2 10.1 9.9 24.2 24.1 4.6 4.8 o n e O, z; & Vi , a a a & f' dO P c 270-5(d) Propan-Zol C3M,3CI2N ui o 10.0 10.0 en, 21.2 4.2 r. z: ; a w w w a aw a CM2 NEt2 CI 142-3 ffi oC.bM:oCl2N 59.2 59.4 9.7 m m 23.4 4.3 4.6 a r e w s) ~ m vl ec o o eq < ; es E e o e- tt I eq eq es eq ~ es es ex Y Q X Q ~ o o N i ~ Z Z X Z Z Z C Z X Z 5 W w X 6 ssH o O 00 0 0 ~ eq e t m Z eq es es es e rn < TABLE 2 (Continued)
crJ o d I t j: z i AMINO)- AND 1-(HYDROXYALKYLAMlNO)-7 ,7-DIMEThYLNO RBORNANES U 1 > e e eq * es U m c\ < H oo N X =: ~ No. X NR1R2 R2 0C tion Solvent Formula Found Req. Found Req. Found Req.. Found Req.
36 cH2 ~ Cl e- C17M11C12N 64.0 63.7 10.1 9.8 22.25 22.1 4.2 4.4 > 1 9 om U 8 o 37 cH2 Cl 217 Pwpan-2-ol/ C1,H21C12N 63.6 63.7 9.7 9.8 22.4 22.1 4.6 4.4 Ether i e É 267(d) Prupan-2oV C11M21Cl2N 64.4 63.7 9.7 Z Z Z Y vE WE' U U U U 39 CM2 o o 258-260(d) Pnopan-2-ol CisM27Cl2N 61.5 61.6 9.4 9.3 24.1 24.3 4.6 4.8 Id~C ~ 'ij 5 l oo.o D o H 313-6(d) Propan-2-ol C17M,2C1 o 71.3 71.4 11.1 11.3 12.2 12.4 4.8 4.9 ~ nst3 Dz Q S e o ev es > oo e es tS ew w5u z 64 9 b U Q ft ~ tf X 6 P - piperidino; M.A: - methyl acetate; E.A. ethyl acetate; I.M.S. industrial methylated spirits; d decomposition.
Example 41.
1-(2-Aminoethyl) -2-endo-chloro-7,7
dimethylnorbornane hydrochloride.
A solution of boron trifluoride diethyl etherate (26.8 ml) in tetrahydrofuran (20 ml) was added, over a period of 10 minutes, to a stirred suspension of sodium borohydride (5.40g) in tetrahydrofuran (80 ml) at 0 and the resulting mixture stirred at room temperature for 1 hour. A solution of 1 - (2 - amino - 2 - oxo)ethyl - 2 - endochloro - 7,7 - dimethylnorbornane (2.58 g) in tetrahydrofuran (20 ml) was added to the stirred mixture and stirring continued for a further 20 hours. The resulting mixture was carefully poured onto ice-water (200 ml) and concentrated hydrochloric acid (40 ml) added to the mixture. The mixture was then heated under reflux for 0.5 hours, cooled and partitioned between ether and water. The aqueous layer was separated, basified with 30% sodium hydroxide solution and extracted with ether. The combined extracts were washed with water, dried (MgSO4) and evaporated in vacuo. The residual crude amine (0.89 g) was dissolved in ether and the hydrochloride precipitated by the addition of an ethereal solution of hydrogen chloride. The title product (0.68 g) was collected by filtration and recrystallised from propan-2-ol, m.p. 283284 (d)
Found: C, 54.3; H, 9.1; Cl, 29.2; N, 5.7.
Cl,H2lCl2N.O.25H2O requires C, 54.3; H, 8.9; Cl, 29.2; N, 5.8%.
Examples 42-50.
Preparation of 1- (2-amino-n-propyl ) -7,7- dimethylnorbornanes.
Method A.
1 - (2 - Methylamino - n - propyl) - 7,7 dimethylnorbomane.
A mixture of 7,7 - dimethyl - 1 - (2oxo - n - propyl)norbornane (4.69 g) glacial acetic acid (10 ml), methylamine (10 g) and ethanol (100 ml) was heated under reflux for 1 hour, cooled to room temperature and hydrogenated for 4 hours at 4 atmospheres using platinum oxide (0.25 g) as catalyst.
The catalyst was removed by filtration and the filtrate evaporated to low volume before extracting with ether. The aqueous phase was basified with 2N-sodium hydroxide solution and the liberated base extracted into ether.
The combined extracts were washed with water, dried (MgSO4) and evaporated in vacuo to yield the title product (4.15 g) which was characterised as the hydrochloric salt.
Method B.
A solution of the appropriate amine (1.25 equivs.) or amine hydrochloride (1.25 equivs.) in methanol was adjusted to pH 7-8 using 5N methanolic hydrogen chloride solution or potassium hydroxide respectively.
To this solution was added 7,7 - dimethyl1 - (2 - oxo - n - propyl)norbornane (1 equiv., or its 2-chloro derivative where appropriate) and the resulting mixture stirred for 0.25 hours. A solution of sodium cyanoborohydride (2 equiv.) in methanol was added and the reaction mixture stirred for a length of time depending upon the amine used. The mixture was then basified with potassium hydroxide and extracted with ether. The combined extracts were washed with 2Nhydrochloric acid and the combined washings basified with 2N-sodium hydroxide solution.
The liberated base was re-extracted into ether, washed with water, dried (MgSO4) and evaporated to yield the free base which was converted to the hydrochloride salt.
Method C.
Alternative preparation of 1 - (2 - dimethyl
amino - n - propyl) - 7,7 - dimethyl norbomane hydrochloride.
A mixture of 1 - (2 - methylamino propyl) - 7,7 - dimethylnorbornane (2.93 g), 37% aqueous formaldehyde solution (3.75 ml) and 98% formic acid (2.1 ml) was heated on a steam-bath for 23 hours, cooled, and poured into water (100 ml). The mixture was basified with 2N-sodium hydroxide solution and extracted with ether. The combined extracts were washed with water, dried (MgSO4) and evaporated to an oil (2.93 g).
A solution of hydrogen chloride in ether was added to an ice-cold solution of the free base in ether (50 ml) and the title product filtered. The crude material was recrystallized from ethyl acetate. Yield: 2.24 g.
These experiments and the products are summarised in Table 3 below.
TABLE 3
F J o \9 c o eZ d \d v; v; i v; Z O D m < t m t * fi t LL3 \d P 9 Iq CZ 3 nN CU m rV cy y, ALKYL n o 's o v; ci N N hl CV L ? CV. r Vf 00.". cl o\ O\ Q = rrcr r 3 vE m n o F b v! V! h! q q vM LL ;r; P! m O r-r 4 ; d j N' m'o' 9 o v, u, Y, rD 2 m \d H B,C 155-7 Ethyl Acetate Ci4H2aCl N o ^ 64.S 11.5 11.5 14.2 13.7 5.3 o \o Y, \O y) \O g C, 0 45 CM', as Y z 223(d) Ethyl Acetate C17H22C1 z 71.3 71.4 11.2 11.3 12.3 12.4 z z z z 46 CM2 n D D U B 197-9 Ethanol/Ether C12M23Cl2N 56.1 56.1 CS D O ~ ~ ~ ~ N ~ E se O 0.25 o" = E ; N(CM3)2 CI Q 167-170 Ethyl Acetate C14M27Cl2N Do Q 9.9 9.7 25.2 25.2 4.7 5.0 bo d CM2 Py o o s -2. J J J 49 CM, P Cl B 168-171 Ethyl Acetate C27M,LCl2N 63.3 63.7 o 9.8 < < < 50 CM3 Py E B 193-5 Ethyl Acetate C,,M,,Cl N 70.4 ~ ~ n o < ~ m v ó aa O t Eo m x ve > o qz x rs G o m ew o ç Ch | ffi X c m < : ' m m m m m m > n~ m w ~ a M l z z z X Z z X ffi X ssw = v T = v t t td 6 r- Q D c) Q a > o ~ SZ t d decomposition; p piperidino; Py pyrrolidino.
Example 51.
I - (3 - Amino - 2 - hydroxy) - n - propyl 2 - endo - chloro - 7,7 - dimethylnor
bornane hydrochloride.
A solution of 2 - endo - chloro - 1 - (3diazo - 2 - oxo)propyl - 7,7 - dimethylnorbornane (4.81 g) in dry tetrahydrofuran (60 ml) was added to a stirred suspension of lithium aluminium hydride (1.9 g) in tetrahydrofuran (30 ml) over 0.3 hr. The resulting mixture was then stirred at room temperature for 0.25 hr. and cooled in an ice-bath. Water (5 ml) and 2N-sodium hydroxide (10 ml) were added and the mixture stirred at room temperature for 0.5 hr before filtering through Kieselguhr. The fil bathe was evaporated to low volume, partitioned between ether and water and the ether layer separated. The aqueous solution was extracted with a further portion of ether and the extracts combined. After washing with water the ethereal solution was extracted with 2N-hydrochloric acid and the combined acid solution basified with 2N-sodium hydroxide. The liberated free base was extracted with ether, washed with water and dried (MgSO4). Evaporation of the solvent yielded the free base which was converted to the title hydrochloride (0.589 g), m.p. 176 --179" (d) (from propanol-2-ol) (Found:
C, 53.8; H, 8.7; Cl, 26.1; N, 5.6.
Cl2H22ClNO.HCl requires C, 53.7; H, 8.6; Cl, 26.4; N, 5.2%).
Example 52.
1-( 3-Amino-2-hydroxy-n-propyl )-7,7 dimethylnorbomane hydrochloride.
Using the method described in Example 51, 1 - 3 - diazo - 2 - oxo - n - propyl)7,7 - dimethylnorbornane (10.31 g) yielded the title compound (0.67 g), m.p. 268 (d) (from absolute ethanol/ether). (Found: C, 61.5; H, 10.5; Cl, 15.0; N, 5.95.
Cl2Hs4CINO requires C, 61.65; H, 10.35; Cl, 15.2; N, 6.0%).
Example 53.
Alternative preparation of 1 - (3 - Amino n - propyl) - 2 - endo - chloro - 7,7
dimethyl norbornane hydrochloride.
(1) 2 - endo - Chloro - 1 - apocamphone - ,,ss - ethyl methane sulphonate.
A solution of methane sulphonyl chloride (0.43 ml) in methylene chloride (5 ml) was added over 10 min. to a stirred solution of 2 - endo - chloro - 1 - apocamphane ethanol (1 g) and triethylamine (1 ml) in methylene chloride (20 ml) at OOC. After 30 min. the reaction mixture was washed successively with iced-water, cold N-hydrochloric acid solution, saturated sodium hydrogen carbonate solution and brine. The organic layer was dried (MgSO4) and evaporated under reduced pressure. The residue (1.28 g) was purified by preparative layer chromatography to give the title compound as an oil (1.1 g), (Found: C, 51.7; H, 7.6;
C1, 12.4; S, 11.4. Cl2H2lCIO3S requires C, 51.3; H, 7.5; Cl, 12.6; S, 11.4%).
(2) 2 - endo - Chloro - 1 - (2 - cyanoethyl) - 7,7 - dimethylnorbornane.
A mixture of 2 - endo - chloro - apocamphane - ss - ethyl methane sulphonate (0.9 g), sodium cyanide (0.45 g) and dimethylformamide (8 ml) was stirred at 5e600 for 4 h. The reaction mixture was then cooled and partitioned between ether and water. The organic layer was washed with water, dried (MgSO4) and evaporated under reduced pressure. The residue (0.74 g) was purified by preparative layer chromatography to give the title compound as an oil (0.57 g). (Found: C, 68.1; H, 8.55; Cl, 16.7;
N, 6.6. Cl2HlsCl3N requires C, 68.1; H, 8.6; Cl, 16.75; N, 6.6%).
(3) 1 - (3 - Amino - n - propyl) - 2endo - chloro - 7,7 - dimethylnorbornane hydrochloride.
A solution of 2 - endo - chloro - 1 - (2ethyl) - 7,7 - dimethylnorbornane (0.5 g) in anhydrous ether (15 ml) was added slowly to a stirred suspension of lithium aluminium hydride (0.5 g) in ether (15 ml). The mixture was stirred at room temperature for 1.5 h. and then cooled in ice. Water was added cautiously and the suspension was filtered.
The filtrate was washed with water, dried (MgSO4) and evaporated under reduced pressure. The residue (0.46 g) in ether (15 ml) was treated with a slight excess of an 8N-ethanolic hydrogen chloride solution and the salt (0.38 g) was collected by filtration.
Crystallization from ethanol/ether gave the title compound (0.34 g, 57%), m.p. 248 decomp.).
Example 54.
1. Tablet containing 40 mg active in gre- dient (per tablet)..
Active ingredient 40.0 mg
Lactose 201.5 mg
Maize Starch (dry) 45.0 mg
Aerosil 200 6.0 mg
Polyvinylpyrrolidone (p.v.p) 6.0 mg
Magnesium stearate 1.5 mg
Tablet weight:- 300.0 mg
The compound is screened 100 mesh, blended with lactose, starch and Aerosil and re-screened through 60 mesh ('Aerosol' is a trade mark). The p.v.p. is dissolved in
I.M.S. and used to granulate the powder blend. The wet granulate is passed through 12 mesh and dried before screening 20 mesh, lubricating with magnesium stearate and compressing.
2. Alternative formula for tablet containing 500 mg active ingredient.
Active ingredient 500.0 mg
Icing Sugar 82.0 mg
Polyvinylpyrrolidone (p.v.p) 12.0 mg
Magnesium Stearate 6.0 mg
Tablet weight:-- 600.0 mg
Tablets are prepared as for (1) i.e. the powder blend is granulated with an I.M.S. solution of p.v.p.
The preparation of certain intermediates required in the above examples is described below.
Preparation 1.
Ethyl apocamphaneacetate.
Apocamphaneacetic acid (9.13 g) and thionyl chloride (10 ml) were heated on a steam-bath for 1 hour and evaporated in vacuo. Absolute ethanol (6 ml) was added, over 0.25 hours, to a cooled, stirred solution of the residue in sodium dried ether (25 ml). The solution was then stirred at room temperature for 1.5 hours and poured into water (150 ml). The product was extracted with ether and the combined extracts washed successively with water, dilute sodium bicarbonate and water. The ethereal solution was dried (MgSO4) and evaporated in vacuo to yield the title product which was distilled at 650C and 0.3 mm of Hg. Yield: 9.10 g.
(Found: C, 73.9; H, 10.7. C1,,H22O2 requires
C, 74.2; H, 10.5%).
Preparation 2.
Ethyl 2-(7,7-dimethylnorborn-1-yl)
propionate.
A 2.1M solution (10.5 ml) of butyl lithium in hexane was added dropwise to a stirred solution of N-isopropylcyclohexylamine (3.11 g) in dry tetrahydrofuran (20 ml) cooled at -78 C under nitrogen. The resulting pale yellow solution was stirred at --78" for 0.25 hours before ethyl apochamphaneacetate (4.20 g) was added and the mixture stirred at -780C for 0.75 hours. Iodomethane (1.87 ml) was added to the stirred mixture and the temperature maintained at - 780C for 0.25 hours before allowing the temperature to rise to --200 over 0.75 hours. The resulting mixture was then acidified with SNhydrochloric acid and extracted with ether.
The combined extracts were washed several times with water, dried ( MgSO4) and evaporated to yield the crude product (4.33 g). The oil was distilled at 60 and 0.2 mm to yield the title compound (2.92 g) as a pale yellow liquid. (Found: C, 75.6; H, 11.2.
Cl,H2402 requires C, 75.0; H, 10.8%).
Preparation 3.
2- (7,7-Dimethylnorborn 1 -yl ) - propionic acid.
Boron tribromide (38.0 ml) was added dropwise to a stirred solution of ethyl 2 (7,7 - dimethyinorbom - 1 - yl) - propionate (22.4 g) in dichloromethane (170 ml), cooled at 780. When the addition was complete the temperature was maintained at -780C for 1 hour and then allowed to attain room temperature and stirred overnight. The mixture was then poured onto ice/water (1 1.) and extracted with dichloromethane. The combined extracts were washed with water, dried (MgSO4), and evaporated in vacuo to yield an oil (20.66 g).
A solution of the oil in ether was extracted several times with 2N-sodium hydroxide. The remaining ethereal solution was washed with water, dried (MgSO4) and evaporated in vacuo to an oil (15.01 g) which was identified (by infrared and nuclear magnetic resonance spectra) as 2 - (7,7 - dimethylnorborn - 1yl)propionic anhydride. The alkaline extracts were acidified with 2N-hydrochloric acid and the free acid extracted into ether. The combined extracts were washed with water, dried (MgSO4) and evaporated in vacuo to yield the title compound (4.80 g) as a cream coloured solid, m.p. 9395 [from lightpetroleum (b.p. 40-600)] (Found: C, 73.6;
H, 10.25. C12H,0O2 requires C, 73.4; H, 10.3%).
A mixture of the above anhydride (14.72 g) and 2N-sodium hydroxide (59 ml) was stirred and heated at 100"C for 2 hours and cooled. The cooled solution was extracted with ether and extracts discarded. The remaining alkaline solution was acidified with SNhydrochloric acid and extracted with ether.
The extracts were combined, washed with water, dried (MgSO4) and evaporated in vacuo to yield the title compound (12.36 g), identical with an authentic sample.
Preparation 4.
7,7-Dimethyl-1-(2-oxo-n-propyl)- norbornane.
A solution of 1-apocamphaneacetic acid (9.12 g) in sodium dried ether (50 ml) was cooled in an ice-bath and stirred under nitrogen whilst a 1.9M solution (58 ml) of methyl lithium was added dropwise. When the addition was complete the mixture was heated under reflux for 2 hours, cooled in an icebath and acidified with 2N-hydrochloric acid.
After stirring for 0.5 hours the mixture was extracted with ether and the combined extracts washed with water, dilute sodium bicarbonate and finally with water. The ethereal solution was dried (MgSO4), evaporated in vacuo and the residual oil distilled at 0.1 mm. The fraction boiling at 44.5- 47 , the title product, was collected. Yield: 5.1 g. (Found: C, 80.3; H, 11.3. 62H,,O requires C, 79.9; H, 11.3 ).
Preparation 5.
1 - (2-Bromoethyl) -7,7-dimethylnorbomane.
A stirred mixture of 1 - (2 - hydroxy ethyl) - 7,7 - dimethyl - norbornane ( 42.0 g, 0.25 mole), 48% hydrobromic acid (63.0 ml) and concentrated sulphuric acid (14 ml) was heated under reflux for 4 hours, cooled, poured into water (500 ml) and extracted with ether. The combined extracts were washed with water, sodium bicarbonate solution and water. After drying (MgSO4) the solvent was evaporated in vacuo to yield the title product (50.9 g), m.p. 6871 [from light-petroleum (b.p. 4060")1. (Found:
C, 57.0; H, 8.1; Br, 34.2. CllHl9Br requires
C, 57.0; H, 8.3; Br, 34.5%).
Preparations 6-36.
Preparation of 7,7-dimethylnoiborn-1-yl alkylcarbonamides.
The amides whose properties are summarised in Table 4 were prepared by one or both of the following methods.
The appropriate carboxylic acid and excess thionyl chloride were heated on a steamboth for 1 hour and evaporated to an oil in vacuo. The acid chloride was then used in the following preparations without further purification.
Method A.
A solution of the freshly prepared acid chloride in toluene was stirred and cooled in an ice-bath whilst a solution (usually 30% w/v) of the appropriate amine (2.2 equivalents) in toluene was added dropwise. When addition was complete the mixture was allowed to come to room temperature and filtered. The filtrate was evaporated, dissolved in ether, washed with 2N-hydrochloric acid, water, dilute sodium bicarbonate, water and dried over magnesium sulphate. Evaporation of the organic solvent afforded the crude amine which was purified by preparative thinlayer chromatography and/or crystallisation.
Method B.
A solution of the appropriate acid chloride in dry ether was added dropwise with stirring to an ice-cold solution of diazomethane (approximately 2 equivalents) in ether; the mixture was stirred at 0 for 1 hour and then left at room temperature overnight.
Removal of the solvent in vacuo gave a yellow oil which was used without further purification.
A mixture of concentrated ammonia (d, 0.880) (15 ml) and 10% silver nitrate solution (12 ml) was added to a stirred solution of the crude diazoketone [1 - (3 - diazo2 - oxo) - n - propyl - 7,7 - dimethylnorbornane] (5.16 g) in dioxan (25 ml) at 70". When evolution of gas had ceased (0.75 hours), further ammonia solution (15 ml) was added and the stirred mixture heated to 90-1000 for 2 hours. The mixture was allowed to stand overnight at room temperature and then filtered. The filtrate was extracted with ether and the combined extracts washed with water, dilute hydrochloric acid, water, dilute sodium bicarbonate solution and water. After drying (MgSO4) the solvent was evaporated in vacuo to yield 1 - (3 - amino3 - oxo) - n - propyl - 7,7 - dimethylnor- bornane (3.80 g).
Other amides indicated in Table 4 were prepared using the above procedure.
Method A was used in Preparations 6-21 and 25-36 and method B was additionally used as an alternative method in Preparations 18 and 20. Method B was used in Preparations 22-24.
TABLE 4
I cr In N \o CF\ QPI Ir; \d \d V; -i \d 7,7 RBO \0 aD m ' t ar N U c v, 0 1 i In' i ci d \9 f 00 09 9 a'. N. 1 ffi o oo o oo H = s 1 " r a, cO cO N O ; 1 L o oo o oo ~ cra o ex ç 7 NH2 Cl 103-5 Light-Petroleum C,1H,8Cl NO 61.2 61.2 8.5 8.4 16.5 16.4 6.4 6.5 Z ss 608Oo) 8 NHMe H 119-121 Light Petroleum C12H21N0 73.7 73.8 10.8 10.8 6.8 7.2 m cj ~ m. CC! '1 00 Y 'U. C? \9 9 NIlMe Cl 129-130 Ethyl C,2H20Cl NO 62.7 62.7 8.8 8.8 15.3 15.4 6.1 6.1 Li ght-Petroleurr, (b.p. 801)0o) $I o- TABLE 4 (Continued)
a o e, eh X ox 7,7 -DIMEThYLNORBO g oo ALKYL CARBONAMIDES 09 a U C,3H25N0 r 76.5 m0 10.7 5.5 5.95 c ccl & ,E Ci7H2aCl NO 68.3 68.55 i, 9.5 11.8 11.9 4.4 4.7 J R aGX cW = x = cs wx z ; Q ~ O;z n (c): In Preparations 14 and 15, the group at the 10-position is -CH-(i.e. R8 = CH3); in Preparations 6-13 and 16 and 17 R8 is H.
(b): Purified by preparative t.l.c.: P = piperidino.
TABLE 4 (Continued)
I cj v, m IN CI rC, m 12 CC cc, v; \d z a -DIMETHYLNORBORN-1-YL ALKYL '" U t n ~ X 1 ocoo ELO m' a' ni p!; 0 H 143-5 LightPetroleum C12H21NO 73.9 73.4 10.9 10.8 7.0 7.2 L 2 NHMe H 85-6 Light Petroleum C,,lI,,NO 7.4.6 74.6 11.2 11.0 6.8 6.7 i 6080o) % o m' f I v; r-' i a' od i v; o 2 b H > Light Petroleum C14H,5NO 75.4 75.3 11.6 11.3 6.1 6.3 tY U ~ c a 21 2 P H 53-4 Ethyl Acetate/ C17H29N0 77.5 77.5 11.1 11.1 5.1 5.3 Light-Petroleum 2 ~ ~ i ;am 23 2 NMe2 ~ O C141124ClNO 63.9 64.1 9.5 9.4 14.0 13.5 4.9 5.3 : ffi 2 L - E N ç N so O U 04 N N = SN xN N ,L N N N V V C) V V V O V V V zl & < 80 a q \ E a > , ~ E 0n oÔ O0 cC O0 O0s sa < 3 w P | 0 O 2 \ 0l t s > oD o~0 ;0 X v > o O F Q .+ ~ C i L oO - t tOD 3 3 3 X D 3 CV go | [ t t a t omo n I H PS = V V = t ~ N i S N = G n es cS cS cS N Oto oo o ~ n t m e | c z N TABLE 4 (Continued)
I I 3 I z M Z lc; O. o o.
V ~ < < H E 1 09 P! 1 LO \o v, vl w CLrr o\ o\ C11 28 3 P H ( oo C1,H31N0 77.7 77.9 11.0 11.3 m 5.05 i U r F 30 3 P od od 31 1 Net2 Cl (b) C,,H 26C1 NO 66.6 66.3 9.6 9.6 12.8 13.0 5.3 5.15 3 32 a Z e3 Z z Z ~ Z z EO ZO,OZ,I; 33 . CI (b) C17H28Cl NO v 68.55 9.45 9.5 12.2 v 4.6 4.7 0 w s U > bo > ) VO] D ~ D B D 3 < w n I V V V V V V O N Q Q Z e0 Z Z X Z C Z C n e n m ÇoL F 00 O ~ O TABLE 4 (Continued)
7 ,7-DlMEThYLNO RBORN-I-YL ALK n 1S CONR R2 -R3 35 1 - Cl 109-112 Light-Petroleum C,H,4Cl NO 66.35 66,8 9.1 9.0 13.1 13.1 5.0 5.2 (b.p. 60-80) ffi ;E H (b) C17H29NO 77.4 77.5 10.8 11.1 5.1 5.3 Preparation 37.
3-(7,7-Dimethylnorborn-1-yl) propionic acid.
Method A.
A solution of 1 - (2 - bromoethyl) -7,7dimethylnorbornane (4.623 g) in dry ether (20 ml) was added to magnesium turnings (0.534 g) and a crystal of iodine. The reaction mixture was stirred and addition of the bromo compound was made at such a rate as to maintain gentle reflux. When the addition was complete the mixture was stirred and heated under reflux for 0.5 hours and cooled. Carbon dioxide was passed through the stirred mixture for 0.5 hours and the resulting mixture poured onto excess solid carbon dioxide. The excess carbon dioxide was allowed to evaporate and the mixture acidified with 5N-hydrochloric acid to yield the title product (0.89 g), m.p. 123-125 (from n-pentane). Found: C, 73.2; H, 10.45. C12H20O2 requires C, 73.4; H, 10.3%).
Method B.
A mixture of 1 - (2- bromoethyl) - 7,7dimethylnorbornane (11.56 g), I.M.S. (40 ml) and potassium cyanide (7.2 g) was stirred and heated under reflux for 47 hours. Potassium hydroxide (16.84 g) was added and the stirred mixture heated under reflux for a further 6 hours. After standing at room temperature overnight the mixture was added to hot water (200 ml), cooled, and extracted with ether. The remaining aqueous phase was cooled in an ice-bath and acidified with concentrated hydrochloric acid. The title product (5.96 g) was filtered and dried.
Preparation 38.
4-(7,7-Dimethylnorborn-l-yl)buytric acid.
Sodium metal (3.79 g) was dissolved in absolute ethanol (75 ml) and redistilled diethyl malonate (24.00 g) was added dropwise, followed by 1 - (2 - bromoethyl)7,7 - dimethylnorbornane (23.20 g). After stirring and heating the mixture under reflux for 2.5 hr. most of the ethanol was distilled and a solution of potassium hydroxide (33.0 g) in water (50 ml) was added to the residue. The resulting solution was stirred and heated under reflux for 1.25 hr. and more ethanol removed by distillation. The resulting mixture was cooled, acidified with 50% sulphuric acid and extracted several times with ether. The solid residue from evaporation of the dried (MgSO4) ether extracts was heated in an oil bath at 170180 for 0.75 hr. The residue was cooled, taken up in ether and extracted with 2N-sodium hydroxide. The alkaline extracts were acidified with 5Nhydrochloric acid and the liberated acid extracted with ether, washed with water and dried (MgSO4). Evaporation of the ether in vacuo yielded the title product (14.15 g). A small amount of the product was purified by preparative thin-layer chromatography yielding a white solid, m.p. 72-730.
(Found: C, 74.15; H, 10.5. C,2H22O2 requires C, 74.2; H, 10.5%).
The bulk of the material was used without purification.
Preparation 39.
1 - (2-Chloroethyl ) -2-endo-chloro-7,7
dimethylnorbornane.
Thionyl chloride (9.52 g) was added dropwise to a stirred solution of 2 - endo1 - (2 - hydroxyethyl) - 7,7 - dimethylnorbornane (8.1 g) in dry pyridine (3.16 g) and the resulting mixture heated under reflux for 0.75 hr. After allowing to cool to room temperature the reaction mixture was poured into ice/water (100 ml) and stirred for 0.75 hr. The mixture was extracted with ether and the combined extracts washed with water, dilute sodium bicarbonate solution and finally with water. After drying (MgSO4) and evaporating the solvent, the title product was distilled. Yield, 7.20 g. b.p. 102-1080 at 1.2 mm. of Hg. (Found: C, 59.7; H, 7.9;
Cl, 31.6; C,lHlSCl. requires C, 59.7; H, 8.2; Cl, 32.1).
Preparation 40.
4 - (2 - endo - Chloro - 7,7 - dimethyl- norborn - 1 - yl) - butyric acid.
By a similar procedure to Preparation 38, l - (2 - chloroethyl) - 2 - endo - chloro7,7 - dimethylnorbornane (21.4 g) yielded title product (12.64 g) which was used without further purification.
A small portion was purified by preparative tlc and recrystallization from n-pentane. m.p. 5153c. (Found: C, 65.2; H, 8.9; Cl, 12.9. C,2H21ClO2.0.25C5H,2 requires C, 65.1;
H, 9.2; Cl, 13.5%).
Preparation 41.
2-endo-Chloro- 1 - (3-diazo-2-oxo ) propyl- 7,7-dimethylnorbornane.
2 - endo - Chloro - 1 - ampocamphaneacetic acid (10.85 g) and excess thionyl chloride were heated on a steam bath for 1 hour. and evaporated to an oil under reduced pressure.
A solution of the oil in dry ether was added dropwise with stirring at 0 to an ethereal solution of diazomethane (ca. 2 equiv.). The solution was stirred at 0 for 1 hr. and then left at room temperature overnight. Removal of the solvent in vacuo yielded the title product (12.0 g) which was used without further purification.
Preparation 42.
2-endo-Chloro-7,7-dimethyl-1- (2-oxo- n-propyl)norbornane.
Using the method of Preparation 4, with 2 - endo - chloro - 1 - apocamphaneacetic acid (10.84 g) as the starting material, the residual oil was distilled at 0.25 mm, and the fraction collected at 8085 was redistilled at 8285 and 0.3 mm to yield the title product (6.17 g).
Claims (1)
- WHAT WE CLAIM IS:1. 7,7 - Dimethyl - [2,2,1] - bicycloheptanes of the formula:wherein A is (CH2)nNRlR2 wherein n is 2, 3 or 4; R and R, which may be the same or different, are hydrogen atoms or C1-6 alkyl or C2-6 alkenyl groups, or together with the intervening nitrogen atom, represent a 4-7 membered saturated heterocyclic ring which is unsubstituted or substituted by a C1 6 alkyl group; and R2 is a hydrogen or chlorine atom in the endo configuration; which compounds are optionally substituted by a Cl-4 alkyl group at any position on the alkylene chain of A, or by an oxo or hydroxy group of the ,8- position of the alkylene chain of A relative to the nitrogen atom; and the physiologically acceptable salts thereof.2. Compounds as claimed in claim 1 wherein R3 is a chlorine atom.3. Compounds as claimed in claim 1 or claim 2 wherein the alkylene chain of A is unsubstituted.4. Compounds as claimed in any one of the preceding claims wherein R1 and R2 are both hydrogen atoms.5. Compounds as claimed in any one of claims 1 to 3 wherein R2 is a methylamino group.6. Compounds as claimed in any one of the preceding claims wherein n is 2.7. Compounds as claimed in any one of claims 1 to 5 wherein n is 3.8. Compounds as claimed in any one of claims 1 to 5 wherein n is 4.9. 1 - (2 - Aminoethyl) - 7,7 - dimethyl- norbornane; 1 - (2 - aminoethyl) - 2 - endo - chloro7,7 - dimethylnorbornane; 1 - (2 - methylaminoethyl) - 7,7dimethylnorbornane; 1 - (2 - dimethylaminoethyl) - 7,7dimethylnorbornane; 1 - (2 - dimethylaminoethyl) - 2 - endochloro - 7,7 - dimethylnorbornane; 1 - (2 - piperidinoethyl) - 2 - endochloro - 7,7 - dimethylbornane; 1 - (2 - amino - n - propyl) - 7,7dimethylnorbornane; 1 - (1 - oxo - 2 - dimethylaminoethyl)7,7 - dimethylnorbornane; 1 - (2 - pyrrolidinoethyl) - 7,7 - dimethyl- norbornane; or 1 - (2 - piperidinoethyl) - 7,7 - dimethyl- norbornane; and the physiologically acceptable salts thereof.10. 1 - (3 - Amino - n - propyl) - 7,7dimethylnorbornane; 1 - (3 - methylamino - n - propyl) - 7,7dimethylnorbornane; 1 - (3 - methyl - n - propyl-) 2 - endochloro - 7,7 - dimethylnorbornane; 1 - (3 - dimethylamino - n - propyl - 2endo - chloro - 7,7 - dimethylnorbornane; 1 - (2 - oxo - 3 - methylamino - n - propyl)2 - endo - chloro - 7,7 - dimethylnorbornane; 1 - (2 - hydroxy - 3 - amino - n - propyl)2 - endo - chloro - 7,7 - dimethylnorbornane; 1 - (4 - amino - n - butyl) - 7,7 - dimethyl- norbornane; or 1 - ( 4 - methylamino - n - butyl) - 7,7dimethylnorbornane; and the physiologically acceptable salts thereof.11. 1 - (3 - Amino - n - propyl) - 2endo - chloro - 7,7 - dimethylnorbornane and the physiologically acceptable salts thereof.12. The compound of claim 11 in the form of its hydrochloride salt.13. 1 - (2 - Pyrrolidinoethyl) - 2 - endochloro - 7,7 - dimethylnorbornane; 1 - (2 - amino - n - propyl) - 2 - endochloro - 7,7 - dimethylnorbornane; 1 - (2 - hydroxy - 3 - amino - n - propyl)7,7 - dimethoxynorbornane; or 1 - (2 - hexamethyleneiminoethyl) - 7,7 dimethylnorbomane; and the physiologically acceptable salts thereof.14. A pharmaceutical composition comprising a compound as claimed in any one of the preceding claims or a physiologically acceptable salt thereof together with a pharmaceutical carrier or excipient15. A composition as claimed in claim 14 comprising a compound as claimed in any one of claims 6 to 12.16. A process for the preparation of a compound as claimed in claim 1, which process comprises: a) where the a-position in relation to the nitrogen atom is unsubstituted and the ss- position is not substituted by an oxo or hydroxy group, reducing the corresponding carbonamide; b) where the position in relation to the nitrogenation is not substituted by hydroxy, reacting the corresponding haloalkyl compound with ammonia or an amine of the formula HNR1R2; c) where the position in relation to the nitrogen atom is substituted by a hydroxy group, reducing the corresponding B-oxo compound; d) where the position in relation to the nitrogen atom is substituted by a hydroxy group and both R1 and R2 are hydrogen atoms, reducing the corresponding ss-keto diazo compound; e) where the a-position in relation to the nitrogen atom is substituted by a C1 < alkyl group, reductive amination of the corresponding ketone of formula I as defined in claim 1 except in that A is the group -(CH2)n-1COR7 where R7 is the desired C14 alkyl group; f) where R1 is a C'-6 alkyl group and R2 is a Cl-6 alkyl or C,-6 alkenyl group, alkylating the corresponding compound in which R1 is a hydrogen atom and R2 is C--6 6 alkyl or C26 alkenyl or in which both R1 and R2 are hydrogen atoms; or g) where R1 and R2 are both hydrogen atoms, the position in relation to the nitrogen atom is not substituted by an oxo or hydroxy group, and the a-position in relation to the nitrogen atom is unsubstituted, reducing the corresponding cyanoalkyl compound.17. A process as claimed in any one of parts (a), (b), (e) or (f) of claim 16 for the preparation of a compound as defined in claim 6 or claim 9.18. A process as claimed in any one of parts (a)-(c) of claim 16 for the preparation of a compound as defined in any one of claims 7, 8, 10 or 11.20. A process for the preparation of a compound as claimed in claim 1 substantially as described herein in any one of Examples 1, 2, 7-19 and 41-45.21. A process for the preparation of a compound as claimed in claim 1 substan dally as described herein in any one of Examples 36, 20-34 and 51.22. A process for the preparation of a compound as claimed in claim 1 substantially as described herein in any one of Examples 35-40, 46-50, 52 and 53.23. Compounds as claimed in claim 1 when prepared by a process as claimed in any one of claims 16 to 18 or 20 to 22.24. A method for the treatment of Parkinson's disease or anxiety comprising administering to an animal other than man an effective amount of a compound as claimed in claim 1.
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4227875A GB1567902A (en) | 1975-10-15 | 1975-10-15 | 1-aminoalkyl-7,7-dimethylnorbornanes |
US05/730,980 US4118499A (en) | 1975-10-15 | 1976-10-08 | Anti-anxiety and anti-parkinsonian 1-aminoalkyl-2-endo-chloro-7,7-dimethylnorbornanes |
CH1303576A CH626869A5 (en) | 1975-10-15 | 1976-10-14 | |
FR7630925A FR2327766A1 (en) | 1975-10-15 | 1976-10-14 | NEW DERIVATIVES OF 7,7-DIMETHYLNORBORNANE |
JP51122369A JPS5251355A (en) | 1975-10-15 | 1976-10-14 | Chemical compound |
AU18692/76A AU511156B2 (en) | 1975-10-15 | 1976-10-14 | 7, 7-Dimethylnorbornane derivatives |
NL7611337A NL7611337A (en) | 1975-10-15 | 1976-10-14 | NEW DERIVATIVES OF 7,7-DIMETHYLNORBORNAN AND METHODS FOR THEIR PREPARATION AND USE. |
DE19762646445 DE2646445A1 (en) | 1975-10-15 | 1976-10-14 | BICYCLOHEPTAN DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND THE MEDICINAL PRODUCTS CONTAINING THESE |
CH954280A CH626870A5 (en) | 1975-10-15 | 1980-12-23 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4227875A GB1567902A (en) | 1975-10-15 | 1975-10-15 | 1-aminoalkyl-7,7-dimethylnorbornanes |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1567902A true GB1567902A (en) | 1980-05-21 |
Family
ID=10423716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4227875A Expired GB1567902A (en) | 1975-10-15 | 1975-10-15 | 1-aminoalkyl-7,7-dimethylnorbornanes |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1567902A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4628061A (en) * | 1981-12-23 | 1986-12-09 | National Research Development Corporation | Prostaglandins |
EP2376447A2 (en) * | 2009-01-09 | 2011-10-19 | Orchid Research Laboratories Limited | Dipeptidyl peptidase iv inhibitors |
RU2574410C2 (en) * | 2009-01-09 | 2016-02-10 | Оркид Рисерч Лабораториз Лтд. | Dipeptidyl peptidase-iv inhibitors |
-
1975
- 1975-10-15 GB GB4227875A patent/GB1567902A/en not_active Expired
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4628061A (en) * | 1981-12-23 | 1986-12-09 | National Research Development Corporation | Prostaglandins |
US5006539A (en) * | 1981-12-23 | 1991-04-09 | National Research Development Corporation | Prostaglandins |
EP2376447A2 (en) * | 2009-01-09 | 2011-10-19 | Orchid Research Laboratories Limited | Dipeptidyl peptidase iv inhibitors |
EP2376447A4 (en) * | 2009-01-09 | 2012-06-20 | Orchid Res Lab Ltd | Dipeptidyl peptidase iv inhibitors |
RU2574410C2 (en) * | 2009-01-09 | 2016-02-10 | Оркид Рисерч Лабораториз Лтд. | Dipeptidyl peptidase-iv inhibitors |
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