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GB1429861A - Vincamine derivatives - Google Patents

Vincamine derivatives

Info

Publication number
GB1429861A
GB1429861A GB1444273A GB1444273A GB1429861A GB 1429861 A GB1429861 A GB 1429861A GB 1444273 A GB1444273 A GB 1444273A GB 1444273 A GB1444273 A GB 1444273A GB 1429861 A GB1429861 A GB 1429861A
Authority
GB
United Kingdom
Prior art keywords
formula
compound
vincamine
subjecting
march
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1444273A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH466772A external-priority patent/CH567507A5/xx
Priority claimed from CH583372A external-priority patent/CH575415A5/en
Priority claimed from CH731072A external-priority patent/CH576472A5/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1429861A publication Critical patent/GB1429861A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1429861 Vincamine derivatives SANDOZ Ltd 26 March 1973 [29 March 1972 20 April 1972 17 May 1972 2 Feb 1973] 14442/73 Heading C2C The invention comprises compounds of Formula (VI) in which R is a C 1 -C 4 alkyl group in the form of their various stereoisomers and nacenates they may be made by catalytically reducing a salt having a cation of Formula (V) which may be made by subjecting a compound of Formula (IV) to a Bischler-Napieralski ring closure. The compound of Formula (IV) above may be obtained by reacting a compound of Formula II in the presence of a basic condensation agent with compound of Formula (III) in which R and R<SP>1</SP> are C 1 -C 4 alkyl. The product of Formula (VI) may be converted to vincamine or apovincamine by subjecting it to ring closure in the presence of an acid.
GB1444273A 1972-03-29 1973-03-26 Vincamine derivatives Expired GB1429861A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH466772A CH567507A5 (en) 1972-03-29 1972-03-29
CH583372A CH575415A5 (en) 1972-04-20 1972-04-20 Vincamine and apovincamine synthesis - via novel inters
CH731072A CH576472A5 (en) 1972-05-17 1972-05-17 Vincamine and apovincamine synthesis - via novel inters
CH140873 1973-02-02

Publications (1)

Publication Number Publication Date
GB1429861A true GB1429861A (en) 1976-03-31

Family

ID=27428176

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1444273A Expired GB1429861A (en) 1972-03-29 1973-03-26 Vincamine derivatives

Country Status (2)

Country Link
FR (1) FR2178027B1 (en)
GB (1) GB1429861A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0045918A1 (en) * 1980-08-04 1982-02-17 Paolo Corvi Mora A process for the synthesis of vincamine and related indole alkaloids

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU532001B2 (en) * 1978-11-20 1983-09-15 Sumitomo Chemical Company, Limited Polycyclic indole derivatives
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0045918A1 (en) * 1980-08-04 1982-02-17 Paolo Corvi Mora A process for the synthesis of vincamine and related indole alkaloids

Also Published As

Publication number Publication date
FR2178027B1 (en) 1979-01-12
FR2178027A1 (en) 1973-11-09

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee