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GB1492973A - Process for preparing injectable compositions - Google Patents

Process for preparing injectable compositions

Info

Publication number
GB1492973A
GB1492973A GB7156/74A GB715674A GB1492973A GB 1492973 A GB1492973 A GB 1492973A GB 7156/74 A GB7156/74 A GB 7156/74A GB 715674 A GB715674 A GB 715674A GB 1492973 A GB1492973 A GB 1492973A
Authority
GB
United Kingdom
Prior art keywords
allergen
dialdehyde
extract
tyrosine
aqueous solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7156/74A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to GB7156/74A priority Critical patent/GB1492973A/en
Priority to IE158/75A priority patent/IE40370B1/en
Priority to ZA00750634A priority patent/ZA75634B/en
Priority to AU77943/75A priority patent/AU489860B2/en
Priority to FR7503870A priority patent/FR2261013B2/fr
Priority to NLAANVRAGE7501582,A priority patent/NL186295C/en
Priority to DE2505814A priority patent/DE2505814C2/en
Priority to JP50018110A priority patent/JPS5822444B2/en
Priority to BE153404A priority patent/BE825579R/en
Priority to US05/729,489 priority patent/US4070455A/en
Publication of GB1492973A publication Critical patent/GB1492973A/en
Priority to KE3113A priority patent/KE3113A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A61K39/36—Allergens from pollen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

1492973 Modified allergens BEECHAM GROUP Ltd 5 Feb 1975 [16 Feb 1974] 7156/74 Addition to 1377074 Heading A5B Finely divided micro-particles of tyrosine having a water soluble dialdehyde - treated allergen dispersed therein are prepared by mixing an aqueous solution of a water - soluble dialdehyde e.g. glutaraldehyde modified allergenic extract of an allergenic material with a solution of tyrosine in a strong aqueous acid e.g. hydrochloric acid; and simultaneously or subsequently neutralising (i.e. adjusting the pH to from 4 to 7.5) such mixture of solutions thereby precipitating the required product. Sodium hydroxide may be employed to neutralise the reaction mixture. The aqueous solution of modified allergen may be obtained directly by reacting an aqueous solution of an extract of allergenic material with a dialdehyde under neutral conditions. The allergen may be an extract of one or more pollens e.g. grass or ragweed pollen; house dust, the house dust mite Dermatophagoides pteronyssinus, moulds, animal hair, dander or fur. The precipitate of tyrosine containing the dialdehyde treated allergen may be removed from the solution by centrifugation or filtration and washed before being resuspended in a physiologically acceptable carrier such as phenol-saline or sterile water, to produce an injectable composition for use in desensitisation therapy.
GB7156/74A 1974-02-16 1974-02-16 Process for preparing injectable compositions Expired GB1492973A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
GB7156/74A GB1492973A (en) 1974-02-16 1974-02-16 Process for preparing injectable compositions
IE158/75A IE40370B1 (en) 1974-02-16 1975-01-27 Process for preparing injectable compositions
ZA00750634A ZA75634B (en) 1974-02-16 1975-01-30 Process for preparing injectionable compositions
AU77943/75A AU489860B2 (en) 1974-02-16 1975-02-05 Process for preparing injectionable compositions
FR7503870A FR2261013B2 (en) 1974-02-16 1975-02-07
NLAANVRAGE7501582,A NL186295C (en) 1974-02-16 1975-02-11 PROCESS FOR PREPARING FINE DISTRIBUTED MICROPARTICLES OF TYROSINE, IN WHICH AN ALLERGEN IS DISPERSED.
DE2505814A DE2505814C2 (en) 1974-02-16 1975-02-12 Process for the production of finely divided microparticles of tyrosine with a content of a glutaraldehyde-modified allergen dispersed therein and an injectable solution containing these microparticles as an active ingredient
JP50018110A JPS5822444B2 (en) 1974-02-16 1975-02-14 Allergen Oyuusurutyrosinno Seizouhou
BE153404A BE825579R (en) 1974-02-16 1975-02-14 PROCESS FOR THE PREPARATION OF INJECTABLE COMPOSITIONS
US05/729,489 US4070455A (en) 1974-02-16 1976-10-04 Process for preparing injectable desensitizing compositions and products thereof in microparticle form
KE3113A KE3113A (en) 1974-02-16 1981-01-21 Process for preparing injectable compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7156/74A GB1492973A (en) 1974-02-16 1974-02-16 Process for preparing injectable compositions

Publications (1)

Publication Number Publication Date
GB1492973A true GB1492973A (en) 1977-11-23

Family

ID=9827690

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7156/74A Expired GB1492973A (en) 1974-02-16 1974-02-16 Process for preparing injectable compositions

Country Status (9)

Country Link
JP (1) JPS5822444B2 (en)
BE (1) BE825579R (en)
DE (1) DE2505814C2 (en)
FR (1) FR2261013B2 (en)
GB (1) GB1492973A (en)
IE (1) IE40370B1 (en)
KE (1) KE3113A (en)
NL (1) NL186295C (en)
ZA (1) ZA75634B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998044947A1 (en) * 1997-04-05 1998-10-15 Allergy Therapeutics Limited Allergen formulation
EP0988862A2 (en) * 1998-09-21 2000-03-29 Allergy Therapeutics Limited Formulation for use in immunisation
EP2042192A2 (en) 1997-10-30 2009-04-01 Laboratorios LETI, S.L. Tolerogenic fragments of natural allergens
US8470331B2 (en) 2000-01-14 2013-06-25 Allergy Therapeutics (Uk) Limited Composition of antigen and glycolipid adjuvant for sublingual administration

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234569A (en) * 1978-10-04 1980-11-18 The Johns Hopkins University Production of aldehyde-treated allergen-containing substances
US5057317A (en) * 1987-03-24 1991-10-15 Chugai Seiyaku Kabushiki Kaisha Slow-release pharmaceutical agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3541201A (en) * 1968-12-18 1970-11-17 Ethan Alan Brown Novel sodium chloride encapsulated injectionable substances
BE754523A (en) * 1969-08-06 1971-02-08 Beecham Group Ltd VACCINES
GB1377074A (en) * 1971-07-13 1974-12-11 Beecham Group Ltd Process for preparing injectable compositions

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998044947A1 (en) * 1997-04-05 1998-10-15 Allergy Therapeutics Limited Allergen formulation
AU729631B2 (en) * 1997-04-05 2001-02-08 Allergy Therapeutics Limited Allergen formulation
US7718178B2 (en) 1997-04-05 2010-05-18 Allergy Therapeutics Limited Allergen formulation
US8105605B2 (en) 1997-04-05 2012-01-31 Allergy Therapeutics (Uk) Ltd. Allergen formulation
EP2042192A2 (en) 1997-10-30 2009-04-01 Laboratorios LETI, S.L. Tolerogenic fragments of natural allergens
EP0988862A2 (en) * 1998-09-21 2000-03-29 Allergy Therapeutics Limited Formulation for use in immunisation
EP0988862A3 (en) * 1998-09-21 2001-06-20 Allergy Therapeutics Limited Formulation for use in immunisation
US6440426B1 (en) 1998-09-21 2002-08-27 Allergy Therapeutics Limited Antigen-containing formulation and methods of use thereof
US7815920B2 (en) 1998-09-21 2010-10-19 Allergy Therapeutics (UK) Ltd Method of preparing an antigen-containing formulation
US8470331B2 (en) 2000-01-14 2013-06-25 Allergy Therapeutics (Uk) Limited Composition of antigen and glycolipid adjuvant for sublingual administration

Also Published As

Publication number Publication date
DE2505814A1 (en) 1975-09-18
DE2505814C2 (en) 1984-11-15
AU7794375A (en) 1976-08-05
IE40370L (en) 1975-08-16
IE40370B1 (en) 1979-05-09
NL7501582A (en) 1975-08-19
BE825579R (en) 1975-08-14
NL186295B (en) 1990-06-01
FR2261013A2 (en) 1975-09-12
KE3113A (en) 1981-02-20
JPS5822444B2 (en) 1983-05-09
FR2261013B2 (en) 1978-07-21
NL186295C (en) 1990-11-01
ZA75634B (en) 1976-01-28
JPS50116626A (en) 1975-09-12

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Legal Events

Date Code Title Description
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