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GB1336871A - Method for preparing biologically active substituted amidines - Google Patents

Method for preparing biologically active substituted amidines

Info

Publication number
GB1336871A
GB1336871A GB1336871DA GB1336871A GB 1336871 A GB1336871 A GB 1336871A GB 1336871D A GB1336871D A GB 1336871DA GB 1336871 A GB1336871 A GB 1336871A
Authority
GB
United Kingdom
Prior art keywords
biologically active
prepared
formula
active substituted
substituted amidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of GB1336871A publication Critical patent/GB1336871A/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1336871 Amidinoureas WELLCOME FOUNDATION Ltd 23 Dee 1970 [2 Jan 1970] 323/70 Heading C2C Novel compounds of Formula I (in which R<SP>1</SP> and R<SP>2</SP> are halogen or CN, at least one being halogen, R is H, alkyl or aryl and A is H or aroyl) and acid addition salts thereof, are prepared by reacting a 3-R<SP>2</SP>-4-R<SP>1</SP>-phenylisocyanate with an appropriate guanidine. Amidinoureas of Formula II and acid addition salts thereof, are prepared by hydrolysing a compound of Formula I. 3 - R<SP>2</SP> - 4 - R<SP>1</SP> - Phenylisocyanates are prepared in situ from the corresponding azides.
GB1336871D 1970-01-02 1970-12-23 Method for preparing biologically active substituted amidines Expired GB1336871A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB32370 1970-01-02

Publications (1)

Publication Number Publication Date
GB1336871A true GB1336871A (en) 1973-11-14

Family

ID=9702371

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1336871D Expired GB1336871A (en) 1970-01-02 1970-12-23 Method for preparing biologically active substituted amidines

Country Status (6)

Country Link
BE (1) BE761075A (en)
CH (1) CH555325A (en)
DK (1) DK128494C (en)
ES (1) ES386969A1 (en)
GB (1) GB1336871A (en)
NL (1) NL7019013A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0648749A2 (en) * 1993-08-18 1995-04-19 Bayer Ag N-cynanoaryl nitrogencontaining heterocycles
EP0901788A2 (en) * 1997-08-28 1999-03-17 Hoechst Marion Roussel Deutschland GmbH Use of inhibitors of the sodium hydrogen exchange in the manufacture of a medicament
US6110870A (en) * 1993-08-18 2000-08-29 Bayer Aktiengesellschaft N-cyanoaryl-nitrogen heterocycles
KR100345044B1 (en) * 1993-08-18 2002-12-05 바이엘 악티엔게젤샤프트 N-cyanoaryl-nitrogen heterocycle

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL37047A0 (en) * 1970-06-30 1971-08-25 Wellcome Found Substituted amidines,their preparation and pharmaceutical compositions containing them

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0648749A2 (en) * 1993-08-18 1995-04-19 Bayer Ag N-cynanoaryl nitrogencontaining heterocycles
EP0648749A3 (en) * 1993-08-18 1995-04-26 Bayer Ag N-cynanoaryl nitrogencontaining heterocycles
US5593945A (en) * 1993-08-18 1997-01-14 Bayer Aktiengesellschaft N-cyanoaryl-nitrogen heterocycles
CN1052476C (en) * 1993-08-18 2000-05-17 拜尔公司 N-cyanoaryl-nitrogen heterocycles
US6110870A (en) * 1993-08-18 2000-08-29 Bayer Aktiengesellschaft N-cyanoaryl-nitrogen heterocycles
KR100345044B1 (en) * 1993-08-18 2002-12-05 바이엘 악티엔게젤샤프트 N-cyanoaryl-nitrogen heterocycle
EP0901788A2 (en) * 1997-08-28 1999-03-17 Hoechst Marion Roussel Deutschland GmbH Use of inhibitors of the sodium hydrogen exchange in the manufacture of a medicament
EP0901788A3 (en) * 1997-08-28 2004-01-02 Aventis Pharma Deutschland GmbH Use of inhibitors of the sodium hydrogen exchange in the manufacture of a medicament

Also Published As

Publication number Publication date
ES386969A1 (en) 1973-04-16
DK128494B (en) 1974-05-13
NL7019013A (en) 1971-07-06
BE761075A (en) 1971-06-30
DK128494C (en) 1974-09-23
CH555325A (en) 1974-10-31

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee