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GB1309692A - N-substituted lactams - Google Patents

N-substituted lactams

Info

Publication number
GB1309692A
GB1309692A GB697870A GB697870A GB1309692A GB 1309692 A GB1309692 A GB 1309692A GB 697870 A GB697870 A GB 697870A GB 697870 A GB697870 A GB 697870A GB 1309692 A GB1309692 A GB 1309692A
Authority
GB
United Kingdom
Prior art keywords
formula
alkyl
alkenyl
hydrogen atom
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB697870A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Priority to GB697870A priority Critical patent/GB1309692A/en
Priority to FR7104195A priority patent/FR2081508B2/fr
Priority to NLAANVRAGE7101697,A priority patent/NL168830C/xx
Priority to FI383/71A priority patent/FI54916C/fi
Priority to ES388135A priority patent/ES388135A2/es
Priority to DK59571AA priority patent/DK137451B/da
Priority to YU306/71A priority patent/YU34876B/xx
Priority to BE762728A priority patent/BE762728R/xx
Priority to CS987A priority patent/CS167911B2/cs
Priority to ZA710877A priority patent/ZA71877B/xx
Priority to CH200171A priority patent/CH530395A/fr
Priority to DE2106418A priority patent/DE2106418C2/de
Priority to JP612471A priority patent/JPS535301B1/ja
Priority to SU1621307A priority patent/SU508185A3/ru
Priority to SU1893858A priority patent/SU508186A3/ru
Priority to CS140674A priority patent/CS167912B2/cs
Publication of GB1309692A publication Critical patent/GB1309692A/en
Priority to CY72774A priority patent/CY727A/xx
Priority to MY197472A priority patent/MY7400072A/xx
Priority to JP13335277A priority patent/JPS53130656A/ja
Priority to YU01445/78A priority patent/YU144578A/xx
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GB697870A 1964-08-06 1970-02-13 N-substituted lactams Expired GB1309692A (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
GB697870A GB1309692A (en) 1970-02-13 1970-02-13 N-substituted lactams
FR7104195A FR2081508B2 (cs) 1970-02-13 1971-02-08
NLAANVRAGE7101697,A NL168830C (nl) 1970-02-13 1971-02-09 Werkwijze voor het bereiden van therapeutische preparaten, alsmede werkwijze voor het bereiden van daarvoor geschikte amiden.
FI383/71A FI54916C (fi) 1970-02-13 1971-02-10 Foerfarande foer framstaellning av terapeutiskt verksamma n-substituerade 2-pyrrolidoner
ES388135A ES388135A2 (es) 1970-02-13 1971-02-10 Procedimiento para la obtencion de lactamas sustituidas en el nitrogeno.
DK59571AA DK137451B (da) 1970-02-13 1971-02-10 Analogifremgangsmåde til fremstilling af derivater af 2-oxo-pyrrolidin.
YU306/71A YU34876B (en) 1970-02-13 1971-02-10 Process for obtaining novel n-substituted pyrrolidines
BE762728A BE762728R (fr) 1970-02-13 1971-02-10 Nouveaux lactames n-substitues
CS987A CS167911B2 (cs) 1970-02-13 1971-02-10
ZA710877A ZA71877B (en) 1970-02-13 1971-02-11 New n-substituted lactams
CH200171A CH530395A (fr) 1970-02-13 1971-02-11 Procédé de préparation de nouveaux lactames N-substitués
DE2106418A DE2106418C2 (de) 1970-02-13 1971-02-11 N-substituierte 2-Pyrrolidon-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
JP612471A JPS535301B1 (cs) 1970-02-13 1971-02-12
SU1621307A SU508185A3 (ru) 1970-02-13 1971-02-12 Способ получени -замещенных лактамов
SU1893858A SU508186A3 (ru) 1970-02-13 1971-02-12 Способ получени -замещенных лактамов
CS140674A CS167912B2 (cs) 1970-02-13 1971-12-10
CY72774A CY727A (en) 1964-08-06 1974-03-01 New n-substituted lactams
MY197472A MY7400072A (en) 1970-02-13 1974-12-31 New n-substituted lactams
JP13335277A JPS53130656A (en) 1970-02-13 1977-11-07 Method of producing novel nnsubstituted lactams
YU01445/78A YU144578A (en) 1970-02-13 1978-06-19 Process for obtaining new n-substituted pyrrolidones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB697870A GB1309692A (en) 1970-02-13 1970-02-13 N-substituted lactams

Publications (1)

Publication Number Publication Date
GB1309692A true GB1309692A (en) 1973-03-14

Family

ID=9824325

Family Applications (1)

Application Number Title Priority Date Filing Date
GB697870A Expired GB1309692A (en) 1964-08-06 1970-02-13 N-substituted lactams

Country Status (15)

Country Link
JP (2) JPS535301B1 (cs)
BE (1) BE762728R (cs)
CH (1) CH530395A (cs)
CS (2) CS167911B2 (cs)
DE (1) DE2106418C2 (cs)
DK (1) DK137451B (cs)
ES (1) ES388135A2 (cs)
FI (1) FI54916C (cs)
FR (1) FR2081508B2 (cs)
GB (1) GB1309692A (cs)
MY (1) MY7400072A (cs)
NL (1) NL168830C (cs)
SU (2) SU508185A3 (cs)
YU (2) YU34876B (cs)
ZA (1) ZA71877B (cs)

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2368275A1 (fr) * 1976-10-19 1978-05-19 Ucb Sa 2-(2-oxo-pyrrolidino)-alkylamides pour le traitement d'affections vasculaires
DE2808067A1 (de) * 1977-03-03 1978-09-07 Parke Davis & Co N-(substituierte aminoalkyl)-2-oxo-1- pyrrolidinacetamide und verfahren zu deren herstellung
US4221789A (en) 1978-05-08 1980-09-09 Ucb, Societe Anonyme Lactam-N-acetic acids and their amides
EP0071216A2 (de) * 1981-07-24 1983-02-09 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 3-Hydroxypyrrolidin-2-on-Derivate, Verfahren und Zwischenprodukte zu deren Herstellung und diese enthaltende Arzneimittel
EP0089900A1 (en) * 1982-03-24 1983-09-28 Prodes S.A. New N-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts
JPS60252461A (ja) * 1984-05-15 1985-12-13 ユセベ　ソシエテ　アノニム 抗低酸素および虚血薬理組成物
JPS60255764A (ja) * 1984-05-15 1985-12-17 ユセベ　ソシエテ　アノニム （ｒ）‐アルフア‐エチル‐２‐オキソ‐１‐ピリジンアセトアミド及びその製法並びに該化合物を含有する製薬組成物
US4670456A (en) * 1984-05-30 1987-06-02 Boehringer Ingelheim Kg 4-Aminocarbonylaminomethyl-1-benzylpyrrolidin-2-ones as nootropic agents and as agents for treating cerebral insufficiency
US4929272A (en) * 1986-09-12 1990-05-29 Ciba-Geigy Corporation N-phenyl-maleimides and N-phenyl-succinimides and their use in a herbicidal and/or plant growth regulating action
GB2225322A (en) * 1988-11-23 1990-05-30 Ucb Sa The preparation of S-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
WO2001062726A2 (en) * 2000-02-23 2001-08-30 Ucb, S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
WO2002026705A2 (en) * 2000-09-29 2002-04-04 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and their preparation
WO2002094787A1 (en) * 2001-05-23 2002-11-28 Ucb, S.A. 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders
WO2003014080A2 (en) * 2001-08-10 2003-02-20 Ucb, S.A. Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues
WO2003030899A2 (en) * 2001-10-08 2003-04-17 Ucb, S.A. Use of 2-oxo-1-pyrrolidine derivatives for the treatment of dyskinesia and movement disorders
ES2214147A1 (es) * 2003-02-28 2004-09-01 Farma-Lepori S.A. Procedimiento de obtencion de un agente antiepileptico.
EP1566376A1 (en) 2004-02-18 2005-08-24 Dr. Reddy's Laboratories Limited Preparation of amino acid amides
WO2006053441A1 (en) 2004-11-22 2006-05-26 Apotex Pharmachem Inc. Improved process for the preparation of (s)-alpha-etyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
WO2006095362A1 (en) * 2005-03-10 2006-09-14 Rubamin Limited Process for preparing levetiracetam
US7132552B2 (en) 2003-02-03 2006-11-07 Teva Pharmaceutical Industries, Ltd. Process for producing levetiracetam
EP2147911A1 (en) 2008-07-24 2010-01-27 ZaCh System S.p.A. Process for the preparation of levetiracetam
EP2308867A2 (en) 2005-06-01 2011-04-13 UCB Pharma S.A. 2-oxo-1-pyrrolidine deriatives, processes for preparing them and their uses
US7939676B2 (en) 2009-09-17 2011-05-10 Zach System S.P.A. Process for the preparation of levetiracetam
WO2011100373A1 (en) 2010-02-09 2011-08-18 The Johns Hopkins University Methods and compositions for improving cognitive function
US8604075B2 (en) 2008-10-16 2013-12-10 The Johns Hopkins University Methods and compositions for improving cognitive function
US8785661B2 (en) 2009-05-13 2014-07-22 Nektar Therapeutics Oligome-containing pyrrolidine compounds
WO2014144801A1 (en) 2013-03-15 2014-09-18 Agenebio Inc. Methods and compositions for improving cognitive function
CN104059010A (zh) * 2014-06-12 2014-09-24 浙江华海药业股份有限公司 一种制备2-(2-氧代吡咯烷-1-基)-丁酸酯的方法
WO2015110435A1 (en) 2014-01-21 2015-07-30 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
EP3827820A1 (en) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam for improving cognitive function
US11369606B2 (en) 2014-01-21 2022-06-28 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
US11384050B1 (en) 2021-02-03 2022-07-12 Vitaworks Ip, Llc Method for preparing levetiracetam and intermediates thereof
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1045043B (it) * 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
IT1141287B (it) * 1979-06-13 1986-10-01 Nattermann A & Cie Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono
AR020115A1 (es) * 1998-08-06 2002-04-10 Daiichi Seiyaku Co Agente terapeutico o preventivo para epilepsias rebeldes y uso del compuesto para la produccion de los mismos
CN106591179B (zh) * 2016-12-05 2018-07-03 长兴制药股份有限公司 甲基包囊菌及其在选择性拆分制备(S)-α-乙基-2-氧-1-吡咯烷乙酸盐上的应用
RU2663899C1 (ru) * 2017-07-19 2018-08-13 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" Способ получения 1-карбамоилметил-4-фенил-2-пирролидона

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1039113A (en) * 1964-08-06 1966-08-17 Ucb Sa New n-substituted lactams

Cited By (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2368275A1 (fr) * 1976-10-19 1978-05-19 Ucb Sa 2-(2-oxo-pyrrolidino)-alkylamides pour le traitement d'affections vasculaires
US4115579A (en) 1976-10-19 1978-09-19 U C B, Societe Anonyme Process for inhibiting blood platelet aggregation
DE2808067A1 (de) * 1977-03-03 1978-09-07 Parke Davis & Co N-(substituierte aminoalkyl)-2-oxo-1- pyrrolidinacetamide und verfahren zu deren herstellung
US4221789A (en) 1978-05-08 1980-09-09 Ucb, Societe Anonyme Lactam-N-acetic acids and their amides
EP0071216B1 (de) * 1981-07-24 1986-12-30 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 3-Hydroxypyrrolidin-2-on-Derivate, Verfahren und Zwischenprodukte zu deren Herstellung und diese enthaltende Arzneimittel
EP0071216A2 (de) * 1981-07-24 1983-02-09 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 3-Hydroxypyrrolidin-2-on-Derivate, Verfahren und Zwischenprodukte zu deren Herstellung und diese enthaltende Arzneimittel
US5034402A (en) * 1981-07-24 1991-07-23 Hoffmann-La Roche Inc. Methods and pharmaceutical compositions using pyrrolidine derivatives
EP0089900A1 (en) * 1982-03-24 1983-09-28 Prodes S.A. New N-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts
US4696942A (en) * 1984-05-15 1987-09-29 Ucb Societe Anonyme Treatment of memory impairment using (R)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
US4696943A (en) * 1984-05-15 1987-09-29 U C B Societe Anonyme (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
JPS60255764A (ja) * 1984-05-15 1985-12-17 ユセベ　ソシエテ　アノニム （ｒ）‐アルフア‐エチル‐２‐オキソ‐１‐ピリジンアセトアミド及びその製法並びに該化合物を含有する製薬組成物
AU574175B2 (en) * 1984-05-15 1988-06-30 Ucb (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
AU574465B2 (en) * 1984-05-15 1988-07-07 Ucb (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
JPS60252461A (ja) * 1984-05-15 1985-12-13 ユセベ　ソシエテ　アノニム 抗低酸素および虚血薬理組成物
JPH0629186B2 (ja) 1984-05-15 1994-04-20 ユセベ ソシエテ アノニム 抗低酸素および虚血薬理組成物
US4670456A (en) * 1984-05-30 1987-06-02 Boehringer Ingelheim Kg 4-Aminocarbonylaminomethyl-1-benzylpyrrolidin-2-ones as nootropic agents and as agents for treating cerebral insufficiency
US4929272A (en) * 1986-09-12 1990-05-29 Ciba-Geigy Corporation N-phenyl-maleimides and N-phenyl-succinimides and their use in a herbicidal and/or plant growth regulating action
GB2225322A (en) * 1988-11-23 1990-05-30 Ucb Sa The preparation of S-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
GB2225322B (en) * 1988-11-23 1992-03-25 Ucb Sa A process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
CZ304420B6 (cs) * 2000-02-23 2014-04-30 Ucb Pharma S.A. 2-Oxo-1-pyrrolidinové deriváty, způsob jejich přípravy a jejich použití
US6806287B2 (en) 2000-02-23 2004-10-19 Ucb, S.A. 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses
US7217826B2 (en) 2000-02-23 2007-05-15 Ucb Farchim S.A. 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses
KR100720784B1 (ko) 2000-02-23 2007-05-23 유씨비 소시에떼아노님 2-옥소-1-피롤리딘 유도체, 이의 제조 방법 및 용도
CN1303066C (zh) * 2000-02-23 2007-03-07 Ucb公司 2－氧代－1－吡咯烷衍生物、其制备方法和用途
CZ304702B6 (cs) * 2000-02-23 2014-09-03 Ucb Pharma S.A. (4R) a (4S) diastereoizomery (2S)-2-[2-oxo-4-propylpyrrolidinyl] butanamidu, farmaceutická kompozice s jejich obsahem a jejich použití
AU2005200717B2 (en) * 2000-02-23 2007-05-17 Ucb Farchim S.A. (Ag-Ltd) 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses
US8492416B2 (en) 2000-02-23 2013-07-23 Ucb Pharma, S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
US8034958B2 (en) 2000-02-23 2011-10-11 UOB Pharma, S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
AU2001252144C1 (en) * 2000-02-23 2008-03-20 Ucb Biopharma Sprl 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
EP1447399A1 (en) * 2000-02-23 2004-08-18 Ucb, S.A. "2-oxo-1-pyrrolidine derivative and its pharmaceutical uses"
US6784197B2 (en) * 2000-02-23 2004-08-31 Ucb S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
EP1452524A1 (en) 2000-02-23 2004-09-01 Ucb, S.A. "2-oxo-1-pyrrolidine derivative and its pharmaceutical uses"
BG65923B1 (bg) * 2000-02-23 2010-05-31 Ucb S.A. 2-оксо-1-пиролидинови производни, методи за тяхното получаване и приложенията им
US7692028B2 (en) 2000-02-23 2010-04-06 Ucb Pharma, S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
WO2001062726A3 (en) * 2000-02-23 2002-01-17 Ucb Sa 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
AU2001252144B2 (en) * 2000-02-23 2005-04-28 Ucb Biopharma Sprl 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
WO2001062726A2 (en) * 2000-02-23 2001-08-30 Ucb, S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
US6911461B2 (en) 2000-02-23 2005-06-28 Ucb, S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
MY139420A (en) * 2000-02-23 2009-09-30 Ucb Sa 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
EP1577296A1 (en) * 2000-02-23 2005-09-21 Ucb S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their use
EP1604979A1 (en) * 2000-02-23 2005-12-14 UCB Farchim S.A. 2-oxo-1-pyrrolidine derivative and its pharmaceutical uses
US7358276B2 (en) 2000-02-23 2008-04-15 Ucb, S.A. 2-Oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
US6977303B2 (en) 2000-09-29 2005-12-20 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
US6897323B2 (en) 2000-09-29 2005-05-24 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
US6686477B2 (en) 2000-09-29 2004-02-03 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
WO2002026705A3 (en) * 2000-09-29 2002-07-11 Eastman Chem Co Highly enantiomerically pure lactam-substituted propanoic acid derivatives and their preparation
US7214803B2 (en) 2000-09-29 2007-05-08 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
WO2002026705A2 (en) * 2000-09-29 2002-04-04 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and their preparation
US7473697B2 (en) 2001-05-23 2009-01-06 Ucb S.A. 2-Oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives for the treatment of epilepsy and other neurological disorders
US7087596B2 (en) 2001-05-23 2006-08-08 Ucb, S.A. 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives for the treatment of epilepsy and other neurological disorders
WO2002094787A1 (en) * 2001-05-23 2002-11-28 Ucb, S.A. 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders
US7122682B2 (en) 2001-08-10 2006-10-17 Ucb, S.A. Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues
AU2002329233B2 (en) * 2001-08-10 2007-08-16 Ucb Pharma Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues
WO2003014080A3 (en) * 2001-08-10 2003-11-06 Ucb Sa Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues
US7563912B2 (en) 2001-08-10 2009-07-21 Ucb Pharma, S.A. Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of Levetiracetam and analogues
WO2003014080A2 (en) * 2001-08-10 2003-02-20 Ucb, S.A. Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues
WO2003030899A2 (en) * 2001-10-08 2003-04-17 Ucb, S.A. Use of 2-oxo-1-pyrrolidine derivatives for the treatment of dyskinesia and movement disorders
AU2002340971B2 (en) * 2001-10-08 2007-04-26 Ucb Use of 2-oxo-1-pyrrolidine derivatives for the treatment of dyskinesia and movement disorders
WO2003030899A3 (en) * 2001-10-08 2004-01-08 Ucb Sa Use of 2-oxo-1-pyrrolidine derivatives for the treatment of dyskinesia and movement disorders
US7132552B2 (en) 2003-02-03 2006-11-07 Teva Pharmaceutical Industries, Ltd. Process for producing levetiracetam
WO2004076416A1 (es) 2003-02-28 2004-09-10 Farma-Lepori S.A. Procedimiento de obtención de un agente antiepiléptico
ES2214147A1 (es) * 2003-02-28 2004-09-01 Farma-Lepori S.A. Procedimiento de obtencion de un agente antiepileptico.
EP1566376A1 (en) 2004-02-18 2005-08-24 Dr. Reddy's Laboratories Limited Preparation of amino acid amides
US7902380B2 (en) 2004-11-22 2011-03-08 Apotex Pharmachem Inc. Process for the preparation of (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (R)-alpha-ethyl-2-oxo-pyrrolidineacetamide
WO2006053441A1 (en) 2004-11-22 2006-05-26 Apotex Pharmachem Inc. Improved process for the preparation of (s)-alpha-etyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
WO2006095362A1 (en) * 2005-03-10 2006-09-14 Rubamin Limited Process for preparing levetiracetam
US8586623B2 (en) 2005-06-01 2013-11-19 Ucb Pharma, S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
EP2308867A2 (en) 2005-06-01 2011-04-13 UCB Pharma S.A. 2-oxo-1-pyrrolidine deriatives, processes for preparing them and their uses
US8178533B2 (en) 2005-06-01 2012-05-15 Ucb Pharma, S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
US8183241B2 (en) 2005-06-01 2012-05-22 Ucb Pharma, S.A. 2-oxo-1-pyrrolidine derivatives
US8518943B2 (en) 2005-06-01 2013-08-27 Ucb Pharma, S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
EP2308870A2 (en) 2005-06-01 2011-04-13 UCB Pharma S.A. 2-oxo-1-pyrrolidine deriatives, processes for preparing them and their uses
EP2147911A1 (en) 2008-07-24 2010-01-27 ZaCh System S.p.A. Process for the preparation of levetiracetam
US8604075B2 (en) 2008-10-16 2013-12-10 The Johns Hopkins University Methods and compositions for improving cognitive function
EP3260118A1 (en) 2008-10-16 2017-12-27 The Johns Hopkins University Methods and compositions for improving cognitive function
US9096517B2 (en) 2009-05-13 2015-08-04 Nektar Therapeutics Oligomer-containing pyrrolidine compounds
US8785661B2 (en) 2009-05-13 2014-07-22 Nektar Therapeutics Oligome-containing pyrrolidine compounds
US9399033B2 (en) 2009-05-13 2016-07-26 Nektar Therapeutics Oligomer-containing pyrrolidine compounds
US7939676B2 (en) 2009-09-17 2011-05-10 Zach System S.P.A. Process for the preparation of levetiracetam
WO2011100373A1 (en) 2010-02-09 2011-08-18 The Johns Hopkins University Methods and compositions for improving cognitive function
US10624875B2 (en) 2012-11-14 2020-04-21 The Johns Hopkins University Methods and compositions for treating schizophrenia
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2014144801A1 (en) 2013-03-15 2014-09-18 Agenebio Inc. Methods and compositions for improving cognitive function
EP3827820A1 (en) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam for improving cognitive function
WO2015110435A1 (en) 2014-01-21 2015-07-30 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
EP3827830A1 (en) 2014-01-21 2021-06-02 Janssen Pharmaceutica NV Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
US11369606B2 (en) 2014-01-21 2022-06-28 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
US12048696B2 (en) 2014-01-21 2024-07-30 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
CN104059010A (zh) * 2014-06-12 2014-09-24 浙江华海药业股份有限公司 一种制备2-(2-氧代吡咯烷-1-基)-丁酸酯的方法
US11384050B1 (en) 2021-02-03 2022-07-12 Vitaworks Ip, Llc Method for preparing levetiracetam and intermediates thereof
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

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Publication number Publication date
NL7101697A (cs) 1971-08-17
FI54916C (fi) 1979-04-10
DE2106418A1 (de) 1971-08-19
DK137451B (da) 1978-03-06
CS167912B2 (cs) 1976-05-28
NL168830B (nl) 1981-12-16
SU508186A3 (ru) 1976-03-25
FI54916B (fi) 1978-12-29
ES388135A2 (es) 1973-05-01
JPS5420491B2 (cs) 1979-07-23
YU34876B (en) 1980-04-30
ZA71877B (en) 1971-10-27
MY7400072A (en) 1974-12-31
JPS535301B1 (cs) 1978-02-25
NL168830C (nl) 1982-05-17
BE762728R (fr) 1971-08-10
YU30671A (en) 1979-10-31
FR2081508A2 (cs) 1971-12-03
JPS53130656A (en) 1978-11-14
DK137451C (cs) 1978-07-24
SU508185A3 (ru) 1976-03-25
FR2081508B2 (cs) 1975-06-06
CH530395A (fr) 1972-11-15
CS167911B2 (cs) 1976-05-28
YU144578A (en) 1982-10-31
DE2106418C2 (de) 1983-12-22

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