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GB1388146A - Hydroxycrotonic acid derivatives - Google Patents

Hydroxycrotonic acid derivatives

Info

Publication number
GB1388146A
GB1388146A GB2248572A GB2248572A GB1388146A GB 1388146 A GB1388146 A GB 1388146A GB 2248572 A GB2248572 A GB 2248572A GB 2248572 A GB2248572 A GB 2248572A GB 1388146 A GB1388146 A GB 1388146A
Authority
GB
United Kingdom
Prior art keywords
alkyl
acid derivatives
acid
hydroxycrotonic acid
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2248572A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of GB1388146A publication Critical patent/GB1388146A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1388146 Derivatives of 4-hydroxy-4-phenylcrotonic acid DR KARL THOMAE GmbH 12 May 1972 [13 May 1971] 22485/72 Heading C2C The invention comprises compounds of formula and their salts, wherein R is C 1-8 alkyl, allyloxy, pyrrolidino, piperidino or 5-7 membered cycloalkyl (possibly CN- or C 1-3 -alkyl-substituted), and X is halogen, NO 2 , CN or MeO; and a method of making them by reducing the oxogroup of the corresponding-4-oxo-4-xhenylcrotonic acid. Therapeutic compositions for nasal, oral, parenteral, rectal or topical administration comprise compounds of the above formula, which have anti-inflammatory and anti-tussive activity.
GB2248572A 1971-05-13 1972-05-12 Hydroxycrotonic acid derivatives Expired GB1388146A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712123858 DE2123858A1 (en) 1971-05-13 1971-05-13

Publications (1)

Publication Number Publication Date
GB1388146A true GB1388146A (en) 1975-03-26

Family

ID=5807798

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2248572A Expired GB1388146A (en) 1971-05-13 1972-05-12 Hydroxycrotonic acid derivatives

Country Status (8)

Country Link
AT (1) AT319206B (en)
AU (1) AU4222572A (en)
BE (1) BE783424A (en)
DE (1) DE2123858A1 (en)
ES (1) ES402648A1 (en)
FR (1) FR2137844B1 (en)
GB (1) GB1388146A (en)
NL (1) NL7206399A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002042250A1 (en) 2000-11-27 2002-05-30 Universite Louis Pasteur (Etablissement Public A Caractere Scientifique, Culturel Et Professionnel) DERIVATIVES OF 4-HYDROXYBUTANOIC ACID AND OF ITS HIGHER HOMOLOGUE AS LIGANDS OF η-HYDROXYBUTYRATE (GHB) RECEPTORS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND PHARMACEUTICAL USES

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3600401A1 (en) * 1986-01-09 1987-07-16 Henkel Kgaa USE OF ALKYLBENZOYL ACRYLIC ACIDS AS CORROSION INHIBITORS

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002042250A1 (en) 2000-11-27 2002-05-30 Universite Louis Pasteur (Etablissement Public A Caractere Scientifique, Culturel Et Professionnel) DERIVATIVES OF 4-HYDROXYBUTANOIC ACID AND OF ITS HIGHER HOMOLOGUE AS LIGANDS OF η-HYDROXYBUTYRATE (GHB) RECEPTORS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND PHARMACEUTICAL USES
FR2817256A1 (en) * 2000-11-27 2002-05-31 Univ Pasteur DERIVATIVES OF 4-HYDROXYBUTANOIC ACID AND ITS SUPERIOR APPROACHES AS GAMMA-HYDROXYBUTYRATE (GHB) RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND PHARMACEUTICAL USES

Also Published As

Publication number Publication date
AU4222572A (en) 1973-11-15
AT319206B (en) 1974-12-10
NL7206399A (en) 1972-11-15
FR2137844A1 (en) 1972-12-29
DE2123858A1 (en) 1972-12-07
BE783424A (en) 1972-11-13
ES402648A1 (en) 1975-03-16
FR2137844B1 (en) 1975-10-17

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Legal Events

Date Code Title Description
CSNS Application of which complete specification have been accepted and published, but patent is not sealed