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GB1286199A - Penicillins - Google Patents

Penicillins

Info

Publication number
GB1286199A
GB1286199A GB02508/70A GB1250870A GB1286199A GB 1286199 A GB1286199 A GB 1286199A GB 02508/70 A GB02508/70 A GB 02508/70A GB 1250870 A GB1250870 A GB 1250870A GB 1286199 A GB1286199 A GB 1286199A
Authority
GB
United Kingdom
Prior art keywords
penicillanic acid
amino
sodium
potassium
trihydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB02508/70A
Inventor
John Kirby Quick
Raymond Walder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to GB02508/70A priority Critical patent/GB1286199A/en
Priority to ZA711170A priority patent/ZA711170B/en
Priority to CH341971A priority patent/CH552623A/en
Priority to ES389076A priority patent/ES389076A1/en
Priority to AT205671A priority patent/AT302527B/en
Priority to NL7103460A priority patent/NL7103460A/xx
Priority to FR7108877A priority patent/FR2085711B1/fr
Priority to DK126771AA priority patent/DK129128B/en
Priority to DE2112634A priority patent/DE2112634C3/en
Priority to BE764353A priority patent/BE764353A/en
Publication of GB1286199A publication Critical patent/GB1286199A/en
Priority to DK297374A priority patent/DK139753B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

1286199 Penicillins BEECHAM GROUP Ltd 19 April 1971 [16 March 1970] 12508/70 Heading C2A A process for reducing the water content of 6-(D-α-amino-p-hydroxypheynlacetamido) penicillanic acid trihydrate comprises treating the trihydrate with a lower alkanol, e.g. methanol or ethanol, and separating the resultant undissolved material. Also, a method for the preparation of sodium or potassium 6-(D-α-amino-phydroxyphenylacetamido) penicillanate comprises treating the separated undissolved material mentioned above in an inert organic liquidwith an organic amine to form a solution of the corresponding amine salt of the penicillanic acid, and thereafter adding a sodium or potassium compound to precipitate the required sodium or potassium salt of the penicillanic acid. The potassium salt of 6-(D-α-amino-p-hydroxypheylacetamido) penicillanic acid is claimed per se. Reference has been directed by the Comptroller to Specification 978,178.
GB02508/70A 1970-03-16 1970-03-16 Penicillins Expired GB1286199A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
GB02508/70A GB1286199A (en) 1970-03-16 1970-03-16 Penicillins
ZA711170A ZA711170B (en) 1970-03-16 1971-02-23 Penicillins
CH341971A CH552623A (en) 1970-03-16 1971-03-09 METHOD OF REDUCING THE WATER CONTENT OF 6 (D- (ALPHA) -AMINO-P-HYDROXYPHENYLACETAMIDO) -PENICILLANIC ACID TRIHYDRATE.
ES389076A ES389076A1 (en) 1970-03-16 1971-03-10 Penicillins
AT205671A AT302527B (en) 1970-03-16 1971-03-10 Process for the preparation of 6- (D-α-amino-p-hydroxyphenylacetamido) -penicillanic acid with a low water content, or the sodium or potassium salt of this acid
NL7103460A NL7103460A (en) 1970-03-16 1971-03-15
FR7108877A FR2085711B1 (en) 1970-03-16 1971-03-15
DK126771AA DK129128B (en) 1970-03-16 1971-03-16 Process for reducing the water content of 6- (D-α-amino-p-hydroxyphenylacetamido) -penicillanic acid trihydrate.
DE2112634A DE2112634C3 (en) 1970-03-16 1971-03-16 Process for the production of low water 6- (Da-amino-p-hydroxyphenyl-acetamido) penicillanic acid and its sodium and potassium salt
BE764353A BE764353A (en) 1970-03-16 1971-03-16 PENICILLINS
DK297374A DK139753B (en) 1970-03-16 1974-05-31 Process for the preparation of sodium or potassium 6- (D-alpha-amino-p-hydroxyphenylacetamido) -penicillanate.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB02508/70A GB1286199A (en) 1970-03-16 1970-03-16 Penicillins

Publications (1)

Publication Number Publication Date
GB1286199A true GB1286199A (en) 1972-08-23

Family

ID=10005896

Family Applications (1)

Application Number Title Priority Date Filing Date
GB02508/70A Expired GB1286199A (en) 1970-03-16 1970-03-16 Penicillins

Country Status (10)

Country Link
AT (1) AT302527B (en)
BE (1) BE764353A (en)
CH (1) CH552623A (en)
DE (1) DE2112634C3 (en)
DK (1) DK129128B (en)
ES (1) ES389076A1 (en)
FR (1) FR2085711B1 (en)
GB (1) GB1286199A (en)
NL (1) NL7103460A (en)
ZA (1) ZA711170B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4014868A (en) * 1974-09-25 1977-03-29 Beecham Group Limited Preparation of β-lactam antibiotics
EP0220925A1 (en) * 1985-10-21 1987-05-06 Antibioticos, S.A. A process for the preparation of sodium amoxycillin
US6103897A (en) * 1995-10-26 2000-08-15 Biochemie Gesellschaft M.B.H. Production of a crystalline salt of amoxicillin

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1465694A (en) * 1973-05-15 1977-02-23 Beecham Group Ltd Preparation of penicillin salts

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE32238B1 (en) * 1967-08-18 1973-05-30 Beecham Inc Production of water-soluble salts of alpha-aminobenzylpenicillin

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4014868A (en) * 1974-09-25 1977-03-29 Beecham Group Limited Preparation of β-lactam antibiotics
EP0220925A1 (en) * 1985-10-21 1987-05-06 Antibioticos, S.A. A process for the preparation of sodium amoxycillin
US6103897A (en) * 1995-10-26 2000-08-15 Biochemie Gesellschaft M.B.H. Production of a crystalline salt of amoxicillin

Also Published As

Publication number Publication date
FR2085711A1 (en) 1971-12-31
DE2112634C3 (en) 1979-03-22
NL7103460A (en) 1971-09-20
FR2085711B1 (en) 1975-08-01
ES389076A1 (en) 1974-04-01
DK129128B (en) 1974-08-26
CH552623A (en) 1974-08-15
ZA711170B (en) 1971-11-24
DE2112634B2 (en) 1978-07-27
BE764353A (en) 1971-09-16
DK129128C (en) 1975-01-06
DE2112634A1 (en) 1971-09-30
AT302527B (en) 1972-10-25

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee