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GB1187680A - New Heterocyclic Substituted Piperazines - Google Patents

New Heterocyclic Substituted Piperazines

Info

Publication number
GB1187680A
GB1187680A GB51999/67A GB5199967A GB1187680A GB 1187680 A GB1187680 A GB 1187680A GB 51999/67 A GB51999/67 A GB 51999/67A GB 5199967 A GB5199967 A GB 5199967A GB 1187680 A GB1187680 A GB 1187680A
Authority
GB
United Kingdom
Prior art keywords
radical
carbethoxy
formula
compound
carboxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB51999/67A
Inventor
Gilbert Regnier
Roger Canevari
Michel Laubie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Priority to GB51999/67A priority Critical patent/GB1187680A/en
Priority to SE14647/68A priority patent/SE344462B/xx
Priority to FR1591665D priority patent/FR1591665A/fr
Priority to US774478A priority patent/US3585193A/en
Priority to ES360066A priority patent/ES360066A1/en
Priority to BR203981/68A priority patent/BR6803981D0/en
Priority to CH1693268A priority patent/CH498862A/en
Priority to BE723944D priority patent/BE723944A/xx
Priority to DE19681809225 priority patent/DE1809225A1/en
Priority to AT1113768A priority patent/AT281041B/en
Priority to FR183231A priority patent/FR8193M/fr
Publication of GB1187680A publication Critical patent/GB1187680A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/22—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to two ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,187,680. 1 - [Methylenedioxybenzyl]- 4 - hetercyclic - piperazines. SCIENCE UNION ET CIE. SOC. FRANCAISE DE RECHERCHE MEDICALE. 5 Nov., 1968 [15 Nov., 1967], No.51999/67. Heading C2C. Novel compounds of formula and acid addition salts thereof in which " Het " represents a pyrimidinyl radical attached in the 4-position, or a pyrazinyl, s-triazinyl or quinazolinyl radical which may be unsubstituted or substituted by one or two lower alkyl radicals containing 1 to 4 carbon atoms, by lower alkoxy radicals containing 1 to 4 carbon atoms or by an amino group, or represents a pyrimidinyl radical attached in the 2-position which is mono-substituted by a halogen atom or by a carboxy, carbethoxy or carbethoxy-methoxy group or disubstituted by an ethoxy radical and a carboxy or carbethoxy radical, are prepared by reaction of a compound of formula with a compound of formula Halogen-Het optionally in the presence of an acid acceptor and optionally followed by salt formation. Pharmaceutical compositions in conventional forms for oral, rectal or parenteral administration and having use as peripheral vasodilators and bronchodilators comprise an above novel compound or salt and one or more carriers and/or diluents.
GB51999/67A 1967-11-15 1967-11-15 New Heterocyclic Substituted Piperazines Expired GB1187680A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
GB51999/67A GB1187680A (en) 1967-11-15 1967-11-15 New Heterocyclic Substituted Piperazines
SE14647/68A SE344462B (en) 1967-11-15 1968-10-29
FR1591665D FR1591665A (en) 1967-11-15 1968-10-30
US774478A US3585193A (en) 1967-11-15 1968-11-08 Heterocyclic compounds
ES360066A ES360066A1 (en) 1967-11-15 1968-11-09 Procedure for preparation of new heterociclic derivatives. (Machine-translation by Google Translate, not legally binding)
BR203981/68A BR6803981D0 (en) 1967-11-15 1968-11-13 PREPARATION PROCESS FOR NEW HETEROCYCLIC DERIVATIVES
CH1693268A CH498862A (en) 1967-11-15 1968-11-13 Process for the preparation of novel derivatives of (methylenedioxy-3 ', 4'-benzyl) -1-piperazine
BE723944D BE723944A (en) 1967-11-15 1968-11-14
DE19681809225 DE1809225A1 (en) 1967-11-15 1968-11-15 New heterocyclic compounds and processes for their preparation
AT1113768A AT281041B (en) 1967-11-15 1968-11-15 Process for the preparation of new piperazine compounds and their acid addition salts
FR183231A FR8193M (en) 1967-11-15 1969-01-27

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB51999/67A GB1187680A (en) 1967-11-15 1967-11-15 New Heterocyclic Substituted Piperazines
GB5799967 1967-11-15

Publications (1)

Publication Number Publication Date
GB1187680A true GB1187680A (en) 1970-04-15

Family

ID=26266976

Family Applications (1)

Application Number Title Priority Date Filing Date
GB51999/67A Expired GB1187680A (en) 1967-11-15 1967-11-15 New Heterocyclic Substituted Piperazines

Country Status (5)

Country Link
US (1) US3585193A (en)
CH (1) CH498862A (en)
DE (1) DE1809225A1 (en)
FR (2) FR1591665A (en)
GB (1) GB1187680A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2062940A1 (en) * 1993-03-11 1994-12-16 Vita Invest Sa Gastrokinetic agent, process for its preparation and pharmaceutical compositions containing said agent
ES2063700A1 (en) * 1993-04-28 1995-01-01 Vita Invest Sa Agent acting on the central nervous system, method for its preparation and pharmaceutical compositions containing such agent.

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3859438A (en) * 1971-07-08 1975-01-07 Boehringer Sohn Ingelheim Pharmaceutical compositions containing an n-(1-bicyclic aryl-propyl-2)-n-bicyclic aryl-piperazine and method of use
GB1369379A (en) * 1972-04-07 1974-10-09 Science Union & Cie Benzodioxole derivatives and processes for preparing them
US4166852A (en) * 1974-08-09 1979-09-04 Produits Chimiques Ugine Kuhlmann Piperazino-pyrimidines and their use as spasmolytic agents
OA06083A (en) * 1977-11-09 1981-06-30 Science Union & Cie Ste Franca New disubstituted piperazines, their preparation processes and pharmaceutical compositions containing them.
FR2519986A1 (en) * 1982-01-21 1983-07-22 Adir NOVEL BENZODIOXINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME
CH651027A5 (en) * 1982-11-12 1985-08-30 Sandoz Ag HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE.
US20070219213A1 (en) * 2004-05-20 2007-09-20 Soares Romeiro Luiz A Use of Adrenergic N-Phenylpiperazine Antagonists, Pahrmaceutical Compositions Containning Them, and Methods of Preparing Them
MA41169A (en) * 2014-12-17 2017-10-24 Acraf WIDE-SPECTRUM ANTIBACTERIAL COMPOUNDS

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2062940A1 (en) * 1993-03-11 1994-12-16 Vita Invest Sa Gastrokinetic agent, process for its preparation and pharmaceutical compositions containing said agent
ES2063700A1 (en) * 1993-04-28 1995-01-01 Vita Invest Sa Agent acting on the central nervous system, method for its preparation and pharmaceutical compositions containing such agent.

Also Published As

Publication number Publication date
US3585193A (en) 1971-06-15
CH498862A (en) 1970-11-15
FR1591665A (en) 1970-05-04
FR8193M (en) 1970-09-07
DE1809225A1 (en) 1971-04-22

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years