FR3034999A1 - METHOD AND DEVICE FOR COSMETIC ANTI-AGE TREATMENT OF THE SKIN BY PHOTOMODULATION, IONTOPHORESIS AND VIBRATIONS - Google Patents

Abstract

The invention relates to a method of cosmetic anti-aging treatment (wrinkles, senescence redness spots) of the skin by photomodulation, iontophoresis and vibrations and a device for the implementation of such a cosmetic treatment of the skin, said method comprising the steps of: a. a step of exposing said zone of the skin to be treated to a light source (20) emitting in the wavelength spectrum is between 590 and 598 nm, for a luminous intensity of between 8000 and 12000 mcd and during a fixed period, b. a step of exposing said area of the skin to be treated to a light source (20) emitting light at a wavelength is between 515 and 535 nm, for a light intensity of between 8000 and 12000 mcd and during a fixed period, c. a step of exposing said zone of the skin to be treated to a light source (20) emitting a light whose wavelength spectrum is between 630 and 660 nm, for a luminous intensity of between 8000 and 12000 mcd and during a specified period, and d. concomitantly with at least one of steps a), b) and c) a step of exposing said zone of the skin to be treated to ionotherapy advantageously carried out by applying an electric current of 700uA to said zone skin to be treated on which has previously been applied a topical composition comprising an anti-aging agent, e. concomitantly with at least one of steps a) b) c) a step of exposing said zone of the skin to be treated to micro-vibrations.

Description

A method and a device for the anti-aging cosmetic treatment of the skin by photomodulation, iontophoresis and vibrations.

The present invention relates to a method of cosmetic anti-aging treatment (wrinkles, senescence spots, redness) of the skin by photomodulation, iontophoresis and vibration and a device for the implementation of such a cosmetic treatment of the skin.

Maintaining a youthful appearance is a constant concern today. Over time, and particularly chronological and / or photoinduced aging, the skin undergoes numerous modifications and degradations that are reflected, at the tissue level, by a disorganization of the architecture of the epidermis, of the dermal junction. epidermal, dermis, as well as blood supply and innervation systems, and a slowing down or disruption of various cellular metabolisms, such as those involved in the balance of the barrier function or involved in melanogenesis. At the cellular level, aging thus results in an alteration of the physiology or metabolism of the main cell types such as dermal fibroblasts, epidermal keratinocytes, and also melanocytes.

Skin aging results from two separate and independent processes that involve intrinsic or extrinsic factors. Intrinsic or chrono-biological aging corresponds to age-related normal or physiological aging. The intrinsic aging results in a slowing down of the renewal of the cells of the epidermis and the appearance of fine lines or wrinkles. At the level of the dermis, the biosynthesis of macromolecules such as collagen decreases with age, changing the mechanical properties of the dermis, hence slackening of the skin, one of the clinical signs of aging. Extrinsic aging corresponds to aging caused in general by the environment and corresponds more particularly to the photo-aging due to exposure to the sun. Photo-induced skin aging, that is to say, caused following exposure to the sun is still called photo-aging or heliodermia. Photo-aging is the result, at the level of the dermis, of the degradation of collagen fibers, in particular resulting in clinical alterations such as thick wrinkles and the formation of a soft, tanned skin. The aging of the skin is accelerated by chronic UV exposure. There is thus a large number of so-called "anti-aging" cosmetic treatments intended to prevent and / or treat aging, in particular photo-aging and their signs, in particular to prevent the appearance of wrinkles and to visibly reduce wrinkles already present, but also attenuate or remove the tasks of senescence (due to age). Among these cosmetic treatments there may be mentioned, for example, the regular application of so-called anti-wrinkle lotions or creams, "peels" intended to remove one or more superficial layers of the skin, the injection of collagen or other agent. skin filling, dermabrasion, botulinum toxin injection or surgical methods such as the "facelift". Recently, methods of treating the skin with light have appeared. Such methods use, for example, a laser or a source of intense pulsed light. The concept of photorejuvenation developed a few years ago aims to improve the heliodermia by non-ablative means, that is without removing the superficial layers of the skin and therefore without annoying side effects. Dr. Mac Daniel first showed that by using cold light sources such as LEDs (emitting from 0.01 to 2 Joules / cm 2) fibroblast activity could be regulated and procollagen formation induced (collagen type I ). At the same time, there was a significant reduction in Metalloproteinases type 1 (MMP1 or collagenase). This concept has been confirmed by NASA's Dr. Wheland team. Intense Pulse Light (IPL) is also a technology widely used in aesthetic care. It complements the action of lasers in the treatment of signs of aging such as photo-depigmentation and wrinkles. Flash lamps are high-intensity discharge lamps filled with a rare gas, xenon, for example. They work by converting stored electrical energy into 30 intense bursts of radiant energy. The light emitted covers the ultraviolet, visible and infrared light spectrum regions, i.e. from about 350 nm to about 1200 nm. Unlike lasers, flash lamps are therefore polychromatic. This broad spectrum of the lamp allows to act simultaneously on different types of skin problem. Indeed, it has been determined that a given range of wavelengths can have a particular beneficial effect on the skin. It is then necessary to use filters allowing selection of the desired wavelength depending on the treatment envisaged. This particularity of flash lamps explains that their manipulation must be reserved for experienced practitioners.

Another disadvantage of flash lamps, as well as lasers, is the relatively large size of these devices. As an alternative to the use of lasers or flashlamps, a technology has developed around the use of light-emitting diodes (LEDs) for the cosmetic and therapeutic treatment of the skin. Light-emitting diodes are electronic components which, when traversed by an electric current, emit low-frequency light. It emits a light that is considered cold because it does not produce heat. This characteristic is due to a lack of resistance present in other bulbs. LEDs fall into the category of LLLTs (Low Level Laser Therapy). They have the advantage of being inexpensive in comparison with lasers or flashlamps and, because of their lower light intensity, do not present any danger of burns or other injuries to the skin if the exposure is not not properly performed. Light-emitting diodes emit light in a spectrum that extends from visible to infrared. Some are said to be monochromatic but emit light 20 whose wavelength is within a small spectrum corresponding to a given color of light. Others, such as white diodes, are polychromatic. It is therefore possible to use light-emitting diodes for the cosmetic treatment of the skin and to select them according to the result that it is desired to obtain.

One of the targets in the cosmetic treatment of wrinkles, as well as in the prevention of the appearance of wrinkles, is collagen. Collagen is a fibrous protein secreted by the fibroblasts of the connective tissue This protein ensures the cohesion of the connective tissue The appearance of the wrinkles is due, to a large extent, to the deterioration of the connective tissue and to the decrease with the age of the collagen synthesis by fibroblasts.

It is now known that exposing the skin to light can stimulate collagen synthesis or even prevent the deterioration of collagen present in the connective tissue. This is the case, for example, of light which corresponds substantially to the yellow light of the visible spectrum of light. One possible explanation is that at this wavelength range, the light flow can inactivate collagenase, an enzyme that degrades collagen. However, if the choice of a range of wavelengths is important for a given light treatment, it is also important to select the adequate light intensity and the duration of exposure of the area to be treated which will, in combination, to obtain a satisfactory result. The Applicant had already been able to demonstrate in patent FR2917299 that a cosmetic treatment of the skin with a device enabling the delivery of a light source emitting light in a wavelength spectrum of between 590 and 10 598 nm, for a light intensity of between 8000 and 12000 millicandelas (mcd), a frequency of the light pulses of about 5 Hz and a duration of each light pulse of about 1 ms allowed an action of prevention and reduction of wrinkles.

Today the Applicant continues to innovate in this field of cosmetic skin treatment in the anti-aging having designed a cosmetic treatment process combining 3 ranges of wavelength and a range of light intensity which, in combination, allow the prevention and reduction of wrinkles by stimulating the synthesis of collagen by fibroblasts, but also the prevention and reduction of senescence tasks by regulating the production of melanin, by modulating the activity of melanocytes, the Redness of the skin This cosmetic treatment also includes treatment with iontophoresis and micro-vibrations. The Applicant also proposes a device allowing the implementation of this cosmetic treatment.

The present invention thus relates to a method of cosmetic anti-aging treatment (wrinkles, senescence spots, redness) of the skin by photomodulation, and / or iontophoresis and / or vibrations and a device for the implementation of a such cosmetic treatment of the skin.

The method according to the invention is characterized in that it comprises several steps, the order of which is immaterial and which can be carried out simultaneously, successively, separately or spread over time: a step of exposing said area of the skin to be treated to a light source emitting light in a wavelength spectrum of between 590 and 3034999 598 nm, preferably 596 nm, for a light intensity of between 8000 and 12000 millicandelas (mcd ) and for a determined period, advantageously between 30 sec and 3 min, preferably 45 seconds; a step of exposing said zone of the skin to be treated to a light source 5 emitting light at a wavelength of between 515 and 535, preferably 525 nm, for a luminous intensity of between 8000 and 12000 millicandelas (mcd ) and for a determined period, advantageously between 30 sec and 3 min, preferably 1 minute; a step of exposing said zone of the skin to be treated to a light source emitting light in a wavelength spectrum of between 630 and 660 nm, preferably 630 nm for a light intensity of between 8000 and 12000 millicandelas (mcd) and for a determined period, advantageously between 30 sec and 3 min, preferably 1 minute; optionally a step of exposing said zone of the skin to be treated to ionotherapy concomitant with the period of exposure to a light source according to the preceding steps, and preceded by the application to the skin of a cosmetic composition comprising an anti-aging active; optionally a step of exposing said zone of the skin to be treated to micro-vibrations concomitant with the period of exposure to a light source 20 according to the preceding steps. The applicants have observed, surprisingly, that the step of the cosmetic light treatment according to the invention in a wavelength spectrum of between 590 and 598 nm, preferably 596 nm, made it possible to stimulate the synthesis of collagen by the fibroblasts of the skin significantly. This is the result of combining the range of wavelengths and the intensity of the emitted light used. As mentioned above, stimulating collagen synthesis helps reduce skin wrinkles and prevent them from appearing. Applicants have also observed, surprisingly, that the step of the cosmetic light treatment according to the invention at a wavelength of between 515 and 535, preferably 525 nm, made it possible to regulate the synthesis of melanin by melanocytes, responsible for irregular pigmentation. As mentioned above, the regulation of melanin synthesis by melanocytes makes it possible to reduce pigmentation irregularities, in particular senescence tasks of the skin and to prevent their appearance, and thus to increase the homogeneity of the complexion. Applicants have also surprisingly observed that the cosmetic light treatment step according to the invention in a wavelength range of 630 to 660 nm, preferably 630 nm, made it possible to reduce the production of pro-inflammatory cytokines and therefore reduce redness. Applicants have also observed, surprisingly, that the step of the cosmetic treatment with ionotherapy according to the invention allowed to increase temporarily and controlled cutaneous permeability. As mentioned above, this increase in skin permeability makes it possible to promote the penetration of skincare active ingredients, in particular anti-aging active ingredients and thus to increase and / or accelerate their effect on the skin. These anti-aging active agents may be anti-wrinkle, anti-stain, anti-redness or any anti-aging active ingredient known to those skilled in the art.

Finally, the applicants have also observed, surprisingly, that the cosmetic microvalent treatment step according to the invention made it possible to help restart the local microcirculation. As mentioned above, this makes it possible to improve intercellular communication, and in the case where an anti-aging active is applied beforehand on the skin, this makes it possible, especially in combination with ionotherapy, to increase and / or accelerate its effect on the skin. According to the invention, the term "prevention" or "prevention" means reducing the risk of occurrence or slowing down the occurrence of a given phenomenon, namely, according to the present invention, skin disorders and / or imperfections. cutaneous associated with the aging of the skin. According also to this first aspect, the cosmetic treatment according to the present invention makes it possible to prevent and / or treat wrinkles and / or fine lines, the thinning of the skin, in particular the dermis, and / or senescence spots. By "cosmetic treatment of the wrinkles and / or fine lines" is meant according to the present invention the fact of fading wrinkles and / or fine lines, or to reduce the appearance of wrinkles and / or fine lines. According to the invention, ionotherapy is intended to denote a cosmetic treatment which relies on the use of a low intensity electric current to penetrate molecules, preferably hydrophilic, into the skin, according to two mechanisms (Morrow et al. (2007) Innovative strategies for enhancing topical and transdermal drug delivery.The Open Drug Delivery Journal, 1; TEAIMA (2012) Electronically-assisted transdermal delivery of escin.International Journal of Pharmacy and Pharmaceutical Sciences, 4.) 5 - Electro-repulsion (Morrow et al.): principle of transport of charged molecules. A charged molecule (for example positively) is repelled by an electrode of the same polarity (in our positively charged example) when applying an electric current (very low). And conversely for negative charges. 10 - electro-osmosis (TEAIMA, 2012) principle of the transport of uncharged molecules. The skin is negatively charged: the positively charged ions (eg Na +), circulate better in the skin, and thus create a flow, which induces an osmotic flow of water, when applying an electric current (very low). It is this flow of water that will facilitate the penetration of neutral molecules. Ionotherapy thus makes it possible to promote the penetration of active ingredients in the skin, whatever their polarity, thanks to electro-osmosis, but even better by the combined action of electro-osmosis and electro-repulsion. the case where it is chosen to apply to the skin prior to the ionotherapy step at least one anti-aging active having the same charge as the electrode used for the application of low-intensity electric current. According to the present invention, said low intensity electric current is between 400 and 1000 pt, A, preferably 700 t, A. By microvibration is meant according to the present invention vibrations between 700 and 950 hz on the skin, preferably 843 hz.

For the ionotherapy and microvibration steps, the device is advantageously placed in contact with the skin. According to one characteristic of the invention, said light source is composed of a plurality of light-emitting diodes. In a preferred manner according to the invention, said light source comprises at least 20, preferably at least 25 light-emitting diodes. Even more preferably, said light source is composed of 29 light-emitting diodes.

In a preferred manner according to the invention, said light-emitting diodes are multifunctional diodes, capable of alternately producing each of the wavelength spectra according to the present invention. More preferably, these light-emitting diodes have a power of 0.06W.

In a preferred manner according to the invention, said light whose wavelength spectrum is between 590 and 598 nm is emitted in the form of bursts of light pulses. More preferably, the frequency of said pulses is about 5 Hz and the duration of said pulses is about 1 ms.

In a preferred manner according to the invention, each light exposure step has a determined period of between 30 seconds and 3 minutes. Advantageously, said exposure step is repeated every day for two weeks. Advantageously, said light source is disposed at a distance 20 from said zone to be treated of between 2 and 5 cm, preferably 2 to 3 cm, and even on the skin. for ionotherapy and microvibration steps. According to a second subject, the present invention relates to a device for implementing the method of cosmetic anti-aging treatment (wrinkles, senescence spots, redness) of the skin by photomodulation, and / or iontophoresis and / or vibrations such as it has just been described. Such a device according to the invention comprises a housing comprising a light source. It is characterized in that said light source can emit alternately or concomitantly, preferably alternately, light in a spectrum of wavelengths between 590 and 598 nm, with a luminous intensity of between 8000 and 12000 mcd, a light at a wavelength of between 515 and 535, preferably 525 nm, with a luminous intensity of between 8000 and 12000 mcd, and in a wavelength range of between 630 and 660 nm, with an intensity of 3034999 9 bright between 8000 and 12000 mcd. In a preferred manner, the light is alternately emitted for each wavelength. According to one characteristic of the invention, said light source comprises a plurality of light-emitting diodes, advantageously arranged in a matrix. Even more preferably, the light source represents a surface area of 30 to 35 cm 2 making it possible to treat the same skin surface in a single application. According to one characteristic of the invention, said light source is composed of a plurality of light-emitting diodes. In a preferred manner according to the invention, said light source comprises at least 20, preferably at least 25 light-emitting diodes. Even more preferably, said light source is composed of 29 light-emitting diodes. In a preferred manner according to the invention, said light-emitting diodes are multifunctional diodes, capable of alternately producing each of the wavelength spectra according to the present invention. More preferably, these light-emitting diodes have a power of 0.06W. According to yet another feature of the invention, said device comprises an iontophoresis device (for performing ion therapy). The person skilled in the art knows from his general knowledge the devices that can be used to generate a current of low intensity according to the invention. For example, a donor electrode assembly, a counter-electrode assembly and an electric current generator may be associated. In particular, it is possible to use a device that creates a non-sinusoidal sawtooth wave. According to yet another characteristic of the invention, said device comprises a motor 25 for creating micro-vibrations. It is preferably a motor running at 800 rpm. According to yet another characteristic of the invention, said device comprises a timer provided to control the duration of each step.

Advantageously, said power source consists of a rechargeable battery. The characteristics of the invention mentioned above, as well as others, will emerge more clearly on reading the following description and examples of embodiment, said description being given in relation to the attached drawings, among which: FIG. 1 is a front view of a device for the anti-aging cosmetic treatment according to the invention. Fig. 2 is a side view of a device for the anti-aging cosmetic treatment according to the invention. The device for the cosmetic treatment of the skin according to the invention shown in FIG. 1 comprises a housing 10 comprising a light source 20. The light source 20 is composed of a plurality of light-emitting diodes, such as the diode 210. These are assembled in a matrix 21, advantageously of oval shape. The matrix 21 may comprise a number of light-emitting diodes advantageously between fifteen and seventy-five, ordered in several rows and columns. Each diode 210 of the light source 20 emits either a light in the visible spectrum, of yellow-orange color, whose wavelengths are between 590 and 598 nm and whose intensity is between 8000 and 12000 mcd, ie light in the visible spectrum, of green color, whose wavelength is between 515 and 535, preferably 15 525 nm and whose intensity is between 8000 and 12000 mcd, ie a light in the visible spectrum, of color red, whose wavelengths are between 630 and 660 nm and whose intensity is between 8000 and 12000 mcd. Advantageously, the light source 20, when it emits a light in the visible spectrum, of yellow-orange color, whose wavelengths are between 590 and 598 nm, emits in pulses of light. To do this, the device of the invention comprises an electrical pulse generating means 50 supplying the diodes 210, with a pulse frequency of about 5 Hz and a duration of 1 ms. As can be seen in FIG. 2, the device of the invention further comprises a timer 60 connected, via the pulse generator 50, 25 to the matrix of diodes 21. It controls the pulse generator 50 for a predetermined duration for issuing bursts of light pulses with a frequency of about 5 Hz during said duration, for example between 30 seconds and 3 minutes, preferably 45 seconds. Said device further comprises a battery supply 40 for the general power supply of the device 1, that is to say the timer 60, the pulse generator 50 and the matrix of diodes 20. A button for setting operation M and a stop button A present on the housing 10 are also connected to the battery 40 to enable the user to respectively turn on or off the operation of said device of the present invention.

A "mode of treatment" button allows the user to choose the wavelength of the light (a light in a wavelength spectrum of between 590 and 598 nm, with a luminous intensity of between 8000 and 12000 mcd, or a light at a wavelength of between 515 and 535, preferably 525 nm, with a light intensity of between 8000 and 12000 mcd, or a light in a wavelength spectrum of between 630 and 660 nm, with luminous intensity between 8000 and 12000 mcd). The device advantageously comprises a detector (D) enabling it to automatically switch on the skin with the steps of ion therapy and microvibration treatment. Preferably, the detector (D) is a micro-current contactor. The package 10 has a weight and dimensions enabling it to be portable and can advantageously be held in one hand. Advantageously, the device weighs less than 250 g, preferably less than 115 g with battery.

The device 1 according to the invention can be used in an anti-aging cosmetic treatment of an area of the skin. Such a method comprises a step during which the user grasps the device 1 in his hand and selects a wavelength with the button MDT then presses the start button M and then places the device in contact with the skin or at a distance from the area of the skin to be treated of between 2 and 5 cm, preferably 2 and 3 cm. The timer 60 allows the device 1 to operate for a light exposure period of between 30 seconds and 3 minutes per selected wavelength. Thus if during this step the user has selected a light of yellow color whose wavelength spectrum is between 590 and 598 nm by pressing the button 25 MDT, during this step, the light source 20 emits this light preferably for 45 seconds. If the user then presses the MDT key again and selects a green light whose wavelength is between 515 and 535 nm, the light source 20 emits a green light whose wavelength is between 515 and 535 nm and the light intensity is between 8000 and 12000 mcd, preferably for a period of one minute. And finally, if the user presses the MDT key again and selects a red light whose wavelength spectrum is between 630 and 660 nm, the light source 20 emits a red light whose spectrum in wavelengths is between 630 and 660 3034999 12 nm and the light intensity is between 8000 and 12000 mcd, for a period of one minute. The user can then apply a cosmetic composition, preferably anti-aging, and put the device in contact with the skin to initiate the steps of ionotherapy and 5 simultaneous microvibrations. The user then presses the M / A button to turn off the device. If the user does not use the device for 2 or 3 seconds, the device turns off automatically. The light source 20 emits, in addition, said yellow light whose wavelength spectrum is between 590 and 598 nm in the form of bursts of light characterized by the electrical pulses generated by the pulse generator 50. mentioned above, the frequency of the yellow light pulses is about 5 Hz and the duration of each light pulse is about 1 ms. In addition, the emission of yellow light in the form of bursts of light pulses contributes to the success of the anti-aging cosmetic treatment process. Excellent results were obtained one hour after a single exposure to 630 nm light and with a repeated exposure period once a day for 28 days for a wavelength of 596 nm, and two months once per day for 525 nm. The selection of both a combination of 3 different wavelength ranges and a suitable light intensity makes it possible to obtain a surprising result, as attested by the analyzes described in the following. Lastly, ionotherapy preceded by an application of an anti-aging cosmetic composition and the micro-vibrations associated with the light exposure to the 3 ranges of wavelengths described make it possible to obtain even more interesting results.

Example 1: Clinical evaluation on 25 subjects of an anti-aging cosmetic treatment using a device emitting light at the wavelength of 630 nm. Treatment with a device emitting light at wavelengths of 630 nm was performed on a half-face on 25 healthy subjects (Caucasian women aged 23 to 68 years with a mean of age of 49.40 * 10.64 years). a) Realization of a model of erythema in the face after mesotherapy 3034999 13 Realization of a session of mesotherapy using a roller with needles of 1 mm length associated with the application of a solution polyrevitalizing. This roller allows the stimulation of skin cells in response to the mechanical aggression of the needles and creation of micro-channels optimizing the penetration of active ingredients.

In the immediate aftermath and usually continuing 30 minutes after the mesotherapy session, a significant erythema in the cheeks and extending on the chin and forehead is observed. B) Performing the light application session at 630 nm on the right half-face To enable quantification of the anti-redness effect, each treatment session was performed with a device emitting continuous red light at 630 nm for 3 minutes on the right half face. Chromametric evaluations associated with dermatologic scoring have been used to measure the modulation of redness of the skin. 3D photographs illustrate the effect of the device according to the invention. C) Analyzes at TO, after mesotherapy, 30 minutes and 1 hour after the session with the device according to the invention * Dermatological analysis, using a scoring (0 to 5) carried out from the photographs taken with the LifeViz II device by selecting the option to visualize the red components of the skin (erythema, rosacea, vascular disease ...). * Chromametric analysis of skin color using Konica Minolta Chromameter CR / DP-400e parameter a: red. The decrease in parameter (a) correlates with the decrease in erythema. 30 * 3D photographs (profile) using the LifeViz II device to visualize the modulation of erythema after treatment. d) RESULTS 3034999 14 This mesotherapy model made it possible to significantly increase the erythema at the level of both cheeks with an average score of 2.88 versus 0.37 (p = 4.66x10-9) for the two cheeks. right cheek and 2.76 versus 0.24 for the untreated left cheek 5 (p = 3.14x10-9). The erythema observed at the level of the right cheek treated by the device according to the invention emitting light at 630 nm is significantly decreased compared to the untreated left cheek with an average score of 1.36 versus 2.08 (p. = 0.00076).

The anti-redness effect obtained by the device according to the invention emitting light at 630 nm is 52%. d) CONCLUSION In this clinical trial carried out on 25 subjects, using a cutaneous erythema model induced by mesotherapy, a statistically significant reduction in redness was obtained by dermatological and chromameric evaluation after treatment with the device according to the invention emitting light at 630 nm. The anti-redness effect of the device according to the invention emitting light at 630 nm is 52% after mesotherapy. It can probably be extended to other inflammatory conditions of the skin, such as sunburn and skin irritations in sensitive skin. The cutaneous tolerance after use of the device according to the invention emitting light at 630 nm was excellent for all subjects.

The device according to the invention for carrying out the cosmetic treatment method according to the invention thus makes it possible to reduce the redness of a zone of the skin in a significant manner.

Example 2: Clinical evaluation on 30 subjects of an anti-aging cosmetic treatment using a device emitting light at a wavelength of 525 nm a) Selection criteria 3034999 A treatment at the Using a device emitting light at wavelengths of 525 nm was performed on 30 subjects (23 women and 7 men) with pigmented spots (lentigos) on the face, back of the hands or neck of 43 to 71 years, an average age of 54.4 ± 9.3 years.

The topography of the lentigos selected as the target area was evaluated for 25 cases the back of the hands, 4 times the face and 1 time the neckline. b) Performing the 525 nm light application session on the pigmented lesions. Each subject performed a 525 nm continuous mode treatment session for 2 minutes for 2 months on each selected pigmented lesion. The device was placed a few inches from the skin or in contact with the skin. The treatment of facial lesions was done before makeup. c) Results In this clinical study, it was found a statistically very significant decrease on day 30 of the pigmentation of the lentigos with an average score of 1.54 versus 20 2.21 at OJ (p = 2.10-11) ie a decrease of 30.3%. The maximum score for decreased pigmentation was 75% for some subjects. The decrease in lentigo pigmentation was confirmed at J60 with an average score of 1.19 versus 2.21 at OJ (p = 3.5.10-14), a decrease of 46%. The maximum score for decreasing lentigo pigmentation was 90% for some cases.

All subjects found a decrease in pigmentation and stain surface and were satisfied with the treatment. The use of the device was in all cases considered easy. The tolerance of the device was in all cases excellent. D) Conclusion In this clinical trial carried out on 30 subjects, we demonstrated a significant lightening of the lentigo pigmented lesions of the back of the hands or the face: After 30 days of treatment with LED (Light Emitting Diodes of the laboratory 10 15 3034999 16 Talika) emitting at 525 nm, we observe an average score of 1.54 versus 2.21 (at OJ), a decrease of 30.3%. The maximum score of decreased pigmentation was 75%. After 60 days, we observe an average score of 1.19 versus 2.21 at OJ, a decrease of 46%. The maximum score for decreasing lentigo pigmentation was 90% for some cases. These results obtained on the lentigo suggest an identical depigmenting effect on melasma and an increase in the radiance of the complexion after treatment with LED emitting in the green (525 nm). It can also be used as a precaution to prevent progressive repigmentation of lentigos after destruction by Laser or IPL (Flash lamps). The device according to the invention for the implementation of the cosmetic treatment method according to the invention thus makes it possible to reduce the pigmentation of the skin tasks significantly.

Example 3: Clinical evaluation of 30 subjects of an anti-aging cosmetic treatment using a device emitting light at the wavelength of 590 nm The clinical study involved a total of 30 elderly women from 35 to 60, the average age is 45 (37 to 59). A) Performing the 590 nm light application session on the pigmented lesions in the wrinkles of the paw or in the orbital region. The device has been used daily, preferably at the same time in the day (45-second session in pulsed mode) in the fine lines of crow's feet or in the orbital region for four weeks. Two visits were planned: at OJ for inclusion and at D28 (closing visit). At each visit, a dermatological clinical examination of the tone of the skin (touch analysis) and wrinkles or fine lines was done (semi-quantitative scores). Macrophotographies (subject not made up, standard poses) were taken. Measurements of the surface of the wrinkles, their depth and the roughness of the skin were made at OJ and D28 with a measuring device (Skin Station).

An assessment of the tolerance and cosmetic comfort as well as that of the effectiveness of the product was collected. b) Results 5 - The average clinical score of skin tone was 1.93 at OJ. It is 1.57 to D28, corresponding to a statistically significant 18% improvement in skin tone - The average clinical score for fine lines and wrinkles was 2.13 at OJ. It is 1.73 to D28, 10 a statistically significant decrease of 19% - The average percentage of area occupied by fine lines and wrinkles, calculated by the Skin Station, was 5.76% at OJ. It is 3.66% at D28, a statistically significant decrease of 36.4% - The average roughness of the crow's foot area and periorbital, calculated by the Skin 15 Station, was 0.479 to OJ . It is 0.391 to D28, a statistically significant decrease of 18.4% - The average volume of fine lines and wrinkles (V / mm), calculated by the Skin Station, was 57.5 at OJ. It is 40.2 to D28, a statistically significant decrease of 30%. The largest decrease in the volume of fine lines and wrinkles was 72% and the lowest 20 among responders was 15%. The tolerance was excellent and no adverse effects were noted. c) Conclusion The clinical improvement after treatment with the device was observed in 27 of the 30 subjects. The results of the open clinical study on 30 women who daily applied the device at the level of the crow's foot and the suborbital region for 28 days show an improvement in the clinical scores of the tone of the skin and the appearance of wrinkles respectively 18 and 19% on average. The surface of wrinkles and fine lines is reduced by 36.4% and their volume by 30% (measured by the Skin Station).

The tolerance of the product was excellent and the cosmetological appreciation globally very good. The device according to the invention for the implementation of the cosmetic treatment method according to the invention thus makes it possible to reduce the wrinkles of the skin significantly. 5

Claims (9)

REVENDICATIONS1. A method of cosmetic anti-aging treatment of the skin, characterized in that it comprises: a. a step of exposing said zone of the skin to be treated to a light source (20) emitting light whose wavelength spectrum is between 590 and 598 nm, for a light intensity of between 8000 and 12000 mcd and during a specified period, b. a step of exposing said zone of the skin to be treated to a light source (20) emitting light at a wavelength is between 515 and 535 nm, preferably 525 nm, for a light intensity of between 8000 and 12000 mcd and for a determined period, c. a step of exposing said zone of the skin to be treated to a light source (20) emitting a light whose wavelength spectrum is between 630 and 660 nm, for a luminous intensity of between 8000 and 12000 mcd and during a specified period, and d. concomitantly with at least one of steps a), b) and c) a step of exposing said zone of the skin to be treated to ion therapy and which will be preceded by the application of a topical composition comprising an anti-aging active agent, said ionotherapy step being advantageously carried out by the application of an electrical current of 700 [LIA on said area of the skin to be treated having previously received the application of said topical composition; e. concomitantly with at least one of steps a) b) c) a step of exposing said zone of the skin to be treated to micro-vibrations. 2. Cosmetic treatment method according to claim 1, characterized in that said light whose wavelength spectrum is between 590 and 598 nm is emitted in the form of burst pulses of light. 3034999 20 3. Cosmetic treatment method according to claim 2, characterized in that the frequency of said pulses is about 5 Hz and the duration of said pulses is about 1 ms. 4. Cosmetic treatment method according to one of the preceding claims, characterized in that each determined period is between 30 seconds and 3 minutes. 5. Cosmetic treatment method according to one of the preceding claims, characterized in that said exposure steps are repeated every day for two weeks. 10 6. Cosmetic treatment method according to one of the preceding claims, characterized in that said light source (20) is disposed at a distance from said area to be treated between 2 and 5 cm and on the skin for ion therapy steps and microvibrations. 7. Device (1) for an anti-aging cosmetic treatment of an area of the skin according to the method according to one of claims 1 to 6, said device comprising a housing comprising a light source (20), characterized in that said light source (20) emits alternately or concomitantly, alternatively alternately light in a wavelength spectrum of between 590 and 598 nm, with a luminous intensity of between 8000 and 12000 mcd, light with a length of a wave of between 515 and 535 nm, preferably 525 nm, with a luminous intensity of between 8000 and 12000 mcd, and a light in a wavelength spectrum of between 630 and 660 nm, with a light intensity of between 8000 and and 12000 mcd, an iontophoresis device and a motor for creating microvibrations. 8. Device (1) according to claim 7, characterized in that said light source (20) comprises a plurality of light-emitting diodes (210) preferably 29 diodes, more preferably 29 multifunction diodes. 9. Device (1) according to one of claims 7 or 8, characterized in that it comprises a detector (D) allowing it to start automatically in contact with the skin ion therapy steps and microvibrations.