FR2830197A1 - The use of a haloalkynyl derivative, especially iodo-3-propynyl-2-butylcarbamate, as a stabilizer for ultrafine oil-in-water emulsions used for cosmetic compositions and impregnated skin cleansing towelettes - Google Patents

Abstract

Use of a haloalkynyl derivative as a stabilizer for an oil-in-water emulsion cosmetic or dermatological composition with average oil globule size 50-1000 nm and the composition itself for topical application comprising an oily phase dispersed in water the haloalkynyl derivative and having a viscosity at 25 deg C of 1-20 mPa.s. Independent claims are included for: (1) a method of treating the skin including the scalp, the hair, eyebrows, nails and/or the lips by applying the composition; (2) a method of preparing the composition by producing a classic emulsion at a temperature within or above the phase inversion domain or heating to it, refrigerating and adding the haloalkynyl derivative and additional components which are unstable at the phase inversion temperature; (3) an article comprising a water insoluble substrate and the composition added to it or impregnated into it; and (4) a cosmetic procedure of care, cleansing and/or makeup removal from the skin by wiping with the article.

Description

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The present invention relates to a cosmetic and / or dermatological composition in the form of an ultrafine oil-in-water emulsion which can be obtained by phase inversion, stabilized with 3-iodo-2-propynylbutylcarbamate, and its uses in particular in the cosmetic field, as is or in the form of an article impregnated with said composition.

For various reasons related in particular to a better comfort of use (softness, emollience and others), the current cosmetic or dermatological compositions are most often in the form of an emulsion of the oil-in-water type (oily phase dispersed in an aqueous phase constituting the continuous phase) or a water-in-oil type emulsion (aqueous phase dispersed in an oily phase constituting a continuous phase). Oil-in-water emulsions are the most demanded in the field of cosmetics because they provide the skin with a softer, less greasy and lighter feel than the water-oil emulsion systems.

The oil-in-water emulsions are stabilized generally by emulsifying surfactants of the oil-in-water type, which, thanks to their amphiphilic structure, are placed at the oil phase-1 aqueous phase interface, and thus stabilize the oil droplets. dispersed. Despite the presence of emulsifiers, the emulsions may tend to be out of phase (separation of the aqueous and oily phases with release of oil). The increase in the emulsifier content most often makes it possible to improve the stability of the emulsion.

However, the presence of emulsifiers at high concentrations leads to problems of discomfort of the composition obtained in terms of cosmetics, such as, for example, a rough feel or sticky or sticky feel, as well as problems of safety against against the skin, eyes and scalp due to a large amount of surfactants.

To solve the stability problems of conventional O / W emulsions, it has been proposed to make specific "ultrafine" O / W emulsions in which the mean size of the globules constituting the oily phase is within clearly defined limits, namely between 50 and 1000 nm, said ultrafilter emulsions of HIE type being themselves generally obtained by a technique of emulsification by phase inversion.

This technique is, in principle, well known to those skilled in the art and is described in particular in the articles "Phase Inversion Emusification", by Th.

Fôrster et al, published in Cosmetics & Toiletries, vol. 106, December 1991, pp. 49-52; Application of the phase-inversion-temperature method to the emulsification of cosmetics by T. MITSUI et al, published in American Cosmetics and Perfumery, Vol 87, December 1972. The principle of this technique is as follows: an emulsion W / H is prepared (introduction of the aqueous phase into the oily phase) at a temperature which must be greater than the phase inversion temperature of the system (in English: Phase Inversion Temperature or PIT), that is to say the

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 temperature at which the balance between the hydrophilic and lipophilic properties of the emulsifier (s) used is reached; at high temperature, that is to say higher than the phase inversion temperature (> PIT), the emulsion is of the water-in-oil type, and during its cooling, this emulsion is reversed at the phase inversion temperature, to become an oil-water emulsion, and this having previously passed through a microemulsion state.

These ultrafine emulsions are most often extremely fluid. They have a bluish appearance and can be translucent. However, these emulsions are fragile and still pose a number of stability problems. In particular, phenomena of creaming and / or phase shift after several freezing cycles are observed, as well as the appearance of volutes and / or deposits that are difficult to identify.

One of the parameters strongly influencing the stability of oil-in-water emulsions (which will be noted hereinafter H / E) is the size of the dispersed oil droplets, which size is related to the surface tension between the phase discontinuous (oily) and continuous phase (aqueous). The smaller the size of the oil droplets, the lower the surface tension and the higher the stability of the emulsion.

It is known to gel this type of emulsion in order to improve their stability and to widen the range of viscosities so as to be able to use it in all cosmetic and dermatological fields and to diversify its textures in order to adapt them to all skin types.

Unfortunately, the gelling agents commonly used in cosmetics are for the most part inefficient for this type of composition. In addition, some gelling agents are incompatible with this type of emulsion. In general, conventional gelling agents do not make it possible to homogeneously thicken the emulsions obtained by phase inversion and to stabilize them in different viscosity ranges. Moreover, since these gelling agents thicken the compositions, they do not make it possible to obtain compositions having the desired fluidity for certain uses, for example to be used in the form of a spray.

There remains the need for ultrafine emulsion, which can be very fluid while having a satisfactory stability. Satisfactory stability is understood to mean that the oil globules remain well distributed in the continuous aqueous phase without any phase shift, volute, deposit, creaming or other phenomenon of emulsion instability occurring.

The Applicant has surprisingly found that the addition of 3-iodo-2-propynylbutylcarbamate allowed to obtain a stable ultrafine O / W emulsion, without occurrence of creaming, without phase shift or deposition, even if the emulsion is very fluid. .

The ultrafine O / W emulsions of the invention have, in addition to their greater stability, cosmetic properties compared with conventional O / W emulsions.

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 noticeably improved such as softness, freshness and comfort at application as well as an original feeling of fondant and slippery.

The subject of the present invention is therefore a composition for topical application in the form of an oil-in-water emulsion comprising an oily phase dispersed in an aqueous phase, in which the average size of the oil globules ranges from 50 nm to 1000 nm ( nanometers), characterized in that it contains 3-iodo-2-propynylbutylcarbamate. This composition may constitute in particular a cosmetic or dermatological composition.

The oil-in-water emulsions of the invention are capable of being obtained according to the technique of emulsification by phase inversion.

Because it is intended for topical application, the composition of the invention contains a physiologically acceptable medium. By "physiologically acceptable medium" is meant a medium that is suitable for topical application to the skin or integuments, that is to say, compatible with the skin, the mucous membranes, the lips, the hair and the nails.

The invention makes it possible in particular to obtain ultrafine emulsions which are very fluid and stable. The term "highly fluid" is intended to mean compositions having a viscosity ranging from 1 to 20 cPoise (1 to 20 mPa · s), the viscosity being measured at ambient temperature (approximately 20 to 25 ° C.) with a Rheomat RM 180 (generally on a mobile basis). ).

3-iodo-2-propynylbutylcarbamate is known as a fungicide, especially for wood (see Lee et al., Bokin Bobai, 1990, 18 (8), pp. 365-370). Moreover, it is described as being a suitable preservative for cosmetic products by the company Lonza which markets it under the name Glycacil. However, its use to affect the stability of ultrafine emulsions has never been described.

The subject of the present invention is also the use of 3-iodo-2-propynylbutylcarbamate as a stabilizer of an oil-in-water emulsion in which the average size of the oil globules ranges from 50 nm to 1000 nm.

According to an essential characteristic of the compositions according to the present invention, the average number-size of the liquid particles (or globules) of oil (or oily phase) within the aqueous dispersant phase ranges from 50 nm to 1000 nm. Preferably, this average size ranges from 70 nm to 350 nm and more particularly from 70 to 300 nm.

In addition, the compositions according to the invention are characterized by a very low polydispersity, that is to say that the size of the globules is very homogeneous.

As a rule, 90% of the oil globules of the ultrafine oil-in-water emulsion according to the invention have a number average size ranging from 100 to 300 nm. The difference in size between the largest and the smallest globules generally ranges from 20 to 400 nm and preferably from 30 to 200 nm, whereas

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 in conventional emulsions (other than PIT emulsions or microemulsions), the difference in size between the largest and the smallest globules is generally greater than 1000 nm.

Dans la composition selon l'invention, l'iodo-3 propynyl-2 butylcarbamate peut être utilisé tel quel ou sous forme d'une solution dans un ou plusieurs solvants choisis parmi les esters d'acide gras et de polyéthylène glycol ; les polyéthylène glycols de faible poids moléculaire, c'est-à-dire de poids moléculaire inférieur ou égal à 450 ; et leurs mélanges. 3-iodo-2-propynylbutylcarbamate corresponds to the compound of formula (1) below:

In the composition according to the invention, the 3-iodo-2-propynyl butylcarbamate may be used as it is or in the form of a solution in one or more solvents chosen from fatty acid esters and polyethylene glycol; polyethylene glycols of low molecular weight, that is to say of molecular weight less than or equal to 450; and their mixtures.

By fatty acid is meant acids having from 8 to 26 carbon atoms and preferably from 12 to 22 carbon atoms. The fatty acid ester may be derived from a fatty acid or mixture of fatty acids. Examples of fatty acid esters of polyethylene glycol that may be mentioned include polyethylene glycol mono-cocoate and di-cocoate.

As polyethylene glycols with a molecular weight less than or equal to 450, mention may be made, for example, of polyethylene glycol (4 EO) or PEG-4, polyethylene glycol (6 EO) or PEG-6, polyethylene glycol (8 EO) or PEG -8 and polyethylene glycol (9 EO) or PEG-9, and mixtures thereof.

According to a particular embodiment of the invention, the 3-iodo-2-propynyl butylcarbamate used is in a mixture with polyethylene glycol monococoate, polyethylene glycol dicocoate, polyethylene glycol (4 EO) or mixtures thereof. According to a preferred embodiment of the invention, use is made of the mixture comprising the 4 constituents and sold by Lonza under the name Glycacil L. This Glycacil L mixture comprises, in addition to 3-iodo-2-propynyl butylcarbamate, polyethylene glycol monococoate, polyethylene glycol dicocoate and PEG-4 in a 10/40/40/10 ratio, ie ie 10% iodo-3-propynyl butylcarbamate, 40% polyethylene glycol monococoate, 40% polyethylene glycol dicocoate and 10% PEG-4.

The amount of solvent for 3-iodo-2-propynylbutylcarbamate may range, for example, from 0.01 to 20% by weight, preferably from 0.05 to 10% by weight and better still from 0.01 to 5% by weight per relative to the total weight of the composition.

3-iodo-2-propynylbutylcarbamate may also be used in the composition according to the invention in solid form, as such or in admixture, especially in admixture with an alkali metal or alkaline earth metal carbonate or bicarbonate, and more particularly sodium bicarbonate.

The amount of 3-iodo-2-propynylbutylcarbamate in the composition of the invention must be sufficient to obtain the desired stability. In practice, the quantity

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 3-iodo-2-propynyl butylcarbamate may range, for example, from 0.001 to 10% by weight of active material, preferably from 0.005 to 5% by weight of active material, and more preferably from 0.01 to 1% by weight of active ingredient, and more preferably from 0.01 to 0.5% by weight of active material relative to the total weight of the composition.

The nature of the oily phase forming part of the composition of the emulsions according to the invention is not critical. Thus, the oily phase may consist of all the compounds which are already generally known to be suitable for the manufacture of oil-in-water emulsions, in particular in the cosmetic or dermatological fields. In particular, these compounds can be chosen, alone or in mixtures, from oils of vegetable, animal or mineral origin, natural or synthetic waxes, and the various other fatty substances, these oils, in particular cosmetics, and other fatty substances before be physiologically acceptable.

l'huile d'avocat, l'huile de ricin, l'huile de coriandre, l'huile d'olive, l'huile de jojoba, l'huile de sésame, l'huile d'arachide, l'huile de pépins de raisin, l'huile de colza, l'huile de coprah, l'huile de noisette, le beurre de karité, l'huile de palme, l'huile de noyau d'abricot, l'huile de calophyllum, l'huile de son de riz, l'huile de germes de maïs, l'huile de germes de blé, l'huile de soja, l'huile de tournesol, l'huile d'onagre, l'huile de carthame, l'huile de passiflore, l'huile de seigle, les triglycérides des acides caprylique/caprique comme ceux vendus par la société Stearineries Dubois ou ceux vendus sous les dénominations Miglyol 810,812 et 818 par la société Dynamit Nobel ; - les huiles de synthèse, telles que l'huile de purcellin, le myristate de butyle, le myristate d'isopropyle, le myristate de cétyle, le palmitat d'isopropyle, le palmitat

d'ethyl-2 hexyle, l'adipate d'isopropyle, l'adipate d'éthylhéxyle, le stéarate de butyle, le stéarate d'héxadécyle, le stéarate d'isopropyle, le stéarate d'octyle, le stéarate d'isocétyle, l'oléate de décyle, le laurate d'héxyle, le dicaprylate de propylène glycol et les esters dérivés d'acide lanolique tels que le lanolate d'isopropyle, le lanolate d'isocétyle, le dioctylcyclohexane, les isoparaffines et les poly-a-oléfines. The oily phase usually contains at least one oil. Among the oils that can be included in the composition of the oily phase, mention may be made in particular of: mineral oils such as paraffin oil and liquid petroleum jelly; hydrocarbon oils of animal origin, such as perhydrosqualene; hydrocarbon oils of vegetable origin, such as sweet almond oil,

avocado oil, castor oil, coriander oil, olive oil, jojoba oil, sesame oil, peanut oil, seed oil of grapes, rapeseed oil, coconut oil, hazelnut oil, shea butter, palm oil, apricot kernel oil, calophyllum oil, oil of rice bran, corn germ oil, wheat germ oil, soybean oil, sunflower oil, evening primrose oil, safflower oil, passionflower, rye oil, triglycerides of caprylic / capric acids such as those sold by Stearineries Dubois or those sold under the names Miglyol 810, 812 and 818 by Dynamit Nobel; synthetic oils, such as purcellin oil, butyl myristate, isopropyl myristate, cetyl myristate, isopropyl palmitate, palmitate

2-ethylhexyl, isopropyl adipate, ethylhexyl adipate, butyl stearate, hexadecyl stearate, isopropyl stearate, octyl stearate, isocetyl stearate, decyl oleate, hexyl laurate, propylene glycol dicaprylate and esters derived from lanolic acid such as isopropyl lanolate, isocetyl lanolate, dioctylcyclohexane, isoparaffins and poly-α-amines. olefins.

cétylique et d'alcool stéarylique) ; les acétylglycérides ; les octanoates et décanoates d'alcools et de polyalcools tels que ceux de glycol et de glycérol ; les As other oils that can be used in the emulsions according to the invention, mention may also be made of ethers such as dicaprylic ether (CTFA name: Dicaprylyl ether); CC fatty alcohol benzoates (Finsotv TN from FINETEX); fatty alcohols containing from 8 to 26 carbon atoms, such as the alcohols, cetyl, myristic, stearyl, palmitic, oleic, linoleic, 2-octyldodecanol, and mixtures thereof such as cetearyl alcohol (alcohol mixture)

cetyl alcohol and stearyl alcohol); acetylglycerides; octanoates and decanoates of alcohols and polyalcohols such as those of glycol and glycerol; the

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phénylées comme les phényltriméthicones, les phényldiméthicones, les phényltriméthylsiloxydiphényl-siloxanes, les diphényl-diméthicones, les diphénylméthyldiphényl trisiloxanes, les 2-phényléthyltriméthyl-siloxysilicates, les polyméthyl-phényisiloxanes. ricinoleates of alcohols and polyalcohols such as those of cetyl; fluorinated and perfluorinated oils; lanolin; hydrogenated lanolin; acetylated lanolin; and finally volatile or non-volatile silicone oils, such as volatile or non-volatile polymethylsiloxanes (PDMS) with a linear or cyclic silicone chain, which are liquid or pasty at room temperature, in particular cyclopolydimethylsiloxanes (cyclomethicones) such as cyclohexasiloxane; polydimethylsiloxanes comprising alkyl, alkoxy or phenyl groups, during or at the end of the silicone chain, groups having from 2 to 24 carbon atoms; silicones

phenyls such as phenyltrimethicones, phenyldimethicones, phenyltrimethylsiloxydiphenylsiloxanes, diphenyldimethicones, diphenylmethyldiphenyltrisiloxanes, 2-phenylethyltrimethylsiloxysilicates, polymethylphenylsiloxanes.

By hydrocarbon oil is meant in the list of oils mentioned above, any oil predominantly comprising carbon and hydrogen atoms, and optionally ester, ether, fluoro, carboxylic acid and / or alcohol groups.

An oil or a mixture of several of the oils mentioned above can be used.

According to one particular embodiment of the invention, the composition comprises at least one vegetable oil, and for example palm oil, or at least one mineral oil such as liquid petroleum jelly, or a mixture of at least one mineral oil and at least one vegetable oil.

According to another particular embodiment of the invention, the composition comprises at least one emollient chosen from the oils indicated above, and more particularly the dicaprylic ether, dioctylcyclohexane, and mixtures thereof.

propylène glycol, le butylène glycol ; le sorbitol ; les sucres tels que le glucose, le fructose, le maltose, le lactose, le sucrose ; et leurs mélanges. Comme alcools inférieurs, on peut citer par exemple l'éthanol, l'isopropanol, le butanol et leurs mélanges. In a conventional manner, the aqueous phase may contain, in addition to water, one or more water-soluble solvents chosen from polyols (or polyhydric alcohols), water-soluble lower alcohols (s) and mixtures thereof. By lower alcohol is meant an alcohol having 1 to 8 carbon atoms. Examples of polyols that may be mentioned include glycerine; glycols like the

propylene glycol, butylene glycol; sorbitol; sugars such as glucose, fructose, maltose, lactose, sucrose; and their mixtures. Lower alcohols include, for example, ethanol, isopropanol, butanol and mixtures thereof.

Preferably, the oil-in-water emulsions according to the invention comprise: (i) from 50 to 95% by weight, more preferably from 70 to 90% by weight of aqueous phase, relative to the total weight of the composition ;

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 (ii) from 0.5 to 50% by weight, more preferably from 10 to 30% by weight of oily phase, relative to the total weight of the composition.

tensioactifs émulsionnants, nécessaire à la réalisation de l'émulsion. The emulsions according to the invention also generally contain one or more emulsifying surfactants whose use is most often necessary for the preparation and obtaining of the ultrafine emulsion. They may furthermore contain specific co-emulsifiers whose role, during the preparation of the emulsion, is to substantially reduce the quantity of agents

emulsifying surfactants, necessary for producing the emulsion.

The emulsifiers that may be used in the present invention are preferably chosen from nonionic compounds consisting, on the one hand, of a lipophilic residue chosen, for example, from the C 6 -C 30 alkyl or acyl functional groups and, on the other hand, from a chosen hydrophilic residue. for example, among the polyol groups (glycerol, glycol, glucose) and the polyol ethers. Their balance HLB (Hydrophilic Lipophilic Balance) can range from 9 to 18 and more preferably from 9.5 to 11.5.

Nonionic emulsifiers which are preferably used in the present invention include, in particular, ethylene oxide adducts with fatty alcohols having 6 to 30 carbon atoms or with partial esters of polyols having 3 to 16 carbon atoms. carbon and fatty acid atoms having 14 to 22 carbon atoms, and mixtures thereof.

dans laquelle R représente un résidu hydrocarboné saturé ou insaturé, ramifié ou linéaire, ayant de 8 à 30 atomes de carbone et n représente un nombre allant de 8 à 50, préférentiellement de 8 à 30. On peut citer par exemple les produits d'addition d'oxyde d'éthylène avec l'alcool béhénylique, comme par exemple Beheneth-9 (9 moles d'oxyde d'éthylène) et Beheneth-10 (10 moles d'oxyde d'éthylène) ; ceux obtenus avec l'alcool cétylique ou avec l'alcool stéarylique ou avec leurs mélanges, notamment ceux comportant 12 à 20 moles d'oxyde d'éthylène, comme par exemple ceux obtenus à partir du mélange d'alcool cétylique et d'alcool stéarylique (alcool cétéarylique) comme Ceteareth-12, Ceteareth-13, Ceteareth-14, Ceteareth-15, Ceteareth-16, Ceteareth-17, Ceteareth-18, Ceteareth-20 ; ceux obtenus à partir de l'alcool cétylique comme Ceteth-14, Ceteth-15, Ceteth-16, Ceteth-20 ; ceux obtenus à partir de l'alcool stéarylique comme Steareth-13, Steareth-14, Steareth-15, Steareth-16, Steareth- 20, et les mélanges de ces différents émulsionnants. Thus, as adducts of ethylene oxide with fatty alcohols, an emulsifier having the formula (I) can be used:

in which R represents a saturated or unsaturated, branched or linear hydrocarbon residue having from 8 to 30 carbon atoms and n represents a number ranging from 8 to 50, preferably from 8 to 30. Mention may be made, for example, of addition products ethylene oxide with behenyl alcohol, for example Beheneth-9 (9 moles of ethylene oxide) and Beheneth-10 (10 moles of ethylene oxide); those obtained with cetyl alcohol or with stearyl alcohol or with their mixtures, in particular those containing 12 to 20 moles of ethylene oxide, for example those obtained from the mixture of cetyl alcohol and stearyl alcohol; (cetearyl alcohol) such as Ceteareth-12, Ceteareth-13, Ceteareth-14, Ceteareth-15, Ceteareth-16, Ceteareth-17, Ceteareth-18, Ceteareth-20; those obtained from cetyl alcohol such as Ceteth-14, Ceteth-15, Ceteth-16, Ceteth-20; those obtained from stearyl alcohol such as Steareth-13, Steareth-14, Steareth-15, Steareth-16, Steareth-20, and mixtures of these different emulsifiers.

The ethylene oxide adducts with partial esters of polyols and fatty acids can be obtained by ethoxylation of partial esters of glycerol fatty acids or mono or di-esters of fatty acids. sorbitol. For example, the adducts of 4 to 20 moles of ethylene oxide can be used on one or

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obtenus par estérification d'une mole de glycérol par 1 ou 2 moles d'un acide gras en Co'-'oEn outre, les émulsions selon l'invention peuvent comprendre en plus un ou plusieurs co-émulsionnants. Ce ou ces co-émulsionnants peuvent être choisis par exemple parmi les alcools gras en C16-C22 ou les esters de polyols en C3-C6 avec des acides gras en C14-C22, et leurs mélanges. Comme co-émulsionnant, on peut citer par exemple l'alcool cétylique, l'alcool stéarylique, l'alcool cétéarylique (mélange d'alcool cétylique et d'alcool stéarylique), le stéarate de glycéryle, et leurs mélanges. several partial esters of glycerol. By partial esters of glycerol is meant, for example, mixtures of C10-C20 mono-, di- and tri-glycerides of fatty acids.

obtained by esterification of one mole of glycerol with 1 or 2 moles of a fatty acid in Co '-' o In addition, the emulsions according to the invention may further comprise one or more coemulsifiers. This co-emulsifier or these co-emulsifiers may be chosen for example from C 16 -C 22 fatty alcohols or C 3 -C 6 polyol esters with C 14 -C 22 fatty acids, and mixtures thereof. Examples of co-emulsifiers include cetyl alcohol, stearyl alcohol, cetearyl alcohol (mixture of cetyl alcohol and stearyl alcohol), glyceryl stearate, and mixtures thereof.

The mixture sold under the name Emulgade SEV by the company Cognis containing ceteareth-20, ceteareth-12, hydrogenated palm oil and cetearyl alcohol can be used, for example, as an emulsifying and co-emulsifying mixture.

The amount of emulsifiers and co-emulsifiers in the composition of the invention is generally from 0.05 to 30% by weight, preferably from 0.5 to 20% by weight and better still from 2 to 10% by weight. relative to the total weight of the composition.

The composition according to the invention may also contain any adjuvant or additive usually used in the fields in question and in particular in the cosmetic or dermatological fields.

Among the conventional adjuvants likely to be contained in the aqueous phase and / or in the oily phase of the emulsions according to the invention (according to the water-soluble or fat-soluble nature of these adjuvants), mention may be made in particular of gelling agents and ionic thickeners or nonionic; cosmetic or dermatological active agents, hydrophilic or lipophilic; the perfumes ; conservatives ; sequestering agents (EDTA); pigments; mother-of-pearl; mineral or organic fillers such as talc, kaolin, silica or polyethylene powders; soluble dyes; solar filters; alkanizing or acidifying agents; and their mixtures. The amounts of these various adjuvants are those conventionally used in the field under consideration, and for example from 0.01 to 20% of the total weight of the composition.

According to one particular embodiment of the invention, the composition according to the invention further contains polyhexamethylene biguanide hydrochloride (CTFA name: polyaminopropyl biguanide). This compound is a preservative having the advantage of complementing perfectly with its antibacterial effectiveness, the antifungal efficacy of iodopropynylbutylcarbamate, to obtain a microbiological protection of the composition as possible. The polyhexamethylene biguanide hydrochloride is present in the composition of the invention in an amount sufficient to act as a preservative. Thus, this compound is present in an amount ranging for example

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 from 0.001 to 5% of the total weight of the composition, preferably from 0.005 to 2% of the total weight of the composition and better still from 0.01 to 1% of the total weight of the composition.

Furthermore, the composition according to the invention may contain one or more active agents, and the cosmetic or dermatological active agents that may be used depend on the purpose of this composition. As active agents that can be used in the invention, mention may be made, for example, of antibacterials such as octopirox, triclosan and triclocarban; keratolytic and anti-aging agents such as hydroxy acids (α-hydroxy acids and hydroxy acids) such as lactic acid, glycolic acid, citric acid, salicylic acid and their derivatives; essential oils ; vitamins and in particular retinol (vitamin A), ascorbic acid (vitamin C), tocopherol (vitamin E), niacinamide (vitamin PP or B3), panthenol (vitamin B5) and their derivatives (esters, for example ); coenzymes and in particular coenzyme Q10 or ubiquinone; enzymes such as, for example, lipases, proteases, phospholipases, cellulases, peroxidases, especially lactoperoxidases, catalases, superoxide dimutases and plant extracts containing the abovementioned enzymes; yeasts such as Saccharomyces cerevisiae; steroids; free anti-oxidants and antiradicals; moisturizers such as polyols (glycerol, sorbitol, sugars), protein hydrolysas, urea and mixtures thereof; slimming as caffeine; anti-elastase and anticollagenase agents; oily skin treatment agents; and their mixtures.

salicylique, 5-tert-octylsalicylique, 5-butoxy-salicylique, 5-éthoxy-salicylique, 5méthoxysalicylique, 5-propoxysalicylique, 5-méthylsalicylique, 5-éthylsalicylique, 5-propylsalicylique, et leurs mélanges. Ces acides peuvent être éventuellement salifiés par une base. Salicylic acid derivatives that may especially be mentioned include noctanoyl-5-salicylic acid (CTFA name: Capryloyl Salicylic Acid), n-decanoyl-5-salicylic acid, n-dodecanoyl-5-salicylic acid, n-octyl-5-salicylic acid, n -heptyloxy-5-

salicylic, 5-tert-octylsalicylic, 5-butoxy-salicylic, 5-ethoxy-salicylic, 5-methoxysalicylic, 5-propoxysalicylic, 5-methylsalicylic, 5-ethylsalicylic, 5-propylsalicylic, and mixtures thereof. These acids can be optionally salified with a base.

Examples of steroids include, for example, dehydroepiandrosterone (or DHEA), as well as (1) its precursors and biological derivatives, in particular DHEA salts and esters, such as DHEA sulfate and salicylate, hydroxy DHEA, 7-keto DHEA, 7-hydroxy and 7-keto DHEA esters, especially 3-beta-acetoxy-7-oxo DHEA, and (2) its precursors and chemical derivatives, in particular sapogenins such as diosgenin or hecogenin, and / or their derivatives such as hecogenin acetate, and / or natural extracts containing it and in particular extracts of Dioscoreae, such as wild yam (Wild Yam).

The solar filters (or U.V. filters) optionally present in the composition may be chosen from organic screening agents, physical screening agents and their mixtures.

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As chemical sunscreens that can be used in the composition of the invention, the composition of the invention can comprise all the UVA and UVB filters that can be used in the cosmetic field.

As UVB filters, there may be mentioned for example: (1) salicylic acid derivatives, in particular homomenthyl salicylate and octyl salicylate; (2) derivatives of cinnamic acid, in particular 2-ethylhexyl p-methoxycinnamate, sold by Givaudan under the name Parsol MCX; (3) liquid P, P'-diphenylacrylate derivatives, in particular α-cyano-α, 2-ethylhexyl diphenylacrylate or octocrylene, sold by BASF under the name UVINUL N539; (4) p-aminobenzoic acid derivatives; (5) 4-methyl benzylidene camphor sold by Merck under the name EUSOLEX 6300; (6) 2-phenylbenzimidazole 5-sulfonic acid sold under the name Eusolex 232 by Merck; (7) 1,3,5-triazine derivatives, in particular: 2,4,6-tris [p- (2'-ethylhexyl-1'-oxycarbonyl) anilino] -1,3,5-triazine sold by the company BASF under the name UVINUL T150, and - dioctyl butamido triazone marketed by the company Sigma 3V under the name UVASORB HEB; (8) mixtures of these filters.

As UVA filters, there may be mentioned for example: (1) dibenzoylmethane derivatives, in particular 4- (tert-butyl) -4'-methoxy dibenzoylmethane sold by the company Givaudan under the name PARSOL 1789; (2) benzene 1,4 [di (3-methylidenecampho-10-sulfonic acid)] optionally in partially or totally neutralized form, sold under the name Mexoryl SX by the company Chimex.

(3) benzophenone derivatives, for example: 2,4-dihydroxybenzophenone (benzophenone-1); 2,2 ', 4,4'-tetrahydroxybenzophenone (benzophenone-2); - 2-hydroxy-4-methoxy-benzophenone (benzophenone-3), sold under the name Uvinul M40 by the company BASF;

<Desc / Clms Page number 11>

- la 5-chloro-2-hydroxybenzophénone (benzophénone-7) ; - la 2, 2'-dihydroxy-4-méthoxy-benzophénone (benzophénone-8) ; - le sel disodique du diacide 2,2'-dihydroxy-4, 4'-diméthoxy-benzophénone-5,5'disulfonique (benzophénone-9) ; -la 2-hydroxy-4-méthoxy-4'-méthyl-benzophénone (benzophénone-10) ; - la benzophénone-11 ; - la 2-hydroxy-4- (octyloxy) benzophénone (benzophénone-12). - 2-hydroxy-4-methoxy-benzophenone-5-sulfonic acid (benzophenone-4) and its form sulfonate (benzophenone-5), sold by BASF under the name Uvinul MS40; 2,2'-dihydroxy-4,4'-dimethoxybenzophenone (benzophenone-6);

5-chloro-2-hydroxybenzophenone (benzophenone-7); 2, 2'-dihydroxy-4-methoxy-benzophenone (benzophenone-8); the disodium salt of 2,2'-dihydroxy-4,4'-dimethoxy-benzophenone-5,5'-diisulfonic acid diacid (benzophenone-9); 2-hydroxy-4-methoxy-4'-methyl-benzophenone (benzophenone-10); benzophenone-11; 2-hydroxy-4- (octyloxy) benzophenone (benzophenone-12).

- le 2-[1-[3-[1, 3, 3, 3-tétraméthyl-1- [ (triméthylsilyl) oxy] disiloxanyl] propyl]-1 H- benzimidazol-2-yl]-benzothiazole ; - le 2-[1- (3-trimethylsilanyl-propyl) -1 H-benzimidazol-2-yl]-benzoxazole ; - le 6-méthoxy-1, 1'-bis- (3-triméthylsilanyl-propyl)-1 H, 1'H- [2, 2'] bibenzimidazolyl- benzoxazol ; - le 2-[1-(3-trimethylsilanyl-propyl)-1H-benzimidazol-2-yl]-benzothiazole ; qui sont décrits dans la demande de brevet EP-A-1 028 120 ; (8) les dérivés de triazine, et en particulier la 2,4-bis {[4- (2-éthyl-hexyloxy)-2- hydroxy]-phényt}-6- (4-méthoxy-phényt)-1, 3,5-triazine commercialisé par la société Ciba Geigy sous la dénomination TINOSORB S, et le 2, 2'-méthylènebis-[6- (2H benzotriazol-2-yl) 4- (1, 1,3, 3-tétraméthylbutyl) phénol] commercialisé par la société Ciba Geigy sous la dénomination TINOSORB M ; (9) leurs mélanges. (4) silane derivatives or polyorganosiloxanes containing a benzophenone group; (5) anthranilates, in particular menthyl anthranilate marketed by Haarman & Reiner under the name NEO HELIOPAN MA; (6) the compounds comprising, per molecule, at least two benzoazolyl groups or at least one benzodiazolyl group, in particular 1,4-bis-benzimidazolyl-phenylen-3,3 ', 5,5'-tetrasulfonic acid and its salts; marketed by Haarman &Reimer; (7) the silicon derivatives of N-substituted benzimidazolyl-benzazoles or of benzofuranyl-benzazoles, and in particular: 2- [1- [3- [1,,3,3,3-tetramethyl-1 - [(trimethylsilyl)) oxy] disiloxanyl] propyl] -1H-benzimidazol-2-yl] benzoxazole;

2- [1- [3- [1, 3, 3, 3-tetramethyl-1 - [(trimethylsilyl) oxy] disiloxanyl] propyl] -1H-benzimidazol-2-yl] benzothiazole; 2- [1- (3-trimethylsilanyl-propyl) -1H-benzimidazol-2-yl] benzoxazole; 6-methoxy-1,1'-bis- (3-trimethylsilanyl-propyl) -1H, 1'H- [2,2'] bibenzimidazolylbenzoxazol; 2- [1- (3-trimethylsilanyl-propyl) -1H-benzimidazol-2-yl] benzothiazole; which are described in the patent application EP-A-1 028 120; (8) triazine derivatives, and especially 2,4-bis {[4- (2-ethylhexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3 5-triazine marketed by Ciba Geigy under the name Tinosorb S, and 2,2'-methylenebis- [6- (2H benzotriazol-2-yl) 4- (1,1,3,3-tetramethylbutyl) phenol). ] marketed by the company Ciba Geigy under the name TINOSORB M; (9) their mixtures.

It is also possible to use a mixture of several of these filters and a mixture of UVB filters and UVA filters and also mixtures with physical filters.

As physical filters, there may be mentioned titanium oxides (amorphous titanium dioxide or crystallized rutile form and / or anatase), zinc, iron, zirconium, cerium or mixtures thereof. These metal oxides can be

<Desc / Clms Page number 12>

 in the form of particles having a micrometric or nanometric size (nanopigments). In the form of nano-pigments, the average particle sizes range, for example, from 5 to 100 nm. Nano-pigments are preferably used in the composition of the invention.

Of course, those skilled in the art will take care to choose the optional compounds to be added to the composition according to the invention in such a way that the advantageous properties intrinsically attached to the composition according to the invention are not or substantially not , altered by the envisaged addition.

du domaine d'inversion de phase, ou bien on prépare l'émulsion directement à une telle température, puis (3) on refroidit l'émulsion et on ajoute l'iodo-3 propynyl-2 butylcarbamate et éventuellement les adjuvants ou actifs instables à la température d'inversion de phase, tels que par exemple les parfums. The emulsions according to the invention are generally obtained by a phase inversion method. This preparation process is characterized in that: 1) the oil phase is mixed: (A) the oily phase comprising at least one oil and optionally other oils and fats and the liposoluble adjuvants which are stable at the inversion temperature; of the phase, (B) at least one emulsifier and optionally a co-emulsifier, (D) the aqueous phase, this aqueous phase comprising water and optionally the water-soluble solvents and the water-soluble adjuvants which are stable at the phase inversion temperature in order to obtain a conventional emulsion, (2) the emulsion is heated to a temperature located inside or above

of the phase inversion domain, or the emulsion is prepared directly at such a temperature, and then (3) the emulsion is cooled and 3-iodo-2-propynylbutylcarbamate and optionally unstable additives or active agents are added to the phase inversion temperature, such as, for example, perfumes.

The phase inversion temperature domain is set for a given composition by measuring the conductivity of a sample of the composition being heated. When the phase inversion domain is reached, the conductivity of the emulsion increases very rapidly: in the phase inversion domain, an increase of the conductivity of about 50 microsiemens per centimeter can be observed on a temperature range of 5 to 15 C, while it will be only about 5 micro-siemens per centimeter over an equivalent temperature range outside the phase inversion domain.

The compositions according to the invention may be more or less fluid and may therefore be in the form of lotion, milk or in the form of cream more or less thick. They can be used as they are or in aerosol or spray form. According to a preferred embodiment of the invention, the composition is in the form of a very fluid emulsion of the lotion or milk type, and it is preferably used in the form of a spray. As indicated above, the very fluid emulsions are those having a viscosity ranging from 1 to 20 cPoise (1 to 20 mPa · s), the viscosity being measured at room temperature (approximately 20 to 25 C) with a Rheomat RM 180 (generally at mobile 1).

<Desc / Clms Page number 13>

pour l'hydratation et/ou le raffermissement de la peau et/ou pour nourrir la peau. The compositions of the invention may constitute skincare, protection and / or hygiene products for the skin of the face and / or the body, the hair, the scalp, the eyelashes, the eyebrows, the nails or the mucous membranes. , such as sprays for the protection, treatment or care of the face, the hands or the body, body milks or lotions for protecting or caring for the skin, the scalp or the mucous membranes or for removing makeup and / or the cleaning of the skin, lips and / or hair. They can be used for example

for hydration and / or firming of the skin and / or for nourishing the skin.

The compositions according to the invention may also constitute hair products, sun products to protect the skin of the body and / or the face or the hair from the harmful effects of the sun or UV, and also products for the makeup of keratin materials and especially skin, lips and / or eyelashes.

Thus, the subject of the present invention is the cosmetic use of the composition as defined above, for the treatment, the protection, the care, the cleansing and / or the cleansing of the skin, lips and / or hair , and / or for makeup of the skin and / or lips.

The subject of the present invention is also a process for the cosmetic treatment of the skin, including the scalp, the hair, the eyebrows, the nails and / or the lips, characterized in that the skin is applied to the skin. hair, eyebrows, nails and / or lips, a composition as defined above.

The type of treatment may vary in particular depending on the asset or assets present in the composition.

According to another embodiment of the invention, the compositions according to the invention can be used to impregnate a water-insoluble substrate in order to constitute an article to be applied to the skin, such as a wipe. The water insoluble substrate may be selected from the group consisting of woven materials, nonwoven materials, foams, sponges, wadding, sheets, balls or films. It may be in particular a non-woven substrate based on fibers of natural origin (flax, wool, cotton, silk) or of synthetic origin (cellulose derivatives, viscose, polyvinyl derivatives, polyesters such as polyethylene terephthalate, polyolefins such as polyethylene or polypropylene, polyamides such as nylon, acrylic derivatives). Nonwovens are generally described in RIEDEL Nonwoven Bonding Methods & Materials, Nonwoven World (1987). These substrates are obtained according to the usual methods of the technique for preparing nonwovens. According to a particular embodiment of the invention, the insoluble substrate may contain at least one of the preservatives of the invention, attached to the support by the known means for grafting the biocidal agents onto the fibers.

This substrate may comprise one or more layers having identical or different properties and have elasticity, softness and other properties appropriate to the desired use. The substrates may comprise, for example, two parts having different elastic properties as described in FIG.

<Desc / Clms Page number 14>

 WO-A-99/13861 or comprise a single layer with different densities as described in WO-A-99/25318 or comprise two layers of different textures as described in WO-A-98/18441.

The substrate can be any size and any form appropriate to the desired purpose. It generally has an area of between 0.005 m2 and 0.1 m2, preferably between 0.01 m2 and 0.05 m2. It is preferably in the form of rectangular wipes or round compresses.

The final article comprising the substrate and the impregnating composition is generally in the wet state, with an impregnation rate of the composition ranging, for example, from 200 to 1000%, and preferably from 250 to 350% by weight of composition relative to the weight of the substrate. Techniques for impregnating substrates with compositions are well known in the art and are all applicable to the present invention. In general, the impregnating composition is added to the substrate by one or more techniques including dipping, coating, spraying, etc.

It is also possible to constitute an article (or wipe) presented in the dry state either by removing the water from the composition after its impregnation on the substrate, or by impregnating the substrate with a composition in dry form in the form of powder, granule or film, by all the known means of realization such as the welding and the gluing of multilayers by thermal or ultrasonic ways. In this latter embodiment, the composition is dried by any known means: atomization, yophylization or other similar process.

Depending on the intended use, it is thus possible to obtain wet wipes or dry wipes. The wet wipes can be used as is while the dry wipes are wet before use.

The subject of the invention is therefore also an article comprising (A) a substrate that is insoluble in water, (B) a composition as defined above, added or impregnated on the substrate, as well as the uses of said article in the field. cosmetic or dermatological, especially for the care (nourish, firm moisturize), cleansing and / or make-up removal of the skin.

la peau, et/ou des lingettes de nettoyage et/ou de démaquillage de la peau et/ou des yeux. This article may constitute, in particular, care wipes and / or treatment wipes.

skin, and / or wipes for cleaning and / or removing makeup from the skin and / or eyes.

The invention also relates to a cosmetic process for the care, cleaning and / or removal of makeup of the skin, consisting of passing on the skin, an article as defined above.

The examples given below will make it possible to better understand the invention without, however, being limiting in nature. The quantities indicated are in% by weight unless otherwise indicated. The names are in chemical names and CTFA names according to the compounds.

<Desc / Clms Page number 15>

Example 1: very fluid milk

<Tb>
<tb> Phase <SEP> A
<tb> Oil <SEP> mineral <SEP> 5 <SEP>%
<tb> Ether <SEP> d-caprylic <SEP> (Cetiol <SEP> OE <SEP> of <SEP> the <SEP> Company <SEP> Cognis) <SEP> 3 <SEP>%
<tb><SEP> Mixture of <SEP> Ceteareth-20, <SEP> Ceteareth-12, <SEP> Oil <SEP> of <SEP> Palm
<tb> hydrogenated <SEP> and <SEP> alcohol <SEP> cetearyl
<tb> (Emulgade <SEP> SEV <SEP> of <SEP> the <SEP> Company <SEP> Cognis) <SEP> 3 <SEP>%
<tb> Ceteareth-20 <SEP> (Emulgin <SEP> B2 <SEP> from <SEP> the <SEP> Company <SEP> Cognis) <SEP> 1 <SEP>%
<tb> Phase <SEP> B
<tb> Glycerin <SEP> 5 <SEP>%
<tb> Water <SEP> distilled <SEP> 15 <SEP>%
<tb> Phase <SEP> C
<tb> Oil <SEP> of <SEP> palm <SEP> 1 <SEP>%
<tb> Fragrance <SEP> 0, <SEP> 3 <SEP>%
<tb> Phase <SEP> D
<tb> Glycacil <SEP> L <SEP> (marketed <SEP> by <SEP> the <SEP> company <SEP> Lonza) <SEP> 0.2 <SEP>%
<tb> (ie <SEP> 0.02 <SEP>% <SEP> of iodo-3 <SEP> propynyl-2 <SEP> butylcarbamate)
<tb> Water <SEP> distilled <SEP> qsp <SEP> 100 <SEP>%
<Tb>
Procedure: The phases A and B are heated to 70 ° C. and homogenized. Under slow stirring, phase B is slowly poured onto phase A and the mixture is heated to the phase inversion temperature (PIT) which is around 80 C. The resulting water-in-oil emulsion becomes almost -Transparent and very bluish. The heating is stopped and phase C is poured into the emulsion with slow stirring. After cooling to room temperature (20 to 25 ° C.), the emulsion was inverted and phase D was added with slow stirring.

A very fluid oil-in-water emulsion (fluid such as water) is obtained, slightly bluish which can be used as a spray or impregnated on a non-woven support to form a wipe to be applied to the face or the body in view by example of nourishing, moisturizing and firming the skin.

Example 2 Milky Lotion

<Tb>
<tb> Phase <SEP> A
<tb> Oil <SEP> mineral <SEP> 5 <SEP>%
<tb> Ether <SEP> d-caprylic <SEP> (Cetiol <SEP> OE <SEP> of <SEP> the <SEP> Company <SEP> Cognis) <SEP> 3 <SEP>%
<tb><SEP> Mixture of <SEP> Ceteareth-20, <SEP> Ceteareth-12, <SEP> Oil <SEP> of <SEP> Palm
<tb> hydrogenated <SEP> and <SEP> alcohol <SEP> cetearyl
<tb> (Emulgade <SEP> SEV <SEP> of <SEP> the <SEP> Company <SEP> Cognis) <SEP> 3 <SEP>%
<tb> Ceteareth-20 <SEP> (Emulgin <SEP> B2 <SEP> from <SEP> the <SEP> Company <SEP> Cognis) <SEP> 1 <SEP>%
<Tb>

<Desc / Clms Page number 16>

<Tb>
<tb> Phase <SEP> B
<tb> Glycerin <SEP> 5 <SEP>%
<tb> Water <SEP> distilled <SEP> 15 <SEP>%
<tb> Phase <SEP> C
<tb> Oil <SEP> of <SEP> palm <SEP> 0,5 <SEP>%
<tb> Fragrance <SEP> 0.5 <SEP>%
<tb> Phase <SEP> D
<tb> Glycacil <SEP> L <SEP> (from <SEP> the <SEP> company <SEP> Lonza) <SEP> 0.2 <SEP>%
<tb> (ie <SEP> 0.02 <SEP>% <SEP> of iodo-3 <SEP> propynyl-2 <SEP> butylcarbamate)
<tb> Hydrochloride <SEP> of <SEP> polyhexamethylene <SEP> guanide <SEP> 0.5 <SEP>%
<tb> Water <SEP> distilled <SEP> qsp <SEP> 100 <SEP>%
<Tb>
The procedure is the same as for example 1.

We obtain a very fluid oil-in-water emulsion (such as milk), slightly bluish that can be used in spray or impregnated on a support to form a wipe to apply on the face or body.

Claims (44)

 1. A composition for topical application in the form of an oil-in-water emulsion comprising an oily phase dispersed in an aqueous phase, in which the average size of the oil globules ranges from 50 nm to 1000 nm, characterized in that it contains 3-iodo-2-propynylbutylcarbamate. 2. Composition according to Claim 1, characterized in that it is capable of being obtained according to the technique of emulsification by phase inversion. 3. Composition according to claim 1 or 2, characterized in that the average size of the oil globules is from 70 nm to 350 nm. 4. Composition according to any one of the preceding claims, characterized in that 90% of the oil globules have a size ranging from 100 to 300 nm and the difference in size between the largest and the smallest particles ranges from 20 to 400 nm. 5. Composition according to any one of the preceding claims, characterized in that the 3-iodo-2-propynyl butylcarbamate is used in the form of a solution with one or more solvents chosen from fatty acid esters of polyethylene glycol; polyethylene glycols with a molecular weight less than or equal to 450; and their mixtures. 6. Composition according to the preceding claim, characterized in that the solvent is selected from PEG-4, PEG-6, PEG-8, PEG-9, mono-and dicocoates of polyethylene glycol, and mixtures thereof. . 7. Composition according to Claim 5 or 6, characterized in that the 3-iodo-2-propynyl butylcarbamate is used in the form of a mixture with polyethylene glycol monococoate, polyethylene glycol dicocoate and PEG-4. 8. Composition according to any one of the preceding claims, characterized in that the 3-iodo-2-propynylbutylcarbamate is used in solid form, mixed with an alkali metal or alkaline earth metal carbonate or bicarbonate. 9. Composition according to any one of the preceding claims, characterized in that the amount of 3-iodo-2-propynyl butylcarbamate ranges from 0.001 to 10% by weight of active material and preferably from 0.005 to 5% by weight of active ingredient relative to the total weight of the composition. 10. Composition according to any one of the preceding claims, characterized in that the oily phase comprises at least one oil selected from mineral oils; hydrocarbon oils of animal origin; <Desc / Clms Page number 18>  hydrocarbon oils of vegetable origin; synthetic oils; the ethers; benzoates of C12-C15 fatty alcohols; fatty alcohols having from 8 to 26 carbon atoms; acetylglycerides; octanoates and decanoates of alcohols and polyalcohols; ricinoleates of alcohols and polyalcohols; fluorinated and perfluorinated oils; lanolin; hydrogenated lanolin; acetylated lanolin; silicone oils, and mixtures thereof. 11. Composition according to any one of the preceding claims, characterized in that the oily phase contains at least one mineral oil and at least one vegetable oil. 12. Composition according to any one of the preceding claims, characterized in that the oily phase contains at least one emollient selected from dicaprylic ether, dioctylcyclohexane, and mixtures thereof. 13. Composition according to any one of the preceding claims, characterized in that the aqueous phase consists of water, or a mixture of water and one or more water-soluble solvents chosen from polyols, alcohol ( s) water soluble (s) having 1 to 8 carbon atoms, and mixtures thereof. 14. Composition according to any one of the preceding claims, characterized in that the aqueous phase represents from 50 to 95% by weight and preferably from 70 to 90% by weight, relative to the total weight of the composition. 15. Composition according to any one of the preceding claims, characterized in that the oily phase represents from 0.5 to 50% by weight, and preferably from 10 to 30% by weight of the total amount of the composition. 16. Composition according to any one of the preceding claims, characterized in that it contains at least one emulsifier chosen from nonionic compounds consisting on the one hand of a lipophilic residue chosen from alkyl or acyl groups. -Cso and on the other hand a hydrophilic residue chosen from among the polyol groups and the polyol ethers. 17. Composition according to the preceding claim, characterized in that the emulsifier has an HLB balance ranging from 9 to 18. 18. Composition according to Claim 16 or 17, characterized in that the emulsifier is chosen from the group consisting of: the compounds corresponding to formula (li):

 in which R represents a saturated or unsaturated, branched or linear hydrocarbon residue having from 8 to 28 carbon atoms and n represents a number ranging from 8 to 50, preferably from 8 to 30; <Desc / Clms Page number 19>  adducts of 4 to 20 moles of ethylene oxide on one or more partial esters of glycerol; - and their mixtures. 19. Composition according to the preceding claim, characterized in that the emulsifier is chosen from ethylene oxide adducts with behenyl alcohol, cetyl alcohol, stearyl alcohol, and mixtures thereof. 20. Composition according to any one of the preceding claims, characterized in that it additionally contains a co-emulsifier chosen from

 fatty alcohols in C-C or partial esters of po! C 8 -C 8 fatty acids with C -C fatty acids, and mixtures thereof. 21. Composition according to the preceding claim, characterized in that the co-emulsifier is selected from cetyl alcohol, stearyl alcohol, cetearyl alcohol, glyceryl stearate, and mixtures thereof. 22. Composition according to any one of claims 16 to 21, characterized in that the amount of emulsifiers and co-emulsifiers is generally from 0.05 to 30% by weight, preferably from 0.5 to 20% by weight. weight relative to the total weight of the composition. 23. Composition according to any one of the preceding claims, characterized in that it additionally contains at least one additive selected from the group consisting of gelling agents; thickeners; hydrophilic or lipophilic active agents; the perfumes ; conservatives ; sequestering agents pigments; mother-of-pearl; the charges ; soluble dyes; solar filters; alkanizing or acidifying agents; and their mixtures. 24. Composition according to any one of the preceding claims, characterized in that it contains poly-hexamethylene biguanide hydrochloride. 25. Composition according to the preceding claim, characterized in that the poly-hexamethylene biguanide hydrochloride is present in an amount ranging from 0.001 to 5% of the total weight of the composition. 26. Composition according to claim 23, characterized in that it contains one or more active agents selected from antibacterials; keratolytic agents; essential oils ; vitamins; coenzymes; enzymes; yeasts; steroids; anti-oxidants and anti-free radicals; moisturizers; slimming; anti-elastase and anticollagenase agents; oily skin treatment agents; and their mixtures. 27. Composition according to any one of the preceding claims, characterized in that it constitutes a cosmetic or dermatological composition. <Desc / Clms Page number 20> 28. Composition according to any one of the preceding claims, characterized in that it constitutes a care product, protection and / or hygiene for the skin of the face and / or body, hair, scalp. , eyelashes, eyebrows, nails or mucous membranes. 29. Cosmetic use of a cosmetic composition according to any one of claims 1 to 26, for the treatment, protection, care, removal of make-up and / or cleansing of the skin, lips and / or hair. 30. Cosmetic use of a cosmetic composition according to any one of claims 1 to 26, for the make-up of the skin and / or the lips. 31. Cosmetic use of a cosmetic composition according to any one of claims 1 to 26, as a solar product. 32. A method of cosmetic treatment of the skin, including the scalp, hair, eyebrows, nails and / or lips, characterized in that it is applied to the skin, hair, eyebrows, nails and / or the lips, a cosmetic composition according to any one of claims 1 to 26. 33. Use of the composition according to any one of claims 1 to 27 for impregnating a water insoluble substrate. 34. A process for the preparation of a composition according to any one of claims 1 to 27, characterized in that: 1) the oil phase is mixed: (A) the oily phase comprising at least one oil and optionally other oils and fats and liposoluble adjuvants which are stable at the phase inversion temperature, (B) at least one emulsifier and optionally a co-emulsifier, (D) the aqueous phase, this aqueous phase comprising water and optionally water-soluble solvents and water-soluble builders which are stable at the phase inversion temperature, in order to obtain a conventional emulsion, (2) the emulsion is heated to a temperature located inside or above the inversion range of phase where the emulsion is prepared directly at such a temperature, and then (3) the emulsion is cooled and 3-iodo-2-propynylbutylcarbamate and optionally unstable additives or active agents are added at the inversion temperature. we live. An article comprising (A) a water-insoluble substrate, and (B) a composition according to any one of claims 1 to 27, added or impregnated onto the substrate. 36. Article according to the preceding claim, characterized in that the substrate is selected from the group consisting of woven materials, nonwoven materials, foams, sponges, wadding. <Desc / Clms Page number 21> 37. Article according to claim 35 or 36, characterized in that the substrate is a non-woven based on fibers of natural origin or of synthetic origin. 38. Article according to any one of claims 35 to 37, characterized in that it comprises from 200 to 1000% by weight of composition relative to the weight of the substrate. 39. Article according to any one of claims 35 to 38, characterized in that it is in the form of rectangular wipes or round compresses. 40. Article according to any one of claims 35 to 39, characterized in that it constitutes a care wipe and / or treatment of the skin. 41. Article according to any one of claims 35 to 39, characterized in that it constitutes a wipe for cleaning and / or removing makeup from the skin and / or eyes. 42. Cosmetic use of the article according to any one of claims 35 to 39, for the care, cleaning and / or removal of makeup of the skin and / or eyes. 43. A cosmetic process for caring for, cleaning and / or removing make-up from the skin, consisting in passing on the skin, an article according to any one of claims 35 to 39. 44. Use of the 3-iodo-2-propynylbutylcarbamate of a cosmetic and / or dermatological composition in the form of an oil-in-water emulsion in which the average size of the oil globules ranges from 50 nm to 1000 nm.