FR2870126A1 - Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin - Google Patents
Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccinInfo
- Publication number
- FR2870126A1 FR2870126A1 FR0405366A FR0405366A FR2870126A1 FR 2870126 A1 FR2870126 A1 FR 2870126A1 FR 0405366 A FR0405366 A FR 0405366A FR 0405366 A FR0405366 A FR 0405366A FR 2870126 A1 FR2870126 A1 FR 2870126A1
- Authority
- FR
- France
- Prior art keywords
- lentiviral vector
- vaccine
- expression
- applications
- recombinant lentiviral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Utilisation d'un vecteur lentiviral recombinant comprenant un fragment polynucléotidique codant pour au moins une protéine d'un virus de la famille des Flaviviridae ou un peptide immunogène d'au moins 8 acides aminés de ladite protéine, pour la préparation d'une composition pharmaceutique destinée à la prévention et/ou au traitement d'une infection à Flaviviridae chez une espèce sensible.
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0405366A FR2870126B1 (fr) | 2004-05-17 | 2004-05-17 | Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin |
EP11167507.0A EP2371966B1 (fr) | 2004-05-17 | 2005-05-16 | Vecteur de lentivirus recombinant pour l'expression d'une protéine de Flaviviridés et applications associées en tant que vaccin |
MXPA06013388A MXPA06013388A (es) | 2004-05-17 | 2005-05-16 | Vector lentiviral recombinante para la expresion de una proteina flaviviridae y sus aplicaciones como vacuna. |
EP05748053.5A EP1751291B1 (fr) | 2004-05-17 | 2005-05-16 | Vecteur lentiviral recombine utilise dans l'expression d'une proteine flaviviridae et utilisations associees de ce vecteur sous forme de vaccin |
CN200580015744XA CN1981043B (zh) | 2004-05-17 | 2005-05-16 | 用于表达黄病毒科蛋白的重组慢病毒载体及其作为疫苗的应用 |
US11/596,675 US20090214589A1 (en) | 2004-05-17 | 2005-05-16 | Recombinant lentiviral vector for expression of a flaviviridae protein and applications thereof as a vaccine |
PCT/IB2005/001753 WO2005111221A1 (fr) | 2004-05-17 | 2005-05-16 | Vecteur lentiviral recombine utilise dans l'expression d'une proteine flaviviridae et utilisations associees de ce vecteur sous forme de vaccin |
JP2007517517A JP2008508863A (ja) | 2004-05-17 | 2005-05-16 | フラビウイルス科ウイルスタンパク質発現のための組換えレンチウイルスベクター、及びワクチンとしてのそれらの使用 |
BRPI0510016A BRPI0510016B8 (pt) | 2004-05-17 | 2005-05-16 | vetor lentiviral recombinante, composição imunogênica e uso dos mesmos como vacina |
CA2564934A CA2564934C (fr) | 2004-05-17 | 2005-05-16 | Vecteur lentiviral recombine utilise dans l'expression d'une proteine flaviviridae et utilisations associees de ce vecteur sous forme de vaccin |
US12/929,215 US8716013B2 (en) | 2004-05-17 | 2011-01-07 | Recombinant lentiviral vector for expression of a flaviviridae protein and applications thereof as a vaccine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0405366A FR2870126B1 (fr) | 2004-05-17 | 2004-05-17 | Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2870126A1 true FR2870126A1 (fr) | 2005-11-18 |
FR2870126B1 FR2870126B1 (fr) | 2009-07-17 |
Family
ID=34945000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0405366A Expired - Lifetime FR2870126B1 (fr) | 2004-05-17 | 2004-05-17 | Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin |
Country Status (9)
Country | Link |
---|---|
US (2) | US20090214589A1 (fr) |
EP (2) | EP1751291B1 (fr) |
JP (1) | JP2008508863A (fr) |
CN (1) | CN1981043B (fr) |
BR (1) | BRPI0510016B8 (fr) |
CA (1) | CA2564934C (fr) |
FR (1) | FR2870126B1 (fr) |
MX (1) | MXPA06013388A (fr) |
WO (1) | WO2005111221A1 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU784910B2 (en) | 1999-10-12 | 2006-07-27 | Centre National De La Recherche Scientifique | Lentiviral triplex DNA, and vectors and recombinant cells containing lentiviral triplex DNA |
FR2870126B1 (fr) * | 2004-05-17 | 2009-07-17 | Pasteur Institut | Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin |
US8222029B2 (en) * | 2005-05-16 | 2012-07-17 | Institut Pasteur | Lentiviral vector-based vaccine |
CA2508266A1 (fr) | 2005-06-20 | 2006-12-20 | Institut Pasteur | Polypeptides chimeriques et leurs applications therapeutiques contre une infection a flaviviridae |
EP1939214B1 (fr) | 2006-12-22 | 2013-07-10 | Institut Pasteur | Cellules et méthodes pour générer des virus à ARN, non-segmenté et de brin négatif |
GB0701253D0 (en) | 2007-01-23 | 2007-02-28 | Diagnostics For The Real World | Nucleic acid amplification and testing |
AU2009240011A1 (en) * | 2008-04-22 | 2009-10-29 | Cytos Biotechnology Ag | Vaccine compositions for the treatment of dengue fever and uses thereof |
EP2666477A1 (fr) | 2012-05-23 | 2013-11-27 | Theravectys | Vecteurs lentiviraux contenant un promoteur du MHC classe I |
WO2012021741A2 (fr) * | 2010-08-12 | 2012-02-16 | Clontech Laboratories, Inc. | Dosages à flux latéral pour analytes non diagnostiqués |
EP3031923A1 (fr) * | 2014-12-11 | 2016-06-15 | Institut Pasteur | Composition immunogène contre l'encéphalite japonaise à base de vecteurs lentiviraux |
CA3003890A1 (fr) | 2015-11-09 | 2017-05-18 | Immune Design Corp. | Compositions comprenant des vecteurs lentiviraux exprimant l'il-12 et leurs methodes d'utilisation |
EP3184119A1 (fr) | 2015-12-23 | 2017-06-28 | Themis Bioscience GmbH | Chromatographie basée sur des stratégies de purification pour les virus de la rougeole basés sur un échafaudage |
US11305003B2 (en) | 2017-11-09 | 2022-04-19 | Institut Pasteur | Zika virus chimeric polyepitope comprising non-structural proteins and its use in an immunogenic composition |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2777909A1 (fr) * | 1998-04-24 | 1999-10-29 | Pasteur Institut | Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex |
WO2000075665A1 (fr) * | 1999-06-09 | 2000-12-14 | Institut Pasteur | Detection precoce des flavivirus en utilisant la clycoproteine ns1 |
EP1092779A1 (fr) * | 1999-10-11 | 2001-04-18 | Institut Pasteur | Vecteurs lentiviraux pour la préparation des compositions immunothérapeutiques |
US20030104611A1 (en) * | 1998-01-16 | 2003-06-05 | Johnston Julie C. | Feline immunodeficiency virus gene therapy vectors |
CA2456873A1 (fr) * | 2003-02-26 | 2004-08-26 | Centre National De La Recherche Scientifique (C.N.R.S.) | Proteines du virus du nil occidental, genes codant celles-ci et applications vaccinales, therapeutiques et diagnostiques a base de celles-ci |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0586065B1 (fr) * | 1992-07-16 | 2010-03-24 | Advanced Life Science Institute, Inc | Peptides antigéniques pour grouper le virus de l'hépatite C, nécessaire et méthodes |
US5883081A (en) * | 1995-07-26 | 1999-03-16 | The Regents Of The University Of California | Isolation of novel HIV-2 proviruses |
US5888767A (en) * | 1996-11-27 | 1999-03-30 | The Johns Hopkins University School Of Medicine | Method of using a conditionally replicating viral vector to express a gene |
WO1998017815A1 (fr) | 1996-10-17 | 1998-04-30 | Oxford Biomedica (Uk) Limited | Vecteurs retroviraux |
JP4578678B2 (ja) | 1997-12-22 | 2010-11-10 | オックスフォード バイオメディカ(ユーケー)リミテッド | ウマ伝染性貧血ウイルス(eiav)系 |
US7052830B1 (en) * | 1998-06-09 | 2006-05-30 | Branch Andrea D | Hepatitis C virus peptides and uses thereof |
AU4554899A (en) | 1998-06-09 | 1999-12-30 | Andrea D. Branch | Novel hepatitis c virus peptides and uses thereof |
AU784910B2 (en) | 1999-10-12 | 2006-07-27 | Centre National De La Recherche Scientifique | Lentiviral triplex DNA, and vectors and recombinant cells containing lentiviral triplex DNA |
EP1092780A1 (fr) | 1999-10-13 | 2001-04-18 | Boehringer Ingelheim International GmbH | Virus CELO recombinant et incapable de replication ainsi que l'ADN du virus CELO |
ATE428725T1 (de) | 2001-04-04 | 2009-05-15 | Pasteur Institut | Neurovirulenter stamm des west-nile-virus und anwendungen davon |
US20040037848A1 (en) * | 2001-04-06 | 2004-02-26 | Audonnet Jean-Christophe Francis | Recombinant vaccine against West Nile Virus |
BRPI0211492B1 (pt) | 2001-07-27 | 2016-06-21 | Pah W Llc | "composição de vacina para uso na prevenção ou melhora de encefalite de west nile em equídeos, e uso de um componente imunogenicamente ativo na preparação da mesma |
JP4580650B2 (ja) | 2002-01-10 | 2010-11-17 | アメリカ合衆国 | 西ナイルウイルスにより引き起こされる疾患を予防するために生ウイルスワクチン中に用いるための西ナイルウイルスおよびデングウイルスキメラの構築 |
SG165155A1 (en) * | 2002-02-26 | 2010-10-28 | Maxygen Inc | Novel flavivirus antigens |
US20030194392A1 (en) * | 2002-04-10 | 2003-10-16 | Pierre Charneau | Lentiviral triplex DNA, and vectors and recombinant cells containing lentiviral triplex DNA |
DE10249594A1 (de) * | 2002-10-24 | 2004-05-13 | Jassoy, Christian, Dr. | Immunisierung gegen Bestandteile des Humanen Immunschwächevirus (HIV) |
CA2432738A1 (fr) * | 2003-02-26 | 2004-08-26 | Philippe Despres | Nouvelles proteines des virus de la dengue et du nil et genes codant pour ces proteines, et leurs utilisations dans des vaccins et dans des applications therapeutiques et diagnostiques |
FR2870126B1 (fr) * | 2004-05-17 | 2009-07-17 | Pasteur Institut | Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin |
US8158413B2 (en) * | 2005-10-17 | 2012-04-17 | Institut Pasteur | Lentiviral vector-based vaccine |
US8222029B2 (en) * | 2005-05-16 | 2012-07-17 | Institut Pasteur | Lentiviral vector-based vaccine |
-
2004
- 2004-05-17 FR FR0405366A patent/FR2870126B1/fr not_active Expired - Lifetime
-
2005
- 2005-05-16 CA CA2564934A patent/CA2564934C/fr active Active
- 2005-05-16 MX MXPA06013388A patent/MXPA06013388A/es active IP Right Grant
- 2005-05-16 JP JP2007517517A patent/JP2008508863A/ja active Pending
- 2005-05-16 EP EP05748053.5A patent/EP1751291B1/fr active Active
- 2005-05-16 CN CN200580015744XA patent/CN1981043B/zh active Active
- 2005-05-16 WO PCT/IB2005/001753 patent/WO2005111221A1/fr active Application Filing
- 2005-05-16 BR BRPI0510016A patent/BRPI0510016B8/pt active IP Right Grant
- 2005-05-16 US US11/596,675 patent/US20090214589A1/en not_active Abandoned
- 2005-05-16 EP EP11167507.0A patent/EP2371966B1/fr active Active
-
2011
- 2011-01-07 US US12/929,215 patent/US8716013B2/en active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030104611A1 (en) * | 1998-01-16 | 2003-06-05 | Johnston Julie C. | Feline immunodeficiency virus gene therapy vectors |
FR2777909A1 (fr) * | 1998-04-24 | 1999-10-29 | Pasteur Institut | Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex |
WO1999055892A1 (fr) * | 1998-04-24 | 1999-11-04 | Institut Pasteur | Utilisation de sequences d'adn de structure triplex pour le transfert de sequences nucleotidiques |
WO2000075665A1 (fr) * | 1999-06-09 | 2000-12-14 | Institut Pasteur | Detection precoce des flavivirus en utilisant la clycoproteine ns1 |
EP1092779A1 (fr) * | 1999-10-11 | 2001-04-18 | Institut Pasteur | Vecteurs lentiviraux pour la préparation des compositions immunothérapeutiques |
CA2456873A1 (fr) * | 2003-02-26 | 2004-08-26 | Centre National De La Recherche Scientifique (C.N.R.S.) | Proteines du virus du nil occidental, genes codant celles-ci et applications vaccinales, therapeutiques et diagnostiques a base de celles-ci |
Non-Patent Citations (2)
Title |
---|
BARTOSCH B ET AL: "Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 197, no. 5, 3 March 2003 (2003-03-03), pages 633 - 642, XP002267934, ISSN: 0022-1007 * |
COLOMBAGE G ET AL: "DNA-Based and Alphavirus-Vectored Immunisation with PrM and E Proteins Elicits Long-Lived and Protective Immunity against the Flavivirus, Murray Valley Encephalitis Virus", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 250, no. 1, 10 October 1998 (1998-10-10), pages 151 - 163, XP004445627, ISSN: 0042-6822 * |
Also Published As
Publication number | Publication date |
---|---|
EP1751291A1 (fr) | 2007-02-14 |
CA2564934C (fr) | 2014-07-08 |
BRPI0510016B1 (pt) | 2020-03-10 |
WO2005111221A1 (fr) | 2005-11-24 |
MXPA06013388A (es) | 2007-06-19 |
FR2870126B1 (fr) | 2009-07-17 |
EP2371966A1 (fr) | 2011-10-05 |
CA2564934A1 (fr) | 2005-11-24 |
US8716013B2 (en) | 2014-05-06 |
CN1981043B (zh) | 2010-06-09 |
BRPI0510016B8 (pt) | 2021-05-25 |
CN1981043A (zh) | 2007-06-13 |
EP2371966B1 (fr) | 2015-11-25 |
US20090214589A1 (en) | 2009-08-27 |
EP1751291B1 (fr) | 2013-07-31 |
BRPI0510016A (pt) | 2007-09-18 |
US20110206710A1 (en) | 2011-08-25 |
JP2008508863A (ja) | 2008-03-27 |
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