FR2790671A1 - Disinfecting tissue for various surfaces and skin is impregnated with mixture of antibiotic of polymyxin, aminoglycosides or lincosanides family and anti-fungal agent, in physiological solution - Google Patents

Abstract

The impregnating mixture consists of a mixture of antibiotic of polymyxin, aminoglycosides or lincosanides family and anti-fungal agent, in physiological solution. The tissue is impregnated with a mixture consisting of (a) one or more polyhydric alcohols, (b) one or more liquefying solvents, (c) (meth)acrylate-based polymer, and (d) water. The tissue is made of natural or synthetic fibers, has the form of woven or nonwoven fabric, and contains 100-200 g of impregnating mixture per 1 m<2>. Tissue can be additionally impregnated with one or more softeners, fresheners, healing agents, perfumes and other aseptic substances and hydrating agents. Independent claims are also included for (1) the use of tissue as claimed for disinfection of surfaces and (2) the use of tissue as claimed for disinfection of skin.

Description

i Disinfectant wipe The present invention relates to the field of

disinfection, and in particular

disinfectant wipes, usable in particular for the skin.

There are currently on the market various types of cleaning and / or refreshing wipes, as well as wipes for applying a disinfectant product to

ethanol based.

In the case of disinfectant wipes, the impregnation product is a mixture containing mainly ethanol (of the order of 30%), one or more surfactants, and

one or more preservative (s).

To be effective, any preservative must act chemically by destroying either the cell wall or the biochemical mechanisms of microbial cells. It is not surprising that these same biocidal molecules sometimes have a harmful effect on human cells with which they come into contact, particularly in the mucous membranes. It is a fact that with the increase in the consumption of cosmetic, dermopharmaceutical and cleansing products, there is a parallel increase in cases of intolerance (irritation, allergy) towards these products. The analyzes carried out by various dermatologists, pharmacists, or health authorities, reveal that a certain number of these incidents can be attributed to the preservatives contained

in said products.

In addition, the ecological trend of our time reinforces the desire of industries to offer "natural", "soft", or "hypoallergenic" products. We are therefore looking for a way to avoid incorporating preservatives; and if only the disinfectant action is

desired, also to avoid the presence of surfactants, ionic or nonionic.

In addition, the ethanol mainly impregnating current disinfectant wipes is very volatile, it is therefore imperative to keep them in a closed packaging: dispenser, box to be closed immediately after removing a wipe, or individual sealed pouch, and it is necessary to keep them in a closed packaging. necessary to use them quickly (a few minutes) after opening. In addition, ethanol is well known to cause drying out

of the skin by dissolving the superficial sebum layer.

The object of the present invention is therefore to remedy the drawbacks of current disinfectant wipes by providing a disinfectant wipe impregnated with a mixture which does not contain any surfactant, does not require the presence of preservative, does not contain ethanol or other alcohol. volatile, and endowed with a remarkable moisturizing power for the skin. Another object of the invention is also to provide a disinfectant wipe impregnated with a mixture of which the components are very little volatile, making it possible to extend its duration of use, and not requiring strictly sealed storage with respect to

the external environment.

These objects are obtained according to the present invention, thanks to a disinfectant wipe impregnated with a mixture consisting of - one or more polyhydric alcohols, - one or more thinning solvents,

- a polymer based (meth) acrylate, and water.

Preferably, the (meth) acrylate-based polymer is a derivative of acrylic and / or methacrylic acid and is in the form of a salt, an ester or an amide of these acids. The impregnation mixture preferably contains a fluidifying solvent corresponding to formula (1): Rl -O- (R2-O-R2) n -OR3 (1) o RI is a hydrogen atom or a linear alkyl chain or branched C1 to C5, R2 is a linear or branched C1 to Cs alkyl chain and R3 is a hydrogen atom or a linear or branched C1 to C5 alkyl chain and n is an integer between I and 200,000. This solvent is advantageously chosen from ethoxy diglycol and

polyethylene glycol.

The polyhydric alcohol can be chosen from propylene glycol, 1,2butylene glycol, 1,3-butylene glycol, hexylene glycol, 1,8octanediol, ethylhexylglycol,

glycerin, sorbitol, and a C8 to C8 alkyl 1,2-diol.

The polyhydric alcohol according to the invention can advantageously be a combination of glycerin and a C5 to C8 alkyl 1,2-diol, such as 1,2-pentanediol, I, 2-hexanediol, 1 , 2-heptanediol, or 1,2octanediol, the latter being more

particularly preferred.

All the constituents of this mixture are molecules with a high boiling point; they are therefore much less volatile than the ethanol used until now in disinfectant wipes. The wipe according to the present invention can be composed of natural fibers or

synthetic, woven or non-woven.

Advantageously, the amount of the impregnation mixture is included

between 100 g and 200 g, per square meter of wipe.

Such a disinfectant wipe can also be impregnated with one or more substance (s) from emollient, refreshing, perfuming substances,

healing, and other aseptic and moisturizing substances.

A preferred composition of the impregnation mixture according to the invention consists of a glycerin concentration of between approximately 1 and 30% (preferably approximately 5 and 10%), a 1,2-octanediol concentration of between approximately 0.01 and 10% (preferably 0.5 and 3% approximately), a concentration of fluidifying between approximately 0.1 and% (preferably 1 to 5% approximately), and a concentration of polymer

((meth) acrylate) between approximately 0.01 and 2% (preferably approximately 0.1 and 1%).

These percentages are expressed by weight, relative to the total weight of the mixture.

impregnation.

The wipe according to the invention can be used to disinfect any surface, for example bathroom, toilet, or telephone handset. It is particularly effective for disinfecting the skin, face and body and in particular the hands. The impregnation composition is free of preservative (s) and surfactant (s)

The following example illustrates the invention, without limiting it.

Wipes impregnated with 3 g of a mixture according to the invention having the following composition: - glycerin between approximately 1 and 30% - 1,2-octanediol between approximately 0.01 and 10% - fluidifying between approximately 0.1 and 10 %

- (meth) acrylate polymer between approximately 0.01 and 2% by weight.

Principle and performance of the test On a panel of 16 volunteers, drawn up at random, one of the wipes is applied to a previously determined area of the inner forearm of approximately 8 cm by 10 cm. The arm is indifferently the right arm or the left arm of each

topic. The other arm is not receiving any treatment.

After 15 minutes, one of the two sides of a Uricult slide (FAMOUZE Laboratories) covered with Cled agar or Mac Conkey agar is applied to the skin. This Uricult blade is then turned over to bring the second medium into contact.

of culture with the skin of the remainder of the predefined surface.

The same process is applied to the other arm with a second Uricult blade. After 48 hours of incubation at 37 C, the colonies developed on each agar

are counted.

Results The number of colonies found therefore corresponds to the number of germs present

on the skin at the time of contact collection.

Cled Nutrient Agar allows the growth of all microorganisms except Proteus whose growth is inhibited by a low electrolyte content. MacConkey agar, on the other hand, inhibits the growth of Gram-positive organisms (except enterococci) and therefore constitutes an excellent medium.

isolation of Gram-negative organisms, including Proteus.

It can be seen that the bactericidal effect of the wipe according to the invention after 15 minutes of contact with the skin is highly significant both on Gram-negative germs only: reduction of 96% (with probability p <0.01) and on l '' all Gram-positive and Gram-negative bacteria in the skin: 85% reduction

(p <0.0001), compared to the skin of the control forearm.

Claims (12)

1 - Disinfectant wipe impregnated with a mixture consisting of - one or more polyhydric alcohols, - one or more thinning solvents, - a polymer based (meth) acrylate, and water. 2 - Wipe according to claim 1, characterized in that the polymer based (meth) acrylate is a derivative of acrylic and / or methacrylic acid and is in form of a salt, ester or amide of these acids. 3 - Wipe according to claim 1 or 2, characterized in that the fluidifying solvent corresponds to the following formula: Ri - O - (R2 - O R2) n - OR3 (1) o RI is a hydrogen atom or a chain linear or branched C1 to C5 alkyl, R2 is a linear or branched C1 to Cs alkyl chain and R3 is a hydrogen atom or a linear or branched C1 to C5 alkyl chain and n is an integer included between 1 and 200,000. 4 - Wipe according to claim 3 characterized in that the fluidifying solvent is chosen from ethoxydiglycol and polyethylene glycol. - Wipe according to any one of the preceding claims, characterized in that the polyhydric alcohol is chosen from propylene glycol, 1,2- butylene glycol, 1,3-butylene glycol, hexylene glycol, 1,8octanediol, ethylhexylglycol, glycerin, sorbitol, and a Cs5 to CS alkyl 1,2-diol. 6 - Wipe according to claim 5, characterized in that the mixture comprises glycerin and a 1,2 C5 to C8 alkyl diol as alcohols polyhydric. 7 - Wipe according to claim 6, characterized in that the C5 alkyl diol at C8 is 1,2-octanediol. 8 - Wipe according to claim 7, characterized in that, in the mixture, the glycerin concentration is between approximately 1 and 30%, that of 1,2-octanediol approximately between 0.01 and 10%, that of the thinner approximately between 0.1 and 10%, and that of (meth) acrylate polymer approximately between 0.01 and 2% by weight. 9 - Wipe according to claim 8, characterized in that, in the mixture, the concentration of glycerin is between approximately 5 and 10%, that of 1,2-octanediol between approximately 0.5 and 3%, that of the thinner approximately between 1 and 5% and that of the polymer between 0.1 and 1% approximately by weight. - Wipe according to any one of the preceding claims, characterized in that it is composed of natural or synthetic fibers, woven or non-woven. 11 - Wipe according to any one of the preceding claims, characterized in that the amount of the impregnation mixture is between 100 g and g per square meter of wipe. 12 - Wipe according to any one of the preceding claims, characterized in that it is further impregnated with one or more substance (s) from emollient, refreshing, perfuming, healing, and other substances aseptic and moisturizing substances. 13 - Use of the wipe according to any one of claims previous to surface disinfection. 14 - Use of the wipe according to any one of claims previous to skin disinfection.