Nothing Special   »   [go: up one dir, main page]

FR2694559B1 - Nouveaux dérivés amphiphiles d'aminoacides ou de peptides, leur procédé de préparation et leur utilisation dans des préparations à usage biomédical. - Google Patents

Nouveaux dérivés amphiphiles d'aminoacides ou de peptides, leur procédé de préparation et leur utilisation dans des préparations à usage biomédical.

Info

Publication number
FR2694559B1
FR2694559B1 FR9209776A FR9209776A FR2694559B1 FR 2694559 B1 FR2694559 B1 FR 2694559B1 FR 9209776 A FR9209776 A FR 9209776A FR 9209776 A FR9209776 A FR 9209776A FR 2694559 B1 FR2694559 B1 FR 2694559B1
Authority
FR
France
Prior art keywords
peptides
preparations
amino acids
preparation process
biomedical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9209776A
Other languages
English (en)
Other versions
FR2694559A1 (fr
Inventor
Leila Zarif
Andre A Pavia
Bernard Pucci
Jean G Riess
Camille Guedj
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ATTA
Original Assignee
ATTA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ATTA filed Critical ATTA
Priority to FR9209776A priority Critical patent/FR2694559B1/fr
Priority to US08/100,688 priority patent/US5446023A/en
Priority to CA002141581A priority patent/CA2141581A1/fr
Priority to EP93917762A priority patent/EP0655069B1/fr
Priority to DE69326954T priority patent/DE69326954T2/de
Priority to AU47081/93A priority patent/AU674157B2/en
Priority to PCT/EP1993/002098 priority patent/WO1994003468A1/fr
Priority to ES93917762T priority patent/ES2141164T3/es
Priority to JP6505023A priority patent/JPH07509709A/ja
Publication of FR2694559A1 publication Critical patent/FR2694559A1/fr
Application granted granted Critical
Publication of FR2694559B1 publication Critical patent/FR2694559B1/fr
Priority to US08/470,140 priority patent/US5637564A/en
Priority to US08/480,143 priority patent/US5650393A/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/734—Fullerenes, i.e. graphene-based structures, such as nanohorns, nanococoons, nanoscrolls or fullerene-like structures, e.g. WS2 or MoS2 chalcogenide nanotubes, planar C3N4, etc.
    • Y10S977/735—Carbon buckyball
    • Y10S977/737—Carbon buckyball having a modified surface
    • Y10S977/738—Modified with biological, organic, or hydrocarbon material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/895—Manufacture, treatment, or detection of nanostructure having step or means utilizing chemical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y10S977/907—Liposome
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nanotechnology (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9209776A 1992-08-06 1992-08-06 Nouveaux dérivés amphiphiles d'aminoacides ou de peptides, leur procédé de préparation et leur utilisation dans des préparations à usage biomédical. Expired - Fee Related FR2694559B1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR9209776A FR2694559B1 (fr) 1992-08-06 1992-08-06 Nouveaux dérivés amphiphiles d'aminoacides ou de peptides, leur procédé de préparation et leur utilisation dans des préparations à usage biomédical.
US08/100,688 US5446023A (en) 1992-08-06 1993-08-02 Amphiphilic compounds derived from amino acids or peptides, their methods of synthesis and their application as drug delivery systems
ES93917762T ES2141164T3 (es) 1992-08-06 1993-08-05 Compuestos amfifilicos derivados de aminoacidos o de peptidos, sus metodos de sintesis y su aplicacion como sistemas de transporte de farmacos.
DE69326954T DE69326954T2 (de) 1992-08-06 1993-08-05 Amphiphile verbindungen abgegleitet von aminosäuren oder peptiden, verfahren zu ihrer herstellung und ihre verwendung als arzeimittelverabreichung
AU47081/93A AU674157B2 (en) 1992-08-06 1993-08-05 Amphiphilic compounds derived from amino acids or peptides, their methods of synthesis and their application as drug delivery systems
PCT/EP1993/002098 WO1994003468A1 (fr) 1992-08-06 1993-08-05 Composes amphiphiles derives d'acides amines ou de peptides, leurs procedes de synthese et leur application comme systemes d'apport de medicament
CA002141581A CA2141581A1 (fr) 1992-08-06 1993-08-05 Composes amphiphiles derives d'acides amines ou de peptides; methode de synthese de ces composes et leur utilisation comme systemes de liberation de medicaments
JP6505023A JPH07509709A (ja) 1992-08-06 1993-08-05 アミノ酸またはペプチドから誘導された両親媒性化合物，その合成方法およびその薬剤分配系としての応用
EP93917762A EP0655069B1 (fr) 1992-08-06 1993-08-05 Composes amphiphiles derives d'acides amines ou de peptides, leurs procedes de synthese et leur application comme systemes d'apport de medicament
US08/470,140 US5637564A (en) 1992-08-06 1995-06-06 Amphiphilic compounds derived from amino acids or peptides, their methods of synthesis and their application as drug delivery systems
US08/480,143 US5650393A (en) 1992-08-06 1995-06-07 Amphiphilic compounds derived from amino acids or peptides, their methods of synthesis and their application as drug delivery systems

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9209776A FR2694559B1 (fr) 1992-08-06 1992-08-06 Nouveaux dérivés amphiphiles d'aminoacides ou de peptides, leur procédé de préparation et leur utilisation dans des préparations à usage biomédical.

Publications (2)

Publication Number Publication Date
FR2694559A1 FR2694559A1 (fr) 1994-02-11
FR2694559B1 true FR2694559B1 (fr) 1994-10-28

Family

ID=9432682

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9209776A Expired - Fee Related FR2694559B1 (fr) 1992-08-06 1992-08-06 Nouveaux dérivés amphiphiles d'aminoacides ou de peptides, leur procédé de préparation et leur utilisation dans des préparations à usage biomédical.

Country Status (9)

Country Link
US (3) US5446023A (fr)
EP (1) EP0655069B1 (fr)
JP (1) JPH07509709A (fr)
AU (1) AU674157B2 (fr)
CA (1) CA2141581A1 (fr)
DE (1) DE69326954T2 (fr)
ES (1) ES2141164T3 (fr)
FR (1) FR2694559B1 (fr)
WO (1) WO1994003468A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
FR2694559B1 (fr) * 1992-08-06 1994-10-28 Atta Nouveaux dérivés amphiphiles d'aminoacides ou de peptides, leur procédé de préparation et leur utilisation dans des préparations à usage biomédical.
US5670483A (en) * 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5955343A (en) * 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
WO1995027770A1 (fr) * 1994-04-08 1995-10-19 Unilever Plc Compositions detergentes contenant des aldobionamides
FR2720943B1 (fr) * 1994-06-09 1996-08-23 Applic Transferts Technolo Emulsions inverses stables à forte concentration en composé(s) fluoré(s) et leur utilisation pour l'administration pulmonaire de médicaments et pour la fabrication d'émulsions multiples.
US5562893A (en) * 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
US5965109A (en) * 1994-08-02 1999-10-12 Molecular Biosystems, Inc. Process for making insoluble gas-filled microspheres containing a liquid hydrophobic barrier
US5861174A (en) * 1996-07-12 1999-01-19 University Technology Corporation Temperature sensitive gel for sustained delivery of protein drugs
TW570805B (en) * 1998-09-01 2004-01-11 Hoffmann La Roche Water-soluble pharmaceutical composition in an ionic complex
AU1830200A (en) 1998-11-25 2000-06-13 Vanderbilt University Cationic liposomes for gene transfer
EP1233752B1 (fr) 1999-11-30 2005-01-26 The Arizona Board of Regents on behalf of The University of Arizona Liposomes radiosensibles
KR20030051680A (ko) 2000-09-26 2003-06-25 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 이산화탄소에 대해 사용되는 인산 플루오로계면활성제
EA006860B1 (ru) * 2002-01-29 2006-04-28 Уайт Композиции и способы модулирования гемиканалов коннексина
FR2846969A1 (fr) * 2002-11-08 2004-05-14 Salles Jean Pierre Nouveaux vecteurs moleculaires amphiphiles fluorocarbones a usage biomedical et medical
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
CN1993357B (zh) 2004-07-02 2011-10-19 伯拉考成像股份公司 用于磁共振成像(mri)的含有具有多羟基化取代基的螯合部分的高弛豫造影剂
EP3434259A1 (fr) 2007-05-04 2019-01-30 Marina Biotech, Inc. Lipides d'acides aminés et utilisations associées
EP2276726A1 (fr) 2008-04-18 2011-01-26 University of Connecticut Composés pour modulation lysosomale et procédés d utilisation
EP2532649B1 (fr) * 2011-06-07 2015-04-08 Incella GmbH Lipides aminés, leur synthèse et utilisations associées
CN103987847B (zh) * 2011-10-18 2017-06-16 迪克纳制药公司 胺阳离子脂质及其用途
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria
CN113549128B (zh) * 2020-04-24 2023-03-31 华东师范大学 含氟烷基链连接的多肽及其在多肽胞内递送中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785152A (en) * 1953-04-13 1957-03-12 Nat Dairy Prod Corp Aldonyl amides of amino acid esters
US2830983A (en) * 1955-05-31 1958-04-15 Ca Nat Research Council Preparation of amino alcohols
CH642068A5 (fr) * 1979-03-14 1984-03-30 Rech Syntheses Organ Cyano-urees et cyano-thiourees therapeutiquement actives.
FR2602774B1 (fr) * 1986-07-29 1990-10-19 Atta Nouvelles molecules amphiphiles polyhydroxylees et perfluoroalkylees ayant des proprietes tensioactives
US5416070A (en) * 1988-07-08 1995-05-16 Immunotherapeutics, Inc. Composition for macrophage activation
US4950645A (en) * 1988-07-08 1990-08-21 Immunotherapeutics, Inc. Composition for macrophage activation
AU639008B2 (en) * 1989-06-22 1993-07-15 Alliance Pharmaceutical Corporation Fluorine and phosphorous-containing amphiphilic molecules with surfactant properties
FR2694559B1 (fr) * 1992-08-06 1994-10-28 Atta Nouveaux dérivés amphiphiles d'aminoacides ou de peptides, leur procédé de préparation et leur utilisation dans des préparations à usage biomédical.

Also Published As

Publication number Publication date
US5637564A (en) 1997-06-10
WO1994003468A1 (fr) 1994-02-17
JPH07509709A (ja) 1995-10-26
FR2694559A1 (fr) 1994-02-11
ES2141164T3 (es) 2000-03-16
EP0655069B1 (fr) 1999-11-03
CA2141581A1 (fr) 1994-02-17
DE69326954T2 (de) 2000-03-30
AU4708193A (en) 1994-03-03
DE69326954D1 (de) 1999-12-09
US5650393A (en) 1997-07-22
EP0655069A1 (fr) 1995-05-31
US5446023A (en) 1995-08-29
AU674157B2 (en) 1996-12-12

Similar Documents

Publication Publication Date Title
FR2694559B1 (fr) Nouveaux dérivés amphiphiles d'aminoacides ou de peptides, leur procédé de préparation et leur utilisation dans des préparations à usage biomédical.
DZ2666A1 (fr) Dérivés d'acide hydroxamique compositions pharmaceutiques les contenant et procédé pour leur préparation.
EE04021B1 (et) 7a-( -aminoalküül)östratrieenid, nende valmistamise meetod, 7a-( -aminoalküül)östratrieene sisaldavad farmatseutilised preparaadid ja nende kasutamine ravimite valmistamiseks
EP1025840A3 (fr) Compositions et procedes d'administration de medicaments par voie orale
FR2707882B1 (fr) Nouveaux kits thérapeutiques anti-médiateurs protéiques, procédé de préparation et compositions pharmaceutiques les renfermant.
DZ2420A1 (fr) Formulations nouvelles comprenant l'amoxycilline et du clavulanate et procédé pour leur préparation.
OA08694A (fr) Acides 3-pyrrolidinylthio-1-azabicyclo [3.2.0] -hept-2-ène-2-carboxyliques et procédés pour leur préparation.
DZ2227A1 (fr) Dérivés d'indole nouveaux, procédé pour leur préparation et formulations pharmaceutiques les contenant.
FR2701948B1 (fr) Produit de couplage de l'histamine ou l'histamine méthyl-substituée et d'un acide aminé, procédé de préparation et applications thérapeutiques, cosmétologiques et agroalimentaires.
DZ2624A1 (fr) Dérivés d'isoquinoléine nouveaux procédé pour leur préparation et compositions pharmaceutiques les contenant.
ATE237610T1 (de) Substituierte dimere carboxamid-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
EP0277612A3 (en) Substituted 3,4-dihydro-2h-benzopyranes, process for their preparation, their use and pharmaceutical preparations based on these compounds
TR199903192T2 (xx) Eritropoetin, de�i�tirilmi� hemoglobin i�eren farmasotik kombine m�stahzarlar.
FR2628973B1 (fr) Composition cosmetique ou pharmaceutique a usage cutane, et procede pour la preparation d'une telle composition
HU902004D0 (en) New trombolitic preparations
EE9600109A (et) a-amino- ja tsüklopentaan-ß-aminohapet(-happeid) ja/või nende derivaate sisaldavad segud ja dipeptiidid, dipeptiidide valmistamismeetod ning nimetatud segusid ja/või dipeptiide sisaldavad ravimid
FR2701847B1 (fr) Compositions pharmaceutiques et cosmétiques à base d'albumine végétale, préparations contenant de telles compositions et procédé de préparation.
FI960688A (fi) Substituoituja bentseenisulfonyyliureoita ja -tioureoita, menetelmä niiden valmistamiseksi ja näihin yhdisteisiin perustuvien farmaseuttisten valmisteiden käyttö sekä niitä sisältäviä lääkkeitä
OA07270A (fr) Dérivés N-(vinblastinoyl-23) d'acide aminés, leur préparation et leur application thérapeutique.
FR2696467B1 (fr) Procédé de préparation de monoesters d'acides gras du D-fructose et leur utilisation dans les domaines cosmétique, bucco-dentaire, pharmaceutique et alimentaire.
ATE57935T1 (de) 16,17-acetalsubstituierte pregnan-21-saeure, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate.
FR2720944B1 (fr) Composition thérapeutique ou diététique sous forme de gel médicamenteux pour l'administration à des animaux de compagnie.
RU95105249A (ru) Гидрохлорид ng монометил-l-аргинина, способы его получения, способ получения фармацевтического препарата и способ лечения
FR2595703B1 (fr) Nouveaux phospholipides, leur procede et les intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2733913B1 (fr) Sequence d'adn a titre de medicament, et compositions pharmaceutiques en contenant

Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse