FR2590169A1 - Cosmetic composition containing biostimulins - Google Patents
Cosmetic composition containing biostimulins Download PDFInfo
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- FR2590169A1 FR2590169A1 FR8517166A FR8517166A FR2590169A1 FR 2590169 A1 FR2590169 A1 FR 2590169A1 FR 8517166 A FR8517166 A FR 8517166A FR 8517166 A FR8517166 A FR 8517166A FR 2590169 A1 FR2590169 A1 FR 2590169A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
Description
La présente invention a pour objet une composition cosmétique contenant des bio-stimulines. The present invention relates to a cosmetic composition containing bio-stimulins.
Il a été constaté que des extraits de rate notamment des extraits de rate de bovins, exercent un effet activateur sur la respiration cellulaire et ont la propriété de favoriser la croissance et la régénération cellulaire . I1 semble que cet effet activateur des extraits de rate résulte du fait qu'ils renferment des biostimulines qui sont des substances dont la structure n'est pas encore élucidée, produites dans certains organes des mammifères, en réponse à des stimulations physiologiques. It has been found that spleen extracts, in particular extracts from bovine spleen, have an activating effect on cellular respiration and have the property of promoting cell growth and regeneration. It seems that this activating effect of the spleen extracts results from the fact that they contain biostimulins which are substances whose structure is not yet elucidated, produced in certain mammalian organs, in response to physiological stimulations.
Les propriétés susmentionnées sont susceptibles d'être mises à profit, en cosmétologie, pour la dégradation des ex cds de déchets et la restauration des tissus de synthèse de nouveaux matériaux, en favorisant ainsi l'amélioration et l'optimalisation de l'état général de la peau, par régularisation des fonctions cutanées.The aforementioned properties are likely to be used, in cosmetology, for the degradation of waste ex cds and the restoration of synthetic fabrics of new materials, thereby promoting the improvement and optimization of the general state of the art. the skin, by regularization of the cutaneous functions.
En conséquence, il a été proposé d'incorporer dans des compositions cosmétiques une certaine quantité d'extrait de rate de bovin, notamment un produit ayant la composition suivante (en pourcentage pondéral) :
Extrait protéolysé de rate en
milieu hydroglycériné 99,65 %
2-méthyl-4-isothiazoline-3-one +
dérivé chloré (solutiqn.a 1,5 %) 0,30 %
2-bromo-2-nitropropane-1,3-diol 0,05 %
Ce produit a été enregistre notamment auprès de la
FDA (Food and Drug Administration) en date du 23 juin 1982, sous le nO FDA : CRMCS R 001 4092 et il est commercialisé sous la dénomination d'OXYDERMINE.As a result, it has been proposed to incorporate in cosmetic compositions a certain amount of bovine spleen extract, in particular a product having the following composition (in percentage by weight):
Proteolysed extract of spleen
Hydroglycerine medium 99.65%
2-methyl-4-isothiazolin-3-one +
chlorinated derivative (1.5% solution) 0.30%
2-bromo-2-nitropropane-1,3-diol 0.05%
This product has been registered in particular with the
FDA (Food and Drug Administration) dated June 23, 1982, under FDA: CRMCS R 001 4092 and is marketed under the name OXYDERMINE.
Un produit connu dans le commerce sous le nom de BIOPROTINE (Marque déposée), consistant en un mélange de 20 à 80 parties, en poids, d'OXXDERMINE et 100 a 200 parties en poids, d'un hydrolysat de protéines liquide, notamment d'un hydrolysat obtenu à partir de collagène, s'est révêlé constituer une forme particulièrement adaptée à l'incorporation des bio-stimulines dans les produits cosmétiques. A product known commercially as BIOPROTIN (Trade Mark), consisting of a mixture of 20 to 80 parts by weight of OXXDERMINE and 100 to 200 parts by weight of a liquid protein hydrolyzate, especially A hydrolyzate obtained from collagen has proved to be a form particularly suitable for the incorporation of bio-stimulins into cosmetic products.
D'autre part, il existe des compositions cosmétiques renfermant des mélanges de substances naturelles, ayant une action cosmétologique et, notamment, des mélanges constituant des complexes biologiques, ayant une composition proche de celle des éléments biologiques de la peau. De tels complexes biologiques sont donc parfaitement tolérés par celle-ci. Leur formulation peut être adaptée au genre d'action a exercer ainsi qu'au type de peau sur lequel ils sont destinés à agir. Par exemple, ces complexes biologiques peuvent exercer une action cosmétologique bio-stimulante, biorégulatrice, bio-hydratante, bio-nettoyante ou bio-équilibrante ou encore une combinaison de ces genres d'actions cosmétologiques. On the other hand, there exist cosmetic compositions containing mixtures of natural substances, having a cosmetic action and, in particular, mixtures constituting biological complexes, having a composition close to that of the biological elements of the skin. Such biological complexes are therefore perfectly tolerated by it. Their formulation can be adapted to the kind of action to be performed as well as the type of skin on which they are intended to act. For example, these biological complexes may exert a cosmetological action bio-stimulating, bioregulatory, bio-moisturizing, bio-cleansing or bio-balancing or a combination of these kinds of cosmetological actions.
La composition cosmétique selon l'invention est caractérisée en ce qu'elle contient un mélange de substances naturelles, ayant une action cosmétologique, ainsi que des bio-stimulines. The cosmetic composition according to the invention is characterized in that it contains a mixture of natural substances, having a cosmetological action, as well as bio-stimulins.
La présente invention résulte de la reconnaissance du fait que, de manière inattendue et pour des raisons qui ne sont pas encore élucidées à ce jour, les actions cosmétologiques de certains complexes biologiques peuvent être renforcées oupotentialisées par les bio-stimulines. The present invention results from the recognition that, unexpectedly and for reasons which have not yet been elucidated, the cosmetological actions of certain biological complexes can be strengthened or potentiated by the bio-stimulins.
Ainsi, dans une composition cosmétique renfermant simul- tanément de tels complexes biologiques et un produit riche en bio-stimulines tel que l'oxydermine ou la bioprotine, l'effet du complexe biologique se manifeste avec une intensité nettement plus élevée que dans une composition ayant une formulation analogue mais ne renfermant pas le produit riche en bio-stimulines.Il est ainsi possible de préparer des compositions cosmétiques ayant une très grande efficacité.Thus, in a cosmetic composition containing simultaneously such biological complexes and a product rich in bio-stimulins such as oxydermine or bioprotin, the effect of the biological complex is manifested with a markedly higher intensity than in a composition having a similar formulation but not containing the product rich in biostimulins.It is thus possible to prepare cosmetic compositions having a very high efficiency.
Avantageusement, le mélange de substances naturelles ayant une action cosmétologique contient de l'acide désoxyribonucléique et/ou de l'acide ribonucléique. Advantageously, the mixture of natural substances having a cosmetic action contains deoxyribonucleic acid and / or ribonucleic acid.
En particulier, des effets particulibrement marqués d'activation par les bio-stimulines de l'action cosmétologique ont été obtenus dans le cas de mélanges de substances naturelles correspondant a l'un des exemples de formulation de complexes biologiques à action cosmétologique suivants
EXEMPLE 1 (Complexe biologique à effet d'optimalisation des fonctions cutanées)
Parties en poids
ADN-LP (extrait de laitance
de poisson, contenant
1,2 % 'ace) : 0,20 a 0,30
ARN : 0,05 à 0,15
Collagène : 0,2= ; 0,35
Sérum de cheval despécifié: 0,50 1,20
Butylène glycol-1,3 : 3,00 à 4,CO
Eau : 2,50 à 3,50
EXEMPLE 2 (Complexe biologique à effet de stimulation des fonctions cutanées)
Parties en poids
ARN : 0,20 a 0,70
Liquide amniotique : 0,70 a 1,50
(provenant de bovins)
Mucopolysaccharide : Ojo à 1,50 Collagène : ,70 0,70 à 1,50
Vitamine E : 0,20 a 0,80
Palmitate de vitamine A : 0,05 à 0,15
AMP cyclique : 0,001
Cytochrome C : 0,001
EXEMPLE 3 (Complexe biologique a effet de régulation des fonctions cutanées) :
Parties en poids :
ARN : 0w20 à 0,80
Soluté d'oligo-élements : 5,00 a 15,00
Vitamine B6 : 0,05 a 0,15
Palmitate de vitamine A : 0,05 a 0,15
AMP cyclique : 0,001
Cytochrome C : 0,001
EXEMPLE 4 (Complexe biologique ayant un effet d'activation des fonctions d'élimination des déchets cutanés)
Parties en poids
Cholestérol : 0,20 à 0,80
Saindoux : 1+00 à 3,00
Crotéine CAA, SF 40 0,20 à 0,80
Lipoprotéol LCO (sel de sodium
et de triéthanolamine de
lipoamino-acide de collagène): 3,00 à 8,00
EXEMPLE 5 (Complexe biologique ayant un effet diactivation des fonctions d'hydratation de la peau)
Parties en poids
Huile de vison : 1,00 à 3,50
Huile de tournesol : 1,00 à 2,50
Syntesqual (nom commercial
d'un polyisoprène constituant
un squalène synthétique) : 0,20 à 0,60
Esters de stérols 0,20 à 0,60
Lécithine de soja : 0,20 à 0,60
Crotéine CAA SF 40 : 0,30 à 1,50
Lactate de sodium : 0,30 à 1,50
Urée : 0,30 à 1,50
Dans les exemples 1 à 5, ci-dessus, les "parties en poids" indiquées correspondent aux quantités d'ingrédient du complexe biologique qui conviennent particulièrement bien pour l'incorporation dans 100 parties en poids de composition cosmétique contenant ce complexe.In particular, particularly marked effects of activation by the bio-stimulins of the cosmetological action have been obtained in the case of mixtures of natural substances corresponding to one of the following examples of formulation of biological complexes with cosmetological action
EXAMPLE 1 (Biological complex with effect of optimizing cutaneous functions)
Parts by weight
LP-DNA (milt extract
of fish, containing
1.2% (ace): 0.20 to 0.30
RNA: 0.05 to 0.15
Collagen: 0.2 =; 0.35
Horse serum despecified: 0.50 1.20
Butylene Glycol-1,3: 3.00 to 4, CO
Water: 2.50 to 3.50
EXAMPLE 2 (Biological complex with effect of stimulation of cutaneous functions)
Parts by weight
RNA: 0.20 to 0.70
Amniotic fluid: 0.70 to 1.50
(from cattle)
Mucopolysaccharide: Ojo to 1.50 Collagen:, 70 0.70 to 1.50
Vitamin E: 0.20 to 0.80
Vitamin A palmitate: 0.05 to 0.15
Cyclic AMP: 0.001
Cytochrome C: 0.001
EXAMPLE 3 (Biological complex with effect of regulation of cutaneous functions):
Parts by weight:
RNA: 0w20 to 0.80
Solute of trace elements: 5.00 to 15.00
Vitamin B6: 0.05 to 0.15
Vitamin A palmitate: 0.05 to 0.15
Cyclic AMP: 0.001
Cytochrome C: 0.001
EXAMPLE 4 (Biological complex having an activation effect of the functions of elimination of cutaneous waste)
Parts by weight
Cholesterol: 0.20 to 0.80
Lard: 1 + 00 to 3,00
CAA Crudein, SF 40 0.20 to 0.80
Lipoproteol LCO (sodium salt
and triethanolamine
lipoamino-collagen acid): 3.00 to 8.00
EXAMPLE 5 (Biological complex having a diactivation effect of the hydration functions of the skin)
Parts by weight
Mink oil: 1.00 to 3.50
Sunflower oil: 1.00 to 2.50
Syntesqual (trade name
of a constituent polyisoprene
synthetic squalene): 0.20 to 0.60
Esters of sterols 0.20 to 0.60
Soy lecithin: 0.20 to 0.60
CAA SF 40 Crotein: 0.30 to 1.50
Sodium lactate: 0.30 to 1.50
Urea: 0.30 to 1.50
In Examples 1 to 5, above, the "parts by weight" indicated correspond to the amounts of ingredient of the biological complex which are particularly suitable for incorporation into 100 parts by weight of cosmetic composition containing this complex.
La "crotéine CAA SF 40" est un mélange d'acides aminés provenant de l'hydrolyse du collagène et ayant la composition suivante
Glycocolle 20 à 35
Proline 13,7 à 18
Hydroxyproline 12,1 à 14,5
Acide glutamique 10 à 11,7
Alanine 8 à ll
Arginine 7,8 à 9
Acide aspartique 5,7 à 7
Lysine 3,9 à 5,2
Le "cytochrome C" est une hémoprotéine, dérivée de la protoporphyrine ferrique, qui joue un rôle fondamental dans les réactions d'oxydation de la chaîne respiratoire.The CAA SF 40 crotein is a mixture of amino acids derived from the hydrolysis of collagen and having the following composition
Glycocolle 20 to 35
Proline 13.7 to 18
Hydroxyproline 12.1 to 14.5
Glutamic acid 10 to 11.7
Alanine 8 to 11
Arginine 7.8 to 9
Aspartic acid 5.7 to 7
Lysine 3.9 to 5.2
"Cytochrome C" is a hemoprotein derived from ferric protoporphyrin, which plays a fundamental role in the oxidation reactions of the respiratory chain.
L'ADN et 1'ARN entrant dans la composition des complexes biologiques susmentionnés peuvent provenir aussi bien du règne animal que du règne végétal et être extraits par tout procédé connu. The DNA and RNA used in the above-mentioned biological complexes can come from both the animal and plant kingdom and can be extracted by any known method.
Avantageusement, on utilise, pour l'activation du complexe biologique, les bio-stimulines sous forme d'un mélange d'oxydermine et d'hydrolysat de protéines liquide et plus particulièrement du produit connu dans le commerce sous le nom de "Bioprotine" (marque déposée). De préférence la quantité de "Bioprotine" incorporée dans 100 parties en poids de composition cosmétique correspond aux proportions suivantes, indiquées en parties en poids
Oxydermine : 0,20 à 0,80
Hydrolysat de protéines
liquide : 1,00 à 2,00
Le produit cosmétique selon l'invention peut éventuellement comprendre, outre les ingrédients actifs susmentionnés, une base cosmétique ou excipient destiné à lui conférer un aspect et une consistance désirés ainsi que des propriétés physico-chimiques appropriées à son application.Advantageously, for the activation of the biological complex, the bio-stimulins are used in the form of a mixture of oxydermine and liquid protein hydrolyzate and more particularly the product known commercially as "Bioprotin" ( trademark). Preferably the amount of "Bioprotin" incorporated in 100 parts by weight of cosmetic composition corresponds to the following proportions, indicated in parts by weight
Oxydermine: 0.20 to 0.80
Protein hydrolyzate
liquid: 1.00 to 2.00
The cosmetic product according to the invention may optionally comprise, in addition to the aforementioned active ingredients, a cosmetic base or excipient intended to give it a desired appearance and consistency as well as physicochemical properties suitable for its application.
Comme base cosmétique ou excipient, on peut utiliser toute matière ou composition appropriée pouvant notamment contenir une certaine quantité d'eau, ainsi que des cyclodextrines, de la glycérine, de la vaseline, etc... As a cosmetic base or excipient, it is possible to use any suitable material or composition that may in particular contain a certain quantity of water, as well as cyclodextrins, glycerine, petrolatum, etc.
D'autre part, le produit cosmétique peut comprendre des vitamines, des agents conservateurs, des antiseptiques, des parfums, des colorants, des désodorisants, des émulsifiants, et, plus généralement, toutes les matières entrant habituellement dans la composition des produits cosmétiques. On the other hand, the cosmetic product may comprise vitamins, preservatives, antiseptics, perfumes, dyes, deodorants, emulsifiers, and, more generally, all the materials usually used in the composition of cosmetic products.
Le produit cosmétique peut se présenter sous toute forme appropriée, notamment sous la forme d'une crème, d'un lait, d'une lotion, d'une émulsion fluide, d'un fluide, d'un gel, d'un sérum, d'un masque de beauté, etc... The cosmetic product may be in any suitable form, especially in the form of a cream, a milk, a lotion, a fluid emulsion, a fluid, a gel or a serum. , a beauty mask, etc ...
La composition et la forme de présentation du produit cosmétique selon l'invention peuvent notamment correspondre à l'un des types indiqués dans les exemples suivants
EXEMPLE 6
(Crème hydratante)
Pourcentage pondéral
Huile de vison 2,10
Huile de tournesol 1,43
Lécithine de soja 0,35
Esters de stérols 0,35
Polyisoprène (= squalène synthétique) 0,35
Urée 1,00
Lactate de sodium 0,60
Amino acides du collagène 1,00
Oxydermine 0,50
Hydrolysat de protéines 1,50
Sorbitol 1,40
Propylène glycol 3,00
Parahydroxybenzoate de méthyle 0,50
Palmitate d'éthyl hexyle 6,00
Alcool cétylique 4,00
Cholestérol de lanoline oxyéthyléné 2,00
Palmitate de sorbitan oxyéthyléné 9,00 p-méthoxycinnamate d'éthyl hexyle 0,60
Cire d'-abeilles 1,00
Palmitostéarate de glycérol 5,00
Parahydroxybenzoate de propyle 0,2
Parfum 0,50
Eau qsp 100,00
Un test d'hydratation de peau,réalisé au moyen c'un appareil (dit "cornéomètre CM 420") permettant de mesurer, à l'aide d'une sonde, la constante diélectrique d'une portion de peau, a permis de mettre en évidence le fait que l'application sur la peau de la crème hydratante ayant la composition indiquée ci-dessus (crème C) permet d'obtenir un taux d'hydratation nettement supérieur à celui que l'on obtient par application d'une crème de même composition mais ne contenant à titre d'ingrédient actif (c'est-à-dire, en plus de la base cosmétique), que la "bio potinez (Oxydermine + hydrolysat de protéines) (crème A) ou que le "complexe biologique hydratant de composition suivante
(Parties en poids)
Huile de vison 2,10
Huile de tournesol 1,40
Lécithine de soja 0,35
Esters de stérols 0,35
Polyisoprène (= squalène
synthétique) 0,35
Urée 1,00
Lactate de sodium 0,60
Amino acides du collagène 1,00
(crème BJ
Les résultats de ce test, effectué sur 7 sujets différents pendant une période de 5 heures, sont reportés au tableau suivant, dans lequel les valeurs indiquées correspondent à des pourcentages d'hydratation (exprimés en une unité arbitraire pour permettre la comparaison).
The composition and the form of presentation of the cosmetic product according to the invention may in particular correspond to one of the types indicated in the following examples.
EXAMPLE 6
(Moisturizer)
Percentage by weight
Mink oil 2.10
Sunflower oil 1.43
Soy Lecithin 0.35
Sterol Esters 0.35
Polyisoprene (= synthetic squalene) 0.35
Urea 1.00
Sodium lactate 0.60
Amino Acids Collagen 1.00
Oxydermine 0.50
Protein hydrolyzate 1.50
Sorbitol 1.40
Propylene glycol 3.00
Methyl parahydroxybenzoate 0.50
Ethyl hexyl palmitate 6.00
Cetyl alcohol 4.00
Oxygenated lanolin cholesterol 2.00
Sorbitan palmitate oxyethylenated 9.00 ethyl hexyl p-methoxycinnamate 0.60
Beeswax 1,00
Glycerol palmitostearate 5.00
Propyl parahydroxybenzoate 0.2
Perfume 0,50
Water qs 100,00
A skin hydration test, carried out by means of a device (called "CM 420 corneometer") making it possible to measure, using a probe, the dielectric constant of a portion of skin, made it possible to put highlight the fact that the application on the skin of the moisturizing cream having the composition indicated above (cream C) makes it possible to obtain a degree of hydration which is definitely higher than that which is obtained by applying a cream of the same composition but containing as an active ingredient (i.e., in addition to the cosmetic base), that the "bio potinez (Oxydermine + protein hydrolyzate) (cream A) or that the" complex Moisturizing organic composition
(Parts by weight)
Mink oil 2.10
Sunflower oil 1.40
Soy Lecithin 0.35
Sterol Esters 0.35
Polyisoprene (= squalene
synthetic) 0.35
Urea 1.00
Sodium lactate 0.60
Amino Acids Collagen 1.00
(BJ cream
The results of this test, carried out on 7 different subjects during a period of 5 hours, are reported in the following table, in which the values indicated correspond to percentages of hydration (expressed in an arbitrary unit to allow comparison).
<tb><Tb>
<SEP> Valeurs <SEP> y <SEP> ratation <SEP> au <SEP> out <SEP> de
<tb> <SEP> 1h <SEP> 2h <SEP> 3h <SEP> 4h <SEP>
<tb> Crème <SEP> wA" <SEP> 100 <SEP> 85 <SEP> 69 <SEP> 46
<tb> Crème <SEP> "B" <SEP> 83 <SEP> 78 <SEP> 61 <SEP> 43
<tb> Crème <SEP> C" <SEP> 98 <SEP> 103 <SEP> 84 <SEP> 61
<tb>
Ces résultats mettent en évidence un net effet de synergie résultant de la combinaison des actions de la "Bioprotine" et du complexe biologique hydratant. <SEP> Values <SEP> y <SEP> failure <SEP> at <SEP> out <SEP> of
<tb><SEP> 1h <SEP> 2h <SEP> 3h <SEP> 4h <SEP>
<tb> Cream <SEP> wA "<SEP> 100 <SEP> 85 <SEP> 69 <SEP> 46
<tb> Cream <SEP>"B"<SEP> 83 <SEP> 78 <SEP> 61 <SEP> 43
<tb> Cream <SEP> C "<SEP> 98 <SEP> 103 <SEP> 84 <SEP> 61
<Tb>
These results highlight a clear synergistic effect resulting from the combination of the actions of "Bioprotin" and the hydrating biological complex.
EXEMPLE 7
(Masque stimulant)
Pourcentage pondéral
Huile de vison 1,50
Huile de tournesol 1,00
Squalène de synthèse 0,25
Esters de stérols et d'acides
gras 0,25
Lécithine de soja 0,25
Huile de vaseline 9,00
Lanoline 10,00
Myristate d'isopropyle 7,00
Parahydroxybenzoate de méthyle 0,30
Glycérol 5,00
Collagène 0,01
Liquide amniotique 2,00
Oxydermine 0,50
Hydrolysat de protéines 1,50
Amidon de mais 10,00
Palmitate de vitamine A 0,10
Vitamine E 0,50
Parfum 0,60
Eau qsp 100,00
EXEMPLE 8
(Lait hydratant)
Pourcentage pondéral
Polyisoprène 0,35
Esters de stérols et d'acides
gras 0,35
Lécithine de soja 0,35
Huile de vison 2,10
Huile de tournesol 1,40
Silicones 14,00
Huile de ricin hydrogénée
oxyéthylénée 1,50
EXEMPLE 8 (Suite)
Pourcentage pondéral
GlycOrol 5,00
Chlorure de sodium 2,00
Parahydroxybenzoate de
méthyle 0,30
Amino acides du collagène 1,00
Urée 1,00
Lactate de sodium 0,60
Pyrrol idone carboxylate
de sodium 0,50
Oxydermine 0,50
Hydrolysat de protéines 1,50
Parfum 0,70
Eau qsp 100,00
La présente invention n'est pas limitée aux exemples de réalisation qui viennent d'être décrits, elle est au contraire susceptible de variantes et de modifications qui apparattront à l'homme de l'art. EXAMPLE 7
(Stimulating mask)
Percentage by weight
Mink oil 1.50
Sunflower oil 1.00
Synthetic Squalene 0.25
Esters of sterols and acids
fat 0.25
Soy Lecithin 0.25
Vaseline oil 9.00
Lanolin 10.00
Isopropyl myristate 7.00
Methyl parahydroxybenzoate 0.30
Glycerol 5.00
Collagen 0.01
Amniotic fluid 2.00
Oxydermine 0.50
Protein hydrolyzate 1.50
Corn starch 10,00
Vitamin A palmitate 0.10
Vitamin E 0.50
Perfume 0.60
Water qs 100,00
EXAMPLE 8
(Hydratant soap)
Percentage by weight
Polyisoprene 0.35
Esters of sterols and acids
fat 0.35
Soy Lecithin 0.35
Mink oil 2.10
Sunflower oil 1.40
Silicones 14,00
Hydrogenated castor oil
oxyethylenated 1.50
EXAMPLE 8 (Continued)
Percentage by weight
GlycOrol 5.00
Sodium chloride 2.00
Parahydroxybenzoate
methyl 0.30
Amino Acids Collagen 1.00
Urea 1.00
Sodium lactate 0.60
Pyrrol idone carboxylate
Sodium 0.50
Oxydermine 0.50
Protein hydrolyzate 1.50
Perfume 0,70
Water qs 100,00
The present invention is not limited to the embodiments which have just been described, it is instead capable of variations and modifications that will occur to those skilled in the art.
Claims (11)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8517166A FR2590169B1 (en) | 1985-11-20 | 1985-11-20 | COSMETIC COMPOSITION CONTAINING BIO-STIMULINS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8517166A FR2590169B1 (en) | 1985-11-20 | 1985-11-20 | COSMETIC COMPOSITION CONTAINING BIO-STIMULINS |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2590169A1 true FR2590169A1 (en) | 1987-05-22 |
FR2590169B1 FR2590169B1 (en) | 1991-03-15 |
Family
ID=9324998
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8517166A Expired - Lifetime FR2590169B1 (en) | 1985-11-20 | 1985-11-20 | COSMETIC COMPOSITION CONTAINING BIO-STIMULINS |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2590169B1 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0260697A3 (en) * | 1986-09-18 | 1988-08-31 | Lion Corporation | Composition for application to hair |
FR2620024A1 (en) * | 1987-09-09 | 1989-03-10 | Dermatologiques Et | Cosmetic composition containing an anti-free-radical agent, and corresponding agent |
WO1989005629A1 (en) * | 1987-12-21 | 1989-06-29 | Gelmex Financing Establishment | Cosmetic preparation |
FR2632186A1 (en) * | 1988-06-03 | 1989-12-08 | Fabre Pierre Cosmetique | DERMATOCOSMETOLOGICAL COMPOSITIONS FOR THE TREATMENT OF SKIN SENESCENCE AND THE PREVENTION OF WRINKLES |
EP0379846A1 (en) * | 1988-11-30 | 1990-08-01 | PROMO INTERNATIONAL S.r.l. | Product for protecting, nourishing and treating the skin |
FR2697750A1 (en) * | 1992-11-06 | 1994-05-13 | Eustatiu Lucien | Cosmetic preparations revitalizing the skin. |
US5520991A (en) * | 1992-11-06 | 1996-05-28 | Eustatiu; Lucien | Cosmetic preparations for revitalizing the skin |
FR2849377A1 (en) * | 2002-12-30 | 2004-07-02 | Jean Noel Thorel | Cosmetic or dermatological skin-treatment composition, useful e.g. for regulating the skin flora, comprises a complex of a specific peptide or protein with a nucleotide or nucleic acid |
FR2849376A1 (en) * | 2002-12-30 | 2004-07-02 | Jean Noel Thorel | Cosmetic or dermatological skin-treatment composition, useful e.g. as a slimming lotion, comprises a complex of specific peptides with a nucleotide or nucleic acid |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1981001514A1 (en) * | 1979-11-28 | 1981-06-11 | Pentapharm Ag | Cosmetic preparation |
FR2533438A2 (en) * | 1979-12-27 | 1984-03-30 | Sederma Sarl | Use of growth factors and biological extracts containing the latter in cosmetology |
JPS6064908A (en) * | 1983-09-20 | 1985-04-13 | Shiseido Co Ltd | Cosmetic |
JPS6064909A (en) * | 1983-09-20 | 1985-04-13 | Shiseido Co Ltd | Cosmetic |
GB2151924A (en) * | 1983-12-28 | 1985-07-31 | Roussel Uclaf | Composition for skin care |
-
1985
- 1985-11-20 FR FR8517166A patent/FR2590169B1/en not_active Expired - Lifetime
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1981001514A1 (en) * | 1979-11-28 | 1981-06-11 | Pentapharm Ag | Cosmetic preparation |
FR2533438A2 (en) * | 1979-12-27 | 1984-03-30 | Sederma Sarl | Use of growth factors and biological extracts containing the latter in cosmetology |
JPS6064908A (en) * | 1983-09-20 | 1985-04-13 | Shiseido Co Ltd | Cosmetic |
JPS6064909A (en) * | 1983-09-20 | 1985-04-13 | Shiseido Co Ltd | Cosmetic |
GB2151924A (en) * | 1983-12-28 | 1985-07-31 | Roussel Uclaf | Composition for skin care |
Non-Patent Citations (2)
Title |
---|
PATENT ABSTRACTS OF JAPAN, vol. 9, no. 196 (C-297)[1919], 13 août 1985; & JP-A-60 64 908 (SHISEIDO K.K.) 13-04-1985 * |
PATENT ABSTRACTS OF JAPAN, vol. 9, no. 196 (C-297)[1919], 13 août 1985; & JP-A-60 64 909 (SHISEIDO K.K.) 13-04-1985 * |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0260697A3 (en) * | 1986-09-18 | 1988-08-31 | Lion Corporation | Composition for application to hair |
FR2620024A1 (en) * | 1987-09-09 | 1989-03-10 | Dermatologiques Et | Cosmetic composition containing an anti-free-radical agent, and corresponding agent |
WO1989005629A1 (en) * | 1987-12-21 | 1989-06-29 | Gelmex Financing Establishment | Cosmetic preparation |
CH674310A5 (en) * | 1987-12-21 | 1990-05-31 | Gelmex Financing Establishment | |
FR2632186A1 (en) * | 1988-06-03 | 1989-12-08 | Fabre Pierre Cosmetique | DERMATOCOSMETOLOGICAL COMPOSITIONS FOR THE TREATMENT OF SKIN SENESCENCE AND THE PREVENTION OF WRINKLES |
EP0346189A1 (en) * | 1988-06-03 | 1989-12-13 | Pierre Fabre Cosmetique | Dermato-cosmetic composition for the treatment of skin aging and for the prevention of wrinkles |
EP0379846A1 (en) * | 1988-11-30 | 1990-08-01 | PROMO INTERNATIONAL S.r.l. | Product for protecting, nourishing and treating the skin |
FR2697750A1 (en) * | 1992-11-06 | 1994-05-13 | Eustatiu Lucien | Cosmetic preparations revitalizing the skin. |
WO1994010974A1 (en) * | 1992-11-06 | 1994-05-26 | Lucien Eustatiu | Cosmetic preparations for revitalising the skin |
US5520991A (en) * | 1992-11-06 | 1996-05-28 | Eustatiu; Lucien | Cosmetic preparations for revitalizing the skin |
FR2849377A1 (en) * | 2002-12-30 | 2004-07-02 | Jean Noel Thorel | Cosmetic or dermatological skin-treatment composition, useful e.g. for regulating the skin flora, comprises a complex of a specific peptide or protein with a nucleotide or nucleic acid |
FR2849376A1 (en) * | 2002-12-30 | 2004-07-02 | Jean Noel Thorel | Cosmetic or dermatological skin-treatment composition, useful e.g. as a slimming lotion, comprises a complex of specific peptides with a nucleotide or nucleic acid |
Also Published As
Publication number | Publication date |
---|---|
FR2590169B1 (en) | 1991-03-15 |
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