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FR2431496A1 - Procede pour la preparation d'esters d'acide 10-bromo-vincaminique et de composes analogues - Google Patents

Procede pour la preparation d'esters d'acide 10-bromo-vincaminique et de composes analogues

Info

Publication number
FR2431496A1
FR2431496A1 FR7918055A FR7918055A FR2431496A1 FR 2431496 A1 FR2431496 A1 FR 2431496A1 FR 7918055 A FR7918055 A FR 7918055A FR 7918055 A FR7918055 A FR 7918055A FR 2431496 A1 FR2431496 A1 FR 2431496A1
Authority
FR
France
Prior art keywords
bromo
preparation
acid esters
similar compounds
vincaminic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7918055A
Other languages
English (en)
Other versions
FR2431496B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HURI000674 external-priority patent/HU177503B/hu
Priority claimed from HURI000672 external-priority patent/HU177502B/hu
Priority claimed from HURI000673 external-priority patent/HU177727B/hu
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of FR2431496A1 publication Critical patent/FR2431496A1/fr
Application granted granted Critical
Publication of FR2431496B1 publication Critical patent/FR2431496B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procédé de préparation d'esters de l'acide 10-bromo-vincaminique racémiques ou optiquement actifs de formule générale :
FR7918055A 1978-07-12 1979-07-11 Procede pour la preparation d'esters d'acide 10-bromo-vincaminique et de composes analogues Granted FR2431496A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HURI000674 HU177503B (hu) 1978-07-12 1978-07-12 Szabadalmi leírás szolgálati találmány
HURI000672 HU177502B (hu) 1978-07-12 1978-07-12 Eljárás 9-bróm-l-alkil-hexahidro-indolo|2,3-alkinolizin-származékok előállítására
HURI000675 1978-07-12
HURI000673 HU177727B (en) 1978-07-12 1978-07-12 Process for preparing 9-halo-1-alkyl-hexahydro-indolo/2,3-a/quinolizine derivatives

Publications (2)

Publication Number Publication Date
FR2431496A1 true FR2431496A1 (fr) 1980-02-15
FR2431496B1 FR2431496B1 (fr) 1983-07-29

Family

ID=27452004

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7918055A Granted FR2431496A1 (fr) 1978-07-12 1979-07-11 Procede pour la preparation d'esters d'acide 10-bromo-vincaminique et de composes analogues
FR8010639A Granted FR2455047A1 (fr) 1978-07-12 1980-05-12 Sels de 1-alkyl-9-bromo-hexahydroindoloquinolizinium, leur procede de preparation, et leur utilisation comme medicament et pour la synthese d'un ester d'acide 10-bromo vincaminique

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8010639A Granted FR2455047A1 (fr) 1978-07-12 1980-05-12 Sels de 1-alkyl-9-bromo-hexahydroindoloquinolizinium, leur procede de preparation, et leur utilisation comme medicament et pour la synthese d'un ester d'acide 10-bromo vincaminique

Country Status (5)

Country Link
US (2) US4315011A (fr)
CH (3) CH653996A5 (fr)
DE (1) DE2928219A1 (fr)
FR (2) FR2431496A1 (fr)
GB (2) GB2036732B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2444037A1 (fr) * 1978-12-15 1980-07-11 Richter Gedeon Vegyeszet Procede de preparation de 10-bromovincamines et composes obtenus
FR2468606A1 (fr) * 1979-10-30 1981-05-08 Richter Gedeon Vegyeszet Procede pour la preparation des derives 11-bromo-e-homo-eburnane
FR2511677A1 (fr) * 1981-08-23 1983-02-25 Richter Gedeon Vegyeszet Procede de preparation d'esters des acides alcoxyvincaminiques et alcoxyapovincaminiques
FR2529551A1 (fr) * 1982-06-30 1984-01-06 Richter Gedeon Vegyeszet Derives d'eburnane-oxime, procede pour leur preparation et compositions pharmaceutiques contenant ces composes

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4315011A (en) * 1978-07-12 1982-02-09 Richter Gedeon Vegyeszeti Gyar Rt. 1-Alkyl-9-bromohexahydroindolo quinolizium salts and use thereof to increase blood flow
HU181941B (en) * 1979-11-23 1983-11-28 Richter Gedeon Vegyeszet Process for producing apovincaminic acid ester derivatives
BE1004471A3 (fr) * 1989-06-21 1992-12-01 Richter Gedeon Vegyeszet Nouveaux derives diester d'octahydro-indolo-[2,3-a]-tetrahydropyranyl [2,3-c] quinolizine racemiques et optiquement actifs et procede pour les preparer.
SE9802974D0 (sv) 1998-09-03 1998-09-03 Astra Ab New crystalline forms

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2081593A1 (en) * 1970-03-31 1971-12-10 Roussel Uclaf Vincamine process
FR2104959A2 (en) * 1970-09-10 1972-04-28 Roussel Uclaf Vincamine process
FR2315273A1 (fr) * 1975-06-27 1977-01-21 Richter Gedeon Vegyeszet Procede de preparation d'indoloquinolizines
FR2444037A1 (fr) * 1978-12-15 1980-07-11 Richter Gedeon Vegyeszet Procede de preparation de 10-bromovincamines et composes obtenus
FR2445328A1 (fr) * 1978-07-12 1980-07-25 Richter Gedeon Vegyeszet Derives du 14-oxo-e-homo-eburnane, leur procede de preparation et leur utilisation comme medicament

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1266201B (de) * 1966-01-11 1968-04-11 Sigri Elektrographit Gmbh Kohle- oder Graphitkoerper mit einer darauf aufgebrachten oxydationshemmenden Schutzschicht, sowie Verfahren zu dessen Herstellung
US3770724A (en) * 1970-03-31 1973-11-06 Roussel Uclaf Process for preparing pentacyclic alkaloids
US3770729A (en) * 1970-12-22 1973-11-06 Yoshitomi Pharmaceutical N substituted piperidine compounds
FR2121360B1 (fr) * 1971-01-06 1974-03-22 Roussel Uclaf
HU163143B (fr) * 1971-05-07 1973-06-28
FR2168853B1 (fr) * 1972-01-24 1975-04-25 Centre Etd Ind Pharma
HU167366B (fr) * 1972-09-06 1975-09-27
SE422798B (sv) * 1973-12-18 1982-03-29 Sandoz Ag Analogiforfarande for framstellning av vincaminderivat
US4146643A (en) * 1973-12-18 1979-03-27 Sandoz Ltd. Increasing vigilance or treating cerebral insufficiency with substituted vincamines
US4156969A (en) * 1976-11-19 1979-06-05 Werber Fred W K R Garment designing aid
US4315011A (en) * 1978-07-12 1982-02-09 Richter Gedeon Vegyeszeti Gyar Rt. 1-Alkyl-9-bromohexahydroindolo quinolizium salts and use thereof to increase blood flow

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2081593A1 (en) * 1970-03-31 1971-12-10 Roussel Uclaf Vincamine process
FR2104959A2 (en) * 1970-09-10 1972-04-28 Roussel Uclaf Vincamine process
FR2315273A1 (fr) * 1975-06-27 1977-01-21 Richter Gedeon Vegyeszet Procede de preparation d'indoloquinolizines
FR2445328A1 (fr) * 1978-07-12 1980-07-25 Richter Gedeon Vegyeszet Derives du 14-oxo-e-homo-eburnane, leur procede de preparation et leur utilisation comme medicament
FR2444037A1 (fr) * 1978-12-15 1980-07-11 Richter Gedeon Vegyeszet Procede de preparation de 10-bromovincamines et composes obtenus

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2444037A1 (fr) * 1978-12-15 1980-07-11 Richter Gedeon Vegyeszet Procede de preparation de 10-bromovincamines et composes obtenus
FR2468606A1 (fr) * 1979-10-30 1981-05-08 Richter Gedeon Vegyeszet Procede pour la preparation des derives 11-bromo-e-homo-eburnane
FR2511677A1 (fr) * 1981-08-23 1983-02-25 Richter Gedeon Vegyeszet Procede de preparation d'esters des acides alcoxyvincaminiques et alcoxyapovincaminiques
FR2529551A1 (fr) * 1982-06-30 1984-01-06 Richter Gedeon Vegyeszet Derives d'eburnane-oxime, procede pour leur preparation et compositions pharmaceutiques contenant ces composes

Also Published As

Publication number Publication date
GB2036732A (en) 1980-07-02
FR2431496B1 (fr) 1983-07-29
CH649999A5 (de) 1985-06-28
CH653996A5 (de) 1986-01-31
US4456607A (en) 1984-06-26
DE2928219A1 (de) 1980-01-24
US4315011A (en) 1982-02-09
GB2106504B (en) 1983-08-03
FR2455047B1 (fr) 1983-07-18
FR2455047A1 (fr) 1980-11-21
GB2106504A (en) 1983-04-13
CH654007A5 (de) 1986-01-31
GB2036732B (en) 1983-05-11

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ST Notification of lapse