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FR2415096A1 - Nouveaux derives de bis(nitrosoureido)-polyols et leur procede de preparation - Google Patents

Nouveaux derives de bis(nitrosoureido)-polyols et leur procede de preparation

Info

Publication number
FR2415096A1
FR2415096A1 FR7820939A FR7820939A FR2415096A1 FR 2415096 A1 FR2415096 A1 FR 2415096A1 FR 7820939 A FR7820939 A FR 7820939A FR 7820939 A FR7820939 A FR 7820939A FR 2415096 A1 FR2415096 A1 FR 2415096A1
Authority
FR
France
Prior art keywords
nitrosoureido
polyols
bis
preparation process
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7820939A
Other languages
English (en)
Other versions
FR2415096B1 (fr
Inventor
Tibor Horvath
Endre Csanyi
Sandor Eckardt
Emilia Kiraly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of FR2415096A1 publication Critical patent/FR2415096A1/fr
Application granted granted Critical
Publication of FR2415096B1 publication Critical patent/FR2415096B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/66—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to halogen atoms or to nitro or nitroso groups
    • C07C275/68—N-nitroso ureas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyurethanes Or Polyureas (AREA)

Abstract

L'invention concerne des dérivés de bisØnitrosouréidoõ-polyols de formule générale : B1 -A- B2 , dans laquelle A est un polyol à chaîne ouverte comportant de 4 à 6 atomes de C ou un polyol cyclique comportant 6 atomes de C ou un polyol cyclique comportant 6 atomes de C, et B1 et B2 , qui peuvent être identiques ou différents et sont liés à deux atomes de C différents de la chaîne A, sont des groupements nitrosouréido- de formule générale :
FR7820939A 1977-12-29 1978-07-13 Nouveaux derives de bis(nitrosoureido)-polyols et leur procede de preparation Granted FR2415096A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU77GO1386A HU176101B (en) 1977-12-29 1977-12-29 Process for producing bis-bracket-nitrozo-ureido-bracket closed-polyol derivatives

Publications (2)

Publication Number Publication Date
FR2415096A1 true FR2415096A1 (fr) 1979-08-17
FR2415096B1 FR2415096B1 (fr) 1982-12-10

Family

ID=10996842

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7820939A Granted FR2415096A1 (fr) 1977-12-29 1978-07-13 Nouveaux derives de bis(nitrosoureido)-polyols et leur procede de preparation

Country Status (28)

Country Link
US (1) US4237273A (fr)
JP (1) JPS5495517A (fr)
AT (1) AT360045B (fr)
AU (1) AU523845B2 (fr)
BE (1) BE868988A (fr)
BG (1) BG30016A3 (fr)
CA (1) CA1108182A (fr)
CH (1) CH639363A5 (fr)
CS (1) CS201010B2 (fr)
DD (1) DD137224A5 (fr)
DE (1) DE2831094A1 (fr)
DK (1) DK155047C (fr)
ES (1) ES471778A1 (fr)
FI (1) FI69058C (fr)
FR (1) FR2415096A1 (fr)
GB (1) GB2011382B (fr)
GR (1) GR64891B (fr)
HU (1) HU176101B (fr)
IL (1) IL55138A (fr)
IT (1) IT1097647B (fr)
NL (1) NL7807587A (fr)
NO (1) NO149960C (fr)
PL (1) PL112198B1 (fr)
PT (1) PT68301A (fr)
RO (1) RO77027A (fr)
SE (1) SE446529B (fr)
YU (1) YU41314B (fr)
ZA (1) ZA783980B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2459231A1 (fr) 1979-06-19 1981-01-09 Anvar Nouveaux derives de la cystamine utiles comme medicaments
JPS5775993A (en) * 1980-10-30 1982-05-12 Tetsuo Suami Novel nitrosourea derivative and its preparation
EP0428849A3 (en) * 1989-09-28 1991-07-31 Hoechst Aktiengesellschaft Retroviral protease inhibitors
EP0538396A1 (fr) * 1990-07-06 1993-04-28 Smithkline Beecham Corporation Inhibiteurs de proteases retrovirales
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH518270A (de) * 1969-03-07 1972-01-31 Hoffmann La Roche Verfahren zur Herstellung von Nitrosoharnstoffverbindungen
JPS5135382B2 (fr) * 1972-08-04 1976-10-01
JPS50128266A (fr) * 1974-03-26 1975-10-09
JPS5126876A (en) * 1974-08-08 1976-03-05 Suami T Shinkina nitorosonyosojudotaino seizohoho
US4066750A (en) * 1976-08-02 1978-01-03 Astra Chemical Products Ab Lactosyl substituted ureides in ruminant feedstuff
JPS5331664A (en) * 1976-09-02 1978-03-25 Suami T Production of novel nitroso urea derivatives
JPS5395917A (en) * 1977-02-03 1978-08-22 Tokyo Tanabe Co Process for preparing nitrosourea derivative of glucopyranose
US4148921A (en) * 1977-07-13 1979-04-10 Suami T Antitumor agents

Also Published As

Publication number Publication date
FI782238A (fi) 1979-06-30
ES471778A1 (es) 1979-02-01
JPS6250461B2 (fr) 1987-10-24
FI69058B (fi) 1985-08-30
DE2831094C2 (fr) 1988-12-15
NO782447L (no) 1979-05-02
PL112198B1 (en) 1980-09-30
BG30016A3 (en) 1981-03-16
DK155047B (da) 1989-01-30
JPS5495517A (en) 1979-07-28
NO149960B (no) 1984-04-16
BE868988A (fr) 1979-01-15
DE2831094A1 (de) 1979-07-12
CS201010B2 (en) 1980-10-31
IL55138A (en) 1982-05-31
FI69058C (fi) 1985-12-10
DK317878A (da) 1979-06-30
NL7807587A (nl) 1979-07-03
GB2011382B (en) 1982-08-18
IL55138A0 (en) 1978-09-29
DK155047C (da) 1989-06-26
AU523845B2 (en) 1982-08-19
RO77027A (fr) 1981-11-04
FR2415096B1 (fr) 1982-12-10
US4237273A (en) 1980-12-02
SE446529B (sv) 1986-09-22
CA1108182A (fr) 1981-09-01
PL208436A1 (pl) 1979-07-02
IT1097647B (it) 1985-08-31
GR64891B (en) 1980-06-06
YU169978A (en) 1982-10-31
AT360045B (de) 1980-12-10
DD137224A5 (de) 1979-08-22
CH639363A5 (de) 1983-11-15
NO149960C (no) 1984-07-25
SE7807804L (sv) 1979-06-30
ATA500178A (de) 1980-05-15
GB2011382A (en) 1979-07-11
AU3802778A (en) 1980-01-17
YU41314B (en) 1987-02-28
ZA783980B (en) 1979-07-25
HU176101B (en) 1980-12-28
IT7825682A0 (it) 1978-07-14
PT68301A (de) 1978-08-01

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Legal Events

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ST Notification of lapse