Nothing Special   »   [go: up one dir, main page]

FR2408561A1 - NEW MONOALKYLANILINS SUBSTITUTED IN POSITION 4, USEFUL AS MEDICINAL PRODUCTS AND METHODS FOR THEIR PREPARATION - Google Patents

NEW MONOALKYLANILINS SUBSTITUTED IN POSITION 4, USEFUL AS MEDICINAL PRODUCTS AND METHODS FOR THEIR PREPARATION

Info

Publication number
FR2408561A1
FR2408561A1 FR7827536A FR7827536A FR2408561A1 FR 2408561 A1 FR2408561 A1 FR 2408561A1 FR 7827536 A FR7827536 A FR 7827536A FR 7827536 A FR7827536 A FR 7827536A FR 2408561 A1 FR2408561 A1 FR 2408561A1
Authority
FR
France
Prior art keywords
useful
new
medicinal products
monoalkylanilins
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7827536A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/836,947 external-priority patent/US4273785A/en
Priority claimed from US05/836,948 external-priority patent/US4198522A/en
Priority claimed from US05/836,949 external-priority patent/US4136256A/en
Priority claimed from US05/836,946 external-priority patent/US4117158A/en
Priority claimed from US05/860,915 external-priority patent/US4154756A/en
Priority claimed from US05/861,736 external-priority patent/US4196208A/en
Priority claimed from US05/874,431 external-priority patent/US4348399A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FR2408561A1 publication Critical patent/FR2408561A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C07C17/2632—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/48—Y being a hydrogen or a carbon atom
    • C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'INVENTION CONCERNE DE NOUVELLES MONOALKILANILINES UTILES NOTAMMENT POUR LE TRAITEMENT DE L'ATHERIOSCLEROSE. ON ADMINISTRE LES MEDICAMENTS SELON L'INVENTION A DES DOSES JOURNALIERES D'ENVIRON 0,35 A 7G D'INGREDIENT ACTIF SOUS FORME DE TABLETTES, PASTILLES, PILULES, CAPSULES ET ANALOGUES CONTENANT ENVIRON 50 A 250MG DE L'INGREDIENT ACTIF PAR DOSE UNITAIRE.THE INVENTION RELATES TO NEW MONOALKILANILINES USEFUL IN PARTICULAR FOR THE TREATMENT OF ATHERIOSCLEROSIS. THE MEDICINAL PRODUCTS ARE ADMINISTERED ACCORDING TO THE INVENTION AT DAILY DOSES OF APPROXIMATELY 0.35 TO 7G OF ACTIVE INGREDIENT IN THE FORM OF TABLETS, PILLS, PILLS, CAPSULES AND THE LIKE CONTAINING ABOUT 50 TO 250MG OF THE ACTIVE INGREDIENT PER UNIT DOSE.

FR7827536A 1977-09-27 1978-09-26 NEW MONOALKYLANILINS SUBSTITUTED IN POSITION 4, USEFUL AS MEDICINAL PRODUCTS AND METHODS FOR THEIR PREPARATION Withdrawn FR2408561A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US05/836,947 US4273785A (en) 1977-09-27 1977-09-27 Benzaldehydes, alkanophenones, and benzophenones and derivatives thereof containing a 4-monoalkylamino group
US05/836,948 US4198522A (en) 1977-09-27 1977-09-27 4-(Monoalkylamino)phenyl carbinols and ester derivatives
US05/836,949 US4136256A (en) 1977-09-27 1977-09-27 4-(monoalkylamino)benzoic acid imidates
US05/836,946 US4117158A (en) 1977-09-27 1977-09-27 4-(monoalkylamino)benzonitriles useful as anti-atherosclerotic agents
US05/860,915 US4154756A (en) 1977-12-15 1977-12-15 2-Substituted-4'-(monoalkylamino)-acetophenones
US05/861,736 US4196208A (en) 1977-12-19 1977-12-19 Certain pyridyl esters of 4-(monoalkylamino) benzoic hydroxyalkanoic acids
US05/874,431 US4348399A (en) 1978-02-02 1978-02-02 Antiatherosclerotic and hypolipidemic 4-(monoalkylamino)phenyl alkane, alkene and alkyne carbinols, aldehydes, carboxylic acids and derivatives

Publications (1)

Publication Number Publication Date
FR2408561A1 true FR2408561A1 (en) 1979-06-08

Family

ID=27569925

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7827536A Withdrawn FR2408561A1 (en) 1977-09-27 1978-09-26 NEW MONOALKYLANILINS SUBSTITUTED IN POSITION 4, USEFUL AS MEDICINAL PRODUCTS AND METHODS FOR THEIR PREPARATION

Country Status (7)

Country Link
DD (1) DD138975A5 (en)
DE (1) DE2841707A1 (en)
DK (1) DK424378A (en)
FI (1) FI782932A (en)
FR (1) FR2408561A1 (en)
GB (1) GB2007661A (en)
NL (1) NL7809759A (en)

Also Published As

Publication number Publication date
FI782932A (en) 1979-03-28
DK424378A (en) 1979-03-27
GB2007661A (en) 1979-05-23
DE2841707A1 (en) 1979-04-05
NL7809759A (en) 1979-03-29
DD138975A5 (en) 1979-12-05

Similar Documents

Publication Publication Date Title
UA29450C2 (en) Derivatives of hydroxamic acid, a PROCESS for PREPARATION thereof, a method for influence on diseases and pharmaceutical composition containing them
KR930702022A (en) Treatment or prevention of type 1 diabetes by oral administration of insulin
BE855409A (en) PHARMACEUTICAL COMPOSITIONS CONTAINING A PURIFIED EXTRACT OF GINSENG ROOTS AND PROCESS FOR THE PREPARATION OF SUCH EXTRACT
BG104727A (en) Pharmaceutical composition of topiramate
HU892559D0 (en) Process for the preparation of transdermal pharmaceutical composition suitable for systemic administration, containing deprenyl as active ingredient
FR2430403A1 (en) NOVEL 15-DEOXY-16-HYDROXY-PROSTAGLANDINS, THEIR PRODUCTION PROCESS AND MEDICAMENTS CONTAINING THEM
FR2698788B1 (en) Effervescent pharmaceutical composition containing ibuprofen and process for its preparation.
EP0279149A3 (en) Benzimidazole derivatives, process for their production and a pharmaceutical composition containing the same
MY103741A (en) Process for producing an administration and/or dosage form for medicinal active substances by means of a printing process
IT1170214B (en) PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF PERIPHERAL ARTERIOPATHIES
ES2063432T3 (en) ORAL PHARMACEUTICAL COMPOUNDS OF UNIT DOSE.
FR2376858A1 (en) NEW IMIDAZO (1,2-A) QUINOXALINES SUBSTITUTED IN POSITION 4, THEIR PROCESS OF PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM
FR2393577A1 (en) B- (P-HALOGENOPHENYL) -G-AMINOBUTYRIC ACID BASED MEDICINAL PRODUCT FOR THE TREATMENT OF ANXIETY NEPROSIS
FR2420346A1 (en) MEDICINAL PRODUCTS CONTAINING ALCENYLXANTHINS AND THEIR PREPARATION PROCESS
DE2967356D1 (en) Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them
OA07029A (en) Gallium chloride, a new anti-cancer drug.
CA2078869A1 (en) Pharmaceutical compositions containing ipriflavone, process for the preparation thereof and relative therapeutic use
KR890004705A (en) Antiviral agents
BE867085A (en) TRIAZINES-1,2,4 PHARMACOLOGICALLY ACTIVE SUBSTITUTES AND MEDICINAL PRODUCTS CONTAINING THESE TRIAZINES
FR2408561A1 (en) NEW MONOALKYLANILINS SUBSTITUTED IN POSITION 4, USEFUL AS MEDICINAL PRODUCTS AND METHODS FOR THEIR PREPARATION
PT80961B (en) Process for the preparation of new pharmaceutical compounds containing mixtures of 4,9-dihydro-4-(1-methyl-4-piperydilene)-10h-benzoý4,5¨-cycloheptaý1,2-b¨thyophene-10-one and antiasthmati c xantines as active ingredient
JPS5551019A (en) Drug containing alllee or 133zz7*88dehydroo retine acid and manufacture thereof
FR2673105B1 (en) NOVEL PHARMACEUTICAL COMPOSITIONS, ESPECIALLY FOR THE TREATMENT OF FUNCTIONAL COLOPATHIES, AND METHODS OF PREPARING COMPOSITIONS AND MEDICAMENTS, ESPECIALLY FOR THE TREATMENT OF THESE CONDITIONS.
US3222253A (en) Antimitotic colchicines
DE3372772D1 (en) Quinazolinone derivatives, process for their preparation and their use in medicaments

Legal Events

Date Code Title Description
ST Notification of lapse