FR2453862A1 - Derives d'acide peneme-3- carboxylique leurs procedes de preparation et leur application en therapeutique - Google Patents
Derives d'acide peneme-3- carboxylique leurs procedes de preparation et leur application en therapeutiqueInfo
- Publication number
- FR2453862A1 FR2453862A1 FR8008137A FR8008137A FR2453862A1 FR 2453862 A1 FR2453862 A1 FR 2453862A1 FR 8008137 A FR8008137 A FR 8008137A FR 8008137 A FR8008137 A FR 8008137A FR 2453862 A1 FR2453862 A1 FR 2453862A1
- Authority
- FR
- France
- Prior art keywords
- peneme
- carboxylic acid
- acid derivatives
- preparation methods
- therapeutic application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000002360 preparation method Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- -1 2-AMINOETHYL Chemical class 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical class C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 abstract 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 241000589516 Pseudomonas Species 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4405079A JPS55153789A (en) | 1979-04-11 | 1979-04-11 | Penem-3-carboxylic acid derivative and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2453862A1 true FR2453862A1 (fr) | 1980-11-07 |
Family
ID=12680777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8008137A Withdrawn FR2453862A1 (fr) | 1979-04-11 | 1980-04-11 | Derives d'acide peneme-3- carboxylique leurs procedes de preparation et leur application en therapeutique |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS55153789A (es) |
| AU (1) | AU5729180A (es) |
| BE (1) | BE882764A (es) |
| DD (1) | DD152561B2 (es) |
| DE (1) | DE3013997A1 (es) |
| DK (1) | DK154180A (es) |
| ES (1) | ES8202015A1 (es) |
| FI (1) | FI801168A (es) |
| FR (1) | FR2453862A1 (es) |
| GB (1) | GB2048261A (es) |
| IT (1) | IT8067576A0 (es) |
| NL (1) | NL8002147A (es) |
| NO (1) | NO801046L (es) |
| PL (1) | PL223390A1 (es) |
| SE (1) | SE8002708L (es) |
| ZA (1) | ZA802155B (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0499196A1 (en) * | 1991-02-13 | 1992-08-19 | Fujisawa Pharmaceutical Co., Ltd. | Intermediates and process for preparing carbapenem derivatives |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5625110A (en) * | 1978-12-18 | 1981-03-10 | Bristol Myers Co | Antibacterial |
| EP0041768B1 (en) * | 1980-04-24 | 1987-11-11 | Beecham Group Plc | Beta-lactam compounds, their preparation and use |
| JPS58198486A (ja) * | 1982-05-14 | 1983-11-18 | Sankyo Co Ltd | ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法 |
| JPS5835190A (ja) * | 1981-08-25 | 1983-03-01 | Sankyo Co Ltd | ペネム−３−カルボン酸誘導体 |
| JPS5857360A (ja) * | 1981-10-01 | 1983-04-05 | Ajinomoto Co Inc | アゼチジノン誘導体 |
| CA1190236A (en) | 1981-10-23 | 1985-07-09 | Edward J.J. Grabowski | Antibiotic synthesis |
| AT379399B (de) * | 1981-12-11 | 1985-12-27 | Erba Farmitalia | Verfahren zur herstellung von optisch aktiven penemen |
| US4431654A (en) * | 1982-04-05 | 1984-02-14 | Schering Corporation | 6-(Hydroxyethyl)-2-[(heterocyclyl or aryl)thioalkylthio]-penem-3-carboxylates |
| US4610823A (en) * | 1983-01-25 | 1986-09-09 | Merck & Co., Inc. | Process for preparing substituted 2-thioxopenams and 2-substituted thiopenems |
| EP0115308A3 (en) * | 1983-01-25 | 1984-10-10 | Merck & Co. Inc. | 2-unsaturated alkylthio-pen-2-em-3-carboxylic acids and process for preparing substituted 2-thioxopenams and 2-substituted thiopenems |
| US4504485A (en) * | 1983-04-04 | 1985-03-12 | Schering Corporation | 5R,6S,8R-6-(1-Hydroxyethyl)-2-(2-carbamoyloxyethylthio)-penem-3-carboxylic acid |
| GB8321004D0 (en) * | 1983-08-04 | 1983-09-07 | Erba Farmitalia | Azetidinones |
| US5075439A (en) * | 1990-08-17 | 1991-12-24 | Pfizer Inc. | Processes for (3S,4R)-3-[1(R)-t-butyl-dimethylsilyloxy)-ethyl]-4-[1-oxo-3-thiolanylthio(thiocarbonyl)thio]azetidin-2-ones and intermediates therefor |
| GB2252769A (en) * | 1991-01-18 | 1992-08-19 | Pfizer | Improved process for azetidin-2-ones and intermediates therefor |
| GB9913932D0 (en) * | 1999-06-15 | 1999-08-18 | Pfizer Ltd | Purine derivatives |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2291748A1 (fr) * | 1974-11-25 | 1976-06-18 | Merck & Co Inc | Nouvel antibiotique utile contre les micro-organismes gram-negatifs et gram-positifs et son procede de preparation |
| EP0002210A1 (en) * | 1977-11-17 | 1979-06-13 | Merck & Co. Inc. | 6- and 6,6- disubstituted-2-substituted-pen-2-em-3-carboxylic acids; processes for their preparation and pharmaceutical compositions containing such compounds |
| GB2013674A (en) * | 1978-02-02 | 1979-08-15 | Ciba Geigy Ag | 6-substituted thia-aza compunds |
| EP0013662A1 (en) * | 1979-01-10 | 1980-07-23 | Schering Corporation | 2-Penem compounds, a method for their preparation and pharmaceutical compositions comprising them |
-
1979
- 1979-04-11 JP JP4405079A patent/JPS55153789A/ja active Granted
-
1980
- 1980-04-10 DK DK154180A patent/DK154180A/da not_active IP Right Cessation
- 1980-04-10 ZA ZA00802155A patent/ZA802155B/xx unknown
- 1980-04-10 SE SE8002708A patent/SE8002708L/xx unknown
- 1980-04-11 NL NL8002147A patent/NL8002147A/xx not_active Application Discontinuation
- 1980-04-11 DE DE19803013997 patent/DE3013997A1/de not_active Withdrawn
- 1980-04-11 FI FI801168A patent/FI801168A/fi not_active Application Discontinuation
- 1980-04-11 IT IT8067576A patent/IT8067576A0/it unknown
- 1980-04-11 NO NO80801046A patent/NO801046L/no unknown
- 1980-04-11 GB GB8012001A patent/GB2048261A/en not_active Withdrawn
- 1980-04-11 PL PL22339080A patent/PL223390A1/xx unknown
- 1980-04-11 BE BE0/200208A patent/BE882764A/fr unknown
- 1980-04-11 ES ES490510A patent/ES8202015A1/es not_active Expired
- 1980-04-11 DD DD80220392A patent/DD152561B2/xx unknown
- 1980-04-11 FR FR8008137A patent/FR2453862A1/fr not_active Withdrawn
- 1980-04-11 AU AU57291/80A patent/AU5729180A/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2291748A1 (fr) * | 1974-11-25 | 1976-06-18 | Merck & Co Inc | Nouvel antibiotique utile contre les micro-organismes gram-negatifs et gram-positifs et son procede de preparation |
| EP0002210A1 (en) * | 1977-11-17 | 1979-06-13 | Merck & Co. Inc. | 6- and 6,6- disubstituted-2-substituted-pen-2-em-3-carboxylic acids; processes for their preparation and pharmaceutical compositions containing such compounds |
| US4168314A (en) * | 1977-11-17 | 1979-09-18 | Merck & Co., Inc. | 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid |
| GB2013674A (en) * | 1978-02-02 | 1979-08-15 | Ciba Geigy Ag | 6-substituted thia-aza compunds |
| EP0013662A1 (en) * | 1979-01-10 | 1980-07-23 | Schering Corporation | 2-Penem compounds, a method for their preparation and pharmaceutical compositions comprising them |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0499196A1 (en) * | 1991-02-13 | 1992-08-19 | Fujisawa Pharmaceutical Co., Ltd. | Intermediates and process for preparing carbapenem derivatives |
| US5306816A (en) * | 1991-02-13 | 1994-04-26 | Fujisawa Pharmaceutical Co., Ltd. | Processes for preparing carbapenem derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| NO801046L (no) | 1980-10-13 |
| DE3013997A1 (de) | 1980-10-30 |
| FI801168A (fi) | 1980-10-12 |
| BE882764A (fr) | 1980-10-13 |
| NL8002147A (nl) | 1980-10-14 |
| ZA802155B (en) | 1981-05-27 |
| SE8002708L (sv) | 1980-10-12 |
| GB2048261A (en) | 1980-12-10 |
| JPS55153789A (en) | 1980-11-29 |
| ES490510A0 (es) | 1981-04-16 |
| ES8202015A1 (es) | 1981-04-16 |
| DK154180A (da) | 1980-10-12 |
| JPH0372630B2 (es) | 1991-11-19 |
| DD152561A5 (de) | 1981-12-02 |
| PL223390A1 (es) | 1981-01-30 |
| DD152561B2 (de) | 1981-12-02 |
| AU5729180A (en) | 1980-10-16 |
| IT8067576A0 (it) | 1980-04-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR2453862A1 (fr) | Derives d'acide peneme-3- carboxylique leurs procedes de preparation et leur application en therapeutique | |
| ATE505206T1 (de) | Verwendung des melanomdifferenzierungs assoziierten gens (mda-7) zur umwandlung eines krebsphänotyps | |
| BG102583A (en) | Phenylthiazole derivatives having antiherpesviral properties | |
| MA23850A1 (fr) | Procede de preparation de compositions vaccinantes | |
| MA23918A1 (fr) | Procede de preparation de compositions vaccinantes | |
| MA23143A1 (fr) | Procede pour la preparation de compositions vaccinantes . | |
| NO924915D0 (no) | Sakkarinderivater med inhiberende virkning paa protolytiske enzymer | |
| SE8001736L (sv) | Indolerivat med terapeutisk verkan jemte sett for deras framstellning | |
| WO1999038877A3 (en) | 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | |
| EP0950657A3 (en) | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitors | |
| MA23118A1 (fr) | Procede pour la preparation de compositions de vaccins contre la grippe . | |
| GB2250466B (en) | Method for the manufacture of golf club shafts | |
| IL106935A0 (en) | Substituted cyclohexane derivatives for the treatment of diseases | |
| EP0379145A3 (en) | Substituted quinolinecarboxylic acids | |
| KR0148213B1 (en) | Phenyla lkan(en)oic acid and pharmaceutical composition comprising the same | |
| FR2311093A1 (fr) | Procede de preparation d'un composant consistant d'un sucre, d'un lipide, d'une proteine, derive de la pseudomonas aeruginosa qui possede des proprietes inductrices antitumeur et d'intervention | |
| MA21265A1 (fr) | Procede de preparation d'acide 5r, 6s-6- (1r-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxyliques diastere-isomeriques. | |
| SE8105079L (sv) | Antibiotikum bmg162-af2 | |
| SE8500965D0 (sv) | Mellanprodukter for framstellning av beta-laktamasinhibitorer | |
| FR2842210B1 (fr) | Determinants de pathogenicite utilisables comme cibles pour l'elaboration de moyens de prevention et de controle d'infections bacteriennes et/ou de la dissemination systemique | |
| FR2450831A1 (fr) | Derives de theobromine, leur preparation et leurs applications therapeutiques | |
| DE3176461D1 (en) | An orally administrable drug form comprising a beta-lactam antibiotic and an adjuvant | |
| AU2128892A (en) | N-substituted aminomethanediphosphonic acids | |
| DE3062787D1 (en) | Novel process for the preparation of 6-aminopenicillanic acid-1,1-dioxide and its salts | |
| FR2688503B1 (fr) | Procede de preparation de derives de 2-(tetrazol-5-yl)-[1,1'-biphenyle]. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |