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FR2291754A2 - 4-(Trimethoxycinnamoyl) piperazin-1-ylacetamides - for treating peripheral, coronary and cerebral circulatory insufficiency, and hypertension - Google Patents

4-(Trimethoxycinnamoyl) piperazin-1-ylacetamides - for treating peripheral, coronary and cerebral circulatory insufficiency, and hypertension

Info

Publication number
FR2291754A2
FR2291754A2 FR7438203A FR7438203A FR2291754A2 FR 2291754 A2 FR2291754 A2 FR 2291754A2 FR 7438203 A FR7438203 A FR 7438203A FR 7438203 A FR7438203 A FR 7438203A FR 2291754 A2 FR2291754 A2 FR 2291754A2
Authority
FR
France
Prior art keywords
ylacetamides
trimethoxycinnamoyl
piperazin
coronary
hypertension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7438203A
Other languages
French (fr)
Other versions
FR2291754B2 (en
Inventor
Claude Fauran
Guy Raynaud
Bernard Pourrias
Michel Turin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7438203A priority Critical patent/FR2291754A2/en
Priority to GB4428375A priority patent/GB1473262A/en
Priority to ZA00756774A priority patent/ZA756774B/en
Priority to IN2075/CAL/1975A priority patent/IN142964B/en
Priority to BE161327A priority patent/BE834957R/en
Priority to LU73671A priority patent/LU73671A1/xx
Priority to CH1411175A priority patent/CH580091A5/xx
Priority to DE2550851A priority patent/DE2550851C2/en
Priority to JP50136403A priority patent/JPS609506B2/en
Priority to AU86658/75A priority patent/AU503778B2/en
Priority to CA239,824A priority patent/CA1054151A/en
Priority to SE7513011A priority patent/SE417515B/en
Priority to NL7513538A priority patent/NL7513538A/en
Priority to IT69852/75A priority patent/IT1055691B/en
Priority to SU752190956A priority patent/SU592357A3/en
Priority to ES442845A priority patent/ES442845A2/en
Priority to US05/633,932 priority patent/US4029650A/en
Publication of FR2291754A2 publication Critical patent/FR2291754A2/en
Application granted granted Critical
Publication of FR2291754B2 publication Critical patent/FR2291754B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

4, 5-Trimethoxycinnamoyl)piperazin-1-ylacetamides of formula (I) are new: (where is piperidino, heptamethyleneimino or 1,2,3,4-tetrahydroisoquinoleino; or R1 is 1-4C alkyl and R2 is dimethoxyphenylethyl). I(R1=Me; R2=3, 4-dimethoxyphenylethyl). is specif. claimed. Cpds. (I) are prepd. by condensn. of the corresp. acid with the amine using butyl chloroformate in presence of NEt3 in THF.
FR7438203A 1969-04-02 1974-11-20 4-(Trimethoxycinnamoyl) piperazin-1-ylacetamides - for treating peripheral, coronary and cerebral circulatory insufficiency, and hypertension Granted FR2291754A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR7438203A FR2291754A2 (en) 1974-11-20 1974-11-20 4-(Trimethoxycinnamoyl) piperazin-1-ylacetamides - for treating peripheral, coronary and cerebral circulatory insufficiency, and hypertension
GB4428375A GB1473262A (en) 1974-11-20 1975-10-28 Derivatives of n-3,4,5-trimethoxy cinnamoyl-piperazine their process of preparation and their therapeutic application
ZA00756774A ZA756774B (en) 1974-11-20 1975-10-28 Novel derivatives of n-(3,4,5-trimethoxy cinnamoyl) piperazine, the process for preparing them
IN2075/CAL/1975A IN142964B (en) 1969-04-02 1975-10-28
BE161327A BE834957R (en) 1974-11-20 1975-10-28 N- (TRIMETHOXY-3,4,5 CINNAMOYL) PIPERAZINE DERIVATIVES AND THEIR PREPARATION PROCESS
LU73671A LU73671A1 (en) 1974-11-20 1975-10-29
CH1411175A CH580091A5 (en) 1974-11-20 1975-10-31
DE2550851A DE2550851C2 (en) 1974-11-20 1975-11-12 N- (3,4,5-trimethoxycinnamoyl) -N'- (carbonylmethyl-piperazine derivatives, their acid addition salts, processes for their preparation and pharmaceuticals containing these compounds
JP50136403A JPS609506B2 (en) 1974-11-20 1975-11-14 Method for producing a novel N-(3,4,5-trimethoxycinnamoyl)piperazine derivative
AU86658/75A AU503778B2 (en) 1974-11-20 1975-11-14 Derivatives of n-(3, 4, 5-trimethoxy cinnamoyl) piperazine
CA239,824A CA1054151A (en) 1974-11-20 1975-11-17 Derivatives of n-(3,4,5-trimethoxycinnamoyl) piperazine, their process of preparation and their therapeutic applications
SE7513011A SE417515B (en) 1974-11-20 1975-11-19 SET TO MAKE N- (3,4,5-TRIMETOXICINNAMOYL) -N '- (PIPERIDINOCARBONYLMETHYL) -PIPERAZINE
NL7513538A NL7513538A (en) 1974-11-20 1975-11-19 PROCEDURE FOR THE PREPARATION OF NEW PIPERAZINE COMPOUNDS, AND THEIR USE IN MEDICINAL PRODUCTS.
IT69852/75A IT1055691B (en) 1974-11-20 1975-11-19 DERIVATIVES OF N TRIMETOSSI 3,4,5, CINNAMOIL PIPERAZINE THEIR APPLICATION IN THERAPY
SU752190956A SU592357A3 (en) 1974-11-20 1975-11-20 Method of preparing derivatives of n-(3,4,5-trimethoxycinnamoyl)-piperazine
ES442845A ES442845A2 (en) 1974-11-20 1975-11-20 Novel derivatives of N-(3,4,5-trimethoxy cinnamoyl)piperazine and the process for preparing them
US05/633,932 US4029650A (en) 1974-11-20 1975-11-20 Novel derivatives of N-(3,4,5-trimethoxy cinnamoyl)piperazine and the process for preparing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7438203A FR2291754A2 (en) 1974-11-20 1974-11-20 4-(Trimethoxycinnamoyl) piperazin-1-ylacetamides - for treating peripheral, coronary and cerebral circulatory insufficiency, and hypertension

Publications (2)

Publication Number Publication Date
FR2291754A2 true FR2291754A2 (en) 1976-06-18
FR2291754B2 FR2291754B2 (en) 1978-07-28

Family

ID=9145105

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7438203A Granted FR2291754A2 (en) 1969-04-02 1974-11-20 4-(Trimethoxycinnamoyl) piperazin-1-ylacetamides - for treating peripheral, coronary and cerebral circulatory insufficiency, and hypertension

Country Status (3)

Country Link
BE (1) BE834957R (en)
FR (1) FR2291754A2 (en)
ZA (1) ZA756774B (en)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHIMIE THERAPEUTIQUE 1969, 4, PAGES 293-297) *

Also Published As

Publication number Publication date
BE834957R (en) 1976-04-28
FR2291754B2 (en) 1978-07-28
ZA756774B (en) 1976-10-27

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