FR2279383A1 - N-(4,4-diphenyl-butyl)-substd alkylene-diamines - cardiovascular agents suitable for treatment of angina - Google Patents
N-(4,4-diphenyl-butyl)-substd alkylene-diamines - cardiovascular agents suitable for treatment of anginaInfo
- Publication number
- FR2279383A1 FR2279383A1 FR7414355A FR7414355A FR2279383A1 FR 2279383 A1 FR2279383 A1 FR 2279383A1 FR 7414355 A FR7414355 A FR 7414355A FR 7414355 A FR7414355 A FR 7414355A FR 2279383 A1 FR2279383 A1 FR 2279383A1
- Authority
- FR
- France
- Prior art keywords
- angina
- treatment
- opt
- agents suitable
- cardiovascular agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
- C07C17/354—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction by hydrogenation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Cpds. of formula (I) and their acid addition salts. (where X is H or halo, n is 1-4, R1 R2 are each opt. branched, opt. satd. 1-6C aliphatic hydrocarbyl m is 1-5, Y is O, -OOC- or -CONH- R4, R5, R6 are each H, halo, R7 OR7 or -COR7 R7 is opt. branched 1-4C alkyl) are Cardiovascular agents suitable for treatment of angina which have superior properties to those of lidoflazine. They are administered orally (daily dose 40-400 m), as suppositories (10-100 mg daily) or parenterally (10-150 mg daily). Pharmacological tests show (I) increase cardiac flow, lower peripheral resistance, increase coronary flow, lower myocardial oxygen consumption and increase cardiac yield.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7414355A FR2279383A1 (en) | 1974-04-25 | 1974-04-25 | N-(4,4-diphenyl-butyl)-substd alkylene-diamines - cardiovascular agents suitable for treatment of angina |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7414355A FR2279383A1 (en) | 1974-04-25 | 1974-04-25 | N-(4,4-diphenyl-butyl)-substd alkylene-diamines - cardiovascular agents suitable for treatment of angina |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2279383A1 true FR2279383A1 (en) | 1976-02-20 |
FR2279383B1 FR2279383B1 (en) | 1978-07-21 |
Family
ID=9138092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7414355A Granted FR2279383A1 (en) | 1974-04-25 | 1974-04-25 | N-(4,4-diphenyl-butyl)-substd alkylene-diamines - cardiovascular agents suitable for treatment of angina |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2279383A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0293925A2 (en) * | 1987-06-05 | 1988-12-07 | Simes, Societa Italiana Medicinali E Sintetici, S.P.A. | Compound active in cardiovascular therapy |
EP0421762A1 (en) * | 1989-10-03 | 1991-04-10 | Philip Morris Products Inc. | Novel nicotine analogs and method |
ES2074946A1 (en) * | 1993-07-19 | 1995-09-16 | Ferrer Int | New n,n,n',n'-tetrasubstituted-1,2-ethanediamine derivative compounds. |
-
1974
- 1974-04-25 FR FR7414355A patent/FR2279383A1/en active Granted
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0293925A2 (en) * | 1987-06-05 | 1988-12-07 | Simes, Societa Italiana Medicinali E Sintetici, S.P.A. | Compound active in cardiovascular therapy |
EP0293925A3 (en) * | 1987-06-05 | 1989-02-15 | Simes, Societa Italiana Medicinali E Sintetici, S.P.A. | Compound active in cardiovasular therapy |
US4988735A (en) * | 1987-06-05 | 1991-01-29 | Simes | Ethylene diamine active cardiovascular therapy |
EP0421762A1 (en) * | 1989-10-03 | 1991-04-10 | Philip Morris Products Inc. | Novel nicotine analogs and method |
ES2074946A1 (en) * | 1993-07-19 | 1995-09-16 | Ferrer Int | New n,n,n',n'-tetrasubstituted-1,2-ethanediamine derivative compounds. |
US5561135A (en) * | 1993-07-19 | 1996-10-01 | Ferrer Internacional, S.A. | N,N,N',N'-tetrasubstituted-1,2-ethanediamine derivative compounds |
Also Published As
Publication number | Publication date |
---|---|
FR2279383B1 (en) | 1978-07-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |